-
2
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D. and Arden K.C. 2004. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell. 117:421-426.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
3
-
-
0033560896
-
Direct control of the Forkhead transcription factor AFX by protein kinase B
-
Kops G.J., et al. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature. 398:630-634.
-
(1999)
Nature
, vol.398
, pp. 630-634
-
-
Kops, G.J.1
-
4
-
-
0034459180
-
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1)
-
Dijkers P.F., et al. 2000. Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol. Cell. Biol. 20:9138-9148.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9138-9148
-
-
Dijkers, P.F.1
-
5
-
-
0036120725
-
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
-
Kops G.J., et al. 2002. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol. 22:2025-2036.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2025-2036
-
-
Kops, G.J.1
-
6
-
-
0034643331
-
AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
-
Medema R.H., Kops G.J., Bos J.L., Burgering B.M. 2000. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 Nature. 404:782-787.
-
(2000)
Nature
, vol.404
, pp. 782-787
-
-
Medema, R.H.1
Kops, G.J.2
Bos, J.L.3
Burgering, B.M.4
-
7
-
-
0037237279
-
The forkhead transcription factor Foxo1 regulates adipocyte differentiation
-
Nakae J., et al. 2003. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell. 4:119-129.
-
(2003)
Dev. Cell.
, vol.4
, pp. 119-129
-
-
Nakae, J.1
-
8
-
-
2342653278
-
Control of cyclin G2 mRNA expression by forkhead transcription factors: Novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead
-
Martinez-Gac L., Marques M., Garcia Z., Campanero M.R., Carrera A.C. 2004. Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol. Cell. Biol. 24:2181-2189.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2181-2189
-
-
Martinez-Gac, L.1
Marques, M.2
Garcia, Z.3
Campanero, M.R.4
Carrera, A.C.5
-
9
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A., et al. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
-
10
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers P.F., Medema R.H., Lammers J.W., Koenderman L., Coffer P.J. 2000. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10:1201-1204.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
11
-
-
0037134040
-
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
-
Tran H., et al. 2002. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science. 296:530-534.
-
(2002)
Science
, vol.296
, pp. 530-534
-
-
Tran, H.1
-
12
-
-
0037178789
-
FOXO fork-head transcription factors induce G(2)-M checkpoint in response to oxidative stress
-
Furukawa-Hibi Y., Yoshida-Araki K., Ohta T., Ikeda K., Motoyama N. 2002. FOXO fork-head transcription factors induce G(2)-M checkpoint in response to oxidative stress. J. Biol. Chem. 277:26729-26732.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26729-26732
-
-
Furukawa-Hibi, Y.1
Yoshida-Araki, K.2
Ohta, T.3
Ikeda, K.4
Motoyama, N.5
-
13
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy C.T., et al. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 424:277-283.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
-
14
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops G.J., et al. 2002. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 419:316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
-
15
-
-
0037192473
-
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
-
Nemoto S. and Finkel T. 2002. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science. 295:2450-2452.
-
(2002)
Science
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
16
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
doi: 10.1172/JCI200112876.
-
Nakae J., Kitamura T., Silver D.L., Accili D. 2001. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108:1359-1367 doi: 10.1172/JCI200112876.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
17
-
-
0036787607
-
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
Nakae J., et al. 2002. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32:245-253.
-
(2002)
Nat. Genet.
, vol.32
, pp. 245-253
-
-
Nakae, J.1
-
18
-
-
15244339047
-
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism
-
doi: 10.1172/JCI200419992.
-
Altomonte J., et al. 2004. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J. Clin. Invest. 114:1493-1503 doi: 10.1172/JCI200419992.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1493-1503
-
-
Altomonte, J.1
-
19
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
Hosaka T., et al. 2004. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U. S. A. 101:2975-2980.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
-
20
-
-
0038152845
-
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
-
Castrillon D.H., Miao L., Kollipara R., Horner J.W., DePinho R.A. 2003. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 301:215-218.
-
(2003)
Science
, vol.301
, pp. 215-218
-
-
Castrillon, D.H.1
Miao, L.2
Kollipara, R.3
Horner, J.W.4
DePinho, R.A.5
-
21
-
-
0033118984
-
RNA polymerase II as a control panel for multiple coactivator complexes
-
Hampsey M. and Reinberg D. 1999. RNA polymerase II as a control panel for multiple coactivator complexes. Curr. Opin. Genet. Dev. 9:132-139.
-
(1999)
Curr. Opin. Genet. Dev.
, vol.9
, pp. 132-139
-
-
Hampsey, M.1
Reinberg, D.2
-
23
-
-
0032213938
-
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
-
McInerney E.M., et al. 1998. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev. 12:3357-3368.
-
(1998)
Genes Dev.
, vol.12
, pp. 3357-3368
-
-
McInerney, E.M.1
-
24
-
-
0030986236
-
A signature motif in transcriptional coactivators mediates binding to nuclear receptors
-
Heery D.M., Kalkhoven E., Hoare S., Parker M.G. 1997. A signature motif in transcriptional coactivators mediates binding to nuclear receptors. Nature. 387:733-736.
-
(1997)
Nature
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, E.2
Hoare, S.3
Parker, M.G.4
-
25
-
-
0033522897
-
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
-
Nakae J., Park B.C., Accili D. 1999. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway J. Biol. Chem. 274:15982-15985.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15982-15985
-
-
Nakae, J.1
Park, B.C.2
Accili, D.3
-
26
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
Rena G., Guo S., Cichy S.C., Unterman T.G., Cohen P. 1999. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274:17179-17183.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17179-17183
-
-
Rena, G.1
Guo, S.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
27
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A., et al. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 303:2011-2015.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
-
28
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
Daitoku H., et al. 2004. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. U. S. A. 101:10042-10047.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
-
29
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta M.C., et al. 2004. Mammalian SIRT1 represses forkhead transcription factors. Cell. 116:551-563.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
-
30
-
-
3142742707
-
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
-
van der Horst A., et al. 2004. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J. Biol. Chem. 279:28873-28879.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 28873-28879
-
-
Van Der Horst, A.1
-
31
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz K.T., et al. 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425:191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
-
32
-
-
20144365700
-
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
-
Frescas D., Valenti L., Accili D. 2005. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J. Biol. Chem. 280:20589-20595.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
33
-
-
0141727772
-
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice
-
Altomonte J., et al. 2003. Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am. J. Physiol. Endocrinol. Metab. 285:E718-E728.
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.285
-
-
Altomonte, J.1
-
34
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S., Armstrong C.M., Kaeberlein M., Guarente L. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403:795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
35
-
-
12944283150
-
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
-
Smith J.S., et al. 2000. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. U. S. A. 97:6658-6663.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6658-6663
-
-
Smith, J.S.1
-
36
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H.A. and Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 410:227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
37
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J., et al. 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107:137-148.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
38
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H., et al. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:149-159.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
-
39
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E., et al. 2002. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21:2383-2396.
-
(2002)
EMBO J.
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
-
40
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng H.L., et al. 2003. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 100:10794-10799.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
-
41
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M., et al. 2003. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell. 12:51-62.
-
(2003)
Mol. Cell.
, vol.12
, pp. 51-62
-
-
Fulco, M.1
-
42
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye R.A. 2000. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273:793-798.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
43
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC1alpha and SIRT1
-
Rodgers J.T., et al. 2005. Nutrient control of glucose homeostasis through a complex of PGC1alpha and SIRT1. Nature. 434:113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
44
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra M.T., Smith B.C., Denu J.M. 2005. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280:17187-17195.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
45
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein M., et al. 2005. Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280:17038-17045.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
-
46
-
-
27644585190
-
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
-
Viswanathan M., Kim S.K., Berdichevsky A., Guarente L. 2005. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell. 9:605-615.
-
(2005)
Dev. Cell.
, vol.9
, pp. 605-615
-
-
Viswanathan, M.1
Kim, S.K.2
Berdichevsky, A.3
Guarente, L.4
-
47
-
-
27144468317
-
FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression
-
Gan L., et al. 2005. FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression. Biochem. Biophys. Res. Commun. 337:1092-1096.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.337
, pp. 1092-1096
-
-
Gan, L.1
-
48
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P., et al. 2003. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 423:550-555.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
-
49
-
-
13244287966
-
Regulation of FoxO activity by CBP/p300-mediated acetylation
-
van der Heide L.P. and Smidt M.P. 2005. Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem. Sci. 30:81-86.
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 81-86
-
-
Van Der Heide, L.P.1
Smidt, M.P.2
-
50
-
-
33744976074
-
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
-
Berdichevsky A., Viswanathan M., Horvitz H.R., Guarente L. 2006. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell. 125:1165-1177.
-
(2006)
Cell
, vol.125
, pp. 1165-1177
-
-
Berdichevsky, A.1
Viswanathan, M.2
Horvitz, H.R.3
Guarente, L.4
-
51
-
-
2542435874
-
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
-
Yamagata K., et al. 2004. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J. Biol. Chem. 279:23158-23165.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 23158-23165
-
-
Yamagata, K.1
-
52
-
-
0034161544
-
Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
-
Nakae J., Barr V., Accili D. 2000. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J. 19:989-996.
-
(2000)
EMBO J.
, vol.19
, pp. 989-996
-
-
Nakae, J.1
Barr, V.2
Accili, D.3
|