Polyion complex micelles as vectors in gene therapy — pharmacokinetics and in vivo gene transfer

Gene Therapy

Volumn 9, Issue 6, 2002, Pages 407-414

  Harada Shiba, M ^a   Yamauchi, K ^b   Harada, A ^b   Takamisawa, I ^a   Shimokado, K ^a   Kataoka, K ^b  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Block copolymer; Non viral vector; Poly L lysine; Polyion complex micelles

Indexed keywords

CIRCULAR DNA; COPOLYMER; LIGAND; LUCIFERASE; MACROGOL; PLASMID DNA; POLYLYSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA DEGRADATION; DNA SUPERCOILING; DNA VECTOR; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER; MICELLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SOUTHERN BLOTTING; ZETA POTENTIAL;

ANIMALIA;

CARCINOMA, HEPATOCELLULAR; GENE THERAPY; GENETIC VECTORS; HUMANS; INJECTIONS, INTRAVENOUS; LIVER NEOPLASMS; LUCIFERASES; MICELLES; MICROSCOPY, ELECTRON; PLASMIDS; POLYETHYLENE GLYCOLS; POLYLYSINE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 85047695467     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301665     Document Type: Article

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