A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle

Gene Therapy

Volumn 7, Issue 11, 2000, Pages 986-991

  Lemieux, P ^a   Guerin N ^a   Paradis, G ^a   Proulx, R ^a   Chistyakova, L ^a   Kabanov, A ^b   Alakhov, V ^a  

^a Supratek Pharma Inc   (Canada)

^b NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Erythropoietin; Gene expression; Plasmid DNA; Poloxamer; Skeletal muscle; SP1017

Indexed keywords

BETA GALACTOSIDASE; ERYTHROPOIETIN; EXCIPIENT; LUCIFERASE; PLASMID DNA; POLOXAMER; POVIDONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HEMATOCRIT; MALE; MEDICAL LITERATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; SKELETAL MUSCLE; TOXICITY;

ANIMALIA;

EID: 0034044578     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301189     Document Type: Article

References (37)

1. Wolff JA et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.
2. Ragot T et al. Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature 1993; 361: 647-650.
3. Alila H et al. Expression of biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmid in rats. Hum Gene Ther 1997; 15: 1785-95.
4. Tokui M et al. Intramuscular injection of expression plasmid DNA is an effective means of long-term systemic delivery of interleukin-5. Biochem Biophys Res Commun 1997; 233: 527-531.
5. Tripathy SK et al. Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. Proc Natl Acad Sci USA 1996; 93: 10876-10880.
6. Manthorpe M et al. Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Hum Gene Ther 1993; 4: 419-431.
7. Blezinger P et al. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nat Biotechnol 1999; 17: 343-347.
8. Davis HL. DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus. Mt Sinai J Med 1999; 66: 84-90.
9. Mahvi DM et al. Particle-mediated gene transfer of granulocyte-macrophage colony-stimulating factor cDNA to tumor cells: implications for a clinically relevant tumor vaccine. Hum Gene Ther 1996; 20: 1535-1543.
10. Wolff JA et al. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum Mol Genet 1992; 1: 363-369.
11. Danko I et al. Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Therapy 1994; 1: 114-121.
12. Mumper RJ et al. PVP as novel interactive polymers for controlled gene delivery to muscle. Pharm Res 1996; 13: 701-709.
13. Shea LD, Smiley E, Bonadio J, Mooney DJ. DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol 1999; 17: 551-554.
14. Krieg AM et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546-549.
15. Krieg AM. CpG DNA: a pathogenic factor in systemic lupus erythematosus? J Clin Immunol 1995; 15: 284-292.
16. Bhatt DL, Gaylor DC, Lee RC. Rhabdomyolysis due to pulsed electric fields. Plast Reconstr Surg 1990; 86: 1-11.
17. Rizzuto G et al. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci USA 1999; 96: 6417-6422.
18. Aihara H, Miyazaki JI. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998; 16: 867-870.
19. Alakhov VYu, Kabanov AV. Block copolymers biotransport carriers as versatile vehicles for drug delivery. Exp Opin Invest Drugs 1998; 7: 1453-1473.
20. Astafieva I et al. Enhancement of the polycation-mediated DNA uptake and cell transfection with Pluronic P85 block copolymer. FEBS Lett 1996; 389: 278-280.
21. Nguyen HK et al. Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Therapy 2000; 7: 126-138.
22. Alakhov VYu et al. Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials. Colloids Surfaces B: Biointerfaces 1999; 16: 113-134.
23. Zhou S, Murphy JE, Dwarki VJ. Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates. Gene Therapy 1998; 5: 665-670.
24. Schwartz B et al. Gene transfer by naked DNA into adult mouse brain. Gene Therapy 1996; 3: 405-411.
25. Davis HL et al. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum Gene Ther 1993; 4: 733-740.
26. Levy MY, Barron LG, Meyer KB, Szoka FC. Characterization of plasmid DNA transfer into mouse skeletal muscle evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Therapy 1996; 3: 201-211.
27. Hartikka J et al. An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum Gene Ther 1996; 7: 1205-1217.
28. Alakhov VYu, Moskaleva EYu, Batrakova EV, Kabanov AV. Hypersensitization of multidrug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer. Bioconjug Chem 1995; 7: 209-216.
29. Venne A et al. Hypersensitizing effect of Pluronic L61 on cytotoxic activity, transport and subcellular distribution of doxorubicin in multiple drug resistant cells. Cancer Res 1996; 56: 3626-3629.
30. Batrakova EV et al. Anthracycline antibiotics non-covalently incorporated into block copolymer micelles: in vivo evaluation of anticancer activity. Br J Cancer 1996; 74: 1545-1552.
31. Miller DW et al. Interactions of Pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. Bioconjug Chem 1997; 8: 649-657.
32. Batrakova EV et al. Effects of Pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharmacol Res 1998; 15: 850-855.
33. Miller DW, Batrakova EV, Kabanov AV. Inhibition of multidrug resistance-associated protein (MRP) functional activity with Pluronic block copolymers. Pharmacol Res 1999; 16: 396-401.
34. Robert J. Multidrug resistance and its reversal. General review of fundamental aspects. Ann Biol Clin 1996; 54: 3-8.
35. Lavie Y, Fiucci G, Czarny M, Liscovitch M. Changes in membrane microdomains and caveolae constituents in multidrug-resistant cancer cells. Lipids 1999; 34: S57-63.
36. Green HJ. Cation pumps in skeletal muscle: potential role in muscle fatigue. Acta Physiol Scand 1998; 162: 201-213.
37. Shoemaker CB, Mitsock LD. Murine erythropoietin gene: cloning, expression, and human gene homology. Mol Cell Biol 1986; 6: 849-858.