Development of systems for targeting the regional lymph nodes for diagnostic imaging: In vivo behaviour of colloidal PEG-coated magnetite nanospheres in the rat following interstitial administration

Pharmaceutical Research

Volumn 18, Issue 5, 2001, Pages 640-645

  Illum, L ^a,b   Church, A E ^b   Butterworth, M D ^a   Arien, A ^a   Whetstone, J ^a   Davis, S S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Drug Delivery and Clinical Research Centre Ltd   (United Kingdom)

Author keywords

Diagnostic imaging; Lymph node targeting; Magnetite; Nanospheres; Poly(ethylene glycol); Subcutaneous administration

Indexed keywords

MACROGOL; MAGNETITE; NANOPARTICLE;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG FORMULATION; DRUG UPTAKE; ELECTROPHORETIC MOBILITY; LYMPH NODE; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE PROPERTY;

ANIMALS; CHEMISTRY, PHYSICAL; COLLOIDS; CONTRAST MEDIA; DEXTRANS; EXCIPIENTS; IRON; IRON RADIOISOTOPES; LYMPH NODES; MAGNETIC RESONANCE IMAGING; MALE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SILANES; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 0034955441     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011081210142     Document Type: Article

References (20)

1. Targeting of colloids to lymph nodes: Influence of lymphatic physiology and colloidal characteristics
2. Lymph and lymphatic pathophysiology
3. Fate of cholesterol-rich liposomes after subcutaneous injection in rats
4. Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes
5. Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block copolymers
6. Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake
7. Detection of metastasis in cervical lymph nodes. CT and MR criteria and differential diagnosis
8. Immunospecific ferromagnetic iron-dextran reagents for the labelling and magnetic separation of cells
9. Preparation and characteristics of magnetite-labelled antibody with the use of poly(ethylene glycol) derivatives
10. Magnetic lipase adsorbed to a magnetic fluid
11. Chemical modification of enzymes with activated magnetic modifier
12. Preparation of ultrafine silica- and PEG-coated magnetite particles
13. Preparation of aqueous magnetic liquids in alkaline and acidic media
14. Surface modification of poly(lactide-coglycolide) nanoparticles by novel biodegradable poly(lactide)poly(ethylene glycol) copolymers
15. Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen
16. A new method for measuring the blood volume of the rat using 113m Indium as a tracer
17. Influence of temperature and electrolytes on the adsorption of poly(ethylene oxide)-poly(propylene oxide) block copolymer on polystyrene latex and the stability of the polymer-coated particles
18. Novel applications of liposomes
19. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection: III. Influence of surface modification with poly(ethylene glycol)