Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling

Oncogene

Volumn 21, Issue 13, 2002, Pages 1945-1954

  Macus, Tien Kuo ^a   Liu, Zesheng ^a   Wei, Yingjie ^a   Lin Lee, Yen Chiu ^a   Tatebe, Shigeru ^a   Mills, Gordon B ^a   Unate, Hitoshi ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

2 acetylaminofluorene; Akt; MDR; PI3 kinase; Rac

Indexed keywords

DNA; GLYCOPROTEIN P; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; N (2 FLUORENYL)ACETAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; GENE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 2-ACETYLAMINOFLUORENE; ACETOXYACETYLAMINOFLUORENE; CARCINOMA, HEPATOCELLULAR; CELL LINE; DRUG RESISTANCE, MULTIPLE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; NADPH OXIDASE; NF-KAPPA B; P-GLYCOPROTEIN; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAC GTP-BINDING PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPEROXIDES; TUMOR CELLS, CULTURED; UP-REGULATION;

ANIMALIA; MARTES PENNANTI; RODENTIA;

EID: 0037150228     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj/onc/1205117     Document Type: Article

References (73)