Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 11, 2005, Pages 4120-4125

  Xu, Zhenrong ^a   Chen, Linyun ^b,d   Leung, Laura ^a   Yen, T S Benedict ^c   Lee, Candy ^a   Chan, Jefferson Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Carney Hospital   (United States)

Author keywords

Hepatocellular carcinoma; Knockout mouse; Oxidative stress

Indexed keywords

CYTOCHROME P450 4A; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE; GENE EXPRESSION; GENE INACTIVATION; LIPID METABOLISM; LIVER CANCER; LIVER CELL; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NRF1 GENE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; ANTIOXIDANTS; DNA-BINDING PROTEINS; FATTY ACIDS; HEPATITIS; LIVER; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; MICROSOMES, LIVER; NUCLEAR RESPIRATORY FACTOR 1; NUCLEAR RESPIRATORY FACTORS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; TRANS-ACTIVATORS;

EID: 15244359632     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500660102     Document Type: Article

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