Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy

Bioconjugate Chemistry

Volumn 16, Issue 1, 2005, Pages 122-130

  Bae, Younsoo ^a   Nishiyama, Nobuhiro ^b   Fukushima, Shigeto ^a   Koyama, Hiroyuki ^b   Yasuhiro, Matsumura ^c   Kataoka, Kazunori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; CONTROLLED DRUG DELIVERY; DISEASES; DRUG PRODUCTS; FUNCTIONAL POLYMERS; POLYETHYLENE GLYCOLS; TARGETED DRUG DELIVERY; TUMORS;

ADRIAMYCIN; BIOLOGICAL CHARACTERIZATION; DRUG CARRIER; DRUG DISTRIBUTION; DRUG RELEASE PROPERTIES; IN-VIVO; INTRACELLULAR PH; POLYMERIC MICELLE; SUB-CELLULAR; TRIGGERED DRUG RELEASE;

MICELLES;

AMPHOPHILE; ASPARTIC ACID; COPOLYMER; DOXORUBICIN; DRUG CARRIER; HYDRAZONE DERIVATIVE; MACROGOL; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; ENDOSOME; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MICELLE; MOUSE; NONHUMAN; PH; SUPRAMOLECULAR CHEMISTRY;

ANIMALIA;

EID: 12344269847     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0498166     Document Type: Article

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