PEG-hemoglobin. Oxygen carrying blood substitute

Drugs of the Future

Volumn 21, Issue 1, 1996, Pages 29-32

  Nucci, Mary L ^a   Shorr, Robert G L ^a   Abuchowski, Abraham ^a  

^a Enzon Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; MACROGOL;

ANIMAL MODEL; CATTLE; DOG; DRUG HALF LIFE; ERYTHROCYTE; HUMAN; HYPOVOLEMIC SHOCK; IMMUNOGENICITY; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; RABBIT; RADIOSENSITIZATION; RAT; SHORT SURVEY; TUMOR CELL; TUMOR GROWTH;

EID: 0029875241     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1996.021.01.334749     Document Type: Article

References (9)

1. Bradley, R., Sloshberg, S., Nho, K., Czuba, B., Szesko, D., Shorr, R. Production of PEG-modified bovine hemoglobin: Economics and feasibility. Artif Cells Blood Substitutes Immobilization Biotechnol 1994, 22: 657-67.
2. Bucci, E., Fronticelli, C. Hemoglobin as an oxygen carrier in cell free fluids. Maryland Med J 1992, 41: 527-31.
3. Dodds, W.J. Blood substitutes. Adv Vet Comp Med 1991, 36: 257-88.
4. Nho, K., Glower, D , Bredehoeft, S., Shankar, H., Shorr, R., Abuchowski, A PEG-bovine hemoglobin: Safety in a canine dehydrated hypovolemic-hemorrhagic shock model. Biomat Artif Cells Immobilization Biotechnol 1992, 20: 511-24.
5. Nho, K., Linberg, R., Johnson, R., Gilbert, C., Shorr, R. PEG-hemoglobin: An efficient oxygen delivery system in the rat exchange transfusion and hypovolemic shock models. Artif Cells Blood Substitutes Immobilization Biotechnol 1994, 22: 795-803.
6. Linberg, R., Johnson, M., Nho, K., Gilbert, C., Shorr, R. Normal oxygen tension resoted in the ischemic rat liver model by PEG-hemoglobin. Artif Cells Blood Substituted Immobilization Biotechnol 1994, 22: 805-12
7. Conover, C., Sedlatchek, L., Linberg, R., Nho, K., Shorr, R.G.L. Polyethylene glycol modified hemoglobin is able to sustain life in the conscious porcine extreme exchange transfusion model. Artif Cells Blood Substitutes Immobilization Biotechnol 1994, 22: A91.
8. Song, D., Olanl, M., Wilson, D.F., Pastuszko, A., Tammela, O., Nho, K., Shorr, R.G.L. Comparison of the efficacy of blood and polyethylene glycol hemoglobin in recovery of newborn piglets from hemorrhagic hypotension: Effect on blood pressure, cortical oxygen and extracellular dopamine in the brain. Transfusion 1995, 35: 552-8.
9. Nho, K., Linberg, R., Fitzpatrick, K., Gilbert, L., Clark, M., Shorr, R.G.L. Increased radiosensitivity of solid tumors following infusion with polyethylene glycol modified bovine hemoglobin. Proc Amer Assoc Cancer Res 1995, 36: Abst 3680.