-
3
-
-
17444383660
-
Apoptosome dysfunction in human cancer
-
Hajra KM, Liu JR (2004) Apoptosome dysfunction in human cancer. Apoptosis 9:691-704
-
(2004)
Apoptosis
, vol.9
, pp. 691-704
-
-
Hajra, K.M.1
Liu, J.R.2
-
4
-
-
1842844414
-
Decreased beta-cell mass in diabetes: Significance, mechanisms and therapeutic implications
-
Donath MY, Halban PA (2004) Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47:581-589
-
(2004)
Diabetologia
, vol.47
, pp. 581-589
-
-
Donath, M.Y.1
Halban, P.A.2
-
5
-
-
85047693458
-
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect?
-
Dickson DW (2004) Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? J Clin Invest 2004; 114:23-27
-
(2004)
J Clin Invest
, vol.2004
-
-
Dickson, D.W.1
-
6
-
-
3543123595
-
The Bcl-2 protein family and its role in the development of neoplastic disease
-
Heiser D, Labi V, Erlacher M, Villunger A. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp Gerontol 39:1125-1135
-
Exp Gerontol
, vol.39
, pp. 1125-1135
-
-
Heiser, D.1
Labi, V.2
Erlacher, M.3
Villunger, A.4
-
7
-
-
0033119372
-
BCL-2 gene family and the regulation of programmed cell death
-
Korsmeyer SJ (1999) BCL-2 gene family and the regulation of programmed cell death. Cancer Res 59:1693s-1700s
-
(1999)
Cancer Res
, vol.59
-
-
Korsmeyer, S.J.1
-
8
-
-
1842360038
-
Mechanism of the t(14;18) chromosomal translocation: Structural analysis of both derivative 14 and 18 reciprocal partners
-
Bakhshi A, Wright JJ, Graninger W, et al (1987) Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci USA 84:2396-2400
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 2396-2400
-
-
Bakhshi, A.1
Wright, J.J.2
Graninger, W.3
-
9
-
-
0030707613
-
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
-
Ottilie S, Diaz JL, Horne W, et al (1997) Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J Biol Chem 272:30866-30872
-
(1997)
J Biol Chem
, vol.272
, pp. 30866-30872
-
-
Ottilie, S.1
Diaz, J.L.2
Horne, W.3
-
10
-
-
0001003612
-
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
-
Hsu SY, Kaipia A, McGee E, et al (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci USA 94:12401-12406
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 12401-12406
-
-
Hsu, S.Y.1
Kaipia, A.2
McGee, E.3
-
11
-
-
17844392101
-
Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL
-
Rashmi R, Kumar S, Karunagaran D (2005) Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis 26:713-723
-
(2005)
Carcinogenesis
, vol.26
, pp. 713-723
-
-
Rashmi, R.1
Kumar, S.2
Karunagaran, D.3
-
12
-
-
0141818136
-
Integral role of Noxa in p53-mediated apoptotic response
-
Shibue T, Takeda K, Oda E, et al (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17:2233-2238
-
(2003)
Genes Dev
, vol.17
, pp. 2233-2238
-
-
Shibue, T.1
Takeda, K.2
Oda, E.3
-
13
-
-
0029807585
-
BID: A novel BH3 domain-only death agonist
-
Wang K, Yin XM, Chao DT, et al (1996) BID: a novel BH3 domain-only death agonist. Genes Dev 10:2859-2869
-
(1996)
Genes Dev
, vol.10
, pp. 2859-2869
-
-
Wang, K.1
Yin, X.M.2
Chao, D.T.3
-
15
-
-
0035008597
-
Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells
-
Lee T, Chau L (2001) Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280:C709-C718
-
(2001)
Am J Physiol Cell Physiol
, vol.280
-
-
Lee, T.1
Chau, L.2
-
16
-
-
0041827347
-
Apoptotic pathways involved in U937 cells exposed to LDL oxidized by hypochlorous acid
-
Vicca S, Massy ZA, Hennequin C, et al (2003) Apoptotic pathways involved in U937 cells exposed to LDL oxidized by hypochlorous acid. Free Radic Biol Med 35:603-615
-
(2003)
Free Radic Biol Med
, vol.35
, pp. 603-615
-
-
Vicca, S.1
Massy, Z.A.2
Hennequin, C.3
-
17
-
-
0037905779
-
Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: Possible role of oxidised LDL
-
Norata GD, Tonti L, Roma P, Catapano AL (2002) Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: possible role of oxidised LDL. Nutr Metab Cardiovasc Dis 12:297-305
-
(2002)
Nutr Metab Cardiovasc Dis
, vol.12
, pp. 297-305
-
-
Norata, G.D.1
Tonti, L.2
Roma, P.3
Catapano, A.L.4
-
18
-
-
0034320568
-
Mechanisms of apoptosis
-
Reed JC (2000) Mechanisms of apoptosis. Am J Pathol 157:1415-1430
-
(2000)
Am J Pathol
, vol.157
, pp. 1415-1430
-
-
Reed, J.C.1
-
19
-
-
0037213368
-
The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions
-
Borner C (2003) The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 39:615-647
-
(2003)
Mol Immunol
, vol.39
, pp. 615-647
-
-
Borner, C.1
-
20
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281:1305-1308
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
21
-
-
0033582526
-
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
-
Sun XM, MacFarlane M, Zhuang J, et al (1999) Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 274:5053-5060
-
(1999)
J Biol Chem
, vol.274
, pp. 5053-5060
-
-
Sun, X.M.1
MacFarlane, M.2
Zhuang, J.3
-
22
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick MR, Weigand MA, Rieser E, et al (2000) FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12:599-609
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
-
23
-
-
0033790715
-
TRAIL receptor-2 signals apoptosis through FADD and caspase-8
-
Bodmer JL, Holler N, Reynard S, et al (2000) TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2:241-243
-
(2000)
Nat Cell Biol
, vol.2
, pp. 241-243
-
-
Bodmer, J.L.1
Holler, N.2
Reynard, S.3
-
24
-
-
0037105386
-
Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8
-
Soderstrom TS, Poukkula M, Holmstrom TH, et al (2002) Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. J Immunol 169:2851-2860
-
(2002)
J Immunol
, vol.169
, pp. 2851-2860
-
-
Soderstrom, T.S.1
Poukkula, M.2
Holmstrom, T.H.3
-
25
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
Scaffidi C, Fulda S, Srinivasan A, et al (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687
-
(1998)
EMBO J
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
Fulda, S.2
Srinivasan, A.3
-
26
-
-
0034667383
-
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
-
Ochs K, Kaina B (2000) Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res 60:5815-5824
-
(2000)
Cancer Res
, vol.60
, pp. 5815-5824
-
-
Ochs, K.1
Kaina, B.2
-
27
-
-
0034123026
-
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome crelease
-
Slee EA, Keogh SA, Martin SJ (2000) Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome crelease. Cell Death Differ 7:556-565
-
(2000)
Cell Death Differ
, vol.7
, pp. 556-565
-
-
Slee, E.A.1
Keogh, S.A.2
Martin, S.J.3
-
28
-
-
0033959317
-
Caspase activation and mitochondrial cytochrome crelease during hypoxia-mediated apoptosis of adult ventricular myocytes
-
de Moissac D, Gurevich RM, Zheng H, et al (2000) Caspase activation and mitochondrial cytochrome crelease during hypoxia-mediated apoptosis of adult ventricular myocytes. J Mol Cell Cardiol 32:53-63
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 53-63
-
-
De Moissac, D.1
Gurevich, R.M.2
Zheng, H.3
-
29
-
-
0032555934
-
Blocking cytochrome cactivity within intact neurons inhibits apoptosis
-
Neame SJ, Rubin LL, Philpott KL (1998) Blocking cytochrome cactivity within intact neurons inhibits apoptosis. J Cell Biol 142:1583-1593
-
(1998)
J Cell Biol
, vol.142
, pp. 1583-1593
-
-
Neame, S.J.1
Rubin, L.L.2
Philpott, K.L.3
-
30
-
-
0031037897
-
The release of cytochrome cfrom mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome cfrom mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
31
-
-
0035803568
-
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
-
Adrain C, Creagh EM, Martin SJ (2001) Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J 20:6627-6636
-
(2001)
EMBO J
, vol.20
, pp. 6627-6636
-
-
Adrain, C.1
Creagh, E.M.2
Martin, S.J.3
-
32
-
-
18244386261
-
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
-
van Loo G, van Gurp M, Depuydt B, et al (2002) The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ 9:20-26
-
(2002)
Cell Death Differ
, vol.9
, pp. 20-26
-
-
Van Loo, G.1
Van Gurp, M.2
Depuydt, B.3
-
33
-
-
0036792475
-
The role of mitochondrial factors in apoptosis: A Russian roulette with more than one bullet
-
van Loo G, Saelens X, van Gurp M, et al (2002) The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ 9:1031-1042
-
(2002)
Cell Death Differ
, vol.9
, pp. 1031-1042
-
-
Van Loo, G.1
Saelens, X.2
Van Gurp, M.3
-
35
-
-
0035920192
-
Alloxan-induced mitochondrial permeability transition triggered by calcium, thiol oxidation, and matrix ATP
-
Sakurai K, Katoh M, Fujimoto Y (2001) Alloxan-induced mitochondrial permeability transition triggered by calcium, thiol oxidation, and matrix ATP. J Biol Chem 276:26942-26946
-
(2001)
J Biol Chem
, vol.276
, pp. 26942-26946
-
-
Sakurai, K.1
Katoh, M.2
Fujimoto, Y.3
-
36
-
-
0034730884
-
Mitochondria: Execution central
-
Gottlieb RA (2000) Mitochondria: execution central. FEBS Lett 482:6-12
-
(2000)
FEBS Lett
, vol.482
, pp. 6-12
-
-
Gottlieb, R.A.1
-
37
-
-
0033021780
-
Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence
-
Petronilli V, Miotto G, Canton M, et al (1999) Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 76:725-734
-
(1999)
Biophys J
, vol.76
, pp. 725-734
-
-
Petronilli, V.1
Miotto, G.2
Canton, M.3
-
38
-
-
0035853721
-
The mitochondrial permeability transition, release of cytochrome cand cell death. Correlation with the duration of pore openings in situ
-
Petronilli V, Penzo D, Scorrano L, et al (2001) The mitochondrial permeability transition, release of cytochrome cand cell death. Correlation with the duration of pore openings in situ. J Biol Chem 276:12030-12034
-
(2001)
J Biol Chem
, vol.276
, pp. 12030-12034
-
-
Petronilli, V.1
Penzo, D.2
Scorrano, L.3
-
39
-
-
0032550363
-
The permeability transition pore complex: A target for apoptosis regulation by caspases and bcl-2-related proteins
-
Marzo I, Brenner C, Zamzami N, et al (1998) The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med 187:1261-1271
-
(1998)
J Exp Med
, vol.187
, pp. 1261-1271
-
-
Marzo, I.1
Brenner, C.2
Zamzami, N.3
-
40
-
-
0033519705
-
Bcl-2 family proteins regulate the release of apoptogenic cytochrome cby the mitochondrial channel VDAC
-
Shimizu S, Narita M, Tsujimoto Y (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome cby the mitochondrial channel VDAC. Nature 399:483-487
-
(1999)
Nature
, vol.399
, pp. 483-487
-
-
Shimizu, S.1
Narita, M.2
Tsujimoto, Y.3
-
41
-
-
0032566649
-
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
-
Marzo I, Brenner C, Zamzami N, et al (1998) Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281:2027-2031
-
(1998)
Science
, vol.281
, pp. 2027-2031
-
-
Marzo, I.1
Brenner, C.2
Zamzami, N.3
-
42
-
-
0037439801
-
Bcl-2 and Bax modulate adenine nucleotide translocase activity
-
Belzacq AS, Vieira HL, Verrier F, et al (2003) Bcl-2 and Bax modulate adenine nucleotide translocase activity. Cancer Res 63:541-546
-
(2003)
Cancer Res
, vol.63
, pp. 541-546
-
-
Belzacq, A.S.1
Vieira, H.L.2
Verrier, F.3
-
43
-
-
0033593230
-
Bax-induced caspase activation and apoptosis via cytochrome crelease from mitochondria is inhibitable by Bcl-xL
-
Finucane DM, Bossy-Wetzel E, Waterhouse NJ, et al (1999) Bax-induced caspase activation and apoptosis via cytochrome crelease from mitochondria is inhibitable by Bcl-xL. J Biol Chem 274:2225-2233
-
(1999)
J Biol Chem
, vol.274
, pp. 2225-2233
-
-
Finucane, D.M.1
Bossy-Wetzel, E.2
Waterhouse, N.J.3
-
44
-
-
0032422488
-
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome crelease in isolated mitochondria
-
Narita M, Shimizu S, Ito T, et al (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome crelease in isolated mitochondria. Proc Natl Acad Sci USA 95:14681-14686
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14681-14686
-
-
Narita, M.1
Shimizu, S.2
Ito, T.3
-
45
-
-
0035853811
-
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
-
Antonsson B, Montessuit S, Sanchez B, Martinou JC (2001) Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 276:11615-11623
-
(2001)
J Biol Chem
, vol.276
, pp. 11615-11623
-
-
Antonsson, B.1
Montessuit, S.2
Sanchez, B.3
Martinou, J.C.4
-
46
-
-
0033956449
-
The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L)
-
Nouraini S, Six E, Matsuyama S, et al (2000) The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L). Mol Cell Biol 20:1604-1615
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1604-1615
-
-
Nouraini, S.1
Six, E.2
Matsuyama, S.3
-
47
-
-
0038025230
-
Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome crelease
-
Mikhailov V, Mikhailova M, Degenhardt K, et al (2003) Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome crelease. J Biol Chem 278:5367-5376
-
(2003)
J Biol Chem
, vol.278
, pp. 5367-5376
-
-
Mikhailov, V.1
Mikhailova, M.2
Degenhardt, K.3
-
48
-
-
0035947596
-
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane
-
Mikhailov V, Mikhailova M, Pulkrabek DJ, et al (2001) Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem 276:18361-18374
-
(2001)
J Biol Chem
, vol.276
, pp. 18361-18374
-
-
Mikhailov, V.1
Mikhailova, M.2
Pulkrabek, D.J.3
-
50
-
-
0033522391
-
Conformation of the Bax C-terminus regulates subcellular location and cell death
-
Nechushtan A, Smith CL, Hsu YT, Youle RJ (1999) Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J 18:2330-2341
-
(1999)
EMBO J
, vol.18
, pp. 2330-2341
-
-
Nechushtan, A.1
Smith, C.L.2
Hsu, Y.T.3
Youle, R.J.4
-
51
-
-
1442359881
-
Bcl-2 family members: Integrators of survival and death signals in physiology and pathology
-
Schinzel A, Kaufmann T, Borner c(2004) Bcl-2 family members: integrators of survival and death signals in physiology and pathology. Biochim Biophys Acta 1644:95-105
-
(2004)
Biochim Biophys Acta
, vol.1644
, pp. 95-105
-
-
Schinzel, A.1
Kaufmann, T.2
Borner, C.3
-
52
-
-
0027525536
-
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence
-
Nguyen M, Millar DG, Yong VW, et al (1993) Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem 268:25265-25268
-
(1993)
J Biol Chem
, vol.268
, pp. 25265-25268
-
-
Nguyen, M.1
Millar, D.G.2
Yong, V.W.3
-
53
-
-
0040185619
-
Study of the secondary structure of the C-terminal domain of the antiapoptotic protein bcl-2 and its interactionwith modelmembranes
-
del Mar Martinez-Senac M, Corbalan-Garcia S, Gomez-Fernandez JC (2000) Study of the secondary structure of the C-terminal domain of the antiapoptotic protein bcl-2 and its interactionwith modelmembranes. Biochemistry 39:7744-7752
-
(2000)
Biochemistry
, vol.39
, pp. 7744-7752
-
-
Del Mar Martinez-Senac, M.1
Corbalan-Garcia, S.2
Gomez-Fernandez, J.C.3
-
54
-
-
0030822420
-
Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family
-
Aritomi M, Kunishima N, Inohara N, et al (1997) Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family. J Biol Chem 272:27886-27892
-
(1997)
J Biol Chem
, vol.272
, pp. 27886-27892
-
-
Aritomi, M.1
Kunishima, N.2
Inohara, N.3
-
55
-
-
5244224827
-
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
-
Muchmore SW, Sattler M, Liang H, et al (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335-341
-
(1996)
Nature
, vol.381
, pp. 335-341
-
-
Muchmore, S.W.1
Sattler, M.2
Liang, H.3
-
56
-
-
0037133676
-
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus
-
Huang Q, Petros AM, Virgin HW, et al (2002) Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc Natl Acad Sci USA 99:3428-3433
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3428-3433
-
-
Huang, Q.1
Petros, A.M.2
Virgin, H.W.3
-
57
-
-
0030614915
-
Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
-
Sattler M, Liang H, Nettesheim D, et al (1997) Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 275:983-986
-
(1997)
Science
, vol.275
, pp. 983-986
-
-
Sattler, M.1
Liang, H.2
Nettesheim, D.3
-
58
-
-
0033510983
-
Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules
-
Korsmeyer SJ, Gross A, Harada H, et al (1999) Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules. Cold Spring Harb Symp Quant Biol 64:343-350
-
(1999)
Cold Spring Harb Symp Quant Biol
, vol.64
, pp. 343-350
-
-
Korsmeyer, S.J.1
Gross, A.2
Harada, H.3
-
59
-
-
0034678367
-
Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization
-
Gilmore AP, Metcalfe AD, Romer LH, Streuli CH (2000) Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization. J Cell Biol 149:431-446
-
(2000)
J Cell Biol
, vol.149
, pp. 431-446
-
-
Gilmore, A.P.1
Metcalfe, A.D.2
Romer, L.H.3
Streuli, C.H.4
-
60
-
-
0033535350
-
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome crelease during apoptosis
-
Desagher S, Osen-Sand A, Nichols A, et al (1999) Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome crelease during apoptosis. J Cell Biol 144:891-901
-
(1999)
J Cell Biol
, vol.144
, pp. 891-901
-
-
Desagher, S.1
Osen-Sand, A.2
Nichols, A.3
-
61
-
-
0030824575
-
Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2
-
He H, Lam M, McCormick TS, Distelhorst CW (1997) Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2. J Cell Biol 138:1219-1228
-
(1997)
J Cell Biol
, vol.138
, pp. 1219-1228
-
-
He, H.1
Lam, M.2
McCormick, T.S.3
Distelhorst, C.W.4
-
62
-
-
0031962324
-
Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide
-
Bruce-Keller AJ, Begley JG, Fu W, et al (1998) Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide. J Neurochem 70:31-39
-
(1998)
J Neurochem
, vol.70
, pp. 31-39
-
-
Bruce-Keller, A.J.1
Begley, J.G.2
Fu, W.3
-
63
-
-
0033605073
-
Oxidative stress is attenuated in mice overexpressing BCL-2
-
Bogdanov MB, Ferrante RJ, Mueller G, et al (1999) Oxidative stress is attenuated in mice overexpressing BCL-2. Neurosci Lett 262:33-36
-
(1999)
Neurosci Lett
, vol.262
, pp. 33-36
-
-
Bogdanov, M.B.1
Ferrante, R.J.2
Mueller, G.3
-
64
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome cfrom mitochondria blocked
-
Yang J, Liu X, Bhalla K, et al (1997) Prevention of apoptosis by Bcl-2: release of cytochrome cfrom mitochondria blocked. Science 275:1129-1132
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
-
65
-
-
0030754701
-
Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
-
Mirkovic N, Voehringer DW, Story MD, et al (1997) Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene 15:1461-1470
-
(1997)
Oncogene
, vol.15
, pp. 1461-1470
-
-
Mirkovic, N.1
Voehringer, D.W.2
Story, M.D.3
-
66
-
-
0031032294
-
Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
-
Decaudin D, Geley S, Hirsch T, et al (1997) Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57:62-67
-
(1997)
Cancer Res
, vol.57
, pp. 62-67
-
-
Decaudin, D.1
Geley, S.2
Hirsch, T.3
-
67
-
-
0035901954
-
Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis
-
Rokhlin OW, Guseva N, Tagiyev A, et al (2001) Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis. Oncogene 20:2836-2843
-
(2001)
Oncogene
, vol.20
, pp. 2836-2843
-
-
Rokhlin, O.W.1
Guseva, N.2
Tagiyev, A.3
-
68
-
-
11144230279
-
Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells
-
Sinicrope FA, Penington RC, Tang XM (2004) Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin Cancer Res 10:8284-8292
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8284-8292
-
-
Sinicrope, F.A.1
Penington, R.C.2
Tang, X.M.3
-
69
-
-
0028790829
-
Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma
-
Memon SA, Moreno MB, Petrak D, Zacharchuk CM (1995) Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J Immunol 155:4644-4652
-
(1995)
J Immunol
, vol.155
, pp. 4644-4652
-
-
Memon, S.A.1
Moreno, M.B.2
Petrak, D.3
Zacharchuk, C.M.4
-
70
-
-
0033370411
-
Apoptosis-induced by TRAIL and TNF-alpha in human multiple myeloma cells is not blocked by BCL-2
-
Gazitt Y, Shaughnessy P, Montgomery W (1999) Apoptosis-induced by TRAIL AND TNF-alpha in human multiple myeloma cells is not blocked by BCL-2. Cytokine 11:1010-1019
-
(1999)
Cytokine
, vol.11
, pp. 1010-1019
-
-
Gazitt, Y.1
Shaughnessy, P.2
Montgomery, W.3
-
71
-
-
0034615860
-
Failure of Bcl-2 to block cytochrome credistribution during TRAIL-induced apoptosis
-
Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ (2000) Failure of Bcl-2 to block cytochrome credistribution during TRAIL-induced apoptosis. FEBS Lett 471:93-98
-
(2000)
FEBS Lett
, vol.471
, pp. 93-98
-
-
Keogh, S.A.1
Walczak, H.2
Bouchier-Hayes, L.3
Martin, S.J.4
-
72
-
-
0027427492
-
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
-
Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240
-
(1993)
Cell
, vol.75
, pp. 229-240
-
-
Veis, D.J.1
Sorenson, C.M.2
Shutter, J.R.3
Korsmeyer, S.J.4
-
73
-
-
0028922885
-
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
-
Motoyama N, Wang F, Roth KA, et al (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510
-
(1995)
Science
, vol.267
, pp. 1506-1510
-
-
Motoyama, N.1
Wang, F.2
Roth, K.A.3
-
74
-
-
0033774569
-
Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells
-
Conus S, Rosse T, Borner c(2000) Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. Cell Death Differ 7:947-954
-
(2000)
Cell Death Differ
, vol.7
, pp. 947-954
-
-
Conus, S.1
Rosse, T.2
Borner, C.3
-
75
-
-
0034625352
-
Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation
-
Murphy KM, Streips UN, Lock RB (2000) Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation. J Biol Chem 275:17225-17228
-
(2000)
J Biol Chem
, vol.275
, pp. 17225-17228
-
-
Murphy, K.M.1
Streips, U.N.2
Lock, R.B.3
-
76
-
-
0037417950
-
Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
-
He L, Perkins GA, Poblenz AT, et al (2003) Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci USA 100:1022-1027
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1022-1027
-
-
He, L.1
Perkins, G.A.2
Poblenz, A.T.3
-
77
-
-
0042090307
-
BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization
-
Ruffolo SC, Shore GC (2003) BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization. J Biol Chem 278:25039-25045
-
(2003)
J Biol Chem
, vol.278
, pp. 25039-25045
-
-
Ruffolo, S.C.1
Shore, G.C.2
-
78
-
-
22244464818
-
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
-
Willis SN, Chen L, Dewson G, et al (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-1305
-
(2005)
Genes Dev
, vol.19
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
-
79
-
-
0030959304
-
Bcl-2 phosphorylation required for anti-apoptosis function
-
Ito T, Deng X, Carr B, May WS (1997) Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272:11671-11673
-
(1997)
J Biol Chem
, vol.272
, pp. 11671-11673
-
-
Ito, T.1
Deng, X.2
Carr, B.3
May, W.S.4
-
80
-
-
0033499801
-
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
-
Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19:8469-8478
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8469-8478
-
-
Yamamoto, K.1
Ichijo, H.2
Korsmeyer, S.J.3
-
81
-
-
0037434841
-
Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis
-
Basu A, Haldar S (2003) Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett 538:41-47
-
(2003)
FEBS Lett
, vol.538
, pp. 41-47
-
-
Basu, A.1
Haldar, S.2
-
82
-
-
0033049597
-
Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells
-
Fadeel B, Hassan Z, Hellstrom-Lindberg E, et al (1999) Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia 13:719-728
-
(1999)
Leukemia
, vol.13
, pp. 719-728
-
-
Fadeel, B.1
Hassan, Z.2
Hellstrom-Lindberg, E.3
-
83
-
-
0036140941
-
Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2
-
Liang Y, Nylander KD, Yan C, Schor NF (2002) Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2. Mol Pharmacol 61:142-149
-
(2002)
Mol Pharmacol
, vol.61
, pp. 142-149
-
-
Liang, Y.1
Nylander, K.D.2
Yan, C.3
Schor, N.F.4
-
84
-
-
0031465443
-
Conversion of Bcl-2 to a Bax-like death effector by caspases
-
Cheng EH, Kirsch DG, Clem RJ, et al (1997) Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278:1966-1968
-
(1997)
Science
, vol.278
, pp. 1966-1968
-
-
Cheng, E.H.1
Kirsch, D.G.2
Clem, R.J.3
-
85
-
-
0033597785
-
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
-
Kirsch DG, Doseff A, Chau BN, et al (1999) Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem 274:21155-21161
-
(1999)
J Biol Chem
, vol.274
, pp. 21155-21161
-
-
Kirsch, D.G.1
Doseff, A.2
Chau, B.N.3
-
86
-
-
0035903220
-
Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes
-
Basanez G, Zhang J, Chau BN, et al (2001) Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes. J Biol Chem 276:31083-31091
-
(2001)
J Biol Chem
, vol.276
, pp. 31083-31091
-
-
Basanez, G.1
Zhang, J.2
Chau, B.N.3
-
87
-
-
0033522391
-
Conformation of the Bax C-terminus regulates subcellular location and cell death
-
Nechushtan A, Smith CL, Hsu YT, Youle RJ (1999) Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J 18:2330-2341
-
(1999)
EMBO J
, vol.18
, pp. 2330-2341
-
-
Nechushtan, A.1
Smith, C.L.2
Hsu, Y.T.3
Youle, R.J.4
-
88
-
-
0033535347
-
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
-
Griffiths GJ, Dubrez L, Morgan CP, et al (1999) Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol 144:903-914
-
(1999)
J Cell Biol
, vol.144
, pp. 903-914
-
-
Griffiths, G.J.1
Dubrez, L.2
Morgan, C.P.3
-
89
-
-
0036236471
-
Calpain-mediated Bid cleavage and calpain-independent Bak modulation: Two separate pathways in cisplatin-induced apoptosis
-
Mandic A, Viktorsson K, Strandberg L, et al (2002) Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol 22:3003-3013
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3003-3013
-
-
Mandic, A.1
Viktorsson, K.2
Strandberg, L.3
-
90
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, et al (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727-730
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
-
91
-
-
0036141029
-
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO
-
Deng Y, Lin Y, Wu X (2002) TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev 16:33-45
-
(2002)
Genes Dev
, vol.16
, pp. 33-45
-
-
Deng, Y.1
Lin, Y.2
Wu, X.3
-
92
-
-
6344253246
-
Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells
-
Han J, Goldstein LA, Gastman BR, et al (2004) Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells. Leukemia 18:1671-1680
-
(2004)
Leukemia
, vol.18
, pp. 1671-1680
-
-
Han, J.1
Goldstein, L.A.2
Gastman, B.R.3
-
94
-
-
0032480260
-
Bax cleavage is mediated by calpain during drug-induced apoptosis
-
Wood DE, Thomas A, Devi LA, et al (1998) Bax cleavage is mediated by calpain during drug-induced apoptosis. Oncogene 17:1069-1078
-
(1998)
Oncogene
, vol.17
, pp. 1069-1078
-
-
Wood, D.E.1
Thomas, A.2
Devi, L.A.3
-
95
-
-
0141481980
-
Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax
-
Cao X, Deng X, May WS (2003) Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax. Blood 102:2605-2614
-
(2003)
Blood
, vol.102
, pp. 2605-2614
-
-
Cao, X.1
Deng, X.2
May, W.S.3
-
96
-
-
0037395017
-
BH3 domains as BCL-2 inhibitors: Prototype cancer therapeutics
-
Letai A (2003) BH3 domains as BCL-2 inhibitors: prototype cancer therapeutics. Expert Opin Biol Ther 3:293-304
-
(2003)
Expert Opin Biol Ther
, vol.3
, pp. 293-304
-
-
Letai, A.1
-
97
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
98
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR, Katsov A, Hu L, et al (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6:41-51
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
-
99
-
-
0036282745
-
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
-
Konishi Y, Lehtinen M, Donovan N, Bonni A (2002) Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell 9:1005-1016
-
(2002)
Mol Cell
, vol.9
, pp. 1005-1016
-
-
Konishi, Y.1
Lehtinen, M.2
Donovan, N.3
Bonni, A.4
-
100
-
-
0037174934
-
JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery
-
Donovan N, Becker EB, Konishi Y, Bonni A (2002) JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 277:40944-40949
-
(2002)
J Biol Chem
, vol.277
, pp. 40944-40949
-
-
Donovan, N.1
Becker, E.B.2
Konishi, Y.3
Bonni, A.4
-
101
-
-
0037155283
-
Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity
-
Dramsi S, Scheid MP, Maiti A, et al (2002) Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J Biol Chem 277:6399-6405
-
(2002)
J Biol Chem
, vol.277
, pp. 6399-6405
-
-
Dramsi, S.1
Scheid, M.P.2
Maiti, A.3
-
102
-
-
0037860975
-
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis
-
Putcha GV, Le S, Frank S, et al (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38:899-914
-
(2003)
Neuron
, vol.38
, pp. 899-914
-
-
Putcha, G.V.1
Le, S.2
Frank, S.3
-
103
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683-694
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
104
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E, Ohki R, Murasawa H, et al (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-1058
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
-
105
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu J, Zhang L, Hwang PM, et al (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7:673-682
-
(2001)
Mol Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
-
106
-
-
0037452759
-
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
-
Yu J, Wang Z, Kinzler KW, et al (2003) PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 100:1931-1936
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1931-1936
-
-
Yu, J.1
Wang, Z.2
Kinzler, K.W.3
-
107
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu CJ, Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
108
-
-
0033534446
-
Caspase cleaved BID targets mitochondria and is required for cytochrome crelease, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
-
Gross A, Yin XM, Wang K, et al (1999) Caspase cleaved BID targets mitochondria and is required for cytochrome crelease, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 274:1156-1163
-
(1999)
J Biol Chem
, vol.274
, pp. 1156-1163
-
-
Gross, A.1
Yin, X.M.2
Wang, K.3
-
109
-
-
0034534795
-
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
-
Zha J, Weiler S, Oh KJ, et al (2000) Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290:1761-1765
-
(2000)
Science
, vol.290
, pp. 1761-1765
-
-
Zha, J.1
Weiler, S.2
Oh, K.J.3
-
110
-
-
0027241856
-
The pathogenesis of atherosclerosis: A perspective for the 1990s
-
Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801-809
-
(1993)
Nature
, vol.362
, pp. 801-809
-
-
Ross, R.1
-
111
-
-
0346363234
-
Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis
-
Kutuk O, Basaga H (2003) Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med 9:549-557
-
(2003)
Trends Mol Med
, vol.9
, pp. 549-557
-
-
Kutuk, O.1
Basaga, H.2
-
112
-
-
0025356230
-
Atherogenesis during low level hypercholesterolemia in the nonhuman primate. I. Fatty streak formation
-
Masuda J, Ross R (1990) Atherogenesis during low level hypercholesterolemia in the nonhuman primate. I. Fatty streak formation. Arteriosclerosis 10:164-177
-
(1990)
Arteriosclerosis
, vol.10
, pp. 164-177
-
-
Masuda, J.1
Ross, R.2
-
113
-
-
0028034055
-
Smooth-muscle-cell proliferation and differentiation in neointima formation and vascular restenosis
-
Pauletto P, Sartore S, Pessina AC (1994) Smooth-muscle-cell proliferation and differentiation in neointima formation and vascular restenosis. Clin Sci 87:467-479
-
(1994)
Clin Sci
, vol.87
, pp. 467-479
-
-
Pauletto, P.1
Sartore, S.2
Pessina, A.C.3
-
114
-
-
0033552883
-
Atherosclerosis-an inflammatory disease
-
Ross R (1999) Atherosclerosis-an inflammatory disease. N Engl J Med 340:115-126
-
(1999)
N Engl J Med
, vol.340
, pp. 115-126
-
-
Ross, R.1
-
116
-
-
0028903234
-
Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques
-
Bennett MR, Evan GI, Schwartz SM (1995) Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 95:2266-2274
-
(1995)
J Clin Invest
, vol.95
, pp. 2266-2274
-
-
Bennett, M.R.1
Evan, G.I.2
Schwartz, S.M.3
-
117
-
-
20344383985
-
Multicolor fluorescence technique to detect apoptotic cells in advanced coronary atherosclerotic plaques
-
Soldani C, Scovassi AI, Canosi U, et al (2005) Multicolor fluorescence technique to detect apoptotic cells in advanced coronary atherosclerotic plaques. Eur J Histochem 49:47-52
-
(2005)
Eur J Histochem
, vol.49
, pp. 47-52
-
-
Soldani, C.1
Scovassi, A.I.2
Canosi, U.3
-
118
-
-
21344443874
-
TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol
-
Lee HS, Chang JS, Baek JA, et al (2005) TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. Biochem Biophys Res Commun 333:1093-1099
-
(2005)
Biochem Biophys Res Commun
, vol.333
, pp. 1093-1099
-
-
Lee, H.S.1
Chang, J.S.2
Baek, J.A.3
-
119
-
-
15944425098
-
The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis
-
Michowitz Y, Goldstein E, Roth A, et al (2005) The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis. J Am Coll Cardiol 45:1018-1024
-
(2005)
J Am Coll Cardiol
, vol.45
, pp. 1018-1024
-
-
Michowitz, Y.1
Goldstein, E.2
Roth, A.3
-
120
-
-
0037391532
-
Oxidized low-density lipoprotein sensitizes human vascular smooth muscle cells to FAS (CD95)-mediated apoptosis
-
Takarada S, Imanishi T, Hano T, Nishio I (2003) Oxidized low-density lipoprotein sensitizes human vascular smooth muscle cells to FAS (CD95)-mediated apoptosis. Clin Exp Pharmacol Physiol 30:289-294
-
(2003)
Clin Exp Pharmacol Physiol
, vol.30
, pp. 289-294
-
-
Takarada, S.1
Imanishi, T.2
Hano, T.3
Nishio, I.4
-
121
-
-
0032537609
-
Apoptosis and related proteins in different stages of human atherosclerotic plaques
-
Kockx MM, De Meyer GR, Muhring J, et al (1998) Apoptosis and related proteins in different stages of human atherosclerotic plaques. Circulation 97:2307-2315
-
(1998)
Circulation
, vol.97
, pp. 2307-2315
-
-
Kockx, M.M.1
De Meyer, G.R.2
Muhring, J.3
-
122
-
-
0036190881
-
Expression of Bcl-x, Bcl-2, Bax, and Bak in endarterectomy and atherectomy specimens
-
Saxena A, McMeekin JD, Thomson DJ (2002) Expression of Bcl-x, Bcl-2, Bax, and Bak in endarterectomy and atherectomy specimens. J Pathol 196:335-342
-
(2002)
J Pathol
, vol.196
, pp. 335-342
-
-
Saxena, A.1
McMeekin, J.D.2
Thomson, D.J.3
-
123
-
-
0031931014
-
Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease
-
Pollman MJ, Hall JL, Mann MJ, et al (1998) Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Nat Med 4:222-227
-
(1998)
Nat Med
, vol.4
, pp. 222-227
-
-
Pollman, M.J.1
Hall, J.L.2
Mann, M.J.3
-
124
-
-
0028036895
-
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
-
Krajewski S, Krajewska M, Shabaik A, et al (1994) Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 145:1323-1336
-
(1994)
Am J Pathol
, vol.145
, pp. 1323-1336
-
-
Krajewski, S.1
Krajewska, M.2
Shabaik, A.3
-
125
-
-
0042342255
-
Modulation of Bcl-2 family proteins in primary endothelial cells during apoptosis
-
Molostvov G, Morris A, Rose P, Basu S (2002) Modulation of Bcl-2 family proteins in primary endothelial cells during apoptosis. Pathophysiol Haemost Thromb 32:85-91
-
(2002)
Pathophysiol Haemost Thromb
, vol.32
, pp. 85-91
-
-
Molostvov, G.1
Morris, A.2
Rose, P.3
Basu, S.4
-
126
-
-
0033059195
-
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells
-
Messmer UK, Briner VA, Pfeilschifter J (1999) Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells. Kidney Int 55:2322-2337
-
(1999)
Kidney Int
, vol.55
, pp. 2322-2337
-
-
Messmer, U.K.1
Briner, V.A.2
Pfeilschifter, J.3
-
127
-
-
0033557372
-
Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB
-
Badrichani AZ, Stroka DM, Bilbao G, et al (1999) Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB. J Clin Invest 103:543-553
-
(1999)
J Clin Invest
, vol.103
, pp. 543-553
-
-
Badrichani, A.Z.1
Stroka, D.M.2
Bilbao, G.3
-
128
-
-
0033574578
-
The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides
-
Ackermann EJ, Taylor JK, Narayana R, Bennett CF (1999) The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides. J Biol Chem 274:11245-11252
-
(1999)
J Biol Chem
, vol.274
, pp. 11245-11252
-
-
Ackermann, E.J.1
Taylor, J.K.2
Narayana, R.3
Bennett, C.F.4
-
129
-
-
3242683251
-
p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L)
-
Grethe S, Ares MP, Andersson T, Porn-Ares MI (2004) p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L). Exp Cell Res 298:632-642
-
(2004)
Exp Cell Res
, vol.298
, pp. 632-642
-
-
Grethe, S.1
Ares, M.P.2
Andersson, T.3
Porn-Ares, M.I.4
-
130
-
-
0037472717
-
Enhancement of TNF-alpha-mediated cell death in vascular smooth muscle cells through cytochrome c-independent pathway by the proteasome inhibitor
-
Kim HH, Kim K (2003) Enhancement of TNF-alpha-mediated cell death in vascular smooth muscle cells through cytochrome c-independent pathway by the proteasome inhibitor. FEBS Lett 535:190-194
-
(2003)
FEBS Lett
, vol.535
, pp. 190-194
-
-
Kim, H.H.1
Kim, K.2
-
131
-
-
0032211819
-
Oxidized LDL activates Fas-mediated endothelial cell apoptosis
-
Sata M, Walsh K (1998) Oxidized LDL activates Fas-mediated endothelial cell apoptosis. J Clin Invest 102:1682-1689
-
(1998)
J Clin Invest
, vol.102
, pp. 1682-1689
-
-
Sata, M.1
Walsh, K.2
-
132
-
-
0033980167
-
Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: Implications for vascular disease and therapy
-
Sata M, Suhara T, Walsh K (2000) Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy. Arterioscler Thromb Vasc Biol 20:309-316
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 309-316
-
-
Sata, M.1
Suhara, T.2
Walsh, K.3
-
133
-
-
1242297561
-
Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells
-
Chen J, Mehta JL, Haider N, et al (2004) Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res 94:370-376
-
(2004)
Circ Res
, vol.94
, pp. 370-376
-
-
Chen, J.1
Mehta, J.L.2
Haider, N.3
-
134
-
-
0041827347
-
Apoptotic pathways involved in U937 cells exposed to LDL oxidized by hypochlorous acid
-
Vicca S, Massy ZA, Hennequin C, et al (2003) Apoptotic pathways involved in U937 cells exposed to LDL oxidized by hypochlorous acid. Free Radic Biol Med 35:603-615
-
(2003)
Free Radic Biol Med
, vol.35
, pp. 603-615
-
-
Vicca, S.1
Massy, Z.A.2
Hennequin, C.3
-
135
-
-
0035716605
-
Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells
-
Kataoka H, Kume N, Miyamoto S, et al (2001) Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 21:955-960
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 955-960
-
-
Kataoka, H.1
Kume, N.2
Miyamoto, S.3
-
136
-
-
0035834740
-
Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway
-
Yao PM, Tabas I (2001) Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway. J Biol Chem 276:42468-42476
-
(2001)
J Biol Chem
, vol.276
, pp. 42468-42476
-
-
Yao, P.M.1
Tabas, I.2
-
137
-
-
11144220581
-
Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice
-
Liu J, Thewke DP, Su YR, et al (2005) Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol 25:174-179
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 174-179
-
-
Liu, J.1
Thewke, D.P.2
Su, Y.R.3
-
138
-
-
0347093316
-
AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis
-
Rusinol AE, Thewke D, Liu J, et al (2004) AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. J Biol Chem 279:1392-1399
-
(2004)
J Biol Chem
, vol.279
, pp. 1392-1399
-
-
Rusinol, A.E.1
Thewke, D.2
Liu, J.3
-
139
-
-
0033820636
-
Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells
-
Napoli C, Quehenberger O, De Nigris F, et al (2000) Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB J 14:1996-2007
-
(2000)
FASEB J
, vol.14
, pp. 1996-2007
-
-
Napoli, C.1
Quehenberger, O.2
De Nigris, F.3
-
140
-
-
0033043803
-
Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins
-
Meilhac O, Escargueil-Blanc I, Thiers JC, et al (1999) Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins. FASEB J 13:485-494
-
(1999)
FASEB J
, vol.13
, pp. 485-494
-
-
Meilhac, O.1
Escargueil-Blanc, I.2
Thiers, J.C.3
-
141
-
-
23044504361
-
Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2Cbeta and induce apoptosis in endothelial cells
-
Hufnagel B, Dworak M, Soufi M, et al (2005) Unsaturated fatty acids isolated from human lipoproteins activate protein phosphatase type 2Cbeta and induce apoptosis in endothelial cells. Atherosclerosis. 180:245-254
-
(2005)
Atherosclerosis
, vol.180
, pp. 245-254
-
-
Hufnagel, B.1
Dworak, M.2
Soufi, M.3
|