Application of comparative functional genomics to identify best-fit mouse models to study human cancer

Nature Genetics

Volumn 36, Issue 12, 2004, Pages 1306-1311

  Lee, Ju Seog ^a   Chu, In Sun ^a   Mikaelyan, Arsen ^a   Calvisi, Diego F ^a   Heo, Jeonghoon ^a   Reddy, Janardan K ^b   Thorgeirsson, Snorri S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFIBRATE; DIETHYLNITROSAMINE; MYC PROTEIN; TRANSCRIPTION FACTOR E2F1; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CANCER SURVIVAL; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOMICS; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LIVER CARCINOGENESIS; LIVER CARCINOMA; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SURVIVAL RATE; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; MUS MUSCULUS;

EID: 9644254191     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1481     Document Type: Article

References (30)

1. Hann, B. & Balmain, A. Building 'validated' mouse models of human cancer. Curr. Opin. Cell Biol. 13, 778-784 (2001).
2. Klausner, R.D. Studying cancer in the mouse. Oncogene 18, 5249-5252 (1999).
3. Rangarajan, A. & Weinberg, R.A. Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat. Rev. Cancer 3, 952-959 (2003).
4. Lee, J.S. et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 40, 667-676 (2004).
5. Kimura, M. Evolutionary rate at the molecular level. Nature 217, 624-626 (1968).
6. King, J.L. & Jukes, T.H. Non-Darwinian evolution. Science 164, 788-798 (1969).
7. Ureta-Vidal, A., Ettwiller, L. & Birney, E. Comparative genomics: genome-wide analysis in metazoan eukaryotes. Nat. Rev. Genet. 4, 251-262 (2003).
8. Cooper, G.M. & Sidow, A. Genomic regulatory regions: insights from comparative sequence analysis. Curr. Opin. Genet. Dev. 13, 604-610 (2003).
9. Eddy, S.R. Computational genomics of noncoding RNA genes. Cell 109, 137-140 (2002).
10. Hardison, R.C. Conserved noncoding sequences are reliable guides to regulatory elements. Trends Genet. 16, 369-372 (2000).
11. Rao, M.S., Lalwani, N.D., Watanabe, T.K. & Reddy, J.K. Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator. Cancer Res. 44, 1072-1076 (1984).
12. Reddy, J.K. & Lalwai, N.D. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 12, 1-58 (1983).
13. Poirier, L.A. Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes. J. Natl. Cancer Inst. 54, 137-140 (1975).
14. Conner, E.A. et al. Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis. Oncogene 19, 5054-5062 (2000).
15. Conner, E.A., Lemmer, E.R., Sanchez, A., Factor, V.M. & Thorgeirsson, S.S. E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models. Biochem. Biophys. Res. Commun. 302, 114-120 (2003).
16. Murakami, H. et al. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res. 53, 1719-1723 (1993).
17. Fan, C.Y. et al. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J. Biol. Chem. 273, 15639-15645 (1998).
18. Calvisi, D.F., Factor, V.M., Ladu, S., Conner, E.A. & Thorgeirsson, S.S. Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice. Gastroenterology 126, 1374-1386 (2004).
19. Bentley, P. et al. Hepatic peroxisome proliferation in rodents and its significance for humans. Food Chem. Toxicol. 31, 857-907 (1993).
20. Gonzalez, F.J., Peters, J.M. & Cattley, R.C. Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. J. Natl. Cancer Inst. 90, 1702-1709 (1998).
21. Rosenwald, A. et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 3, 185-197 (2003).
22. Shirahashi, H. et al. Ubiquitin is a possible new predictive marker for the recurrence of human hepatocellular carcinoma. Liver 22, 413-418 (2002).
23. Alizadeh, A.A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503-511 (2000).
24. Schaner, M.E. et al. Gene expression patterns in ovarian carcinomas. Mol. Biol. Cell 14, 4376-4386 (2003).
25. Sargent, L.M. et al. Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver. Am. J. Pathol. 154, 1047-1055 (1999).
26. Laurent-Puig, P. et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 120, 1763-1773 (2001).
27. Sambrook, J., Fritsch, E. & Maniatis, T. Molecular Cloning 7.19-7.22(Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989).
28. Meyer, K. et al. Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen. Carcinogenesis 24, 975-984 (2003).
29. Etlwood-Yen, K. et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 4, 223-238 (2003).
30. Tusher, V.G., Tibshirani, R. & Chu, G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA. 98, 5116-5121 (2001).