Development of Quantitative Structure - Property Relationship Models for Early ADME Evaluation in Drug Discovery. 2. Blood-Brain Barrier Penetration

Journal of Chemical Information and Computer Sciences

Volumn 41, Issue 6, 2001, Pages 1623-1632

  Liu, Ruifeng ^a,b   Sun, Hongmao ^a   So, Sung Sau ^a,c  

^a HOFFMANN LA ROCHE INC   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

^c Hoftmann La Roche Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BRAIN; CONFORMATIONS; DRUG PRODUCTS; HYDROGEN BONDS; HYDROPHOBICITY; MOLECULAR WEIGHT; REGRESSION ANALYSIS;

DRUG DISCOVERY;

MOLECULAR STRUCTURE;

ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; CHEMICAL STRUCTURE; DRUG SCREENING; HYDROGEN BOND; PHARMACOKINETICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL;

BLOOD-BRAIN BARRIER; DRUG EVALUATION; HYDROGEN BONDING; LINEAR MODELS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NEURAL NETWORKS (COMPUTER); PHARMACOKINETICS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0035498339     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci010290i     Document Type: Article

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