The interaction of dietary fibres with the colon

Current Nutrition and Food Science

Volumn 2, Issue 3, 2006, Pages 243-264

  Brownlee, Iain A ^a   Dettmar, Peter W ^b   Strugala, Vicki ^b   Pearson, Jeff P ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Technostics Ltd   (United Kingdom)

Author keywords

Colon; Dietary fibre; Morphology; Muscus; PYY; Satiety

Indexed keywords

ACETIC ACID; BUTYRIC ACID; CARCINOGEN; CELLULOSE; INDOMETACIN; INSULIN; ISPAGULA; MESALAZINE; MUCIN; NEUROHORMONE; PENTACHLOROBENZENE; PEPTIDE YY; PLACEBO; POLYSACCHARIDE; PROBIOTIC AGENT; PROPIONIC ACID; SHORT CHAIN FATTY ACID;

AEROBIC FERMENTATION; BARLEY; CANCER INHIBITION; CANCER RISK; CLINICAL TRIAL; COLON CARCINOGENESIS; COLON DISEASE; COLON FLORA; COLON MOTILITY; COLON MUCOSA; DIETARY FIBER; ENZYME INHIBITION; HORMONE RELEASE; HUMAN; INTESTINE MUSCLE; INTESTINE TRANSIT TIME; ION TRANSPORT; MUCOSAL IMMUNITY; MUCUS SECRETION; NONHUMAN; PERMEABILITY BARRIER; PLANTAGO OVATA; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SATIETY; ULCERATIVE COLITIS;

EID: 33747434873     PISSN: 15734013     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340106778017896     Document Type: Review

References (246)

1. Asp NG. Definition and analysis of dietary fibre. Scand J Gastroenterol 1987; 22: 16-20.
2. Hipsley EH. Dietary "fibre" and pregnancy toxaemia. Br J Med 1953; 2: 420-2.
3. Trowell H. Ischemic heart disease and dietary fiber. Am J Clin Nutr 1972; 25: 926-32.
4. Englyst HN, Cummings JH. Simplified method for the measurement of total non-starch polysaccharides by gas-liquid chromatography of constituent sugars as alditol acids. Analyst 1984; 109: 937-43.
5. Prosky L, Asp NG, Furda I, DeVries JW, Schweizer TF, Harland B. Determination of total dietary fibre in foods and food products: Collaborative study. J Ass Off Anal Chem 1985; 68: 677-9.
6. Moore MA, Park CB, Tsuda H. Soluble and insoluble fiber influences on cancer development. Crit Rev Oncol Haematol 1998; 27: 229-42.
7. Hill MJ. ECP dietary advice on cancer prevention. Eur J Cancer Prev 2001; 10: 183-9.
8. McIntyre A, Vincent RM, Perkins AC, Spiller RC. Effect of bran, ispaghula and inert plastic particles on gastric emptying and small bowel transit in humans: the role of physical factors. Gut 1997; 40: 223-7.
9. Jenkins DJA, Axelsen M, Kendall CWC, Augustin LSA, Vuksan V, Smith U. Dietary fibre, lente carbohydrates and the insulin-resistant diseases. Br J Nutr 2000; 83: S157-S63.
10. Blackwood AD, Salter J, Dettmar PW, Chaplin MF. Dietary fibre, physicochemical properties and their relationship to health. J Roy Soc Promo Health 2000; 120: 242-7.
11. Ha M-A, Jarvis MC, Mann JI. A definition for dietary fibre. Eur J Clin Nutr 2000; 54: 861-4.
12. Oniang'o RK. Fibre: Implications for the Consumer. Nutr Res 1998; 18: 661-9.
13. Moran BJ, Jackson AA. Function of the human colon. Br J Surg 1992; 79: 1132-7.
14. Sandler RS, Everhart JE, Donowitz M, et al. The Burden of Selected Digestive Diseases in the United States. Gastroenterology 2002; 122: 1500-11.
15. Sandle GI. Salt and water absorption in the human colon: a modern appraisal. Gut 1998; 43: 294-9.
16. Roberton AM. Roles of endogenous substances and bacteria in colorectal cancer. Nutr Res 1993; 290: 71-8.
17. Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiol Rev 2001; 81: 1031-60.
18. Edwards C. Physiology of the colorectal barrier. Adv Drug Deliv 1997; 28: 173-90.
19. Violi V, Cobianchi F, Adami M, Torri T, Ferraro G, Roncoroni L. Human defunctionalized colon: - a histopathological and pharmacological study of muscularis propria in resection specimens. Dig Dis Sci 1998; 43: 616-23.
20. Warth R, Bleich M. K+ channels and colonic function. Rev Physiol Biochem Pharmacol 2000; 140: 1-62.
21. Whitehead R. Mucosal Biopsy of the gastrointestinal Tract. In Major Problems in Pathology, ed. VA Livolsi, JL Bennington. Philadelphia: W.B. Saunders Company, 1990.
22. Lewis SJ, Heaton KW. Roughage Revisited: The Effect on Intestinal Function of Inert Plastic particles of Different Sizes and Shape. Dig Dis Sci 1999; 44: 744-8.
23. Munro JA. Wheat bran equivalents based on faecal bulking indices for dietary management of faecal bulk. Asia Pac J Clin Nutr 2001; 10: 242-8.
24. Cummings JH. Consequences of the metablism of fiber in the human large intestine. In Dietary fibre in health and disease, ed. GV Vahouny, D Kritchevsky, 1982; pp. 9-22. New York: Plenum Press.
25. Heller SN, Hackler LR, Rivers JM, et al. Dietary fiber: the effect of particle size of wheat bran on colonic function in young adult men. Am J Clin Nutr 1980; 33: 1734-44.
26. Ferguson LR, Harris PJ. Particle size of wheat bran in relation to colonic function in rats. Food Sci Technol-Lebensm-Wiss Technol 1997; 30: 735-42.
27. Lewis SJ, Heaton KW. The intestinal effects of bran-like plastic particles: Is the concept of 'roughage' valid after all? Eur J Gastroenterol Hepatol 1997; 9: 553-7.
28. Lewis SJ, Heaton KW. Roughage revisited - The effect on intestinal function of inert plastic particles of different sizes and shape. Dig Dis Sci 1999; 44: 744-8.
29. Anti M, Pignataro G, Armuzzi A, et al. Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepato-Gastroenterol 1998; 45: 727-32.
30. Marlett JA, Kajs TM, Fischer MH. An unfermented gel component of psyllium seed husk promotes laxation as a lubricant in humans. Am J Clin Nutr 2000; 72: 784-9.
31. Hebden JM, Blackshaw E, D'Amato M, Perkins AC, Spiller RC. Abnormalities of GI transit in bloated irritable bowel syndrome: Effect of bran on transit and symptoms. Am J Gastroenterol 2002; 97: 2315-20.
32. Ferguson LR, Harris PJ. Studies on the role of specific dietary fibres in protection against colorectal cancer. Mutat Res 1996; 350: 173-84.
33. Harris PJ, Vallappilakkandy KS, Roberton AM, Triggs CM, Blakeney AB, Ferguson LR. Adsorption of a hydrophobic mutagen to cereal brans and cereal bran dietary fibres. Mutat Res 1998; 412: 323-31.
34. Karakaya S, Kavas A. Adsorption of direct-acting and indirect-acting mutagens by various dietary fibers. Int J Food Sci Nutr 1999; 50: 319-23.
35. Aozasa O, Ohta S, Nakao T, Miyata H, Nomura T. Enhancement in fecal excretion of dioxin isomer in mice by several dietary fibers. Chemosphere 2001; 45: 195-200.
36. Nishiyama C, Nagai T, Yano T. Adsorption of Mutagens in Distilled Water by Dietary-Fibers. Agric Biol Chem 1991; 55: 797-802.
37. Nishiyama C, Nagai T, Yano T. Effects of Ph on the in vitro Sorption of Mutagens to Dietary- Fibers. Biosci Biotechnol Biochem 1992; 56: 1100-3.
38. Ikegami S, Umegaki K, Kawashima Y, Ichikawa T. Viscous Indigestible Polysaccharides Reduce Accumulation of Pentachlorobenzene in Rats. J Nutr 1994; 124: 754-60.
39. Sugiyama K, He PM, Wada S, Saeki S. Teas and other beverages suppress D-galactosamine-induced liver injury in rats. J Nutr 1999; 129: 1361-7.
40. Ochsenkuhn T, Bayerdorffer E, Meining A, et al. Colonic Mucosal Proliferation Is Related to Serum Deoxycholic Acid Levels. Cancer 1999; 85: 1664-9.
41. Owen RW. Faecal Steroids and Colorectal Carcinogenesis. Scand J Gastroenterol 1997; 32: 76-82.
42. Debruyne PR, Bruyneel EA, Li X, Zimber A, Gespach C, Mareel MM. The role of bile acids in carcinogenesis. Mutat Res 2001; 480-481: 359-69.
43. Ikegami S, Harada H, Tsuchihashi N, Nishide E, Innami S. Effect of indigestible polysaccharides on pancreatic exocrine secretion and biliary output. J Nutr Sci Vitaminol 1984; 30: 515-23.
44. Hill MJ. Bile Acids and Human Colorectal Cancer. In Dietary fibre in health and disease, ed. GV Vahouny, D Kritchevsky, 1982; pp. 9-22. New York: Plenum Press.
45. Wang W, Onnagawa M, Yoshie Y, Suzuki T. Binding of bile salts to soluble and insoluble dietary fibers of seaweed. Fish Sci 2001; 67: 1169-73.
46. Camire ME, Zhao J, Violette DA. In Vitro Binding of Bile Acids by Extruded Potato Peels. J Agric Food Chem 1993; 41: 2391-4.
47. Mortensen PB, Clausen MR. Short-chain fatty acids in the human colon: Relation to gastrointestinal health and disease. Scand J Gastroenterol 1996; 31: 132-48.
48. Bourquin LD, Titgemeyer EC, Fahey GC. Vegetable Fiber Fermentation by Human Fecal Bacteria - Cell- Wall Polysaccharide Disappearance and Short-Chain Fatty-Acid Production During Invitro Fermentation and Water-Holding Capacity of Unfermented Residues. J Nutr 1993; 123: 860-9.
49. Bourquin LD, Titgemeyer EC, Fahey GC. Fermentation of various dietary fiber sources by human fecal bacteria. Nutr Res 1996; 16: 1119-31.
50. Bourquin LD, Titgemeyer EC, Fahey GC, Garleb KA. Fermentation of Dietary Fiber by Human Colonic Bacteria - Disappearance of, Short-Chain Fatty-Acid Production from, and Potential Water-Holding Capacity of, Various Substrates. Scand J Gastroenterol 1993; 28: 249-55.
51. Titgemeyer EC, Bourquin LD, Fahey GC, Garleb KA. Fermentability of Various Fiber Sources by Human Fecal Bacteria Invitro. Am J Clin Nutr 1991; 53: 1418-24.
52. Campbell JM, Fahey GC. Psyllium and methylcellulose fermentation properties in relation to insoluble and soluble fiber standards. Nutr Res 1997; 17: 619-29.
53. Sunvold GD, Hussein HS, Fahey GC, Merchen NR, Reinhart GA. In vitro fermentation of cellulose, beet pulp, citrus pulp, and citrus pectin using fecal inoculum from cats, dogs, horses, humans, and pigs and ruminal fluid from cattle. J Anim Sci 1995; 73: 3639-48.
54. Michel C, Lahaye M, Bonnet C, Mabeau S, Barry JL. In vitro fermentation by human faecal bacteria of total and purified dietary fibres from brown seaweeds. Br J Nutr 1996; 75: 263-80.
55. Fujii T, Kuda T, Saheki K, Okuzumi M. Fermentation of Water-Soluble Polysaccharides of Brown-Algae by Human Intestinal Bacteria Invitro. Nippon Suisan Gakkaishi 1992; 58: 147-52.
56. Zampa A, Silvi S, Fabiani R, Morozzi G, Orpianesi C, Cresci A. Effects of different digestible carbohydrates on bile acid metabolism and SCFA production by human gut micro-flora grown in an in vitro semi-continuous culture. Anaerobe 2004; 10: 19-26.
57. El Oufir L, Barry JL, Flourie B, et al. Relationships between transit time in man and in vitro fermentation of dietary fiber by fecal bacteria. Eur J Clin Nutr 2000; 54: 603-9.
58. Blaut M, Collinse MD, Welling GW, Dore J, van Loo J, de Vos W. Molecular biological methods for studying the gut microbiota: the EU human gut flora project. Brit J Nutr 2002; 87: S203-S11.
59. Langlands SJ, Hopkins MJ, Coleman N, Cummings JH. Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut 2004; 53: 1610-6.
60. Bouhnik Y, Raskine L, Simoneau G, et al. The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized placebo-controlled, parallel-group, dose-response relation study. Am J Clin Nutr 2004; 80: 1658-64.
61. Tuohy KM, Kolida S, Lustenberger AM, Gibson GR. The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides - a human volunteer study. Br J Nutr 2001; 86: 341-8.
62. Tuohy KM, Finlay RK, Wynne AG, Gibson GR. A human volunteer study on the prebiotic effects of HP-inulin - Faecal bacteria enumerated using fluorescent in situ hybridisation (FISH). Anaerobe 2001; 7: 113-8.
63. Menne E, Guggenbuhl N, Roberfroid M. Fn-type chicory inulin hydrolysate has a prebiotic effect in humans. J Nutr 2000; 130: 1197-9.
64. Kleessen B, Sykura B, Zunft HJ, Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 1997; 65: 1397-402.
65. Gibson GR, Beatty ER, Wang X, Cummings JH. Selective Stimulation of Bifidobacteria, in the Human Colon by Oligofructose and Inulin. Gastroenterology 1995; 108: 975-82.
66. Atuma C, Strugala V, Allen A, Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol 2001; 280: G922-G9.
67. Strugala V, Dettmar PW, Pearson JP, Allen A. Colonic mucin - Methods of Measuring Mucus Thickness. P Nutr Soc 2003; 62: 237-44.
68. Taylor C, Allen A, Dettmar PW, Pearson JP. Evidence for two discrete mucus secretions in the normal stomach. Gastroenterology 2000; 118: 1425.
69. Allen A, Leonard AJ, L.A. S. The mucus barrier - its role in gastroduodenal mucosal protection. J Clin Gastroenterol 1988; 10: S93-S8.
70. Neutra MN. Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system. Am J Physiol 1998; 274: G785-G91.
71. Flemstrom G, Hallgren A, Nylander O, Engstrand L, Allen A. The Adherent Surface Mucus Gel Prevents Stimulation of Rat Duodenal Mucosa by Luminal Helicobacter pylori and Cholera Toxins. Gastroenterology 1995; 108: A94.
72. Allen A, Hutton DA, Pearson JP. The MUC2 gene product: a human intestinal mucin. Int J Biochem Cell Biol 1998; 30: 797-801.
73. van Klinken BJW, Dekker J, van Gool SA, van Marle J, Buller HA, Einerhand AWC. MUC5B is the prominent mucin in human gallbladder and is also expressed in a subset of colonic goblet cells. Am J Physiol-Gastroint Liver Physiol 1998; 37: G871-G8.
74. Byrd JC, Bresalier RS. Mucins and mucin binding proteins in colorectal cancer. Cancer Metastasis Rev 2004; 23: 77-99.
75. Truant S, Bruyneel E, Gouyer V, et al. Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells. Int J Cancer 2003; 104: 683-94.
76. Sylvester PA, Myerscough N, Warren BF, et al. Differential expression of the chromosome 11 mucin genes in colorectal cancer. J Pathol 2001; 195: 327-35.
77. Jass JR. Serrated adenoma and colorectal cancer. J Pathol 1999; 187: 499-502.
78. Smirnova MG, Guo L, Birchall JP, Pearson JP. LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. Cell Immunol 2003; 221: 42-9.
79. Velcich A, Yang WC, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002; 295: 1726-9.
80. Matsuo Y, Ota H, Akamatsu T, Sugiyama A, Katsuyama T. Histochemistry of surface mucous gel layer of the human colon. Gut 1997; 40: 782-9.
81. Jordan N, Newton J, Pearson JP, Allen A. A novel method for the visualization of the in situ mucus layer in rat and man. Clin Sci 1998; 95: 97-106.
82. Brownlee IA, Dettmar PW, Havler ME, Allen A, Pearson JP. A mixture of soluble and insoluble dietary fibre types is required for the maintenance of the colonic mucus barrier. Gut 2002; 51: A8.
83. Brownlee IA, Havler ME, Dettmar PW, Allen A, Pearson JP. Colonic mucus - secretion and turnover in relation to dietary fibre intake. P Nutr Soc 2003; 62: 245-9.
84. Forstner GG. Signal transduction, packaging and secretion of mucins. Ann Rev Physiol 1995; 57: 585-605.
85. Asker N, Axellson MAB, Olofsson S-O, Hansson GC. Dimerization of the Human MUC2 Mucin in the Endoplasmic Reticulum is Followed by a N-Glycosylation-dependent Transfer of the Mono-and Dimers to the Golgi Apparatus. JBC 1998; 273: 18857-63.
86. Verdugo P. Goblet cell secretion and mucogenesis. Ann Rev Physiol 1990; 52: 157-76.
87. Forstner JF, Forstner GG. Gastrointestinal mucus. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, 1994; pp. 1255-83. New York: Raven Press.
88. Strous GJ, Dekker J. Mucin-type glycoproteins. Crit Rev Biochem Mol Biol 1992; 27: 57-92.
89. Phillips TE, Wilson J. Signal Transduction Pathways Mediating Mucin Secretion from Intestinal Goblet Cells. Dig Dis Sci 1993; 38: 1046-54.
90. Neutra MN, Forstner JF. Gastrointestinal mucus: synthesis, secretion and function. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, 1987; pp. 975-1009. New York: Raven Press.
91. Sababi M, Nilsson E, Holm L. Mucus and alkali secretion in the rat duodenum - effects of indomethacin, N-omega-nitro-L-arginine and luminal acid. Gastroenterology 1995; 109: 1526-34.
92. Akiba Y, Guth PH, Engel E, Nastaskin I, Kaunitz JD. Dynamic regulation of mucus gel thickness in rat duodenum. Am J Physiol 2000; 279: G437-G47.
93. McCool DJ, Marcon MA, Forstner JF, Forstner GG. The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues. Biochem J 1990; 267: 491-500.
94. Augeron C, Voisin T, Maoret JJ, Berthon B, Laburthe M, Laboisse CL. Neurotensin and neuromedin-N stimulate mucin ouput from human goblet cells via neurotensin receptors. Am J Physiol 1992; 262: G470-G6.
95. Hong DH, Forstner JF, Forstner GG. Protein kinase C-epsilon is the likely mediator of mucin exocytosis in human colonic cell lines. Am J Physiol 1997; 272: G31-G37.
96. Epple HJ, Kreusel KM, Hanski C, Schulzke JD, Riecken EO, Fromm M. Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol. Eur J Physiol 1997; 433: 638-47.
97. Leiper K, Campbell BJ, Jenkinson MD, et al. Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis. Clin Sci 2001; 101: 395-402.
98. Plaisancie P, Barcelo A, Moro F, Claustre J, Chayvialle J-A, Cuber J-C. Effects of neurotransmitters, gut hormones and inflammatory mediators on mucus discharge in rat colon. Am J Physiol 1998; 275: G1073-G84.
99. Halm DR, Halm ST. Secretagogue response of goblet cells and columnar cells in human colonic crypts. Am J Physiol 1999; 277: C501-C22.
100. Eggermont E. Gastrointestinal manifestations in cystic fibrosis. Eur J Gastroenterol Hepatol 1996; 8: 731-8.
101. Barcelo A, Claustre J, Abello JA, Chayvialle J-A, Plaisancie P. Selective Involvement of Calcium and Calcium Channels in Stimulated Mucin Secretion from Rat Colon. Scand J Gastroenterol 2001; 36: 1339-43.
102. Phillips TE, Wilson J. Morphometric Analysis of Mucous Granule Depletion and Replenishment in Rat Colon. Dig Dis Sci 1993; 38: 2299-304.
103. Plaisancie P, Bosshard A, Meslin JC, Cuber J-C. Colonic mucin discharge by a cholinergic agonist, prostaglandins, and peptide YY in the isolated vascularly perfused rat colon. Digestion 1997; 58: 168-75.
104. Specian RD, Neutra MN. Mechanisms of rapid mucus secretion in goblet cell stimulated by acetylcholine. J Cell Biol 1980; 85: 626-40.
105. MacDermott RP, Donaldson RM, Trier JP. Glycoprotein Synthesis and Secretion by Mucosal Biopsies of Rabbit Colon and Human Rectum. J Clin Inv 1974; 54: 545-54.
106. Barcelo A, Claustre J, Moro F, Chayvialle J-A, Cuber J-C, Plaisancie P. Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon. Gut 2000; 46: 218-24.
107. Enss ML, Scmidtwittig U, Honer K, Kownatzki R, Gartner K. Mechanical challenge causes alterations of rat colonic mucosa and released mucins - alterations of mucosa and mucins. J Exp Anim Sci 1994; 36: 128-40.
108. Satchithanandam S, Klurfield DM, Calvert RJ, Cassidy MM. Effects of dietary fibre on gastrointestinal mucin in rats. Nutr Res 1996; 16: 1163-77.
109. Allen A. 1989. Gastrointestinal mucus. In Handbook of Physiology-The Gastrointestinal System, ed. JG Forte, pp. 359-82. Bethesda, Maryland: American Physiological Society.
110. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. Sulphated Polysaccharides, but not Cellulose, Increase Colonic Mucus in Rats with Loperamide-Induced Constipation. Dig Dis Sci 2001; 46: 1482-9.
111. Allen A, Pearson JP. Mucus Glycoproteins of the Normal Gastrointestinal-Tract. Eur J Gastroenterol Hepatol 1993; 5: 193-9.
112. Vinall LE, Hill AS, Pigny P, et al. Variable number tandem repeat polymorphism of the mucin genes located in the complex on 11p15.5. Hum Gen 1998; 102: 357-66.
113. Cabotaje LM, Shinnick FL, Lopez-Guisa JM, Marlett JA. Mucin Secretion in Germfree Rats Fed Fiber-Free and Psyllium Diets and Bacterial Mass and Carbohydrate Fermentation After Colonization. Appl Environ Microbiol 1994; 60: 1302-7.
114. Brownlee LA, Atherton MR, Havler ME, Dettmar PW, Allen A, Pearson JP. 2004. The effect of dietary fibre intake on mucus secretion in the rat colon. In Gums and Stabilisers for the Food Industry 12, ed. PA Williams, GO Phillips, pp. 526-34. Cambridge, UK: Royal Society of Chemistry.
115. McCullough JS, B. R, Mandir N, Carr KE, Goodlad RA. Dietary fibre and intestinal microflora: effects on intestinal morphometry and crypt branching. Gut 1998; 42: 799-806.
116. Meslin JC, Fontaine N, Andrieux C. Variation of mucin distribution in the rat intestine, caecum and colon: effect of the bacterial flora. Comp Biochem Physiol A-Mol Integr Physiol 1999; 123: 235-9.
117. Kandori H, Hirayama K, Takeda M, Doi K. Histochemical, lectin-histochemical and morphometrical characteristics of intestinal goblet cells of germfree and conventional mice. Exp Anim 1996; 45: 155-60.
118. Sharma R, Schumacher U. Morphometric analysis of intestinal mucins under different dietary conditions and gut flora in rats. Dig Dis Sci 1995; 40: 2532-9.
119. Enss ML, Grossesiestrup H, Schmidtwittig U, Gartner K. Changes in Colonic Mucins of Germ-Free Rats in Response to the Introduction of a Normal Rat Microbial-Flora - Rat Colonic Mucin. J Exp Anim Sci 1992; 35: 110-9.
120. Szentkuti L, Riedesel H, Enss ML, Gaertner K, Vonengelhardt W. Preepithelial Mucus Layer in the Colon of Conventional and Germ-Free Rats Histochem J 1990; 22: 491-7.
121. Enss ML, Muller H, Scmidtwittig U, Kownatzki R, Coenen M, Hedrich HJ. Effects of Perorally Applied Endotoxin on Colonic Mucins of Germfree Rats. Scand J Gastroenterol 1996; 31: 868-74.
122. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon. Comp Biochem Physiol A-Mol Integr Physiol 2000; 125: 525-31.
123. Willemsen LEM, Koetsier MA, van Deventer SJH, van Tol EAF. Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E-1 and E-2 production by intestinal myofibroblasts. Gut 2003; 52: 1442-7.
124. Carrazza F, Lifschitz C, Hachey D. Direct demonstration of water-absorption in the colon of infants in relationship to carbohydrate fermentation. Ped Res 1994; 36: 825.
125. Koyama N, Ishibashi K, Kuwahara M, et al. Cloning and Functional Expression of Human Aquaporin8 cDNA and Analysis of Its Gene. Genomics 1998; 54: 169-72.
126. Koyama Y, Yamamoto T, Tani T, et al. Expression and localisation of aquaporins in rat gastrointestinal tract. Am J Physiol 1999; 276: C621-C7.
127. Kunzelmann K, Mall M. Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease. Physiol Rev 2002; 82: 245-89.
128. Emery PTJ, Higgs NB, Warhurst AC, Carlson GL, Warhurst G. Anti-secretory properties of non-peptide somatostatin receptor agonists in isolated rat colon: luminal activity and possible interaction with p-glycoprotein. Brit J Pharmacol 2002; 135: 1443-8.
129. Holtug K, Hansen MB, Skadhauge E. Experimental studies of Intestinal Ion and Water Transport. Scand J Physiol 1996; 31: 95-110.
130. Singh SK, Binder HJ, Boron WF, Geibel JP. Fluid Absorption in Isolated Perfused Colonic Crypts. J Clin Inv 1995; 96: 2373-9.
131. 1 receptor in regulating the epithelial functions of the guinea pig distal colon. Am J Physiol 1999; 277: G819-G28.
132. Volant K, Grishina O, Descroix-Vagne M, Pansu D. Guanylin-, heat-stable enterotoxin of Escherichia coli- and vasoactive intestinal peptide-induced water and ion secretion in the rat intestine in vivo. Eur J Pharmacol 1997; 328: 217-27.
133. Agarwal MK, Mirshahi M. General overview of mineralocorticoid hormone action. Pharmacol Therap 1999; 84: 273-326.
134. Grotmol T, Rodnes JT, Buanes T, Christensen G, Landsverk T. Atrial natriuretic factor (ANF) does not affect ion transport in human intestine but does in porcine intestine. Acta Physiol Scand 1993; 147: 417-29.
135. Traynor TR, O'Grady SM. Brain natriuretic peptide stimulates K and Cl secretion across porcine distal colon. Am J Physiol 1991; 260: C750-C5.
136. Argenzio RA, Armstrong M. ANP inhibits NaCl absorption and elicits CL secretion in porcine colon: evidence for cGMP and Ca mediation. Am J Physiol 1993; 34: R57-R65.
137. Chariot J, Tsocas A, Souli A, Presset O, Roze C. Neural mechanism of the antisecretory effect of peptide YY in the rat colon in vivo. Peptides 2000; 21: 59-63.
138. Liu CD, Aloia T, Adrian TE, et al. Peptide YY. A potential proabsorptive hormone for the treatment of malabsorptive disorders. Am Surg 1996; 232-236.
139. 4 receptors mediate Y agonist responses in human colon mucosa. Brit J Pharmacol 2001; 135: 1505-12.
140. Eto B, Boisset M, Griesmar B, Deajeux J-F. Effect of sorbin on electrolyte transport in rat and human intestine. Am J Physiol 1999; 276: G107-G14.
141. +-pathways. Acta Physiol Scand 2001; 171: 145-51.
142. Hatch M, Freel RW, Vaziri ND. Local upregulation of colonic angiotensin II receptors enhances potassium excretion in chronic renal failure. Am J Physiol 1998; 274: F275-F82.
143. Hirasawa K, Sato Y, Hosada Y, Yamamoto T, Hanai H. Immunohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa. J Histochem Cytochem 2002; 50: 275-82.
144. D'Argenio G, Mazzacca G. Short-chain fatty acids in the human colon. In Advances in Nutrition and Cancer 2, ed. Ze al., 1999; pp. 149-58. New York: Kluwer Academic/Plenum Publishers.
145. Velazquez OC, Lederer HM, Rombeau JL. Butyrate and the colonocyte. In Dietary Fiber in health and Disease, ed. D Kritchevsky, C Bonfield. New York: Plenum Press 1997.
146. Cook SI, Sellin JH. Review article: short chain fatty acids in health and disease. Alim Pharmacol Therap 1997; 12: 499-507.
147. Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiol Rev 2001; 81: 1031-64.
148. Chu S, Montrose MH. The glow of the colonic pH microclimate kindled by short chain fatty acids, chloride and bicarbonate. J Physiol 1999; 517: 315.
149. Gonda T, Maouyo D, Rees SE, Montrose MH. Regulation of intracellular pH gradients by identified Na/H exchanger isoforms and a short-chain fatty acid. Am J Physiol 1999; 216: G259-G70.
150. Mariadason JM, Catto-Smith A, Gibson PR. Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats. Gut 1999; 44: 394-9.
151. McCullough JS, Ratcliffe B, Mandir N, Carr KE, Goodlad RA. Dietary fibre and intestinal microflora: effects on intestinal morphometry and crypt branching. Gut 1998; 42: 799-806.
152. Sharma R, Schumacher U, Ronaasen V, Coates M. Rat Intestinal Mucosal Responses to a Microbial-Flora and Different Diets. Gut 1995; 36: 209-14.
153. Jin L, Reynolds LP, Redmer DA, Caton JS, Crenshaw JD. Effects of Dietary Fiber and on Intestinal Growth, Cell- Proliferation, Morphology in Growing Pigs. J Anim Sci 1994; 72: 2270-8.
154. Yu B, Chiou PWS. Effects of crude fibre level in the diet on the intestinal morphology of growing rabbits. Lab Anim 1996; 30: 143-8.
155. Wong CSM, Gibson PR. The trophic effect of dietary fibre is not associated with a change in total crypt number in the distal colon of rats. Carcinogenesis 2003; 24: 343-8.
156. Lu ZX, Gibson PR, Muir JG, Fielding M, O'Dea K. Arabinoxylan fiber from a by-product of wheat flour processing behaves physiologically like a soluble, fermentable fiber in the large bowel of rats. J Nutr 2000; 130: 1984-90.
157. Meslin JC, Andrieux C, Hibert A, Bensaada M, Szylit O. Effects of ingestion of a green seaweed, Ulva lactuca, upon caecal and colonic mucosas in the germ-free rat and in the heteroxenic rat harbouring a human bacterial flora. J Sci Food Agric 1999; 79: 727-32.
158. Roth JA, Frankel WL, Zhang W, Klurfeld DM, Rombeau JL. Pectin Improves Colonic Function in Rat Short-Bowel Syndrome. J Surg Res 1995; 58: 240-6.
159. Fernandes MIM, Torres JD, Muccillo G, Iglesias AC, Zucoloto S. Relationship of a Fiber-Rich Diet and Epithelial-Cell Proliferation in the Denervated Distal Colon in the Rat. Nutr Res 1995; 15: 1173-80.
160. Lee D-YK, Lupton JR, Aukema HM, Chapkin RS. Dietary Fat and Fiber Alter Rat Colonic Mucosal Lipid Mediators and Cell Proliferation. J Nutr 1993; 123: 1808-17.
161. Brunsgaard G. Effects of cereal type and feed particle size on morphological characteristics, epithelial cell proliferation, and lectin binding patterns in the large intestine of pigs. J Anim Sci 1998; 76: 2787-98.
162. Sanderson IR. Nutritional factors and immune functions of gut epithelium. P Nutr Soc 2001; 60: 443-7.
163. Mayer L. The role of epithelium in mucosal immunity. Res Immunol 1998; 148: 498-504.
164. Shanahan F. Role of the microflora in health and disease - an overview. Presented at World Congress of Gastroenterology, Bangkok 2002.
165. Shanahan F. Inflammatory Bowel Disease: Immunodiagnostics, Immunotherapeutics, and Ecotherapeutics. Gastroenterology 2001; 120: 622-35.
166. Mayer L. Antigen presentation in the intestine: new rules and regulations. Am J Physiol 1998; 274: G7-G9.
167. Mayer EA, Naliboff B, Lee O, Munakata J, Chang L. Review article: gender-related differences in functional gastrointestinal disorders. Alim Pharmacol Therap 1999; 13: 65-9.
168. Blumberg RS. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function. Am J Physiol 1998; 274: G227-G31.
169. Salminen S, Bouley C, Boutron-Ruault MC, et al. Functional food science and gastrointestinal physiology and function. Br J Nutr 1998; 80: S147-S71.
170. Bourlioux P, Koletzko B, Guarner F, Braesco V. The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium "The Intelligent Intestine," held in Paris, June 14, 2002. Am J Clin Nutr 2003; 78: 675-83.
171. Azzali G. Structure, lymphatic vascularization and lymphocyte migration in mucosa-associated lymphoid tissue. Immunol Rev 2003; 195: 178-89.
172. Kudsk KA. Current aspects of mucosal immunology and its influence by nutrition. Am J Surg 2002; 183: 390-8.
173. Nagler-Anderson C. Tolerance and immunity in the intestinal immune system. Crit Rev Immunol 2000; 20: 103-20.
174. Brandtzaeg P, Halstensen TS, Kett K, et al. Immunobiology and Immunopathology of Human Gut Mucosa - Humoral Immunity and Intraepithelial Lymphocytes. Gastroenterology 1989; 97: 1562-84.
175. Pulverer G, Lioe-Ko H, Beuth J. Microflora-associated Defense Stimulating Factors. Scand J Gastroenterol 1997; 32: 107-11.
176. + Intrepithelial Lymphocyte Distibution by Dietary Fiber in the Rat Large Intestine. Exp Biol Med 2002; 227: 1017-21.
177. Peuranen S, Tiihonen K, Apajalahti J, Kettunen A, Saarinen M, Rautonen N. Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract. Br J Nutr 2004; 91: 905-14.
178. Trowell H. Western diseases, Western diets and fibre. East Afr Med J 1978; 55: 283-9.
179. Burkitt DP. Related disease - related cause? 1969; 2: 1229-31.
180. Burkitt DP, Walker AR, Painter NS. Effect of dietary fibre on stools and the transit times, and its role in the causation of disease. Lancet 1972; 2: 1408-12.
181. Burkitt DP. Acute abdomens, British and Baganda compared. E Afr Med J 1952; 29: 189-94.
182. Cleave TL. The Neglect of Natural principals in Current Medical Practices. J Roy Nav Med 1956; 42: 55-83.
183. Peters U, Sinha R, Chatterjee N, et al. Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme. Lancet 2003; 361: 1491-5.
184. Bingham SA, Day NE, Luben R, et al. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 2003; 361: 1496-501.
185. Sandler RS, Lyles CM, Peipins LA, McAuliffe CA, Woosley JT, Kupper LL. Diet and Risk of Colorectal Adenomas - Macronutrients, Cholesterol, and Fiber. J Natl Cancer Inst 1993; 85: 884-91.
186. Jacobs ET, Giuliano AR, Roe DJ, Guillen-Rodriguez JM, Alberts DS, Martinez ME. Baseline dietary fiber intake and colorectal adenoma recurrence in the wheat bran fiber randomized trial. J Natl Cancer Inst 2002; 94: 1620-5.
187. Schatzkin A, Lanza E, Corle D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N Engl J Med 2000; 342: 1149-55.
188. Alberts DS, Martinez ME, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. N Engl J Med 2000; 342: 1156-62.
189. Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U, Faivre J. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. Lancet 2000; 356: 1300-6.
190. Giacosa A, Hill MJ, Davies GJ. Fibres and colorectal cancer: should we change our dietary advice on prevention? Dig Liver Dis 2002; 34: S121-S3.
191. Rodriguez-Cabezas ME, Galvez J, Camuesco D, et al. Intestinal anti-inflammatory activity (Plantago ovata seeds) in HLA-B27 of dietary fiber transgenic rats. Clin Nutr 2003; 22: 463-71.
192. Moreau NM, Martin LJ, Toquet CS, et al. Restoration of the integrity of rat caeco-colonic mucosa by resistant starch, but not by fructo-oligosaccharides, in dextran sulfate sodium-induced experimental colitis. Br J Nutr 2003; 90: 75-85.
193. Rodriguez-Cabezas ME, Galvez J, Lorente MD, et al. Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid-induced colitic rats. J Nutr 2002; 132: 3263-71.
194. Kanauchi O, Iwanaga T, Mitsuyama K. Germinated barley foodstuff feeding - A novel neutraceutical therapeutic strategy for ulcerative colitis. Digestion 2001; 63: 60-7.
195. Kanauchi O, Iwanaga T, Mitsuyama K, et al. Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model. J Gastroenterol Hepatol 1999; 14: 880-8.
196. Steinhart AH, Hiruki T, Brzezinski A, Baker JP. Treatment of left-sided ulcerative colitis with butyrate enemas: A controlled trial. Aliment. Pharmacol Ther 1996; 10: 729-36.
197. Bamba T, Kanauchi O, Andoh A, Fujiyama Y. A new prebiotic from germinated barley for nutraceutical treatment of ulcerative colitis. J Gastroenterol Hepatol 2002; 17: 818-24.
198. Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, et al. Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Am J Gastroenterol 1999; 94: 427-33.
199. Venkatraman A, Ramakrishna BS, Shaji RV, Kumar NSN, Pulimood A, Patra S. Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappa B. Am J Physiol-Gastroint Liver Physiol 2003; 285: G177-G84.
200. Okamoto T, Sasaki M, Tsujikawa T, Fujiyama Y, Bamba T, Kusunoki M. Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats. J Gastroenterol 2000; 35: 341-6.
201. Butzner JD, Parmar R, Bell CJ, Dalal V. Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat. Gut 1996; 38: 568-73.
202. Venkatraman A, Ramakrishna BS, Pulimood AB, Patra S, Murthy S. Increased permeability in dextran sulphate colitis in rats: Time course of development and effect of butyrate. Scand J Gastroenterol 2000; 35: 1053-9.
203. Mariadason JM, Kilias D, Catto-Smith A, Gibson PR. Effect of butyrate on paracellular permeability in rat distal colonic mucosa ex vivo. J Gastroenterol Hepatol 1999; 14: 873-9.
204. Rabbani GH, Albert MJ, Rahman A, Isalm MM, Islam KMN, Alam K. Short-chain fatty acids improve clinical, pathologic, and microbiologic features of experimental shigellosis. J Infect Dis 1999; 179: 390-7.
205. Scheppach W, Dusel G, Kuhn T, et al. Effect of L-glutamine and n-butyrate on the restitution of rat colonic mucosa after acid induced injury. Gut 1996; 38: 878-85.
206. Dargenio G, Cosenza V, DelleCave M, et al. Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model. Gastroenterology 1996; 110: 1727-34.
207. Harig JM, Soergel KH, Komorowski RA, Wood CM. Treatment of Diversion Colitis with Short-Chain Fatty-Acid Irrigation. N Engl J Med 1989; 320: 23-8.
208. Scheppach W, Sommer H, Kirchner T, et al. Effect of Butyrate Enemas on the Colonic Mucosa in Distal Ulcerative-Colitis. Gastroenterology 1992; 103: 51-6.
209. Scheppach W, Christl SU, Bartram HP, Richter F, Kasper H. Effects of short-chain fatty acids on the inflamed colonic mucosa. Scand J Gastroenterol 1997; 32: 53-7.
210. Guillemot F, Colombel JF, Neut C, et al. Treatment of Diversion Colitis by Short-Chain Fatty-Acids - Prospective and Double-Blind-Study. Dis Colon Rectum 1991; 34: 861-4.
211. Vernia P, Fracasso PL, Casale V, et al. Topical butyrate for acute radiation proctitis: randomised, crossover trial. Lancet 2000; 356: 1232-5.
212. Huizinga JD, Daniel EE. Control of Human Colonic Motor Function. Dig Dis Sci 1986; 31: 865-77.
213. Steadman CJ, Phillips SF, Camilleri M, Haddad AC, Hanson RB. Variation of Muscle Tone in the Human Colon. Gastroenterology 1991; 101: 373-81.
214. Camilleri M, Ford MJ. Review article: colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders. Alim Pharmacol Therap 1998; 12: 287-302.
215. Wood JD, Alpers DH, Andrews PLR. Fundamentals of neurogastroenterology. Gut 1999; 45: II6-II16.
216. Hagger R, Finlayson C, Jeffrey I, Kumar D. Role of interstitial cells of Cajal in the control of gut motility. Brit J Surg 1997; 84: 445-50.
217. Penning C, Delemarre J, Bemelman WA, Biemond I, Lamers C, Masclee AAM. Proximal and distal gut hormone secretion in slow transit constipation. Eur J Clin Invest 2000; 30: 709-14.
218. van der Sijp JRM, Kamm MA, Nightingale JMD, et al. Circulating gastrointestinal hormone abnormalities in patients with severe idiopathic constipation. Am J Gastroenterol 1998; 93: 1351-6.
219. Feighner SD, Tan CP, McKee KK, et al. Receptor for Motilin Identified in the Human Gastrointestinal System. Science 1999; 284: 2184-8.
220. 2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon. Neurogastroenterol Motil 2001; 13: 27-35.
221. Ward SM, Bayguinov OP, Lee HK, Sanders KM. Excitatory and inhibitory actions of vasopressin on colonic excitation-contaction coupling in dogs. Gastroenterology 1997; 113: 1233-45.
222. Evers BM. Endocrine Gene Neurotensin: Mechanisms and a Model of Intestinal Differentiation. World J Surg 2002; 26: 799-805.
223. Martinez V, Wang L, Rivier JE, Vale W, Tache Y. Differential Actions of Corticotropin-Releasing Factor (CRF), Urocortin II and Urocortin III on Gastric Emptying and Colonic Transit in Mice: Role of CRF Receptor Subtypes 1 and 2. J Pharmacol Exp Ther 2002; 301: 611-7.
224. Bharucha AE, Camilleri M, Zinsmeister AR, Hanson RB. Adrenergic modulation of human colonic motor and sensory function. Am J Physiol 1997; 273: G997-G1006.
225. Brubaker PL, Drucker DJ, Asa SL, Swallow C, Redston M, Greenberg GR. Prolonged Gastrointestinal Transit in a Patient with a Glucagon-Like Peptide (GLP)-1 and-2-Producing Neuroendocrine Tumour. J Clin Endocrinol Metabol 2002; 87: 3078-83.
226. Coffin B, Fossati S, Flourie B, et al. Regional effects of cholecystokinin octapeptide in colonic phasic and tonic motility in healthy humans. Am J Physiol 1999; 276: G767-G72.
227. Andersson A, Sundler F, Ekblad E. Expression and Motor Effects of Secretin in Small and Large Intestine of the Rat. Peptides 2000; 21: 1687-94.
228. Finney GG, Koski RA, Melham MF, Pipas JM, Meisler AI. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res 1993; 53: 2919-26.
229. Baldwin GS. The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. J Gastroenterol Hepatol 1995; 10: 215-32.
230. Morton MF, Welsh NJ, Tavares IA, Shankley NP. Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon. Reg Peptides 2002; 105: 59-64.
231. Rao SSC, Kavelock R, Beaty J, Ackerson K, Strumbo P. Effect of fat and carbohydrate meals on colonic motor response. Gut 2000; 46: 205-11.
232. Ford MJ, Camilleri M, Wiste JA, Hanson RB. Differences in colonic tone and phasic response to a meal in the transverse and sigmoid colon. Gut 1995; 37: 264-9.
233. Hammer J, Hammer K, Kletter K. Lipids infused into the jejunum accelerate small intestinal transit but delay ileocolonic transit of solids and liquids. Gut 1998; 43: 111-6.
234. Eastwood M. Colonic diverticula. P Nutr Soc 2003; 62: 31-6.
235. Aldoori WH, Giovannucci EL, Ruckert HRH, Sampson L, Rimm EB, Willett WC. A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr 1998; 128: 714-9.
236. Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC. A Prospective-Study of Diet and the Risk of Symptomatic Diverticular-Disease in Men. Am J Clin Nutr 1994; 60: 757-64.
237. Jacobs LR. Differential effects of dietary fibers on rat intestinal circular muscle cell size. Dig Dis Sci 1985; 30: 247-52.
238. Le Blay G, Blottiere HM, Ferrier L, et al. Short-chain fatty acids induce cytoskeletal and extracellular protein modifications associated with modulation of proliferation on primary culture of rat intestinal smooth muscle cells. Dig Dis Sci 2000; 45: 1623-30.
239. Spencer NJ, Hennig GW, Smith TK. Stretch-activated pathways to longitudinal and circular muscle in guinea pig distal colon. Am J Physiol. 2003; 284.
240. Cherbut C, Aube AC, Blottiere HM, Galmiche JP. Effects of Short-Chain Fatty Acids on Gastrointestinal Motility. Scand J Gastroenterol 1997; 32: 58-61.
241. Rondeau MP, Meltzer K, Michel KE, McManus CM, Washabau RJ. Short chain fatty acids stimulate feline colonic smooth muscle contraction. J Feline Med Surg 2003; 5: 167-73.
242. Wen J, Phillips SF, Sarr MG, Kost LJ, Holst JJ. PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon. Am J Physiol 1995; 269: G945-G52.
243. Nightingale JMD, Kamm MA, van der Sijp JRM, Ghatei MA, Bloom SR, Lennard-Jones JE. Gastrointestinal hormones in short-bowel syndrome. peptide YY may be the 'colonic brake' to gastric emptying. Gut 1996; 39: 267-72.
244. Savage AP, Adrian TE, Carolan G, Chatterjee VK, Bloom SR. Effects of Peptide Yy (Pyy) on Mouth to Cecum Intestinal Transit-Time and on the Rate of Gastric-Emptying in Healthy- Volunteers. Gut 1987; 28: 166-70.
245. Ghatei MA, Ratcliffe B, Bloom SR, Goodlad RA. Fermentable dietary fibre, intestinal microflora and plasma hormones in the rat. Clin Sci 1997; 93: 109-12.
246. Goodlad RA, Lenton W, Ghatei MA, Adrian TE, Bloom SR, Wright NA. Effects of an Elemental Diet, Inert Bulk and Different Types of Dietary Fiber on the Response of the intestinal Epithelium to Refeeding in the Rat and Relationship to Plasma Gastrin, Enteroglucagon, and Pyy Concentrations. Gut 1987; 28: 171-80.