Role of Caspases in Ox-LDL-Induced Apoptotic Cascade in Human Coronary Artery Endothelial Cells

Circulation Research

Volumn 94, Issue 3, 2004, Pages 370-376

  Chen, Jiawei ^a   Mehta, Jawahar L ^a   Haider, Nezam ^b   Zhang, Xingjian ^d   Narula, Jagat ^b   Li, Dayuan ^a,c  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d NONE

Author keywords

Apoptosis; Caspases; Endothelial cells; LOX 1; Oxidized LDL

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; INHIBITORY APOPTOTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN BCL 2; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELLS, CULTURED; CORONARY VESSELS; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; IN SITU NICK-END LABELING; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPROTEINS, LDL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; OLIGOPEPTIDES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, LDL; RECEPTORS, OXIDIZED LDL; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 1242297561     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000113782.07824.BE     Document Type: Article

References (29)

1. Li D, Yang B, Mehta JL. Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am J Physiol. 1998;275:H568-H576.
2. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999;138:S419-S420.
3. Li D, Williams V, Liu L, Chen H, Sawamura T, Romeo F, Mehta JL. Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction. J Am Coll Cardiol. 2003;41:1048-1055.
4. Inoue T, Yaguchi I, Uchida T, Kamishirado H, Nakahara S, Hayashi T, Morooka S. Clinical significance of the antibody against oxidized low-density lipoprotein in acute myocardial infarction. Cardiology. 2002;98:13-17.
5. Li D, Mehta JL. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol. 2000;20:1116-1122.
6. Kume N, Sawamura T, Moriwaki H, Itokawa S, Hoshikawa H, Aoyama A, Nishi E, Ueno Y, Masaki T, Kita T. Inducible expression of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in vascular endothelial cells. Circ Res. 1998;83:322-327.
7. Li DY, Zhang YC, Philips MI, Sawamura T, Mehta JL. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type-1 receptor activation. Circ Res. 1999;84:1043-1049.
8. Murase T, Kume N, Korenaga R, Ando J, Sawamura T, Masaki T, Kita T. Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res. 1998;83:329-333.
9. Kataoka H, Kume N, Miyamoto S, Minami M, Morimoto M, Hayashida K, Hashimoto N, Kita T. Oxidized LDL modulates Bax/Bcl-2 through the lectin-like Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2001;21:955-960.
10. Hardwick SJ, Hegyi L, Clare K, Law NS, Carpenter KL, Mitchinson MJ, Skepper JN. Apoptosis in human monocyte-macrophages exposed to oxidized low-density lipoprotein. J Pathol. 1996;179:294-302.
11. Kumar D, Lou H, Singal PK. Oxidative stress and apoptosis in heart dysfunction. Herz. 2002;27:662-668.
12. Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, Roy S, Nicholson DW, Vaux DL, Bouillet P, Adams JM, Strasser A. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome C/Apaf-1/caspase-9 apoptosome. Nature. 2002;419:634-637.
13. Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO. 1997;16:6914-6925.
14. Micheau O, Thome M, Schneider P, Holler N, Tschopp J, Nicholson DW, Briand C, Grutter MG. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem. 2002;277:45162-45171.
15. Martin DA, Siegel RM, Zheng L, Lenardo MJ. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal. J Biol Chem. 1998;273:4345-4349.
16. Fadeel B, Hassan Z, Hellstrom-Lindberg E, Henter JI, Orrenius S, Zhivotovsky B. Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia. 1999;3:719-728.
17. Li D, Mehta JL. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation. 2000;101:2889-2895.
18. Li DY, Saldeen T, Mehta JL. γ-Tocopherol decreases ox-LDL-mediated activation of nuclear factor-κB and apoptosis in human coronary artery endothelial cells. Biochem Biophys Res Commun. 1999;259:157-161.
19. Li D, Williams V, Liu L, Chen H, Sawamura T, Antakli T, Mehta JL. LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation. Am J Physiol. 2002;283:H1795-H1801.
20. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386:73-77.
21. Li D, Liu L, Chen H, Sawamura T, Ranganathan S, Mehta JL. LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation. 2003;107:612-617.
22. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 1993;262:1274-1277.
23. Hockenbery DM, Oltvai N, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 1993;75:241-251.
24. Tsai JC, Jain M, Hsieh CM, Lee WS, Yoshizumi M, Patterson C, Perrella MA, Cooke C, Wang H, Haber E, Lee ME. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996;271:3667-3670.
25. Kondo S, Yin D, Aoki T, Takahashi JA, Morimura T, Takeuchi J. Bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp Cell Res. 1994;213:428-432.
26. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima SI, Sameshima M, Hase A, Seto Y, Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 1991;66:233-243.
27. Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Ann Rev Immunol. 1999;17:331-367.
28. Li JH, Kluger MS, Madge LA, Zheng L, Bothwell AL, Pober JS. Interferon-γ augments CD95 (APO-1/Fas) and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95-mediated apoptosis. Am J Pathol. 2002;161:1485-1495.
29. Wang LS, Liu HJ, Zhang JH, Wu CT. Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease. Cancer Lett. 2002;186:177-182.