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Volumn 41, Issue 3, 2002, Pages 512-515
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The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: Discovery of a new method to generate cis-propenyl amides
c
a,b
c
NONE
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Author keywords
Biaryls; Inhibitors; Macrolactamization; Rearrangement; Total synthesis
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Indexed keywords
STEREOCHEMISTRY;
SYNTHESIS (CHEMICAL);
DEHYDROXYLATION;
ENZYMES;
AMIDE;
CYCLOPEPTIDE;
CYSTEINE PROTEINASE;
MULTIENZYME COMPLEX;
PROTEASOME;
PROTEASOME INHIBITOR;
TMC 95A;
TMC 95B;
TMC-95A;
TMC-95B;
UNCLASSIFIED DRUG;
ARTICLE;
CELL MEMBRANE PERMEABILITY;
CHEMICAL STRUCTURE;
CHEMISTRY;
DRUG SYNTHESIS;
FERMENTATION;
HYDROXYLATION;
IC 50;
ISOMER;
STEREOCHEMISTRY;
STEREOISOMERISM;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
DRUG ANTAGONISM;
AMIDES;
CYSTEINE ENDOPEPTIDASES;
MOLECULAR STRUCTURE;
MULTIENZYME COMPLEXES;
PEPTIDES, CYCLIC;
STEREOISOMERISM;
SUPPORT, U.S. GOV'T, NON-P.H.S.;
SUPPORT, U.S. GOV'T, P.H.S.;
PROTEASOME ENDOPEPTIDASE COMPLEX;
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EID: 0036462506
PISSN: 14337851
EISSN: None
Source Type: Journal
DOI: 10.1002/1521-3773(20020201)41:3<512::AID-ANIE512>3.0.CO;2-R Document Type: Article |
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Times cited : (127)
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References (30)
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