Computation of brain-blood partitioning of organic solutes via free energy calculations

Journal of Medicinal Chemistry

Volumn 39, Issue 24, 1996, Pages 4750-4755

  Lombardo, Franco ^a   Blake, James F ^a   Curatolo, William J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CATTLE; CORRELATION FUNCTION; DRUG DISTRIBUTION; DRUG PENETRATION; NONHUMAN;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; MEMBRANE LIPIDS; MICROCIRCULATION; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MONTE CARLO METHOD; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SOFTWARE; SOLUBILITY; THERMODYNAMICS;

EID: 0030462889     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960163r     Document Type: Article

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