Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 5, 2000, Pages 2196-2201

  Factor, Valentina M ^a   Laskowska, Danuta ^a   Jensen, Michael Rugaard ^a   Woitach, Joseph T ^a   Popescu, Nicholas C ^a   Thorgeirsson, Snorri S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME DAMAGE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA STRUCTURE; DYSPLASIA; GENE OVEREXPRESSION; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER TUMOR; MALIGNANT TRANSFORMATION; MITOGENESIS; MOUSE; NONHUMAN; ONCOGENE C MYC; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN STABILITY; TRANSGENE;

ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA, MITOCHONDRIAL; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REACTIVE OXYGEN SPECIES; VITAMIN E;

ANIMALIA; MUS MUSCULUS;

EID: 0034091786     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.040428797     Document Type: Article

References (31)

1. Cerutti, P. A. (1985) Science 227, 375-381.
2. Beckman, K. B. & Ames, B. N. (1998) Physiol. Rev. 78, 547-581.
3. Ames, B. N. (1998) Toxicol. Lett. 102-103, 5-18.
4. Traber, M. G. & Sies, H. (1996) Annu. Rev. Nutr. 16, 321-347.
5. Halliwell, B. & Aruoma, O. I. (1991) FEBS Lett. 281, 9-19.
6. Dianzani, M. U. (1993) Crit. Rev. Oncol Hematol. 15, 125-147.
7. Cachia, O., Benna J. E., Pedruzzi, E., Descomps, B., Gougerot-Pocidalo, M. A. & Leger, C. L. (1998) J. Biol. Chem. 273, 32801-32805.
8. Meydani, M., Lipman, R. D., Han, S. N., Wu, D., Beharka, A., Martin, K. R., Bronson, R., Cao, G., Smith, D. & Meydani, S. N. (1998) Ann. N.Y. Acad. Sci. 854, 352-360.
9. Brigelius-Flohe, R. & Traber, M. G. (1999) FASEB J. 13, 1145-1155.
10. Prasad, K. N., Kumar, A., Kochupillai, V. & Cole, W. C. (1999) J. Am. Coll. Nutr. 18, 13-25.
11. Ricciarelli, R., Tasinato, A., Clement, S., Ozer, N. K., Boscoboinik, D. & Azzi, A. (1998) Biochem. J. 334, 243-249.
12. Blobe, G. C., Obeid, L. M. & Hannun, Y. A. (1994) Cancer Metastasis Rev. 13, 411-431.
13. Livneh, E., Dull, T. J., Berent, E., Prywes, R., Ullrich, A. & Schlessinger, J. (1988) Mol. Cell Biol. 8, 2302-2308.
14. Leo, M. A., Rosman, A. S. & Lieber, C. S. (1993) Hepatology 17, 977-986.
15. Rocchi, E., Seium, Y., Camellini, L., Casalgrandi, G., Borghi, A., D'Alimonte, P. & Cioni, G. (1997) Hepatology 26, 67-72.
16. Yamamoto, Y., Yamashita, S., Fujisawa, A., Kokura, S. & Yoshikawa, T. (1998) Biochem. Biophys. Res. Commun. 247, 166-170.
17. Factor, V. M., Kiss, A., Woitach, J. T., Wirth, P. J. & Thorgeirsson, S. S. (1998) J. Biol. Chem. 273, 15846-15853.
18. Grisham, J. W. (1997) Carcinogenesis 18, 59-81.
19. Murakami, H., Sanderson, N. D., Nagy, P., Merlino, G. & Thorgeirsson, S. S. (1993) Cancer Res. 53, 1719-1723.
20. Santoni-Rugiu, E., Nagy, P., Jensen, M. R., Factor, V. M. & Thorgeirsson, S. S. (1996) Am. J. Pathol. 149, 407-428.
21. Santoni-Rugiu, E., Jensen, M. R., Factor, V. M. & Thorgeirsson, S. S. (1999) Am. J. Pathol. 154, 1693-1700.
22. Sargent, L. M., Sanderson, N. D. & Thorgeirsson, S. S. (1996) Cancer Res. 56, 2137-2142.
23. Sargent, L. M., Zhou, X., Keck, C. L., Sanderson, N. D., Zimonjic, D. B., Popescu, N. C. & Thorgeirsson, S. S. (1999) Am. J. Pathol. 154, 1047-1055.
24. Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H. & Merlino, G. T. (1990) Cell 61, 1137-1146.
25. Frith, C. H., Ward, J. M. & Turusov, V. S. (1994) IARC Sci. Publ. 111, 223-269.
26. Kao, C. Y., Factor, V. M. & Thorgeirsson, S. S. (1996) Biochem. Biophys. Res. Commun. 222, 64-70.
27. ISCN (1985) An International System for Human Cytogeneric Nomenclature, eds. Harnden, D. G., Path, F. R. C. & Klinger, H. P. (S. Karger, Basel).
28. Tanhauser, S. M. & Laipis, P. J. (1995) J. Biol. Chem. 270, 24769-24775.
29. Pratico, D., Tangirala, R. K., Rader, D. J., Rokach, J. & FitzGerald, G. A. (1998) Nat. Med. 4, 1189-1192.
30. Fenech, M. (1998) Ann. N. Y. Acad. Sci. 854, 23-36.
31. Ames, B. N., Shigenaga, M. K. & Gold, L. S. (1993) Environ. Health Perspect. 101, Suppl. 5, 35-44.