Modulating pharmacokinetics of an anti-interleukin-8 F(ab')2 by amine- specific PEGylation with preserved bioactivity

International Journal of Pharmaceutics

Volumn 198, Issue 1, 2000, Pages 83-95

  Koumenis, Iphigenia Leonidou ^a   Shahrokh, Zahra ^a   Leong, Steven ^a   Hsei, Vanessa ^a   Deforge, Laura ^a   Zapata, Gerardo ^a  

^a GENENTECH INC   (United States)

Author keywords

Anti interleukin 8 antibody; Bioactivity; Pharmacokinetics; Polyethylene glycolylation

Indexed keywords

CYTOKINE ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; INTERLEUKIN 8 ANTIBODY; MACROGOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG FORMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

AMINES; ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, CD; AREA UNDER CURVE; CHEMOTAXIS, LEUKOCYTE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN FAB FRAGMENTS; INTERLEUKIN-8; MALE; NEUTROPHILS; POLYETHYLENE GLYCOLS; RABBITS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-8A; SPECTROPHOTOMETRY, ULTRAVIOLET; SURFACE-ACTIVE AGENTS;

EID: 0034732059     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00458-5     Document Type: Article

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