Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells

Journal of Antibiotics

Volumn 54, Issue 12, 2001, Pages 1104-1107

  Takemoto, Yasushi ^a   Nake, Koichi ^a   Kawatani, Makoto ^a   Takahashi, Yoshikazu ^a   Naganawa, Hiroshi ^a   Imoto, Masaya ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CLARITHROMYCIN; DOXORUBICIN; ERYTHROMYCIN; MACROLIDE; MIGRASTATIN; PENDOLMYCIN; PROTEIN BCL 2; PROTEIN BCL X; TELEOCIDIN; TELEOCIDIN B; UNCLASSIFIED DRUG; VINBLASTINE;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; BINDING ASSAY; CANCER GROWTH; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG PURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; MASS SPECTROMETRY; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STREPTOMYCES; ULTRAVIOLET SPECTROSCOPY;

EID: 0035700559     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.1104     Document Type: Note

References (8)

1. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities
2. Similarity of teleocidin B and phorbol ester tumor promoters in effects on membrane receptors
3. Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis
4. Migrastatin, a novel 14-membered lactone from Streptomyces sp. MK929-43F1
5. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility
6. A microplate assay for quantitation of anchorage-independent growth of transformed cells
7. FAK integrates growth-factor and integrin signals to promote cell migration
8. Integrins and anoikis