p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-xL

Experimental Cell Research

Volumn 298, Issue 2, 2004, Pages 632-642

  Grethe, Simone ^a   Ares, Mikko P S ^b   Andersson, Tommy ^a   Pörn Ares, M Isabella ^a  

^a LUND UNIVERSITY   (Sweden)

^b Univ Hospital MAS   (Sweden)

Author keywords

Apoptosis; BAF; Bcl xL; Boc Asp(OMe) fluoromethylketone; cellular FLICE inhibitory protein; cFLIP; CHX; cycloheximide; death inducing signaling complex; DISC; DQMD fmk; Endothelial cells; Mitochondria; p38 MAP kinase; Phosphorylation; TNF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; LACTACYSTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL XL; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CHRONOSEQUENCE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REDUCTION;

EID: 3242683251     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.05.007     Document Type: Article

References (49)

1. Liu Z.G., Han J. Cellular responses to tumor necrosis factor. Curr. Issues Mol. Biol. 3:2001;79-90
2. Baud V., Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11:2001;372-377
3. Hsu H., Shu H.B., Pan M.G., Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 84:1996;299-308
4. Cohen G.M. Caspases: the executioners of apoptosis. Biochem. J. 326:1997;1-16
5. Porter A.G., Jänicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:1999;99-104
6. Stroh C., Schulze-Osthoff K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ. 5:1998;997-1000
7. Hale K.K., Trollinger D., Rihanek M., Manthey C.L. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. J. Immunol. 162:1999;4246-4252
8. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331
9. Gardner A.M., Johnson G.L. Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. J. Biol. Chem. 271:1996;14560-14566
10. Breitschopf K., Haendeler J., Malchow P., Zeiher A.M., Dimmeler S. Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol. Cell. Biol. 20:2000;1886-1896
11. Holmström T.H., Tran S.E.F., Johnson V.L., Ahn N.G., Chow S.C., Eriksson J.E. Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis. Mol. Cell. Biol. 19:1999;5991-6002
12. Alvarado-Kristensson M., Pörn-Ares M.I., Grethe S., Smith D., Zheng L., Andersson T. p38 Mitogen-activated protein kinase and phosphatidylinositol 3-kinase activities have opposite effects on human neutrophil apoptosis. FASEB J. 2001;. (10.1096/fj.01-0817fje)
13. Zechner D., Craig R., Hanford D.S., McDonough P.M., Sabbadini R.A., Glembotski C.C. MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J. Biol. Chem. 273:1998;8232-8239
14. Nemoto S., Xiang J., Huang S., Lin A. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J. Biol. Chem. 273:1998;16415-16420
15. Roulston A., Reinhard C., Amiri P., Williams L.T. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor α J. Biol. Chem. 273:1998;10232-10239
16. Kankaanranta H., DeSouza P.M., Barnes P.J., Salmon M., Giembycz M.A., Lindsay M.A. SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils. J. Pharmacol. Exp. Ther. 290:1999;621-628
17. Schulze-Osthoff K., Ferrari D., Riehemann K., Wesselborg S. Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology. 198:1997;35-49
18. Vanden Berghe W., Plaisance S., Boone E., De Bosscher K., Schmitz M.L., Fiers W., Haegeman G. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:1998;3285-3290
19. Kreuz S., Siegmund D., Scheurich P., Wajant H. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 21:2001;3964-3973
20. Jimenez B., Volpert O.V., Crawford S.E., Febbraio M., Silverstein R.L., Bouck N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat. Med. 6:2000;41-48
21. Nakagami H., Morishita R., Yamamoto K., Yoshimura S., Taniyama Y., Aoki M., Matsubara H., Kim S., Kaneda Y., Ogihara T. Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. Diabetes. 50:2001;1472-1481
22. Razandi M., Pedram A., Levin E.R. Estrogen signals to the preservation of endothelial cell form and function. J. Biol. Chem. 275:2000;38540-38546
23. Wei M.C., Zong W.X., Cheng E.H.Y., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic Bax and Bak: a requisite gateway to mitochondrial dysfunction and death. Science. 292:2001;727-730
24. Cheng E.H.Y., Wei M.C., Weiler S., Flavell R.A., Mak T.W., Lindsten T., Korsmeyer S.J. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell. 8:2001;705-711
25. Ackermann E.J., Taylor J.K., Narayana R., Bennett C.F. The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides. J. Biol. Chem. 274:1999;11245-11252
26. Pober J.S., Cotran R.S. Cytokines and endothelial cell biology. Physiol. Rev. 70:1990;427-451
27. Madge L.A., Pober J.S. TNF signaling in vascular endothelial cells. Exp. Mol. Pathol. 70:2001;317-325
28. Edgell C.J.S., McDonald C.C., Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. U. S. A. 80:1983;3734-3737
29. Samali A., Robertson J.D., Peterson E., Manero F., van Zeijl L., Paul C., Cotgreave I.A., Arrigo A.P., Orrenius S. Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli. Cell Stress Chaperones. 6:2001;49-58
30. Wallach D. Cell death induction by TNF: a matter of self control. Trends Biochem. Sci. 22:1997;107-109
31. Wajant H., Haas E., Schwenzer R., Mühlenbeck F., Kreuz S., Schubert G., Grell M., Smith C., Scheurich P. Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of fas-associated death domain protein (FADD). J. Biol. Chem. 275:2000;24357-24366
32. Kyriakis J.M., Avruch J. Protein kinase cascades activated by stress and inflammatory cytokines. BioEssays. 18:1996;567-577
33. Laird S.M., Graham A., Paul A., Gould G.W., Kennedy C., Plevin R. Tumour necrosis factor stimulates stress-activated protein kinases and the inhibition of DNA synthesis in cultures of bovine aortic endothelial cells. Cell. Signalling. 10:1998;473-48037
34. Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., Debatin K.M., Krammer P.H., Peter M.E. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17:1998;1675-1687
35. Korsmeyer S.J., Wei M.C., Saito M., Weiler S., Oh K.J., Schlesinger P.H. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7:2000;1166-1173
36. Desagher S., Martinou J.-C. Mitochondria as the central control point of apoptosis. Trend Cell Biol. 10:2000;369-377
37. Deng X., Ruvolo P., Carr B., May W.S. Jr. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc. Natl. Acad. Sci. U. S. A. 97:2000;1578-1583
38. Torcia M., De Chiara G., Nencioni L., Ammendola S., Labardi D., Lucibello M., Rosini P., Marlier L.N., Bonini P., Dello Sbarba P., Palamara A.T., Zambrano N., Russo T., Garaci E., Cozzolino F. Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J. Biol. Chem. 276:2001;39027-39036
39. Griffioen A.W., Barendsz-Janson A.F., Mayo K.H., Hillen H.F.P. Angiogenesis, a target for tumor therapy. J. Lab. Clin. Med. 132:1998;363-368
40. Choy J.C., Granville D.J., Hunt D.W.C., McManus B.M. Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J. Mol. Cell. Cardiol. 33:2001;1673-1690
41. Gum R.J., McLaughlin M.M., Kumar S., Wang Z., Bower M.J., Lee J.C., Adams J.L., Livi G.P., Goldsmith E.J., Young P.R. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J. Biol. Chem. 273:1998;15605-15610
42. Grambihler A., Higuchi H., Bronk S.F., Gores G.J. cFLIP-L inhibits p38 MAPK activation. J. Biol. Chem. 278:2003;26831-26837
43. Badrichani A.Z., Stroka D.M., Bilbao G., Curiel D.T., Bach F.H., Ferran C. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB. J. Clin. Invest. 103:1999;543-553
44. Chadebech P., Brichese L., Baldin V., Vidal S., Valette A. Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage. Biochem. Biophys. Res. Commun. 262:1999;823-827
45. Vander Heiden M.G., Li X.X., Gottleib E., Hill R.B, Thompson C.B., Colombini M. Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. J. Biol. Chem. 276:2001;19414-19419
46. Kharbanda S., Saxena S., Yoshida K., Pandey P., Kaneki M., Wang Q., Cheng K., Chen Y.N., Campbell A., Sudha T., Yuan Z.M., Narula J., Weichselbaum R., Nalin C., Kufe D. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-xL in response to DNA damage. J. Biol. Chem. 275:2000;322-327
47. Kazi A., Smith D.M., Zhong Q., Dou Q.P. Inhibition of Bcl-xL phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis. Mol. Pharmacol. 62:2002;765-771
48. Haldar S., Jena N., Croce C.M. Inactivation of Bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 92:1995;4507-4511
49. Basu A., Haldar S. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett. 538:2003;41-47