Pharmacokinetics and distribution of 125I-PLA-b-PEO block copolymers in rats

Pharmaceutical Development and Technology

Volumn 8, Issue 2, 2003, Pages 153-161

  Novakova, K ^a   Laznicek, M ^a   Rypacek, F ^b   Machova, L ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

Biodistribution; Block; Copolymers; Drug delivery; Pharmacokinetics

Indexed keywords

CARRAGEENAN; COPOLYMER; DRUG CARRIER; IODINE 125; MACROGOL; POLYLACTIDE; POLYLACTIDE BLOCK POLYETHYLENE OXIDE; SODIUM CHLORIDE; TETRAHYDROFURAN; UNCLASSIFIED DRUG; LACTIC ACID; LACTIC ACID DERIVATIVE; MACROGOL DERIVATIVE; POLYETHYLENE OXIDE POLYLACTIC ACID BLOCK COPOLYMER; POLYETHYLENE OXIDE-POLYLACTIC ACID BLOCK COPOLYMER; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIODEGRADABILITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; GEL PERMEATION CHROMATOGRAPHY; INFLAMMATION; MALE; MEAN RESIDENCE TIME; MICELLE; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOIODINATION; RAT; ANIMAL; CHEMISTRY; GEL CHROMATOGRAPHY; HALF LIFE TIME; ISOTOPE LABELING; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, GEL; DRUG CARRIERS; HALF-LIFE; INFLAMMATION; ISOTOPE LABELING; LACTATES; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICELLES; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 0038330460     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120018484     Document Type: Article

References (31)

1. Torchilin, V.P. Structure and design of polymeric surfactant-based drug delivery systems. J. Control. Release 2001, 73, 137-172.
2. Kim, S.Y.; Shin, I.G.; Lee, Y.M. Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and DL-lactide block copolymer as novel drug carriers. J. Control. Release 1998, 56 (1-3), 197-208.
3. Yasugi, K.; Nagasaki, Y.; Kato, M.; Kataoka, K. Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly (D,L-lactide) block copolymers as potential drug carrier. J. Control. Release 1999, 62, 89-100.
4. Rösler, A.; Vandermeulen, G.W.M.; Klok, H.A. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv. Drug. Delivery Rev. 2001, 53, 95-108.
5. Kataoka, K.; Kwon, G.S.; Yokoyama, M.; Okano, T.; Sakurai, Y. Block copolymer micelles as vehicles for drug delivery. J. Control. Release 1993, 24, 119-132.
6. Kumar, N.; Ravikumas, M.N.V.; Domb, A.J. Biodegradable block copolymers. Adv. Drug. Delivery Rev. 2001, 53, 23-44.
7. Kwon, G.S. Diblock copolymer nanoparticles for drug delivery. Crit. Rev. Ther. Drug. Carrier Syst. 1998, 15 (5), 481-512.
8. Hutchinson, F.G.; Furr, B.J.A. Design of biodegradable polymers for controlled release. In Drug Delivery Systems: Fundamentals and Techniques; Johnson, P., Lloyd-Jones, J.G., Eds.; VCH u.a.: Weinheim u.a., 1987; 106-119.
9. Li, Y.; Kwon, G.S. Micelle-like structures of poly (ethylene oxide)-block-poly(2-hydroxyethyl aspartamide)-methotrexate conjugates. Colloids Surf. B: Biointerfaces 1999, 16, 217-226.
10. Yokoyama, M.; Kwon, G.S.; Okano,T.; Sakarai, Y.; Seto, T.; Kataoka, K. Preparation of micelle-forming polymer-drug conjugates. Bioconjugate Chem. 1992, 3, 295-301.
11. Kataoka, K.; Harada, A.; Nagasaki, Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug. Delivery Rev. 2001, 47, 113-131.
12. Kwon, G.S.; Okano, T. Polymeric micelles as new drug carriers. Adv. Drug. Delivery Rev. 1996, 21, 107-116.
13. Park, K.; Shalaby, W.S.W.; Park, H. Biodegradable Hydrogels for Drug Delivery; Technomic Publishing Company, Inc.: Lancaster, USA, 1993; 252.
14. Trubetskoy, V.S. Polymeric micelles as carriers of diagnostic agents. Adv. Drug. Delivery Rev. 1999, 37, 81-88.
15. Nishikawa, M.; Takakura, Y.; Hashida, M. Pharmacokinetic evaluation of polymeric carriers. Adv. Drug. Delivery Rev. 1996, 21, 135-155.
16. Moghimi, S.M.; Hunter, A.C.; Murray, J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 2001, 53, 283-318.
17. Rypacek, F.; Machova, L.; Kotva, R.; Skarda, V. Polyesters with functional-peptide blocks: synthesis and application to biomaterials. Polym. Mater. Sci. Eng. 2001, 84, 817-818.
18. Kubies, D.; Rypacek, F.; Kovarova, J.; Lednicky, F. Microdomain structure in polylactide-block-poly(ethylene oxide) copolymer films. Biomaterials 2000, 21, 529-536.
19. Kowalski, A.; Duda, A.; Penczek, S. Kinetics and mechanism of cyclic esters polymerization initiated with tin (II) octoate: 3. Polymerization of L,L-dilactide. Macromolecules 2000, 33, 7359-7370.
20. Van Dijk, J.A.P.P.; Smit, J.A.M. Characterization of poly(D,L-lactic acid) by gel permeation chromatography. J. Polym. Sci., Part A: Polym. Chem. 1983, 21, 197-208.
21. Mori, S.; Barth, H.G. Size Exclusion Chromatography; Springer Verlag: Berlin, Heidelberg, New York, 1999; 106.
22. Bridges, J.F.; Critchlow, M.; Irving, M.P.; Purkiss, S.C.; Taylor, D.C.; Lloyd, J.B. Radiolabeling, stability, and body distribution in rats, of low molecules weight polylactide homopolymer and polylactide-polyethyleneglycol copolymer. Biomaterials 2000, 21, 199-209.
23. Hermanson, G.T. Iodination techniques. In Bioconjugate Techniques; Hermanson, G.T., Ed.; Academic Press, Inc.: San Diego, CA, 1996; 400-416.
24. Saha, G.B. Radiopharmaceuticals and methods of radiolabeling. In Fundamentals of Nuclear Pharmacy; Saha, G.B., Ed.; Springer-Verlag: New York, 1992; 331.
25. Oh, I.; Lee, K.; Kwon, H.Y.; Lee, Y.B.; Shin, S.Ch.; Cho, Ch.S.; Kim, Ch.K. Release of adriamycin from poly(γ-benzyl-L-glutamate)/poly(ethylene oxide) nanoparticles. Int. J. Pharm. 1999, 181, 107-115.
26. Dohery, N.S.; Robinson, B.V. The inflammatory response to carrageenan. J. Pharm. Pharmacol. 1975, 27, 701-703.
27. DiRosa, M.; Sorrentino, L. The mechanism of the inflammatory effect of carrageenin. Eur. J. Pharmacol. 1968, 4, 340-342.
28. Vinegar, R.; Truaw, J.F.; Selph, J.L. Quantitative studies of the pathway to acute carrageenan inflammation. Fed. Proc. 1976, 35, 2447-2456.
29. 125I-labeled PLA/PEO (5000/5000) block copolymer: biodistribution studies in rats. Bioact. Compat. Polym. 2002, 17, 285-296.
30. Stolnik, S.; Dunn, S.E.; Garnett, M.C.; Davies, M.C.; Combes, A.G.A.; Taylor, D.C.; Irving, M.P.; Purkiss, S.C.; Tadros, T.F.; Davis, S.S.; Illum, L. Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharm. Res. 1994, 11, 1800-1808.
31. Kwon, G.S.; Kataoka, K. Block copolymer micelles as long-circulating drug vehicles. Adv. Drug. Delivery Rev. 1995, 16, 295-309.