메뉴 건너뛰기




Volumn 45, Issue 9, 2006, Pages 701-709

Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers

Author keywords

Animal models; Gene regulation; Multidrug resistance; Signal pathway

Indexed keywords

CARCINOGEN; REACTIVE OXYGEN METABOLITE; STEROID HORMONE; TOXIN;

EID: 33748807185     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20240     Document Type: Review
Times cited : (77)

References (96)
  • 3
    • 7044239399 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Current management and future trends
    • Carr BI. Hepatocellular carcinoma: Current management and future trends. Gasteroent 2004;127:S218-S214.
    • (2004) Gasteroent , vol.127
    • Carr, B.I.1
  • 5
    • 0036699940 scopus 로고    scopus 로고
    • Molecular genesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular genesis of human hepatocellular carcinoma. Nature Genet 2002;31:339-346.
    • (2002) Nature Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 6
    • 0344513852 scopus 로고    scopus 로고
    • Mitochondrial generation of reactive oxygen species and its role in aerobic life
    • Inoue M, Sato EF, Nishikawa M, et al. Mitochondrial generation of reactive oxygen species and its role in aerobic life. Curr Med Chem 2003;10:2495-2505.
    • (2003) Curr Med Chem , vol.10 , pp. 2495-2505
    • Inoue, M.1    Sato, E.F.2    Nishikawa, M.3
  • 7
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nature Rev Immunol 2004;4:181-189.
    • (2004) Nature Rev Immunol , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 8
    • 0037376674 scopus 로고    scopus 로고
    • Oxidant signals and oxidative stress
    • Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol 2003;15:247-254.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 247-254
    • Finkel, T.1
  • 9
    • 0034774463 scopus 로고    scopus 로고
    • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-κB via oxidative stress
    • Waris G, Huh K-W, Siddiqui A. Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-κB via oxidative stress. Mol Cell Biol 2001;21:7721-7730.
    • (2001) Mol Cell Biol , vol.21 , pp. 7721-7730
    • Waris, G.1    Huh, K.-W.2    Siddiqui, A.3
  • 10
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB
    • Gong G, Waris G, Tanveer R, Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB. Proc Natl Acad Sci USA 2001;98:9599-9604.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 11
    • 0028567172 scopus 로고
    • Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
    • Hagen TM, Huang S, Curnutte J, Fowler P, Martinez V, Wehr CM, Ames BN, Chisari FV. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci USA 1994;9:12808-12812.
    • (1994) Proc Natl Acad Sci USA , vol.9 , pp. 12808-12812
    • Hagen, T.M.1    Huang, S.2    Curnutte, J.3    Fowler, P.4    Martinez, V.5    Wehr, C.M.6    Ames, B.N.7    Chisari, F.V.8
  • 13
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    • Moriya K, Nakagawa K, Santa T, et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001;61:4365-4370.
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3
  • 14
    • 0030339769 scopus 로고    scopus 로고
    • The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4
    • Gallagher EP, Kunze KL, Stapleton PL, Eaton DL. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmacol 1996;141:595-606.
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 595-606
    • Gallagher, E.P.1    Kunze, K.L.2    Stapleton, P.L.3    Eaton, D.L.4
  • 15
    • 0029892645 scopus 로고    scopus 로고
    • Detection of elevated reactive oxygen species levels in cultured rat hepatocytes treated with aflatoxin B1
    • Shen H-M, Shi C-Y, Shen Y, Ong C-H. Detection of elevated reactive oxygen species levels in cultured rat hepatocytes treated with aflatoxin B1. Free Rad Biol Med 1996;21:134-146.
    • (1996) Free Rad Biol Med , vol.21 , pp. 134-146
    • Shen, H.-M.1    Shi, C.-Y.2    Shen, Y.3    Ong, C.-H.4
  • 16
    • 0029061367 scopus 로고
    • A metabolite of carcinogenic 2-acetylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria
    • Klohn PC, Massalha H, Neumann HG. A metabolite of carcinogenic 2-acetylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria. Biochim Biophys Acta 1995;1229:363-372.
    • (1995) Biochim Biophys Acta , vol.1229 , pp. 363-372
    • Klohn, P.C.1    Massalha, H.2    Neumann, H.G.3
  • 17
    • 0037150228 scopus 로고    scopus 로고
    • Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
    • Kuo MT, Liu Z, Wei Y, et al. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 2002;21:1945-1954.
    • (2002) Oncogene , vol.21 , pp. 1945-1954
    • Kuo, M.T.1    Liu, Z.2    Wei, Y.3
  • 18
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-AKT pathway in human cancer: Rationale and promise
    • Luo J, Manning BD, Cantley LC. Targeting the PI3K-AKT pathway in human cancer: Rationale and promise. Cancer Cell 2003;4:257-262.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 19
    • 2442635417 scopus 로고    scopus 로고
    • Peroxisome proliferators and peroxisome proliferators-activated receptor alpha: Biotic and xenobiotic sensing
    • Reddy JK. Peroxisome proliferators and peroxisome proliferators-activated receptor alpha: Biotic and xenobiotic sensing. Am J Pathol 2004;164:2305-2321.
    • (2004) Am J Pathol , vol.164 , pp. 2305-2321
    • Reddy, J.K.1
  • 20
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990;347:645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 21
    • 11144296372 scopus 로고    scopus 로고
    • Agents enhanced hepatocarcinogenicity by peroxisome proliferator- activated receptor alpha agonists
    • Youaawd JA, Badr MS. Agents enhanced hepatocarcinogenicity by peroxisome proliferator-activated receptor alpha agonists. Ageing Res Rev 2005;4:105-118.
    • (2005) Ageing Res Rev , vol.4 , pp. 105-118
    • Youaawd, J.A.1    Badr, M.S.2
  • 22
    • 0017284938 scopus 로고
    • Hepatocellular carcinoma in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator
    • Reddy JK, Rao MS, Moody DE. Hepatocellular carcinoma in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator. Cancer Res 1976;36:1211-1217.
    • (1976) Cancer Res , vol.36 , pp. 1211-1217
    • Reddy, J.K.1    Rao, M.S.2    Moody, D.E.3
  • 23
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-coA oxidase: Implications for peroxisome proliferator-activated receptor a natural ligand metabolism
    • Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-coA oxidase: Implications for peroxisome proliferator-activated receptor a natural ligand metabolism. J Biol Chem 1998;273:5639-15645.
    • (1998) J Biol Chem , vol.273 , pp. 5639-15645
    • Fan, C.Y.1    Pan, J.2    Usuda, N.3    Yeldandi, A.V.4    Rao, M.S.5    Reddy, J.K.6
  • 24
    • 15144343374 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation
    • Bae YS, Kang SW, Seo MS, Baines IC, Tekle E, Chock PB, Rhee SG. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J Biol Chem 1997;272:217-221.
    • (1997) J Biol Chem , vol.272 , pp. 217-221
    • Bae, Y.S.1    Kang, S.W.2    Seo, M.S.3    Baines, I.C.4    Tekle, E.5    Chock, P.B.6    Rhee, S.G.7
  • 26
    • 5544237716 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of angiogenesis signaling: Role of NAD(P)H oxidase
    • Ushio-Fukai M, Alexander RW. Reactive oxygen species as mediators of angiogenesis signaling: Role of NAD(P)H oxidase. Mol Cell Biochem 2004;264:85-97.
    • (2004) Mol Cell Biochem , vol.264 , pp. 85-97
    • Ushio-Fukai, M.1    Alexander, R.W.2
  • 27
    • 0035966052 scopus 로고    scopus 로고
    • Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes
    • Mahadev K, Wu X, Zilbering A, Zhu L, Lawrence JT, Goldstein BJ. Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J Biol Chem 2001; 276:48662-48669.
    • (2001) J Biol Chem , vol.276 , pp. 48662-48669
    • Mahadev, K.1    Wu, X.2    Zilbering, A.3    Zhu, L.4    Lawrence, J.T.5    Goldstein, B.J.6
  • 28
    • 0029955623 scopus 로고    scopus 로고
    • Reactive oxygen species mediate cytokine activation of c-jun NH2-terminal kinases
    • Lo YY, Wong JM, Cruz TF. Reactive oxygen species mediate cytokine activation of c-jun NH2-terminal kinases. J Biol Chem 1996;271:11727-15730.
    • (1996) J Biol Chem , vol.271 , pp. 11727-15730
    • Lo, Y.Y.1    Wong, J.M.2    Cruz, T.F.3
  • 29
    • 2942564047 scopus 로고    scopus 로고
    • Transforming growth factor b1 induction of tissue inhibitor of metalloproteinase 3 in articular chondrocytes is mediated by reactive oxygen species
    • Li WQ, Qureshi HY, Liachini A, Dehnade F, Zafarullah M. Transforming growth factor b1 induction of tissue inhibitor of metalloproteinase 3 in articular chondrocytes is mediated by reactive oxygen species. Free Radic Biol Med 2004;37:196-205.
    • (2004) Free Radic Biol Med , vol.37 , pp. 196-205
    • Li, W.Q.1    Qureshi, H.Y.2    Liachini, A.3    Dehnade, F.4    Zafarullah, M.5
  • 30
    • 2942625699 scopus 로고    scopus 로고
    • Reactive oxygen species mediate endothelin-1-induced activation of Erk1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells
    • Daou GB, Srivasta AK. Reactive oxygen species mediate endothelin-1-induced activation of Erk1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells. Free Red Biol Med 2004;31:208-215.
    • (2004) Free Red Biol Med , vol.31 , pp. 208-215
    • Daou, G.B.1    Srivasta, A.K.2
  • 31
    • 0036285034 scopus 로고    scopus 로고
    • C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • Vafa O, Wade M, Kern S, et al. C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Molec Cell 2002;9:1031-1044.
    • (2002) Molec Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3
  • 32
    • 0032546792 scopus 로고    scopus 로고
    • Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis
    • Factor VM, Kiss A, Woitach JT, Wirth PJ, thorgeirsson SS. Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis. J Biol Chem 1998;273:15846-15853.
    • (1998) J Biol Chem , vol.273 , pp. 15846-15853
    • Factor, V.M.1    Kiss, A.2    Woitach, J.T.3    Wirth, P.J.4    Thorgeirsson, S.S.5
  • 34
    • 7244260731 scopus 로고    scopus 로고
    • Vitamin e down-modulates iNOS and NADPH oxidase in c-Myc/TGF-α transgenic mouse model of livercancer
    • Calvisi DF, Ladu S, Hironaka K, Factor VM, Thorgeirsson SS. Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-α transgenic mouse model of livercancer. J Hepatol 2004;41:815-822.
    • (2004) J Hepatol , vol.41 , pp. 815-822
    • Calvisi, D.F.1    Ladu, S.2    Hironaka, K.3    Factor, V.M.4    Thorgeirsson, S.S.5
  • 35
    • 13244277942 scopus 로고    scopus 로고
    • CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
    • Elchuri S, Oberley TD, Oi W, et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 2005;24:367-380.
    • (2005) Oncogene , vol.24 , pp. 367-380
    • Elchuri, S.1    Oberley, T.D.2    Oi, W.3
  • 36
    • 0038241789 scopus 로고    scopus 로고
    • Hepatic copper metabolism: Insights from genetic disease
    • Tao TY, Gitlin JD. Hepatic copper metabolism: Insights from genetic disease. Hepatology 2003;37:1241-1247.
    • (2003) Hepatology , vol.37 , pp. 1241-1247
    • Tao, T.Y.1    Gitlin, J.D.2
  • 37
    • 0031857603 scopus 로고    scopus 로고
    • A marked increase in free copper levels in the plasma and liver of LEC rats: An animal model for Wilson disease and liver cancer
    • Koizumi M, Fujii J, Suzuki K, et al. A marked increase in free copper levels in the plasma and liver of LEC rats: An animal model for Wilson disease and liver cancer. Free Radic Res 1998;28:441-450.
    • (1998) Free Radic Res , vol.28 , pp. 441-450
    • Koizumi, M.1    Fujii, J.2    Suzuki, K.3
  • 38
    • 0032878550 scopus 로고    scopus 로고
    • Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation
    • Buiakova OI, Xu J, Lutsenko S, et al. Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Hum Mol Genet 1999;8:1665-1671.
    • (1999) Hum Mol Genet , vol.8 , pp. 1665-1671
    • Buiakova, O.I.1    Xu, J.2    Lutsenko, S.3
  • 39
    • 7044260968 scopus 로고    scopus 로고
    • Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene
    • Meng Y, Miyoshi I, Hirabayashi M, et al. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. Biochim BiophysActa 2004;1690:208-219.
    • (2004) Biochim BiophysActa , vol.1690 , pp. 208-219
    • Meng, Y.1    Miyoshi, I.2    Hirabayashi, M.3
  • 40
    • 15244359632 scopus 로고    scopus 로고
    • Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
    • Xu Z, Chen L, Leung L, Yen TSB, Lee C, Chan JY. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci USA 2005;102:4120-4125.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4120-4125
    • Xu, Z.1    Chen, L.2    Leung, L.3    Yen, T.S.B.4    Lee, C.5    Chan, J.Y.6
  • 41
    • 21244472975 scopus 로고    scopus 로고
    • IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo J-L, Leffert H, Karin M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.-L.3    Leffert, H.4    Karin, M.5
  • 42
    • 0037951705 scopus 로고    scopus 로고
    • A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction
    • Bailey SM. A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction. Free Rad Res 2003;37:585-596.
    • (2003) Free Rad Res , vol.37 , pp. 585-596
    • Bailey, S.M.1
  • 43
    • 16544368662 scopus 로고    scopus 로고
    • Endotoxin and Kupffer cell activation in alcoholic liver disease
    • Wheeler MD. Endotoxin and Kupffer cell activation in alcoholic liver disease. Alcohol Res Health 2003;27:300-306.
    • (2003) Alcohol Res Health , vol.27 , pp. 300-306
    • Wheeler, M.D.1
  • 44
    • 16544383147 scopus 로고    scopus 로고
    • Alcohol, oxidative stress, and free radical damage
    • Wu D, Cederbaum Al. Alcohol, oxidative stress, and free radical damage. Alcohol Res Health 2003;27:277-284.
    • (2003) Alcohol Res Health , vol.27 , pp. 277-284
    • Wu, D.1    Al, C.2
  • 45
    • 0028155839 scopus 로고
    • Alcohol ingestion enhances hepatocarcinogenesis induced by synthetic estrogen and progestin in the rat
    • Yamagiwa K, Mizumoto R, Higashi S, et al. Alcohol ingestion enhances hepatocarcinogenesis induced by synthetic estrogen and progestin in the rat. Cancer Detect Prev 1994;18:103-114.
    • (1994) Cancer Detect Prev , vol.18 , pp. 103-114
    • Yamagiwa, K.1    Mizumoto, R.2    Higashi, S.3
  • 46
    • 0036023302 scopus 로고    scopus 로고
    • Oxidative stress EPR measurement in human liver by radical-probe techynique. Correlation with etiology, histology and cell proliferation
    • Valgimigli M, Valgimigli L, Trere D, et al. Oxidative stress EPR measurement in human liver by radical-probe techynique. Correlation with etiology, histology and cell proliferation. Free Radi Res 2002;36:939-948.
    • (2002) Free Radi Res , vol.36 , pp. 939-948
    • Valgimigli, M.1    Valgimigli, L.2    Trere, D.3
  • 47
    • 0028112392 scopus 로고
    • Decreased activity of scavenger enzymes in human hepatocellular carcinoma, but not in liver metastases
    • Casaril M, Corso F, Bassi A, et al. Decreased activity of scavenger enzymes in human hepatocellular carcinoma, but not in liver metastases. Int J Clin Lab Res 1994;24:94-97.
    • (1994) Int J Clin Lab Res , vol.24 , pp. 94-97
    • Casaril, M.1    Corso, F.2    Bassi, A.3
  • 49
    • 18544392795 scopus 로고    scopus 로고
    • Liver failure and liver disease. Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma
    • Jungst C, Cheng B, Gehrke R, et al. Liver failure and liver disease. Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Hepatol 2004;39:1663-1672.
    • (2004) Hepatol , vol.39 , pp. 1663-1672
    • Jungst, C.1    Cheng, B.2    Gehrke, R.3
  • 50
    • 0035910064 scopus 로고    scopus 로고
    • Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver
    • Xu X-R, Huang J, Xu Z-G, et al. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci USA 2001;98:150890-150894.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 150890-150894
    • Xu, X.-R.1    Huang, J.2    Xu, Z.-G.3
  • 51
    • 0037171936 scopus 로고    scopus 로고
    • Identification, using cDNA macroarray analysis, of distinct expression profiles associated with pathological and virological features of hepatocellular carcinoma
    • Delpuech O, Trabut J-B, Carnot F, Feuillard J, Brechot C, Kremsdorf D. Identification, using cDNA macroarray analysis, of distinct expression profiles associated with pathological and virological features of hepatocellular carcinoma. Oncogene 2002;21:2926-2937.
    • (2002) Oncogene , vol.21 , pp. 2926-2937
    • Delpuech, O.1    Trabut, J.-B.2    Carnot, F.3    Feuillard, J.4    Brechot, C.5    Kremsdorf, D.6
  • 52
    • 20344374424 scopus 로고    scopus 로고
    • Genetic profiling of human hepatocellular carcinoma
    • Lee JS, Thorgeirsson SS. Genetic profiling of human hepatocellular carcinoma. Semin Liver Disease 2005;25:125-132.
    • (2005) Semin Liver Disease , vol.25 , pp. 125-132
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 53
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • Lee J-S, Chu I-S, Mikaelyan A, et al. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat. Genet. 2004;36:1306-1311.
    • (2004) Nat. Genet. , vol.36 , pp. 1306-1311
    • Lee, J.-S.1    Chu, I.-S.2    Mikaelyan, A.3
  • 54
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • Cerutti PA. Oxy-radicals and cancer. Lancet 1994;344:862-863.
    • (1994) Lancet , vol.344 , pp. 862-863
    • Cerutti, P.A.1
  • 55
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher D, Junod AF. Role of oxygen free radicals in cancer development. Eur J Cancer 1996;32:30-38.
    • (1996) Eur J Cancer , vol.32 , pp. 30-38
    • Dreher, D.1    Junod, A.F.2
  • 57
    • 0028342951 scopus 로고
    • Repair of oxidative damage to DNA
    • Demple B, Harrison L. Repair of oxidative damage to DNA. Annu Rev Biochem 1994;63:915-948.
    • (1994) Annu Rev Biochem , vol.63 , pp. 915-948
    • Demple, B.1    Harrison, L.2
  • 58
    • 0031751078 scopus 로고    scopus 로고
    • Chromosomal fragile sites and DNA amplification in drug-resistant cells
    • Kuo MT, Sen S, Hittelman WN, Hsu TC. Chromosomal fragile sites and DNA amplification in drug-resistant cells. Biochem Pharmacol 1998;156:7-13.
    • (1998) Biochem Pharmacol , vol.156 , pp. 7-13
    • Kuo, M.T.1    Sen, S.2    Hittelman, W.N.3    Hsu, T.C.4
  • 59
    • 24044527139 scopus 로고    scopus 로고
    • Activation of DNA damage signaling
    • Ljungman M. Activation of DNA damage signaling. Mutat Res 2005;577:203-216.
    • (2005) Mutat Res , vol.577 , pp. 203-216
    • Ljungman, M.1
  • 60
    • 0025697262 scopus 로고
    • Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injure
    • Janero DR. Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injure. Free Rad Biol Med 1990;9:515-540.
    • (1990) Free Rad Biol Med , vol.9 , pp. 515-540
    • Janero, D.R.1
  • 61
    • 0032080283 scopus 로고    scopus 로고
    • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    • Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998;17:2596-2606.
    • (1998) EMBO J , vol.17 , pp. 2596-2606
    • Saitoh, M.1    Nishitoh, H.2    Fujii, M.3
  • 62
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFα-induced death and sustain JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S-i, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFα-induced death and sustain JNK activation by inhibiting MAP kinase phosphatases. Cell 2005;120:649-661.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.-I.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 63
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarash K, Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999;13:76-86.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarash, K.5    Yamamoto, M.6
  • 64
    • 1242296811 scopus 로고    scopus 로고
    • Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
    • Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 2004;101:2040-2045.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2040-2045
    • Wakabayashi, N.1    Dinkova-Kostova, A.T.2    Holtzclaw, W.D.3
  • 65
    • 14044277556 scopus 로고    scopus 로고
    • Redox regulation of NF-kB activation: Distinct redox regulation between the cytoplasm and the nucleus
    • Kabe Y, Ando K, Hirao S, Yoshida M, Handa H. Redox regulation of NF-kB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxidants Redox Signal 2005;7:395-403.
    • (2005) Antioxidants Redox Signal , vol.7 , pp. 395-403
    • Kabe, Y.1    Ando, K.2    Hirao, S.3    Yoshida, M.4    Handa, H.5
  • 66
    • 0034190367 scopus 로고    scopus 로고
    • Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB
    • Jenssen-Heininger YM, Poynter ME, Bauerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Rad Biol Med 2000;28:1217-1327.
    • (2000) Free Rad Biol Med , vol.28 , pp. 1217-1327
    • Jenssen-Heininger, Y.M.1    Poynter, M.E.2    Bauerle, P.A.3
  • 67
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, Eckmann L, Greten TF, et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3
  • 68
    • 4644324186 scopus 로고    scopus 로고
    • NF-κB functions as a tumor promoter in imflammation-associated cancer
    • Pikarsky E, Porat RM, Stein I, et al. NF-κB functions as a tumor promoter in imflammation-associated cancer. Nature 2004; 431:461-466.
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3
  • 69
    • 0035988849 scopus 로고    scopus 로고
    • Activation of NF-kappaB, AP-1 and Stat transcriptions is a frequent and early event in human carcinomas
    • Liu P, Kimmoun E, Legrand A, et al. Activation of NF-kappaB, AP-1 and Stat transcriptions is a frequent and early event in human carcinomas. J Hepatol 2002;37:63-71.
    • (2002) J Hepatol , vol.37 , pp. 63-71
    • Liu, P.1    Kimmoun, E.2    Legrand, A.3
  • 70
    • 0033963704 scopus 로고    scopus 로고
    • Oxidative stress and gene regulation
    • Allen RG, Tresini M. Oxidative stress and gene regulation. Free Rad Biol Med 2000;28:463-499.
    • (2000) Free Rad Biol Med , vol.28 , pp. 463-499
    • Allen, R.G.1    Tresini, M.2
  • 71
    • 0037201722 scopus 로고    scopus 로고
    • Regulation of the activity of Sp1-related transcription factors
    • Bouwman P, Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol 2002;195:27-38.
    • (2002) Mol Cell Endocrinol , vol.195 , pp. 27-38
    • Bouwman, P.1    Philipsen, S.2
  • 72
    • 0036632368 scopus 로고    scopus 로고
    • Thephosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers SL. Thephosphatidylinositol 3-kinase-AKT pathway in human cancer. Nature Rev Cancer 2002;2:489-501.
    • (2002) Nature Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, S.L.2
  • 73
    • 16244364798 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription
    • Street A, Macdonald A, McCormick C, Harris M. Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. J Virol 2005;79:5006-5016.
    • (2005) J Virol , vol.79 , pp. 5006-5016
    • Street, A.1    Macdonald, A.2    McCormick, C.3    Harris, M.4
  • 74
    • 0033587014 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in hepatocellular carcinomas
    • Yao YJ, Ping XL, Zhang H, et al. PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 1999;18:3181-3185.
    • (1999) Oncogene , vol.18 , pp. 3181-3185
    • Yao, Y.J.1    Ping, X.L.2    Zhang, H.3
  • 75
    • 0344407448 scopus 로고    scopus 로고
    • Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma
    • Hu TH, Huang CC, Lin PR, et al. Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. Cancer 2003;97:1929-1940.
    • (2003) Cancer , vol.97 , pp. 1929-1940
    • Hu, T.H.1    Huang, C.C.2    Lin, P.R.3
  • 76
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774-1783.
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 77
    • 0033590172 scopus 로고    scopus 로고
    • Mechanism and function of signal transduction by the Wnt/b-catenin and Wnt/Ca2+ pathways
    • Miller JR, Hocking AM, Brown JD, Moon RT. Mechanism and function of signal transduction by the Wnt/b-catenin and Wnt/Ca2+ pathways. Oncogene 1999;18:7860-7872.
    • (1999) Oncogene , vol.18 , pp. 7860-7872
    • Miller, J.R.1    Hocking, A.M.2    Brown, J.D.3    Moon, R.T.4
  • 79
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3
  • 80
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3 protects quiescent cells from oxidatgive stress
    • Kos GL, Dansen TB, Polderman PE, et al. Forkhead transcription factor FOXO3 protects quiescent cells from oxidatgive stress. Nature 2002;419:316-321.
    • (2002) Nature , vol.419 , pp. 316-321
    • Kos, G.L.1    Dansen, T.B.2    Polderman, P.E.3
  • 81
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniquchi K, Roberts LR, Aderca IN, et al. Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002;21:4863-4871.
    • (2002) Oncogene , vol.21 , pp. 4863-4871
    • Taniquchi, K.1    Roberts, L.R.2    Aderca, I.N.3
  • 82
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • de la Coste A, Romagnolo B, Billuart P, et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998;95:8847-8851.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8847-8851
    • De La Coste, A.1    Romagnolo, B.2    Billuart, P.3
  • 83
    • 0036775442 scopus 로고    scopus 로고
    • Redox signaling of angiogenesis
    • Maulik N. Redox signaling of angiogenesis. Antioxidants Redox Signal 2002;4:805-815.
    • (2002) Antioxidants Redox Signal , vol.4 , pp. 805-815
    • Maulik, N.1
  • 84
    • 5544237716 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of angiogenesis signaling: Role of NAD(P)H oxidase
    • Ushio-Fukai M, Alexander RW, Reactive oxygen species as mediators of angiogenesis signaling: Role of NAD(P)H oxidase. Mol Cell Biochem 2004;264:85-97.
    • (2004) Mol Cell Biochem , vol.264 , pp. 85-97
    • Ushio-Fukai, M.1    Alexander, R.W.2
  • 85
    • 0027351011 scopus 로고
    • Expression of multidrug-resistance (P-glycoprotein) genes in liver cancers: A molecular example of the convergence theory of hepatocarcinogenesis?
    • Kuo MT. Expression of multidrug-resistance (P-glycoprotein) genes in liver cancers: A molecular example of the convergence theory of hepatocarcinogenesis? Molec Carcinog 1993;7:73-75.
    • (1993) Molec Carcinog , vol.7 , pp. 73-75
    • Kuo, M.T.1
  • 86
    • 0025166025 scopus 로고
    • Overexpression of the multi-drug-resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas
    • Teeter LD, Becker FF, Chisari FV, Li DJ, Kuo MT. Overexpression of the multi-drug-resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Molec Cell Biol 1990;10:5728-5735.
    • (1990) Molec Cell Biol , vol.10 , pp. 5728-5735
    • Teeter, L.D.1    Becker, F.F.2    Chisari, F.V.3    Li, D.J.4    Kuo, M.T.5
  • 87
    • 0027377964 scopus 로고
    • Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis
    • Teeter LD, Estes M, Chan JY, et al. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol Carcinog 1993;8:67-73.
    • (1993) Mol Carcinog , vol.8 , pp. 67-73
    • Teeter, L.D.1    Estes, M.2    Chan, J.Y.3
  • 88
    • 0035808413 scopus 로고    scopus 로고
    • 2-Acetylaminofluorene up-regulates rat mdrlb expression through generating reactive oxygen species that activate NF-kappa B pathway
    • Deng L, Lin-Lee YC, Claret FX, Kuo MT. 2-acetylaminofluorene up-regulates rat mdrlb expression through generating reactive oxygen species that activate NF-kappa B pathway. J Biol Chem 2001;276:413-420.
    • (2001) J Biol Chem , vol.276 , pp. 413-420
    • Deng, L.1    Lin-Lee, Y.C.2    Claret, F.X.3    Kuo, M.T.4
  • 89
    • 0035282671 scopus 로고    scopus 로고
    • Differential sensitivities of MRP gene family and gammaglutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status
    • Lin-Lee Y-C, Tatebe S, Savaraj N, Ishikawa T, Kuo MT. Differential sensitivities of MRP gene family and gammaglutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status. Biochem Pharmacol 2001;61:555-563.
    • (2001) Biochem Pharmacol , vol.61 , pp. 555-563
    • Lin-Lee, Y.-C.1    Tatebe, S.2    Savaraj, N.3    Ishikawa, T.4    Kuo, M.T.5
  • 90
    • 17044400593 scopus 로고    scopus 로고
    • Hepatobiliary transporter expression in human hepatocellular carcinoma
    • Zollner G, Wagner M, Ficklert P, et al. Hepatobiliary transporter expression in human hepatocellular carcinoma. Liver Int 2005;25:367-379.
    • (2005) Liver Int , vol.25 , pp. 367-379
    • Zollner, G.1    Wagner, M.2    Ficklert, P.3
  • 91
    • 0032553308 scopus 로고    scopus 로고
    • Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress
    • Yamane Y, Furuichi M, Song R, et al. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. J Biol Chem 1998;273:31075-31085.
    • (1998) J Biol Chem , vol.273 , pp. 31075-31085
    • Yamane, Y.1    Furuichi, M.2    Song, R.3
  • 92
    • 0029760088 scopus 로고    scopus 로고
    • Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers
    • Kuo MT, Bao JJ, Curley SA, Ikeguchi M, Johnston DA, Ishikawa T. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res 1996;56:3642-3644.
    • (1996) Cancer Res , vol.56 , pp. 3642-3644
    • Kuo, M.T.1    Bao, J.J.2    Curley, S.A.3    Ikeguchi, M.4    Johnston, D.A.5    Ishikawa, T.6
  • 93
    • 0021797851 scopus 로고
    • Purification induction, and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis
    • Sato K, Kitahara A, Soma Y, Inaba Y, Hatayama I, Sato K. Purification induction, and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc Natl Acad Sci USA 1985;82:3964-3968.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 3964-3968
    • Sato, K.1    Kitahara, A.2    Soma, Y.3    Inaba, Y.4    Hatayama, I.5    Sato, K.6
  • 94
    • 0021971350 scopus 로고
    • Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis
    • Sugioka Y, Kano T, Okuda A, Sakai M, Kitagawa T, Maramatsu M. Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis. Cancer Res 1985;45:365-378.
    • (1985) Cancer Res , vol.45 , pp. 365-378
    • Sugioka, Y.1    Kano, T.2    Okuda, A.3    Sakai, M.4    Kitagawa, T.5    Maramatsu, M.6
  • 95
    • 3142570440 scopus 로고    scopus 로고
    • The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
    • Nguyen T, Yang CS, Pickett CB. The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 2004;37:433-441.
    • (2004) Free Radic Biol Med , vol.37 , pp. 433-441
    • Nguyen, T.1    Yang, C.S.2    Pickett, C.B.3
  • 96
    • 23344431879 scopus 로고    scopus 로고
    • Delayed mechanism for induction of γ-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling
    • Song I-S, Tatebe S, Dai W, Kuo MT. Delayed mechanism for induction of γ-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling. J Biol Chem 2005;280:28230-28240.
    • (2005) J Biol Chem , vol.280 , pp. 28230-28240
    • Song, I.-S.1    Tatebe, S.2    Dai, W.3    Kuo, M.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.