메뉴 건너뛰기




Volumn 38, Issue 4, 1998, Pages 726-735

Prediction of human intestinal absorption of drug compounds from molecular structure

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; HUMAN; INTESTINE ABSORPTION; PHARMACOKINETICS; STATISTICAL MODEL; STRUCTURE ACTIVITY RELATION;

EID: 0032112107     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci980029a     Document Type: Article
Times cited : (345)

References (176)
  • 1
    • 0028243847 scopus 로고
    • Application of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries
    • Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Fodor, S. P.; Gordon, E. M. Application of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries. J. Med. Chem. 1994, 37, 1233-1251.
    • (1994) J. Med. Chem. , vol.37 , pp. 1233-1251
    • Gallop, M.A.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.4    Gordon, E.M.5
  • 2
    • 0028318863 scopus 로고
    • Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions
    • Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P.; Gallop, M. A. Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions. J. Med. Chem. 1994, 37, 1385-1401.
    • (1994) J. Med. Chem. , vol.37 , pp. 1385-1401
    • Gordon, E.M.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.4    Gallop, M.A.5
  • 3
    • 0029020035 scopus 로고
    • Comparison of Intestinal Permeabilities Determined in Multiple In Vitro and In Situ Models: Relationship to Absorption in Humans
    • Stewart, B. H.; Chan, O. H.; Lu, R. H.; Reyner, E. L.; Schmid, H. L.; Hamilton, H. W.; Steinbaugh, B. A.; Taylor, M. D. Comparison of Intestinal Permeabilities Determined in Multiple In Vitro and In Situ Models: Relationship to Absorption in Humans Pharm. Res. 1995, 13, 693-699.
    • (1995) Pharm. Res. , vol.13 , pp. 693-699
    • Stewart, B.H.1    Chan, O.H.2    Lu, R.H.3    Reyner, E.L.4    Schmid, H.L.5    Hamilton, H.W.6    Steinbaugh, B.A.7    Taylor, M.D.8
  • 4
    • 0027497560 scopus 로고
    • Comparison of the Permeability Characteristics of a Series of Peptides Using an In Vitro Cell Culture Model (Caco-2) and Those Using an In Situ Perfused Rat Ileum Model of the Intestinal Mucosa
    • Rubas, W.; Jezyk, N.; Grass, G. M. Comparison of the Permeability Characteristics of a Series of Peptides Using an In Vitro Cell Culture Model (Caco-2) and Those Using an In Situ Perfused Rat Ileum Model of the Intestinal Mucosa. Pharm. Res. 1993, 10, 113-118.
    • (1993) Pharm. Res. , vol.10 , pp. 113-118
    • Rubas, W.1    Jezyk, N.2    Grass, G.M.3
  • 5
    • 0027141263 scopus 로고
    • A Correlation between the Permeability Characteristics of a Series of Peptides Using an In Vitro Cell Culture Model (Caco-2) and Those Using an In Situ Perfused Rat Ileum Model of the Intestinal Mucosa
    • Kim, D. C.; Burton, P. S.; Borchardt, R. T. A Correlation Between the Permeability Characteristics of a Series of Peptides Using an In Vitro Cell Culture Model (Caco-2) and Those Using an In Situ Perfused Rat Ileum Model of the Intestinal Mucosa. Pharm. Res. 1993, 10, 1710-1714.
    • (1993) Pharm. Res. , vol.10 , pp. 1710-1714
    • Kim, D.C.1    Burton, P.S.2    Borchardt, R.T.3
  • 6
    • 0024593744 scopus 로고
    • Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability
    • Hidalgo, I. J.; Raub, T. J.; Borchardt, R. T. Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability. Gastroenterology 1989, 96, 736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 7
    • 0026321138 scopus 로고
    • Cell Cultures as Models for Drug Absorption Across the Intestinal Mucosa
    • Artursson, P. Cell Cultures as Models for Drug Absorption Across the Intestinal Mucosa. Crit. Rev. Drug Carrier Systems 1991, 8, 305-330.
    • (1991) Crit. Rev. Drug Carrier Systems , vol.8 , pp. 305-330
    • Artursson, P.1
  • 9
    • 0030588714 scopus 로고    scopus 로고
    • Caco-2 Monolayers in Expertmental and Theoretical Predictions of Drug Transport
    • Artursson, P.; Palm, K.; Luthman, K. Caco-2 Monolayers in Expertmental and Theoretical Predictions of Drug Transport. Adv. Drug Del. Rev. 1996, 22, 67-84.
    • (1996) Adv. Drug Del. Rev. , vol.22 , pp. 67-84
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 11
    • 0342669791 scopus 로고    scopus 로고
    • In Vitro Permeability Across Caco-2 Cells (Colonic) can Predict In Vivo (Small Intestinal) Absorption in Man - Fact or Myth
    • Yee, S. In Vitro Permeability Across Caco-2 Cells (Colonic) can Predict In Vivo (Small Intestinal) Absorption in Man - Fact or Myth. Pharm. Res. 1997, 34, 1242-1250.
    • (1997) Pharm. Res. , vol.34 , pp. 1242-1250
    • Yee, S.1
  • 12
    • 0028534520 scopus 로고
    • Graph Theory and Group Contribution in the Estimation of Boiling Points
    • Wang, S.; Milne, G. W. A.; Klopman, G. Graph Theory and Group Contribution in the Estimation of Boiling Points. J. Chem. Inf. Comput. Sci. 1994, 34, 1242-1250.
    • (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 1242-1250
    • Wang, S.1    Milne, G.W.A.2    Klopman, G.3
  • 13
    • 0001546398 scopus 로고    scopus 로고
    • Prediction of Reduced Ion Mobility Constants of Organic Compounds from Molecular Structure
    • Wessel, M. D.; Sutter, J. M.; Jurs, P. C. Prediction of Reduced Ion Mobility Constants of Organic Compounds from Molecular Structure. Anal. Chem. 1996, 63, 4237-4243.
    • (1996) Anal. Chem. , vol.63 , pp. 4237-4243
    • Wessel, M.D.1    Sutter, J.M.2    Jurs, P.C.3
  • 14
    • 33845183783 scopus 로고
    • Computer-Assisted Prediction of Gas Chromatographic Retention Indices of Pyrazines
    • Stanton, D. T.; Jurs, P. C. Computer-Assisted Prediction of Gas Chromatographic Retention Indices of Pyrazines. Anal. Chem. 1989, 61, 1328-1332.
    • (1989) Anal. Chem. , vol.61 , pp. 1328-1332
    • Stanton, D.T.1    Jurs, P.C.2
  • 15
    • 0025154936 scopus 로고
    • Prediction of Gas and Liquid Chromatographic Retention Indices of Polyhalogenated Biphenyls
    • Hasan, M. N.; Jurs, P. C. Prediction of Gas and Liquid Chromatographic Retention Indices of Polyhalogenated Biphenyls. Anal. Chem. 1990, 62, 2318-2323.
    • (1990) Anal. Chem. , vol.62 , pp. 2318-2323
    • Hasan, M.N.1    Jurs, P.C.2
  • 16
    • 0026703492 scopus 로고
    • Prediction of Carbon-13 Nuclear Magnetic Resonance Chemical Shifts by Artificial Neural Networks
    • Anker, L. S.; Jurs, P. C. Prediction of Carbon-13 Nuclear Magnetic Resonance Chemical Shifts by Artificial Neural Networks. Anal. Chem. 1992, 64, 1157-1164.
    • (1992) Anal. Chem. , vol.64 , pp. 1157-1164
    • Anker, L.S.1    Jurs, P.C.2
  • 17
    • 84951765703 scopus 로고    scopus 로고
    • Prediction of Acute Mammalian Toxicity from Molecular Structure for a Diverse Set of Substituted Anilines Using Regression Regression Analysis and Computational Neural Networks
    • van de Waterbeemd, H., Testa, B.; Folkers, G., Eds.; Wiley-VCH: New York
    • Johnson, S. R.; Jurs, P. C. Prediction of Acute Mammalian Toxicity from Molecular Structure for a Diverse Set of Substituted Anilines Using Regression Regression Analysis and Computational Neural Networks. In Computer-Assisted Lead Finding and Optimization; van de Waterbeemd, H., Testa, B.; Folkers, G., Eds.; Wiley-VCH: New York, 1997; pp 29-48.
    • (1997) Computer-Assisted Lead Finding and Optimization , pp. 29-48
    • Johnson, S.R.1    Jurs, P.C.2
  • 19
    • 0022070123 scopus 로고
    • Absorption Potential: Estimating the Fraction Absorbed for Orally Administered Compounds
    • Dressman, J. B.; Amidon, G. L.; Fleisher, D. Absorption Potential: Estimating the Fraction Absorbed for Orally Administered Compounds. J. Pharm. Sci. 1985, 74, 588-589.
    • (1985) J. Pharm. Sci. , vol.74 , pp. 588-589
    • Dressman, J.B.1    Amidon, G.L.2    Fleisher, D.3
  • 22
    • 0028108085 scopus 로고
    • Hydrogen Bonding. 33. Factors that Influence the Distribution of Solutes between Blood and Brain
    • Abraham, M. H.; Chadha, H. S.; Mitchell, R. C. Hydrogen Bonding. 33. Factors that Influence the Distribution of Solutes Between Blood and Brain. J. Pharm. Sci. 1994, 83, 1257-1268.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1257-1268
    • Abraham, M.H.1    Chadha, H.S.2    Mitchell, R.C.3
  • 23
    • 0029938236 scopus 로고    scopus 로고
    • Predicting Blood-Brain Transport of Drugs: A Computational Approach
    • Basak, S. C.; Gute, B. D.; Drewes, E. R. Predicting Blood-Brain Transport of Drugs: A Computational Approach. Pharm. Res. 1996, 13, 775-778.
    • (1996) Pharm. Res. , vol.13 , pp. 775-778
    • Basak, S.C.1    Gute, B.D.2    Drewes, E.R.3
  • 24
    • 0029618807 scopus 로고
    • A Predictive Algorithm for Skin Permeability: The Effects of Molecular Size and Hydrogen Bond Activity
    • Potts, R. O.; Guy, R. H. A Predictive Algorithm for Skin Permeability: The Effects of Molecular Size and Hydrogen Bond Activity. Pharm. Res. 1995, 12, 1628-1663.
    • (1995) Pharm. Res. , vol.12 , pp. 1628-1663
    • Potts, R.O.1    Guy, R.H.2
  • 25
    • 0029739972 scopus 로고    scopus 로고
    • Unified Model for the Corneal Permeability of Related and Diverse Compounds with Respect to Their Physicochemical Properties
    • Yoshida, F.; Topliss, J. G. Unified Model for the Corneal Permeability of Related and Diverse Compounds with Respect to Their Physicochemical Properties. J. Pharm. Sci. 1996, 85, 819-823.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 819-823
    • Yoshida, F.1    Topliss, J.G.2
  • 26
    • 0025151270 scopus 로고
    • Quantitative Structure- -Pharmacokinetic Relationship of a Series of Sulfonamides in the Rat
    • Kaul, S.; Ritschel, W. A. Quantitative Structure- -Pharmacokinetic Relationship of a Series of Sulfonamides in the Rat. Eur. J. Drug Metab. Pharmacokinet. 1990, 15, 211-217.
    • (1990) Eur. J. Drug Metab. Pharmacokinet. , vol.15 , pp. 211-217
    • Kaul, S.1    Ritschel, W.A.2
  • 27
    • 0029073718 scopus 로고
    • Quantitative Structure-Pharmacokinetic Relationships (QSPR) of Beta Blockers Derived Using Neural Networks
    • Gobburu, J. V. S.; Shelver, W. H. Quantitative Structure-Pharmacokinetic Relationships (QSPR) of Beta Blockers Derived Using Neural Networks. J. Pharm. Sci. 1995, 84, 862-865.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 862-865
    • Gobburu, J.V.S.1    Shelver, W.H.2
  • 28
    • 0029863309 scopus 로고    scopus 로고
    • Quantitative Structure-Metabolism Relationships for Substituted Benzoic Acids in the Rabbit: Prediction of Urinary Excretion of Glycine and Glucuronide Conjugates
    • Cupid, B. C.; Beddell, C. R.; Lindon, J. C.; Wilson, I. D.; Nicholson, J. K. Quantitative Structure-Metabolism Relationships for Substituted Benzoic Acids in the Rabbit: Prediction of Urinary Excretion of Glycine and Glucuronide Conjugates. Xenobiotica 1996, 26, 157-176.
    • (1996) Xenobiotica , vol.26 , pp. 157-176
    • Cupid, B.C.1    Beddell, C.R.2    Lindon, J.C.3    Wilson, I.D.4    Nicholson, J.K.5
  • 29
    • 0027284874 scopus 로고
    • Understanding and Using Genetic Algorithms Part 1. Concepts, Properties and Context
    • Lucasius, C. B.; Kateman, G. Understanding and Using Genetic Algorithms Part 1. Concepts, Properties and Context. Chemom. Intell. Lab. Sys. 1993, 19, 1.
    • (1993) Chemom. Intell. Lab. Sys. , vol.19 , pp. 1
    • Lucasius, C.B.1    Kateman, G.2
  • 30
    • 0027321506 scopus 로고
    • A Hybrid Genetic Algorithm for the Estimation of Kinetic Parameters
    • Hibbert, D. B. A Hybrid Genetic Algorithm for the Estimation of Kinetic Parameters. Chemom. Intell. Lab. Sys. 1993, 19, 319-329.
    • (1993) Chemom. Intell. Lab. Sys. , vol.19 , pp. 319-329
    • Hibbert, D.B.1
  • 31
    • 0028287738 scopus 로고
    • Quantitative Structure-Activity Relationships for Toxicity of Phenols Using Regression Analysis and Computational Neural Networks
    • Xu, L.; Ball, J. W.; Dixon, S. L.; Jurs, P. C. Quantitative Structure-Activity Relationships for Toxicity of Phenols Using Regression Analysis and Computational Neural Networks. Environ. Toxicol. Chem. 1994, 13, 841-851.
    • (1994) Environ. Toxicol. Chem. , vol.13 , pp. 841-851
    • Xu, L.1    Ball, J.W.2    Dixon, S.L.3    Jurs, P.C.4
  • 32
    • 0002801544 scopus 로고
    • The Effect of Structure upon the Reactions of Organic Compounds. Benzene Derivatives
    • Hammet, L. P. The Effect of Structure upon the Reactions of Organic Compounds. Benzene Derivatives. J. Am. Chem. Soc. 1937, 59, 96-103.
    • (1937) J. Am. Chem. Soc. , vol.59 , pp. 96-103
    • Hammet, L.P.1
  • 33
    • 34447521097 scopus 로고
    • Correlation of Biological Activity of Phenoxyacetic Acids with Hammet Substituent Constants and Partitition Coefficients
    • Hansch, C.; Maloney, P. P.; Fujita, T.; Muir, R. Correlation of Biological Activity of Phenoxyacetic Acids with Hammet Substituent Constants and Partitition Coefficients. Nature 1962, 194, 178-180.
    • (1962) Nature , vol.194 , pp. 178-180
    • Hansch, C.1    Maloney, P.P.2    Fujita, T.3    Muir, R.4
  • 34
    • 0242677271 scopus 로고
    • Quantitative Approach to Biochemical Structure - Activity Relationships
    • Hansch, C. A. Quantitative Approach to Biochemical Structure - Activity Relationships. Acc. Chem. Res. 1969, 2, 232-239.
    • (1969) Acc. Chem. Res. , vol.2 , pp. 232-239
    • Hansch, C.A.1
  • 35
    • 0001059812 scopus 로고
    • Quantitative Structure - Activity Relationships and the Unnamed Science
    • Hansch, C. Quantitative Structure - Activity Relationships and the Unnamed Science. Acc. Chem. Res. 1993, 2, 147-153.
    • (1993) Acc. Chem. Res. , vol.2 , pp. 147-153
    • Hansch, C.1
  • 36
    • 85034462052 scopus 로고    scopus 로고
    • Hypercube, Inc. 1115 NW 4th Street, Gainsville, FL 32601-4256
    • Hypercube, Inc. 1115 NW 4th Street, Gainsville, FL 32601-4256.
  • 37
    • 0000490166 scopus 로고
    • From Atoms to Bonds to Three-Dimensional Atomic Coordinates: Automatic Model Builders
    • Sadowski, J.; Gasteiger, J. From Atoms to Bonds to Three-Dimensional Atomic Coordinates: Automatic Model Builders. Chem. Rev. 1993, 93, 2567-2581.
    • (1993) Chem. Rev. , vol.93 , pp. 2567-2581
    • Sadowski, J.1    Gasteiger, J.2
  • 39
    • 0018753824 scopus 로고
    • Olson, E. C., Christoffersen, R. E., Eds.; The American Chemical Society: Washington, D.C.
    • Jurs, P. C.; Chou, J. T.; Yuan, M. In Computer-Assisted Drug Design; Olson, E. C., Christoffersen, R. E., Eds.; The American Chemical Society: Washington, D.C., 1979; pp 103-129.
    • (1979) Computer-Assisted Drug Design , pp. 103-129
    • Jurs, P.C.1    Chou, J.T.2    Yuan, M.3
  • 41
    • 0019410083 scopus 로고
    • Preliminary Observations on the Excretion of Acebutolol and its Acetyl Metabolite in the Urine and Faeces of Man
    • Gabriel, R.; Kaye, C. M.; Sankey, M. G. Preliminary Observations on the Excretion of Acebutolol and its Acetyl Metabolite in the Urine and Faeces of Man. J. Pharm. 1981, 33, 386-387.
    • (1981) J. Pharm. , vol.33 , pp. 386-387
    • Gabriel, R.1    Kaye, C.M.2    Sankey, M.G.3
  • 43
    • 0025804183 scopus 로고
    • Correlation between Oral Drug Absorption in Humans and Apparent Drug Permeability
    • Artursson, P.; Karlsson, J. Correlation between Oral Drug Absorption in Humans and Apparent Drug Permeability. Biochem. Biophys. Res. Commun. 1991, 175, 880-885.
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 44
    • 0004908879 scopus 로고
    • Hormones
    • Gennaro, A. R. Ed.; Mack Publishing Company: Easton, PA
    • Harvey, S. C.; Winthrow, C. D.; Hormones. In Remington's Pharmaceutical Sciences; Gennaro, A. R. Ed.; Mack Publishing Company: Easton, PA, 1985; Vol. 17, pp 951-1001.
    • (1985) Remington's Pharmaceutical Sciences , vol.17 , pp. 951-1001
    • Harvey, S.C.1    Winthrow, C.D.2
  • 45
    • 0021214266 scopus 로고
    • Small Intestinal Permeability to Mannitol, Lactulose, and Polyethylene Glycol 400 in Celiac Disease
    • Ukabam, S. O.; Cooper, B. T. Small Intestinal Permeability to Mannitol, Lactulose, and Polyethylene Glycol 400 in Celiac Disease. Dig. Dis. Sci. 1984, 29, 809-816.
    • (1984) Dig. Dis. Sci. , vol.29 , pp. 809-816
    • Ukabam, S.O.1    Cooper, B.T.2
  • 46
    • 0018823495 scopus 로고
    • The Clinical Important of Cardioselectivity and Lipophilicity in Beta Blockers
    • Cruickshank, J. M. The Clinical Important of Cardioselectivity and Lipophilicity in Beta Blockers. Am. Heart. J. 1980, 100, 160-178.
    • (1980) Am. Heart. J. , vol.100 , pp. 160-178
    • Cruickshank, J.M.1
  • 47
    • 11344290995 scopus 로고
    • A Rational Therapeutic Approach to the Treatment of Essential Hypertension Part I
    • Ruffalo, R. L.; Garabedian-Ruffalo, S. M.; Garret, B. N. A Rational Therapeutic Approach to the Treatment of Essential Hypertension Part I. Cardiovas. Rev. Rep. 1986, 7, 692-700.
    • (1986) Cardiovas. Rev. Rep. , vol.7 , pp. 692-700
    • Ruffalo, R.L.1    Garabedian-Ruffalo, S.M.2    Garret, B.N.3
  • 48
    • 0020411784 scopus 로고
    • Pharmacokinetic Comparison of Pindolol with Other Beta-Adrenoceptor-Blocking Agents
    • Meier, J. Pharmacokinetic Comparison of Pindolol with Other Beta-Adrenoceptor-Blocking Agents. Am. Heart J. 1982, 104, 364-73.
    • (1982) Am. Heart J. , vol.104 , pp. 364-373
    • Meier, J.1
  • 49
    • 0023895637 scopus 로고
    • The Pharmacokinetics of Olsalazine Sodium in Healthy Volunteers after a Single I.V. Dose and after Oral Doses with and Without Food
    • Ryde, E. M.; Ahnfelt, N. O. The Pharmacokinetics of Olsalazine Sodium in Healthy Volunteers After a Single I.V. Dose and After Oral Doses With and Without Food. Eur. J. Clin. Pharmacol. 1988, 34, 481-488.
    • (1988) Eur. J. Clin. Pharmacol. , vol.34 , pp. 481-488
    • Ryde, E.M.1    Ahnfelt, N.O.2
  • 50
    • 0015548585 scopus 로고
    • Pharmacokinetic Studies of Practolol, a Beta Adrenergic Antagonist, in Man
    • Bodem, G.; Chidsey, C. A. Pharmacokinetic Studies of Practolol, a Beta Adrenergic Antagonist, in Man. Clin. Pharmacol. Ther. 1973, 14, 26-29.
    • (1973) Clin. Pharmacol. Ther. , vol.14 , pp. 26-29
    • Bodem, G.1    Chidsey, C.A.2
  • 51
    • 0021225241 scopus 로고
    • Pharmacokinetics and Bioavailability of Ranitidine in Humans
    • Miller, R. Pharmacokinetics and Bioavailability of Ranitidine in Humans. J. Pharm. Sci. 1984, 73, 1376-1379.
    • (1984) J. Pharm. Sci. , vol.73 , pp. 1376-1379
    • Miller, R.1
  • 52
    • 0029096972 scopus 로고
    • Ondansetron Clinical Pharmacokinetics
    • Roila, F.; Del Favero, A. Ondansetron Clinical Pharmacokinetics. Clin. Pharmacokinet. 1995, 29, 95-109.
    • (1995) Clin. Pharmacokinet. , vol.29 , pp. 95-109
    • Roila, F.1    Del Favero, A.2
  • 54
    • 0027171828 scopus 로고
    • Clinical Pharmacokinetics of Sotalol
    • Hanyok, J. J. Clinical Pharmacokinetics of Sotalol. Am. J. Cardiol. 1993, 72, 19A-26A.
    • (1993) Am. J. Cardiol. , vol.72
    • Hanyok, J.J.1
  • 57
    • 0019170399 scopus 로고
    • Absorption, Metabolism, and Excretion of Oral Testosterone in Humans by Mass Fragmentography
    • Shinohara, Y.; Baba, S.; Kasuya, Y. Absorption, Metabolism, and Excretion of Oral Testosterone in Humans by Mass Fragmentography. J. Clin. Endocrinol. Metab. 1980, 51, 1459-1462.
    • (1980) J. Clin. Endocrinol. Metab. , vol.51 , pp. 1459-1462
    • Shinohara, Y.1    Baba, S.2    Kasuya, Y.3
  • 59
    • 0018412395 scopus 로고
    • Relative Systemic Availability of Sulfapyridine from Commercial Enteric-Coated and Uncoated Sulfasalazine Tablets
    • Pieniaszek, H. J., Jr.; Resetarits, D. E.; Wilferth, W. W.; Blumenthal, H. P.; Bates, T. R. Relative Systemic Availability of Sulfapyridine from Commercial Enteric-Coated and Uncoated Sulfasalazine Tablets. J. Clin. Pharmacol. 1979, 1, 39-45.
    • (1979) J. Clin. Pharmacol. , vol.1 , pp. 39-45
    • Pieniaszek Jr., H.J.1    Resetarits, D.E.2    Wilferth, W.W.3    Blumenthal, H.P.4    Bates, T.R.5
  • 61
    • 0026745525 scopus 로고
    • Absorption of Polar Drugs Following Caecal Instillation in Healthy Volunteers. Aliment
    • Riley, S. A.; Kim, M.; Sutcliffe, F.; Rowland, M.; Turnberg, L. A. Absorption of Polar Drugs Following Caecal Instillation in Healthy Volunteers. Aliment. Pharmacol. Ther. 1992, 6, 701-706.
    • (1992) Pharmacol. Ther. , vol.6 , pp. 701-706
    • Riley, S.A.1    Kim, M.2    Sutcliffe, F.3    Rowland, M.4    Turnberg, L.A.5
  • 62
    • 0025082553 scopus 로고
    • Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic Data
    • Macheras, P.; Reppas, C.; Dressman, J. B. Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic Data. Pharm. Res. 1990, 7, 518-522.
    • (1990) Pharm. Res. , vol.7 , pp. 518-522
    • Macheras, P.1    Reppas, C.2    Dressman, J.B.3
  • 64
    • 0023715382 scopus 로고
    • Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds
    • Amidon, G. L.; Sinko, P. J.; Fleisher, D. Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds. Pharm. Res. 1988, 5, 651-654.
    • (1988) Pharm. Res. , vol.5 , pp. 651-654
    • Amidon, G.L.1    Sinko, P.J.2    Fleisher, D.3
  • 65
    • 0015911046 scopus 로고
    • Cephalexin: Pharmacologic Evaluation Following Oral and Parenteral Administration
    • Nicholas, P.; Meyers, B. R.; Hirschman, S. Z. Cephalexin: Pharmacologic Evaluation Following Oral and Parenteral Administration. J. Clin. Pharmacol. 1973, 13, 463-468.
    • (1973) J. Clin. Pharmacol. , vol.13 , pp. 463-468
    • Nicholas, P.1    Meyers, B.R.2    Hirschman, S.Z.3
  • 66
    • 0020075005 scopus 로고
    • Pharmacokinetics and Metabolism of Antipyrine (Phenazone) after Intravenous and Oral Administration
    • Eichelbaum, M.; Ochs, H. R.; Roberts, G.; Somogyi, A. Pharmacokinetics and Metabolism of Antipyrine (Phenazone) after Intravenous and Oral Administration. Drug. Res. 1982, 32, 575-578.
    • (1982) Drug. Res. , vol.32 , pp. 575-578
    • Eichelbaum, M.1    Ochs, H.R.2    Roberts, G.3    Somogyi, A.4
  • 67
  • 68
    • 0025821306 scopus 로고
    • Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach
    • Sinko, P. J.; Leesman, G. D.; Amidon, G. L.; Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach. Pharm. Res. 1991, 8, 979-988.
    • (1991) Pharm. Res. , vol.8 , pp. 979-988
    • Sinko, P.J.1    Leesman, G.D.2    Amidon, G.L.3
  • 69
    • 0017357285 scopus 로고
    • Pharmacokinetics of Amoxicillin: Dose Dependence after Intravenous, Oral, and Intramuscular Administration
    • Spyker, D. A.; Rugloski, R. J.; Vann, R. L.; O'Brien, W. M. Pharmacokinetics of Amoxicillin: Dose Dependence After Intravenous, Oral, and Intramuscular Administration. Antimicrob. Agents Chemother. 1977, 11, 132-141.
    • (1977) Antimicrob. Agents Chemother. , vol.11 , pp. 132-141
    • Spyker, D.A.1    Rugloski, R.J.2    Vann, R.L.3    O'Brien, W.M.4
  • 70
    • 0020683936 scopus 로고
    • The Absolute Bioavailability of Caffeine in Man
    • Blanchard, J.; Sawers, S. J. The Absolute Bioavailability of Caffeine in Man. Eur. J. Clin. Pharmacol. 1983, 24, 93-98.
    • (1983) Eur. J. Clin. Pharmacol. , vol.24 , pp. 93-98
    • Blanchard, J.1    Sawers, S.J.2
  • 72
    • 11344269517 scopus 로고
    • Thiazides II, New Pharmacokinetic Findings on Chlorothiazide Using HPLC Analysis
    • Shah, V. P.; Prasad, V. K.; Cabana, B. E.; Sojka, P. Thiazides II, New Pharmacokinetic Findings on Chlorothiazide Using HPLC Analysis. Curr. Ther. Res. 1981, 29, 802-814.
    • (1981) Curr. Ther. Res. , vol.29 , pp. 802-814
    • Shah, V.P.1    Prasad, V.K.2    Cabana, B.E.3    Sojka, P.4
  • 73
    • 0027402753 scopus 로고
    • A Saturable Transport Mechanism in the Intestinal Absorption of Gabapentin is the Underlying Cause of the Lack of Proprtionality between Increasing Dose and Drug Levels in Plasma
    • Stewart, B. H.; Kugler, A. R.; Thompson, P. R.; Bockbrader, H. N. A Saturable Transport Mechanism in the Intestinal Absorption of Gabapentin is the Underlying Cause of the Lack of Proprtionality Between Increasing Dose and Drug Levels in Plasma. Pharm. Res. 1993, 10, 276-281.
    • (1993) Pharm. Res. , vol.10 , pp. 276-281
    • Stewart, B.H.1    Kugler, A.R.2    Thompson, P.R.3    Bockbrader, H.N.4
  • 74
    • 0029939330 scopus 로고    scopus 로고
    • In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System
    • Chongg, S.; Dando, S. A.; Soucek, K. M.; Morrison, R. A. In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of In Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System. Pharm. Res. 1996, 13, 120-123.
    • (1996) Pharm. Res. , vol.13 , pp. 120-123
    • Chongg, S.1    Dando, S.A.2    Soucek, K.M.3    Morrison, R.A.4
  • 77
    • 0026694388 scopus 로고
    • Pharmacokinetics of Fluvastatin after Single and Multiple Doses in Normal Volunteers
    • Tse, F. L.; Jaffe, J. M.; Troendle, A. Pharmacokinetics of Fluvastatin After Single and Multiple Doses in Normal Volunteers. J. Clin. Pharmacol. 1992, 32, 630-638.
    • (1992) J. Clin. Pharmacol. , vol.32 , pp. 630-638
    • Tse, F.L.1    Jaffe, J.M.2    Troendle, A.3
  • 78
    • 0026452062 scopus 로고
    • Relative Lipophilicities and Structural-Pharmacological Considerations of Various Angiotensin-Converting Enzyme (Ace) Inhibitors
    • Ranadive, S. A.; Chen, A. X.; Serajuddin, A. T. M. Relative Lipophilicities and Structural-Pharmacological Considerations of Various Angiotensin-Converting Enzyme (Ace) Inhibitors. Pharm. Res. 1992, 9, 1480-1483.
    • (1992) Pharm. Res. , vol.9 , pp. 1480-1483
    • Ranadive, S.A.1    Chen, A.X.2    Serajuddin, A.T.M.3
  • 79
    • 0028307188 scopus 로고
    • Intestinal Drug Absorption during Induced Net Water Absorption in Man; A Mechanistic Study Using Antipyrine Atenolol and Enalaprilat
    • Lennernäs, H.; Ahrenstedt, Ö.; Ungell, A. L. Intestinal Drug Absorption During Induced Net Water Absorption in Man; A Mechanistic Study Using Antipyrine Atenolol and Enalaprilat. Br. J. Clin. Pharmacol. 1994, 37, 589-596.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 589-596
    • Lennernäs, H.1    Ahrenstedt, Ö.2    Ungell, A.L.3
  • 80
    • 0030023536 scopus 로고    scopus 로고
    • Comparison between Active and Passive Drug Transport in Human Intestinal Epithelial(Caco-2) Cells In Vitro and Human Jejunum In Vivo
    • Lennarnäs, H.; Palm, K.; Fagerholm, U.; Artursson, P. Comparison Between Active and Passive Drug Transport in Human Intestinal Epithelial(Caco-2) Cells In Vitro and Human Jejunum In Vivo. Int. J. Pharm. 1996, 127, 103-107.
    • (1996) Int. J. Pharm. , vol.127 , pp. 103-107
    • Lennarnäs, H.1    Palm, K.2    Fagerholm, U.3    Artursson, P.4
  • 81
    • 0018405210 scopus 로고
    • Pharmacokinetics/Pharmacodynamics of Furosemide in Man: A Review
    • Benet, L. Z. Pharmacokinetics/Pharmacodynamics of Furosemide in Man: A Review. J. Pharmacokinet. Biopharm. 1979, 7, 1-27.
    • (1979) J. Pharmacokinet. Biopharm. , vol.7 , pp. 1-27
    • Benet, L.Z.1
  • 83
    • 0021340001 scopus 로고
    • Bioavailability of Bromazepam in Man after Single Administration of an Oral Solution
    • Ascalone, V.; Cisternino, M.; Sicolo, N.; De Palo, E. Bioavailability of Bromazepam in Man After Single Administration of an Oral Solution. Arzneimitttelforschung 1984, 34, 96-98.
    • (1984) Arzneimitttelforschung , vol.34 , pp. 96-98
    • Ascalone, V.1    Cisternino, M.2    Sicolo, N.3    De Palo, E.4
  • 87
    • 0018609788 scopus 로고
    • The Pharmacokinetics and Biotransformation of the New Benzodiazepine Lormetazepam in Humans
    • Hümpel, M.; Illi, V.; Milius, W.; Wendt, H.; Kurowski, M. The Pharmacokinetics and Biotransformation of the New Benzodiazepine Lormetazepam in Humans. Eur. J. Drug Metab. Pharmackinet. 1979, 4, 237-243.
    • (1979) Eur. J. Drug Metab. Pharmackinet. , vol.4 , pp. 237-243
    • Hümpel, M.1    Illi, V.2    Milius, W.3    Wendt, H.4    Kurowski, M.5
  • 89
    • 0021045463 scopus 로고
    • Human Intravenous Pharmacokinetics and Absolute Oral Bioavailability of Cefatrizine
    • Pfeffer, M.; Gaver, R. C.; Ximenez, J. Human Intravenous Pharmacokinetics and Absolute Oral Bioavailability of Cefatrizine. Antimicrob. Agents Chemother. 1983, 24, 915-920.
    • (1983) Antimicrob. Agents Chemother. , vol.24 , pp. 915-920
    • Pfeffer, M.1    Gaver, R.C.2    Ximenez, J.3
  • 92
    • 0016259995 scopus 로고
    • Absorption and Decomposition of Potassium-35S-Phenoxymethyl Penicillin
    • Hellström, K.; Rosén, A.; Swahn, A. Absorption and Decomposition of Potassium-35S-Phenoxymethyl Penicillin. Clin. Pharmacol. Ther. 1974, 16, 826.
    • (1974) Clin. Pharmacol. Ther. , vol.16 , pp. 826
    • Hellström, K.1    Rosén, A.2    Swahn, A.3
  • 94
    • 0025126914 scopus 로고
    • Clinical Pharmacokinetics of Ketoprofen and its Enantiomers
    • Jamali, F.; Brocks, D. R. Clinical Pharmacokinetics of Ketoprofen and its Enantiomers. Clin. Pharmacokinet. 1990, 19, 197-217.
    • (1990) Clin. Pharmacokinet. , vol.19 , pp. 197-217
    • Jamali, F.1    Brocks, D.R.2
  • 95
    • 0028260082 scopus 로고
    • Biopharm. Bioavailability and Reversible Metabolism of Prednisone and Prednisolone in Man
    • Garg, V.; Jusko, W. J. Biopharm. Bioavailability and Reversible Metabolism of Prednisone and Prednisolone in Man. Druq Dispos. 1994, 15, 163-172.
    • (1994) Druq Dispos. , vol.15 , pp. 163-172
    • Garg, V.1    Jusko, W.J.2
  • 96
    • 0028905095 scopus 로고
    • Angiotensin-Converting Enzyme (Ace) Inhibitor Transport in Human Intestinal Epithelial (Caco-2) Cells
    • Thwaites, D. T.; Cavet, M.; Hirst, B. H.; Simmons, N. L. Angiotensin-Converting Enzyme (Ace) Inhibitor Transport in Human Intestinal Epithelial (Caco-2) Cells. Br. J. Pharmacol. 1995, 114, 981-986.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 981-986
    • Thwaites, D.T.1    Cavet, M.2    Hirst, B.H.3    Simmons, N.L.4
  • 97
    • 0023897938 scopus 로고
    • Lisinopril: A New Angiotensin-Converting Enzyme Inhibitor
    • Armayor, G. M.; Lopez, L. M. Lisinopril: A New Angiotensin-Converting Enzyme Inhibitor. Drug Intell. Clin. Pharm. 1988, 22, 365-372.
    • (1988) Drug Intell. Clin. Pharm. , vol.22 , pp. 365-372
    • Armayor, G.M.1    Lopez, L.M.2
  • 99
    • 0025355830 scopus 로고
    • Disposition of Pravastatin Sodium, A Tissue-Selective HMG-Coa Reductase Inhibitor, in Healthy Subjects
    • Singhvi, S. M.; Pan, H. Y.; Morrison, R. A.; Willard, D. A. Disposition of Pravastatin Sodium, A Tissue-Selective HMG-Coa Reductase Inhibitor, in Healthy Subjects. Br. J. Clin. Pharmacol. 1990, 29, 239-243.
    • (1990) Br. J. Clin. Pharmacol. , vol.29 , pp. 239-243
    • Singhvi, S.M.1    Pan, H.Y.2    Morrison, R.A.3    Willard, D.A.4
  • 100
    • 0013804478 scopus 로고
    • Absorption of Steroid Hormones from the Human Small Intestine
    • Schedl, H. P. Absorption of Steroid Hormones from the Human Small Intestine. J. Clin. Endocrinol. Metab. 1965, 25, 1309-1316.
    • (1965) J. Clin. Endocrinol. Metab. , vol.25 , pp. 1309-1316
    • Schedl, H.P.1
  • 101
    • 0027987417 scopus 로고
    • Mechanism and Kinetics of Transcellular Transport of a New Beta Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)
    • Hu, M.; Chen, J.; Zhu, Y.; Dantzig, A. H.; Stratford, R. E., Jr.; Kuhfeld, M. T. Mechanism and Kinetics of Transcellular Transport of a New Beta Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2). Pharm. Res, 1994, 11, 1405-1413.
    • (1994) Pharm. Res , vol.11 , pp. 1405-1413
    • Hu, M.1    Chen, J.2    Zhu, Y.3    Dantzig, A.H.4    Stratford Jr., R.E.5    Kuhfeld, M.T.6
  • 102
    • 11344259654 scopus 로고
    • Pharmacokinetic Profile of Loracarbef
    • DeSante, K. A.; Zeckel, M. L. Pharmacokinetic Profile of Loracarbef. Am. J. Med. 1992, 93, 165-195.
    • (1992) Am. J. Med. , vol.93 , pp. 165-195
    • Desante, K.A.1    Zeckel, M.L.2
  • 103
    • 0028825851 scopus 로고
    • Clinical Pharmacokinetics of New Antiepileptic Drugs
    • Walker, M. C.; Patsalos, P. N. Clinical Pharmacokinetics of New Antiepileptic Drugs. Pharmacol. Ther. 1995, 67, 351-384.
    • (1995) Pharmacol. Ther. , vol.67 , pp. 351-384
    • Walker, M.C.1    Patsalos, P.N.2
  • 104
    • 0029886355 scopus 로고    scopus 로고
    • Clinical Pharmacokinetics of Newer Antiepileptic Drugs
    • Elwes, R. D.; Binnie, C. D. Clinical Pharmacokinetics of Newer Antiepileptic Drugs. Clin. Pharmacokinet. 1996, 30, 403-415.
    • (1996) Clin. Pharmacokinet. , vol.30 , pp. 403-415
    • Elwes, R.D.1    Binnie, C.D.2
  • 106
    • 0020526594 scopus 로고
    • Metabolism and Kinetics of Bupropion
    • Schroeder, D. H. Metabolism and Kinetics of Bupropion. J. Clin. Psychiatry 1983, 44, 79-81.
    • (1983) J. Clin. Psychiatry , vol.44 , pp. 79-81
    • Schroeder, D.H.1
  • 107
    • 0026357114 scopus 로고
    • Pharmacokinetics of Second Generation Anti-depressants: Bupropion
    • Goodnick, P. J. Pharmacokinetics of Second Generation Anti-depressants: Bupropion. Psychopharmacol. Bull. 1991, 27, 513-519.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 513-519
    • Goodnick, P.J.1
  • 108
    • 0015028873 scopus 로고
    • Absorption of Alprenolol in Man from Tablets with Different Rates of Release
    • Johansson, R.; Regårdh, C. G.; Sjögren, J. Absorption of Alprenolol in Man from Tablets with Different Rates of Release. Acta Pharm. Suec. 1971, 8, 59-70.
    • (1971) Acta Pharm. Suec. , vol.8 , pp. 59-70
    • Johansson, R.1    Regårdh, C.G.2    Sjögren, J.3
  • 109
    • 0022997648 scopus 로고
    • Clinical Pharmacokinetics and Pharmacodynamics of Warfarin
    • Holford, N. H. Clinical Pharmacokinetics and Pharmacodynamics of Warfarin. Clin. Pharmacokinet. 1986, 11, 483-504.
    • (1986) Clin. Pharmacokinet. , vol.11 , pp. 483-504
    • Holford, N.H.1
  • 111
    • 0023182481 scopus 로고
    • Pharmacokinetics and Pharmacodynamics Studies of Felodipine in Healthy Subjects after Various Single Oral and Intravenous Doses
    • Edgar, B.; Regardh, C. G.; Lundborg, P.; Romare, S.; Nyberg, G.; Rönn, O. Pharmacokinetics and Pharmacodynamics Studies of Felodipine in Healthy Subjects After Various Single Oral and Intravenous Doses. Biopharm. Drug Dispos. 1987, 8, 235-248.
    • (1987) Biopharm. Drug Dispos. , vol.8 , pp. 235-248
    • Edgar, B.1    Regardh, C.G.2    Lundborg, P.3    Romare, S.4    Nyberg, G.5    Rönn, O.6
  • 112
    • 0025036485 scopus 로고
    • Betaxolol: A New Long-Acting Betal-Selective Adrenergic Blocker
    • Frishman, W. H.; Tepper, D.; Lazar, E. J.; Behrman, D.; Betaxolol: A New Long-Acting Betal-Selective Adrenergic Blocker. J. Clin. Pharmacol. 1990, 30, 686-92.
    • (1990) J. Clin. Pharmacol. , vol.30 , pp. 686-692
    • Frishman, W.H.1    Tepper, D.2    Lazar, E.J.3    Behrman, D.4
  • 113
    • 0014604747 scopus 로고
    • Assay and Pharmacokinetics of Trimethoprim in Man and Animals
    • Schwartz, D. E.; Ziegler, W. H. Assay and Pharmacokinetics of Trimethoprim in Man and Animals. Postgrad. Med. J. 1969, 45, Suppl:32-37.
    • (1969) Postgrad. Med. J. , vol.45 , Issue.SUPPL. , pp. 32-37
    • Schwartz, D.E.1    Ziegler, W.H.2
  • 114
    • 0023597540 scopus 로고
    • Effect of Dose and Food on the Bioavailability of Cefuroxime Axetil
    • Finn, A.; Straughn, A.; Meyer, M.; Chubb, J. Effect of Dose and Food on the Bioavailability of Cefuroxime Axetil. Biopharm. Drug Dispos. 1990, 8, 519-526.
    • (1990) Biopharm. Drug Dispos. , vol.8 , pp. 519-526
    • Finn, A.1    Straughn, A.2    Meyer, M.3    Chubb, J.4
  • 115
    • 0025290979 scopus 로고
    • Bioavailability of Cefuroxime Axetil: Comparison of Standard and Abbreviated Methods
    • Lang, C. C.; Moreland, T. A.; Davey, P. G. Bioavailability of Cefuroxime Axetil: Comparison of Standard and Abbreviated Methods. J. Antimicrob. Chemother. 1990, 25, 645-650.
    • (1990) J. Antimicrob. Chemother. , vol.25 , pp. 645-650
    • Lang, C.C.1    Moreland, T.A.2    Davey, P.G.3
  • 117
    • 11344287321 scopus 로고
    • Physical Factors Affecting the Rate of Absorption of Chloramphenicol Esters
    • Glazko, A. J.; Dill, W. A.; Kazenko, A.; Wolf, L. M.; Carnes, H. E. Physical Factors Affecting the Rate of Absorption of Chloramphenicol Esters. Antibiot. Chemother. 1958, 8, 516-526.
    • (1958) Antibiot. Chemother. , vol.8 , pp. 516-526
    • Glazko, A.J.1    Dill, W.A.2    Kazenko, A.3    Wolf, L.M.4    Carnes, H.E.5
  • 118
    • 0021324877 scopus 로고
    • Clinical Pharmacokinetics of Chloramphenicol and Chloramphenicol Succinate
    • Ambrose, P. J. Clinical Pharmacokinetics of Chloramphenicol and Chloramphenicol Succinate. Clin. Pharmacokinet. 1984, 9, 222-238.
    • (1984) Clin. Pharmacokinet. , vol.9 , pp. 222-238
    • Ambrose, P.J.1
  • 122
    • 0015150697 scopus 로고
    • The Absorption, Excretion and Metabolism of Disodium [14C] Cromogylate in Man
    • Walker, S. R.; Richards, A. J.; Paterson, J. W. The Absorption, Excretion and Metabolism of Disodium [14C] Cromogylate in Man. Biochem. J. 1971, 125, 27P.
    • (1971) Biochem. J. , vol.125
    • Walker, S.R.1    Richards, A.J.2    Paterson, J.W.3
  • 123
    • 0025218419 scopus 로고
    • Clinical Pharmacokinetics of Imipramine and Desipramine
    • Sallee, F. R.; Pollock, B. G. Clinical Pharmacokinetics of Imipramine and Desipramine. Clin. Pharmacokinet. 1990, 18, 346-64.
    • (1990) Clin. Pharmacokinet. , vol.18 , pp. 346-364
    • Sallee, F.R.1    Pollock, B.G.2
  • 125
    • 0021843044 scopus 로고
    • The Absorption of Doxorubicin and Mitomycin C in Perioperative Instillation
    • Jauhiainen, K.; Eksborg, S.; Kangas, L.; Perila, M.; Alfthan, O. The Absorption of Doxorubicin and Mitomycin C in Perioperative Instillation. Ear. Urol. 1985, 11, 269-272.
    • (1985) Ear. Urol. , vol.11 , pp. 269-272
    • Jauhiainen, K.1    Eksborg, S.2    Kangas, L.3    Perila, M.4    Alfthan, O.5
  • 127
    • 0014635518 scopus 로고
    • Gentamicin: Antibacterial Activity, Clinical Pharmacology and Clinical Applications
    • Finland, M. Gentamicin: Antibacterial Activity, Clinical Pharmacology and Clinical Applications. Med. Times 1969, 97, 161-174.
    • (1969) Med. Times , vol.97 , pp. 161-174
    • Finland, M.1
  • 131
    • 0017873070 scopus 로고
    • The Clinical Pharmacology of Methotrexate
    • Bleyer, W. A. The Clinical Pharmacology of Methotrexate. Cancer 1978, 41, 36-51.
    • (1978) Cancer , vol.41 , pp. 36-51
    • Bleyer, W.A.1
  • 132
    • 0013791942 scopus 로고
    • The Metabolic Fate of Titrated Methotrexate
    • Henderson, E. S.; Adamson, R. H.; Oliverio, V. T. The Metabolic Fate of Titrated Methotrexate. Cancer Res. 1965, 25, 1018-1024.
    • (1965) Cancer Res. , vol.25 , pp. 1018-1024
    • Henderson, E.S.1    Adamson, R.H.2    Oliverio, V.T.3
  • 133
    • 0003138130 scopus 로고
    • Folk Acid Antagonists in Cancer Chemotherapy
    • Delmonte, L.; Jukes, T. H. Folk Acid Antagonists in Cancer Chemotherapy. Pharmacol. Rev. 1962, 14, 91-135.
    • (1962) Pharmacol. Rev. , vol.14 , pp. 91-135
    • Delmonte, L.1    Jukes, T.H.2
  • 134
    • 67650909877 scopus 로고
    • The Fluorometric Measurement of the Absorption, Distribution and Excretion of Single Doses of 4-Amino-10-Methyl Pteroylglutamic Acid (Amethopterin) in Man
    • Freeman, M. V. The Fluorometric Measurement of the Absorption, Distribution and Excretion of Single Doses of 4-Amino-10-Methyl Pteroylglutamic Acid (Amethopterin) in Man. J. Pharmacol. Exp. Ther. 1956, 15, 154-62.
    • (1956) J. Pharmacol. Exp. Ther. , vol.15 , pp. 154-162
    • Freeman, M.V.1
  • 135
    • 0023614144 scopus 로고
    • Review of the unavailability and Pharmacokinetics of Oral Norfloxacin
    • Stein, G. E. Review of the unavailability and Pharmacokinetics of Oral Norfloxacin. Am. J. Med. 1987, 82, 18-21.
    • (1987) Am. J. Med. , vol.82 , pp. 18-21
    • Stein, G.E.1
  • 136
    • 0022213999 scopus 로고
    • Norfloxacin: A Review of its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use
    • Holmes, B.; Brogden, R. N.; Richards, D. M. Norfloxacin: A Review of its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use. Drugs 1985, 30, 482-513.
    • (1985) Drugs , vol.30 , pp. 482-513
    • Holmes, B.1    Brogden, R.N.2    Richards, D.M.3
  • 137
    • 0027467287 scopus 로고
    • Pharmacokinetics of Prazosin Administered as Gastro-Intestinal-Therapeutic-Systems to 24 Healthy Volunteers
    • Fourtillan, J. B.; Brisson, A. M.; Couet, W. Pharmacokinetics of Prazosin Administered as Gastro-Intestinal-Therapeutic-Systems to 24 Healthy Volunteers. Therapie 1993, 48, 115-118.
    • (1993) Therapie , vol.48 , pp. 115-118
    • Fourtillan, J.B.1    Brisson, A.M.2    Couet, W.3
  • 139
    • 0014976146 scopus 로고
    • The Gastrointestinal Absorption of Atropine in Man
    • Beermann, B.; Hellström, K.; Rosén, A. The Gastrointestinal Absorption of Atropine in Man. Clin. Sci. 1971, 40, 95-106.
    • (1971) Clin. Sci. , vol.40 , pp. 95-106
    • Beermann, B.1    Hellström, K.2    Rosén, A.3
  • 140
    • 0025852162 scopus 로고
    • Scopolamine Blood Levels Following Buccal Versus Ingested Tablets
    • Golding, J. F.; Gosden, E.; Gerrell, J. Scopolamine Blood Levels Following Buccal Versus Ingested Tablets. Aviat. Space Environ. Med. 1991, 62, 521-526.
    • (1991) Aviat. Space Environ. Med. , vol.62 , pp. 521-526
    • Golding, J.F.1    Gosden, E.2    Gerrell, J.3
  • 142
    • 0022553825 scopus 로고
    • Pharmacokinetics of Terazosin
    • Sonders, R. C. Pharmacokinetics of Terazosin. Am. J. Med. 1986, 80, 20-24.
    • (1986) Am. J. Med. , vol.80 , pp. 20-24
    • Sonders, R.C.1
  • 143
    • 0017652396 scopus 로고
    • Pharmacokinetics and Bioavailability of Sodium Valproate
    • Klotz, U.; Antonin, K. H. Pharmacokinetics and Bioavailability of Sodium Valproate. Clin. Pharmacol. Ther. 1976, 21, 736-743.
    • (1976) Clin. Pharmacol. Ther. , vol.21 , pp. 736-743
    • Klotz, U.1    Antonin, K.H.2
  • 144
    • 0018365010 scopus 로고
    • Valproic Acid: Review of New Antiepileptic Drug
    • Bruni, J.; Wilder, B. J. Valproic Acid: Review of New Antiepileptic Drug. Arch. Neurol. 1979, 36, 393.
    • (1979) Arch. Neurol. , vol.36 , pp. 393
    • Bruni, J.1    Wilder, B.J.2
  • 145
    • 0019212040 scopus 로고
    • Clinical Pharmacokinetics of Valproic Acid
    • Gugler, R.; von Unruh, G. E. Clinical Pharmacokinetics of Valproic Acid. Clin. Pharmacokinet. 1980, 5, 67-83.
    • (1980) Clin. Pharmacokinet. , vol.5 , pp. 67-83
    • Gugler, R.1    Von Unruh, G.E.2
  • 146
    • 0023235581 scopus 로고
    • The Clinical Pharmacology of Etoposide and Teniposide
    • Clark, P. I.; Slevin, M. L. The Clinical Pharmacology of Etoposide and Teniposide. Clin. Pharmacokinet. 1987, 12, 223-252.
    • (1987) Clin. Pharmacokinet. , vol.12 , pp. 223-252
    • Clark, P.I.1    Slevin, M.L.2
  • 147
    • 0016755147 scopus 로고
    • Clinical Trial of the Oral Form of a New Podophyllotoxin Derivative, VP-16-213 (NSC-141540), in Patients with Advanced Neoplastic Disease
    • Nissen, N. I.; Hansen, H. H.; Pedersen, H.; Stroyer, I.; Dombernowsky, P.; Hessellund, M. Clinical Trial of the Oral Form of a New Podophyllotoxin Derivative, VP-16-213 (NSC-141540), in Patients with Advanced Neoplastic Disease. Cancer Chemother. Rep. 1975, 59, 1027-1029.
    • (1975) Cancer Chemother. Rep. , vol.59 , pp. 1027-1029
    • Nissen, N.I.1    Hansen, H.H.2    Pedersen, H.3    Stroyer, I.4    Dombernowsky, P.5    Hessellund, M.6
  • 148
    • 85034460547 scopus 로고    scopus 로고
    • MDL Information Systems, Inc. 14600 Catalina Street, San Leandro, CA 94577
    • MDL Information Systems, Inc. 14600 Catalina Street, San Leandro, CA 94577.
  • 149
    • 0022636023 scopus 로고
    • Shape Indexes of Orders One and Three from Molecular Graphs
    • Kier, L. B. Shape Indexes of Orders One and Three from Molecular Graphs. Quant. Struct.-Act. Relat. 1986, 5, 1-7.
    • (1986) Quant. Struct.-Act. Relat. , vol.5 , pp. 1-7
    • Kier, L.B.1
  • 151
    • 8544254107 scopus 로고
    • Structural Determination of Paraffin Boiling Points
    • Wiener, H. Structural Determination of Paraffin Boiling Points. J. Am. Chem. Soc. 1947, 69, 17.
    • (1947) J. Am. Chem. Soc. , vol.69 , pp. 17
    • Wiener, H.1
  • 153
    • 0021477860 scopus 로고
    • On Molecular Identification Numbers
    • Randić, M. On Molecular Identification Numbers. J. Chem. Inf. Comput. Sci. 1984, 24, 164.
    • (1984) J. Chem. Inf. Comput. Sci. , vol.24 , pp. 164
    • Randić, M.1
  • 154
  • 155
    • 0003437218 scopus 로고
    • Addison-Wesley: Reading, MA
    • Goldstein, H. Classical Mechanics; Addison-Wesley: Reading, MA, 1950; pp 144-156.
    • (1950) Classical Mechanics , pp. 144-156
    • Goldstein, H.1
  • 156
  • 157
    • 85034486439 scopus 로고
    • Sinkula, A. A., Valvani, S. C., Eds.; Quantum Chemistry Program Exchange No. 413. Marcel Dekker, Inc.: New York, Chapter 10
    • Pearlman, R. S. In Physical Chemistry Properties of Drugs; Sinkula, A. A., Valvani, S. C., Eds.; Quantum Chemistry Program Exchange No. 413. Marcel Dekker, Inc.: New York, 1980; Chapter 10.
    • (1980) Physical Chemistry Properties of Drugs
    • Pearlman, R.S.1
  • 158
    • 0002233999 scopus 로고
    • A Simple Method for the Representation, Quantification, and Comparison of the Volumes and Shapes of Chemical Compounds
    • Slouch, T. R.; Jurs, P. C. A Simple Method for the Representation, Quantification, and Comparison of the Volumes and Shapes of Chemical Compounds. J. Chem. Inf. Comput. Sci. 1986, 26, 4-12.
    • (1986) J. Chem. Inf. Comput. Sci. , vol.26 , pp. 4-12
    • Slouch, T.R.1    Jurs, P.C.2
  • 159
    • 10344253046 scopus 로고
    • Development and Use of Charged Partial Surface Area Structural Descriptors in Computer-Assisted Quantitative Structure-Property Relationship Studies
    • Stanton, D. T.; Jurs, P. C. Development and Use of Charged Partial Surface Area Structural Descriptors in Computer-Assisted Quantitative Structure-Property Relationship Studies. Anal. Chem. 1990, 62, 2323-2329.
    • (1990) Anal. Chem. , vol.62 , pp. 2323-2329
    • Stanton, D.T.1    Jurs, P.C.2
  • 160
    • 0011785559 scopus 로고
    • A New Definition of Functional Groups and a General Procedure for Their Identification in Organic Structures
    • Sello, G. A New Definition of Functional Groups and a General Procedure for Their Identification in Organic Structures. J. Am. Chem. Soc. 1992, 114, 3306.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 3306
    • Sello, G.1
  • 161
    • 0022758683 scopus 로고
    • Generalized Simulated Annealing for Function Optimization
    • Bohachevsky, I. O.; Johnson, M. E.; Stein, M. L. Generalized Simulated Annealing for Function Optimization. Technometrics 1986, 28, 209.
    • (1986) Technometrics , vol.28 , pp. 209
    • Bohachevsky, I.O.1    Johnson, M.E.2    Stein, M.L.3
  • 162
    • 0029230341 scopus 로고
    • Automated Descriptor Selection for Quantitative Structure-Activity Relationships Using Generalized Simulated Annealing
    • Sutter, J. M.; Dixon, S. L.; Jurs, P. C. Automated Descriptor Selection for Quantitative Structure-Activity Relationships Using Generalized Simulated Annealing. J. Chem. Int. Comput. Sci. 1995, 35, 77.
    • (1995) J. Chem. Int. Comput. Sci. , vol.35 , pp. 77
    • Sutter, J.M.1    Dixon, S.L.2    Jurs, P.C.3
  • 163
    • 85002377847 scopus 로고
    • Application of a Genetic Algorithm to Feature Selection under Fall Validation Conditions and to Outlier Detection
    • Leardi, R. Application of a Genetic Algorithm to Feature Selection Under Fall Validation Conditions and to Outlier Detection. J. Chemom. 1992, 6, 267.
    • (1992) J. Chemom. , vol.6 , pp. 267
    • Leardi, R.1
  • 164
    • 12044254082 scopus 로고
    • Prediction of Reduced Ion Mobility Constants from Structural Information Using Multiple Linear regression Analysis and Computational Neural Networks
    • Wessel, M. D.; Jurs, P. C. Prediction of Reduced Ion Mobility Constants from Structural Information Using Multiple Linear regression Analysis and Computational Neural Networks. Anal. Chem. 1994, 66, 2480.
    • (1994) Anal. Chem. , vol.66 , pp. 2480
    • Wessel, M.D.1    Jurs, P.C.2
  • 167
    • 0027212862 scopus 로고
    • Statistics Using Neural Networks: Chance Effects
    • Livingstone, D. J.; Manallack, D. T. Statistics Using Neural Networks: Chance Effects. J. Med. Chem. 1993, 36, 1295.
    • (1993) J. Med. Chem. , vol.36 , pp. 1295
    • Livingstone, D.J.1    Manallack, D.T.2
  • 169
    • 85034486426 scopus 로고    scopus 로고
    • note
    • 158 This model employs a 6-4-1 neural network architecture. The rms error of prediction for this model is between 20 and 25%HIA units for various neural network training sessions.
  • 170
    • 0026075594 scopus 로고
    • Applications of Neural Networks in Quantitative Structure-Activity Relationships of Dihydrofolate Reduclase Inhibitors
    • Andrea, T. A.; Kalayeh, H. Applications of Neural Networks in Quantitative Structure-Activity Relationships of Dihydrofolate Reduclase Inhibitors. J. Med. Chem. 1991, 34, 2824-2836.
    • (1991) J. Med. Chem. , vol.34 , pp. 2824-2836
    • Andrea, T.A.1    Kalayeh, H.2
  • 171
    • 0026738394 scopus 로고
    • Application of Neural Networks: Quantitative Structure-Activity Relationships of the Derivatives of 2,4-Diamino-5-(substituted-benzyl)pyrmidines as DHFR Inhibitors
    • So, S.-S.; Richards, W. G. Application of Neural Networks: Quantitative Structure-Activity Relationships of the Derivatives of 2,4-Diamino-5-(substituted-benzyl)pyrmidines as DHFR Inhibitors. J. Med. Chem. 1992, 35, 3201-3207.
    • (1992) J. Med. Chem. , vol.35 , pp. 3201-3207
    • So, S.-S.1    Richards, W.G.2
  • 172
    • 84988175790 scopus 로고
    • Application of Neural Networks in Quantitative Structure-Activity Relationships of Cytotoxicity of Antioxidants
    • Suzuki, T.; Ishida, M. Application of Neural Networks in Quantitative Structure-Activity Relationships of Cytotoxicity of Antioxidants. Pharm. Sci. 1995, 1, 297-300.
    • (1995) Pharm. Sci. , vol.1 , pp. 297-300
    • Suzuki, T.1    Ishida, M.2
  • 174
    • 0018709674 scopus 로고
    • Chance Factors in Studies of Quantitative Structure-Activity Relationships
    • Topliss, J. G.; Edwards, R. P. Chance Factors in Studies of Quantitative Structure-Activity Relationships. J. Med. Chem. 1979, 22, 1238-1244.
    • (1979) J. Med. Chem. , vol.22 , pp. 1238-1244
    • Topliss, J.G.1    Edwards, R.P.2
  • 175
    • 0002615508 scopus 로고    scopus 로고
    • Prediction of Aqueous Solubility for a Diverse Set of Heteroatom-Containing Organic Compounds Using a Quantitative Structure-Properly Relationship
    • Sutter, J. M.; Jurs, P. C. Prediction of Aqueous Solubility for a Diverse Set of Heteroatom-Containing Organic Compounds Using a Quantitative Structure-Properly Relationship. J. Chem. Inf. Comput. Sci. 1996, 36, 100-107.
    • (1996) J. Chem. Inf. Comput. Sci. , vol.36 , pp. 100-107
    • Sutter, J.M.1    Jurs, P.C.2
  • 176
    • 11744331329 scopus 로고
    • a for Organic Oxyacids using Calculated Atomic Charges
    • a for Organic Oxyacids using Calculated Atomic Charges. J. Comput. Chem. 1993, 14, 1460-1467.
    • (1993) J. Comput. Chem. , vol.14 , pp. 1460-1467
    • Dixon, S.L.1    Jurs, P.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.