Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells

FASEB Journal

Volumn 14, Issue 13, 2000, Pages 1996-2007

  Napoli, Claudio ^a,b,c   Quehenberger, Oswald ^a   De Nigris, Filomena ^b   Abete, Pasquale ^b   Glass, Christopher K ^a   Palinski, Wulf ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Atherosclerosis; Caspases; FasL; JunK; MAPK; Oxidized LDL; TNF receptors

Indexed keywords

CASPASE; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN BCL 2; PROTEIN P53; SCAVENGER; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR RECEPTOR; XANTHINE; XANTHINE OXIDASE;

ADULT; ARTERY WALL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

LETHRINIDAE;

EID: 0033820636     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.99-0986com     Document Type: Article

References (56)

1. Atherosclerosis - An inflammatory disease
2. Apoptosis in atherosclerosis: Beneficial or detrimental?
3. Evidence for apoptosis in advanced human atheroma: Colocalization with interleukin 1B converting enzyme
4. Apoptosis is abundant in human atherosclerotic lesions especially in inflammatory cells (macrophages and T cells) and may contribute to the accumulation of gruel and plaque instability
5. Colocalization of CPP-32 with apoptotic cells in human atherosclerotic plaques
6. Apoptosis and related proteins in different stages of human atherosclerotic plaques
7. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent
8. Low density lipoprotein undergoes oxidative modification in vivo
9. Low density lipoprotein oxidation and its pathobiological significance
10. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: Intimal accumulation of LDL and its oxidation precede monocyte recruitment into early atherosclerotic lesions
11. Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics
12. Intracranial arteries of human fetuses are more resistant to hypercholesterolemia-induced fatty streak formation than extracranial arteries
13. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of early lesions in children (FELIC) study
14. Immune responses to oxidative neoepitopes on LDL and phospholipids modulate the development of atherosclerosis
15. Cytotoxicity of oxidized low-density lipoprotein to mouse peritoneal macrophages: An ultrastructural study
16. Fragmentation of DNA in P388D1 macrophages exposed to oxidised low-density lipoprotein
17. DNA fragmentation and ultrastructural changes of degenerating cells in atherosclerotic lesions on smooth muscle cells exposed to oxidized LDL in vitro
18. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis
19. OxLDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas
20. Oxidized LDL activates Fas-mediated endothelial cell apoptosis
21. Endothelial cell apoptosis induced by oxidized LDL is associated with the down regulation of the cellular caspase inhibitor FLIP
22. Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins
23. Oxidized LDL activates STAT1 and STAT3 transcription factors: Possible involvement of reactive oxygen species
24. Oxidized LDL modulates activation of NFκB in mononuclear phagocyte by altering the degradation of IκBs.J
25. Multiple signals converging on NFκB
26. Low density lipoprotein oxidation and variant angina: Role of methodologic procedures in assessment of oxidizability of low density lipoprotein
27. A simple and rapid purification procedure minimizes spontaneous oxidative modifications of low density, lipoprotein and lipoprotein (a)
28. Oxidative structural modifications of low density lipoprotein in homozygous familial hypercholesterolemia
29. Decreased low-density lipoprotein oxidation after repeated selective apheresis in homozygous familial hypercholesterolemia
30. Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet activating factor
31. Mildly oxidized low-density lipoprotein impairs responses of carotid but not basilar artery in rabbits
32. Improved functional recovery of ischemic rat hearts due to singlet oxygen scavengers histidine and carnosine
33. Loop diuretics enhance the secretion of prostacyclin in vitro, in healthy persons, and in patients with chronic heart failure
34. Modulation by α and γ-tocopherol and oxidized low-density lipoprotein of signaling induced in human coronary smooth muscle cells
35. Modulation of life and death by the TNF receptor superfamily
36. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
37. Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors
38. Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo
39. Involvement of the Fas death-signaling pathways in cytokine-induced apoptosis of vascular smooth muscle cells during atherogenesis
40. Death receptors: Signaling and modulation
41. The domains of death: Evolution of the apoptosis machinery
42. Induction of apoptosis by the transcription factor c-Jun
43. Organization and regulation of mitogen-activated protein kinase signaling pathways
44. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms
45. Prodomains-adaptors-oligomerization: The pursuit of caspase activation in apoptosis
46. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis
47. Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages
48. Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter
49. p53 Levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
50. Effect of probucol treatment on gene expression of VCAM-1, MCP-1 and M-CSF in the aortic wail of LDL receptor-deficient rabbits during early atherogenesis
51. Oxygen radicals and signaling
52. Apoptosis in human atherosclerotic plaques
53. Expression of the peroxisome proliferator-activated receptor gamma (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating' factors and oxidized low density lipoprotein
54. Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: Potential role in oxidized LDL-induced apoptosis
55. Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides