Colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders

Alimentary Pharmacology and Therapeutics

Volumn 12, Issue 4, 1998, Pages 287-302

  Camilleri, M ^a,c   Ford, M J ^b  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b Eastern General Hospital   (United Kingdom)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALOSETRON; ATROPINE; BISACODYL; CISAPRIDE; CLONIDINE; CODEINE; LACTULOSE; LOPERAMIDE; ONDANSETRON; PANCREAS ENZYME; PARACETAMOL; POLYETHYLENE; SOMATOSTATIN; VERAPAMIL; YOHIMBINE;

CARCINOID; COLON MOTILITY; CONSTIPATION; DIARRHEA; GASTROINTESTINAL TRANSIT; HUMAN; INTESTINE CONTRACTION; INTESTINE FUNCTION; IRRITABLE COLON; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; COLON; COLON DISEASE; GASTROINTESTINAL MOTILITY; NEUROMUSCULAR SYNAPSE; PHYSIOLOGY;

COLON; COLONIC DISEASES; CONSTIPATION; DIARRHEA; GASTROINTESTINAL MOTILITY; HUMANS; NEUROMUSCULAR JUNCTION;

EID: 0031939172     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1998.00305.x     Document Type: Review

References (135)

1. Christensen J. Gross and microscopic anatomy of the large intestine. In: Phillips SF, Pemberton JH, Shorter RG, eds. The Large Intestine: Physiology, Pathophysiology and Disease. New York: Raven Press, 1996; 13-35.
2. Gillis RA, Dias Souza J, Hicks KA, et al. Inhibitory control of proximal colonic motility by the sympathetic nervous system. Am J Physiol 1987; 253: G531-9.
3. Del Tacca M, Tadini P, Blundizzi C, Bernardini MC. Excitatory and inhibitory cholinergic effects of yohimbine on isolated guinea-pig small intestine. Pharmacol Res Comm 1988; 20: 675-84.
4. Hillsley K, Schemann M, Grundy D. Alpha-adrenoreceptor modulation of neurally evoked circular muscle responses of the guinea pig stomach. J Auton Nerv Syst 1992; 40: 5757-62.
5. Bharucha AE, Camilleri M, Zinsmeister AR, Hanson RB. Adrenergic modulation of human colonic motor and sensory function. Am J Physiol. 1997; 273: G997-1006.
6. Proano M, Camilleri M, Phillips SF, Brown ML, Thomforde GM. Transit of solids through the human colon: regional quantification in the unprepared bowel. Am J Physiol 1990; 258: G856-62.
7. Faussone Pellegrini MS, Manneschi LI, Manneschi L. The caecocolonic junction in humans has a sphincteric anatomy and function. Gut 1995; 37: 493-8.
8. Mayer EA, Gebhart CF, Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994; 107: 271-93.
9. Camilleri M, Saslow SB, Bharucha AE. Gastrointestinal sensation: mechanisms and relation to functional gastrointestinal disorders. In: Camilleri M. ed. Gastroenterology Clinics of North America: Gastrointestinal Motility in Clinical Practice, Vol. 25. Philadelphia: WB Saunders, 1996; 247-58.
10. Parkman HP, Ma RC, Stapelfeldt WH, Szurszewski JH. Direct and indirect mechanosensory pathways from the colon to the inferior mesenteric ganglion. Am J Physiol 1993; 265: G499-505.
11. Ritchic JA. Colonic motor activity and bowel function. Part 1 Normal movement of the contents. Gut 1968; 9: 442-56.
12. Krevsky B, Malmud LS, D'Ercole F, Maurer AH, Fisher RS. Colonic transit scintigraphy. A physiologic approach to the quantitative measurement of colonic transit in humans. Gastroenterology 1986; 91: 1102-12.
13. O'Donnell LJ, Virjee J, Heaton KW. Detection of pseudodiarrhoen by simple clinical assessment of intestinal transit rate. Br Med J 1990; 300: 459-40.
14. Degen L, Phillips SF. How well does stool consistency reflect colonic transit? Gut 1996; 39: 109-13.
15. Arhan P, Devroede G, Jehannin B, et al. Segmental colonic transit time. Dis Colon Rect 1981; 24: 625-9.
16. Metcalf AM, Phillips SF, Zinsmeister AR, MacCarty RL, Beart RW, Wolff BG. Simplified assessment of segmental colonic transit. Gastroenterology 1987; 92: 40-7.
17. Camilleri M, Colemont LJ, Phillips SF, et al Human gastric emptying and colonic filling of solids characterized by a new method. Am J Physiol 1989; 257: G284-90.
18. Camilleri M, Thompson WG, Fleshman JW, Pemberton JH. Clinical management of intractable constipation. Ann Intern Med 1994; 121: 520-8.
19. Fordtran JS, Locklear TW. Ionic constituents and osmolality of gastric and small intestinal fluids after eating. Am J Dig Dis 1966; 11: 505-21.
20. Frexinos J, Bueno L, Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology 1985; 88: 1104-10.
21. Schang JC, Hemond M, Hebert M, Pilote M. Myoelectrical activity and intraluminal How in human sigmoid colon. Dig Dis Sci 1986; 31: 1331-7.
22. Narducci F, Bassotti G, Gaburri M, Morelli A. Twenty-four hour manometric recording of colonic motor activity in healthy man. Gut 1987; 28: 17-25.
23. von der Ohe M, Hanson RB, Camilleri M. Comparison of simultaneous recordings of human colonic contractions by manometry and a barostat. Neurogastroenterol Motil 1994; 6: 213-22.
24. Sarna SK, Latimer P, Campbell D, Whitehead WE. Electrical and contractile activities of the human rectosigmoid. Gut 1982; 23: 689-705.
25. Sakari Y, Hada R, Nakajima H, Munakata A. Difficulty in estimating localized bowel contraction by colonic manometry: a simultaneous recording of intraluminal pressure and calibre. Neurogastroenterol Motil 1996; 8: 247-53.
26. Steadman CJ, Phillips SF, Camilleri M, Haddad A, Hanson R. Variation of muscle tone in the human colon. Gastroenterology 1991; 101: 373-81.
27. Hammer J, Phillips SF. Fluid loading of the human colon: effects on segmental transit and stool composition. Gastroenterology 1993; 105: 988-98.
28. Spiller RC, Brown ML, Phillips SF. Decreased fluid tolerance, accelerated transit, and abnormal motility of the human colon induced by oleic acid. Gastroenterology 1986; 91: 100-7.
29. Kamath PS, Phillips SF, O'Connor MK, Brown ML, Zinsmeister AR. Colonic capacitance and transit in man: modulation by Iuminal contents and drugs. Gut 1990; 31: 443-9.
30. Steed KP, Bohemen EK, Lamont GM, Evans DF, Wilson CG, Spiller RC. Proximal colonic response and gastrointestinal transit after high and low fat meals. Dig Dis Sci 1993; 38: 1793-800.
31. Lemann M, Flourie B, Picon L, Coffin B, Jian R, Rambaud JC. Motor activity recorded in the unprepared colon of healthy humans. Gut 1995; 57: 649-53.
32. Barrow L, Steed KP, Spiller RC, et al. Scintigraphic demonstration of lactulose-induced accelerated proximal colon transit. Gastroenterology 1992; 103: 1167-73.
33. Maurer AH, Krevsky B. Whole gut transit scintigraphy in the evaluation of small bowel and colon transit disorders. Semin Nucl Med 1995; 25: 326-38.
34. Maurer AH, Krevsky B, Knight LC, Brown K. Opioid and opioid-like drug effects on whole gut transit measured by scintigraphy. J Nucl Med 1996; 57: 818-22.
35. Proano M, Camilleri M, Phillips SF, Thomforde GM, Brown ML, Tucker RL. The unprepared human colon does not discriminate between solids and liquids. Am J Physiol 1991; 260: G13-16.
36. Waldron DJ, Gill RC, Bowes KL. Pressure response of human colon to intraluminal distension. Dig Dis Sci 1989; 34: 1163-7.
37. Frieri G, Ligas E, Ciccocioppo R, Onori L, Caprilli R. Human colonic compliance. Gastroenterology 1994; 106: A501(Abstract).
38. Burnstock G, Prosser CL. Responses of smooth muscles to quick stretch; relation of stretch to conductance. Am J Physiol 1960; 198: 921.
39. Fink S, Friedman G. The differential effect of drugs on the proximal and distal colon. Am J Med 1960; 28: 534-40.
40. Strom JA, Condon RE, Schulte WJ, Cowles V, Go VL. Glucagon, gastric inhibitory polypeptide and the gastrocolic response. Am J Surg 1982; 145: 155-9.
41. Snape WJ Jr, Wright SH, Battle WM, Cohen S. The gastrocolic response: evidence for a neural mechanism. Gastroenterology 1979; 77: 1235-40.
42. Snape WJ Jr, Matarazzo SA, Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology 1978; 75: 373-8.
43. Snape WJ Jr, Carlson GM, Cohen S. Human colonic myoelectric activity in response to prostigmin and the gastrointestinal hormones. Am J Dig Dis 1977; 22: 881-7.
44. Ford MJ, Camilleri M, Wiste JA, Hanson RB. Differences in colonic tone and phasic responses to a meal in the transverse and sigmoid human colon. Gut 1995; 37: 264-9.
45. Wiley J, Tatum D, Keinath R, Owyang C. Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response. Gastroenterology 1988; 94: 1144-9.
46. Chaudhary NA, Truelove SC. The irritable colon syndrome. A study of the clinical features, predisposing causes and prognosis in 130 cases. Q J Med 1962; 31: 307-22.
47. Steadman CJ, Phillips SF, Camilleri M, Talley NJ, Haddad A, Hanson R. Control of muscle tone in the human colon. Gut 1992; 33: 541-6.
48. O'Brien MD, Camilleri M, Thomforde GM, Wiste JA, Hanson RB, Zinsmeister AR. Effect of cholecyslokinin octapeptide and atropine on human colonic motility, tone and transit. Dig Dis Sci 1997; 42: 26-33.
49. Kellow JE, Miller LJ, Phillips SF, Haddad AC, Zinsmeister AR, Charboneau JW. Sensitivities of human jejunum, ileum, proximal colon, and gallbladder to cholecystokinin octapeptide. Am J Physiol 1987; 252: G345-56.
50. Mangel AW, Brazer SR, Smith JW, Fitz JG, Taylor IL. Inhibition of colonic motility by cholecystokinin. Ann Med 1992; 24: 341-2.
51. Camilleri M, von der Ohe MR. Drugs affecting serotonin receptors. Bailleres Clin Gastroenterol 1994; 8: 301-19.
52. Talley NJ. 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications. Aliment Pharmacol Ther 1992; 6: 273-89.
53. von der Ohe MR, Hauson RB, Camilleri M. Serotonergic mediation of postprandial colonic tonic and phasic responses in humans. Gut 1994; 35: 536-41.
54. Scolapio JS, Camilleri M, von der Ohe MR, Hanson RB. Ascending colon response to feeding: evidence for a 5-hydroxytryptamine-3 mechanism. Scand J Gastroenterol 1995; 50: 562-7.
55. 3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea. Gastroenterology 1994; 106: 1184-9.
56. Delvaux M, Louvel D, Mamet JP, Campos-Oriola R, Forster E, Frexinos J. Effect of alosetron on colonic sensitivity in patients with irritable bowel syndrome. Gastroenterology 1996; 110: A655(Abstract).
57. Cubeddu LX, Hoffmann IS, Fuenmayor NT, Finn AL. Efficacy of ondansetron (GR38032F) and the role of serotonin in cisplatin-induced nausea and vomiting. N Engl J Med 1990; 322: 810-16.
58. von der Ohe MR, Camilleri M, Thomforde GM, Klee GG. Differential regional effects of octreotide on human gastrointestinal motor function. Gut 1995; 36: 743-8.
59. Hasler WL, Soudah HC, Owyang C. A somatostatin analogue inhibits afferent pathways mediating perception of rectal distension. Gastroenterology 1993; 104: 1390-7.
60. Ford MJ, Camilleri M, Zinsmeister AR, Hanson RB. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. Gastroenterology 1995; 109: 1772-80.
61. Musial F, Crowell MD, Kalveram KT, Enck P. Nutrient ingestion increases rectal sensitivity in humans. Physiol Behav 1994; 55: 953-6.
62. Erckenbrecht JF, Hemstege M, Ruhl A, Krause J. The sensory-component of the gaslroeolonic response revisited: post-prandial colonic pain perception depends on meal composition. Gastroenterology 1994; 106: A494(Abstract).
63. Malcolm A, Phillips SF, Camilleri M, Burton DD, Hanson RB. Does rectal tone or compliance influence sensation? Dig Dis Sci 1996; 41: 1883.
64. Ford MJ, Camilleri M, Hanson RB, Wiste JA, Joyner MJ. Hyperventilation, central autonomic control, and colonic tone in humans. Gut 1995; 37: 499-504.
65. Bharucha AE, Camilleri M, Ford MJ, O'Connor MK, Hanson RB, Thomforde GM. Hyperventilation alters colonic motor and sensory function: effects and mechanisms in humans. Glastroenterology 1996; 111: 368-77.
66. Hasler VVL, Soudah HC, Owyang C. Somatostatin analog inhibits afferent response to rectal distension in diarrheapredominant irritable bowel patients. J Pharm Exp Ther 1994; 268: 1206-11.
67. Plourde V, Lembo T, Shui Z, et al. Effects of the somatostatin analogue, octreotide, on rectal afferent nerves in humans. Am J Physiol 1993; 265: G742-51.
68. Mertz H, Walsh JH, Sytnik B, Mayer EA. The effect of octreotide on human gastric compliance and sensory perception. Neurogastroenterol Motil 1995; 7: 175-85.
69. Chey WD, Beydoun A, Roberts DJ, Hasler WL, Owyang C. Octreotide reduces perception of rectal electrical stimulation by spinal afferent pathway inhibition. Am J Physiol 1995; 269: G821-6.
70. Junien JL, Riviere P. Review article: the hypersensitive gut - peripheral kappa agonists as a new pharmacological approach. Aliment Pharmacol Ther 1995; 9: 117-26.
71. Maxton DG, Morris J, Whorwell PJ, Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther 1996; 10: 595-9.
72. Sanger DJ. 5-hydroxytryplamine and functional bowel disorders. Neurogastroenterol Motil 1996; 8: 319-31.
73. Stivland T, Camilleri M, Vassallo M, et al. Scintigraphic measurement of regional gut transit in idiopathic constipation, Gastroenterology 1991; 101: 107-15.
74. Chaussade S, Khyari A, Roche H, et al. Determination of total and segmental colonic transit time in constipated patients. Results in 91 patients with a new simplified method. Dig Dis Sci 1989; 34: 1168-72.
75. Surrenti E, Rath DM, Pemberton JH, Camilleri M. Audit of constipation in a tertiary-referral gastroenterology practice. Am J Gastroenterol 1995; 90: 1471-5.
76. Enck P. Biofeedback training in disordered defecation. A critical review. Dig Dis Sci 1995; 38: 1953-60.
77. Nyam DC, Pemberton JH, Ilstrup DM, Rath DM, Long-term results of surgery for chronic constipation. Dis Colon Rectum 1997; 40: 275-9.
78. Wald A, Burgio K, Holeva K, Locher J. Psychological evaluation of patients with severe idiopathic constipation: which instrument to use. Am J Gastroenterol 1992; 87: 977-80.
79. Redmond JM, Smith GW, Barofsky I, Ratych RE, Goldsborough DC, Schuster MM. Physiological tests to predict long-term outcome of total abdominal colectomy for intractable constipation. Am J Gastroenterol 1995; 90: 748-53.
80. Connell AM, McKelvey ST. The influence of vagotomy on the colon. Gut 1970; 6: 37-9.
81. Connell AM. The motility of the pelvic colon: Part II. Paradoxical motility in diarrhoea and constipation. Gut 1962; 3: 342-8.
82. Bueno L, Fioramonti J, Ruckebusch Y, Frexinos J, Coulom P. Evaluation of colonic myoelectrical activity in health and functional disorders, Gut 1980; 21: 480-5.
83. Bazzocchi G, Ellis J, Villanueva-Meyer J, et al. Postprandial colonic transit and motor activity in chronic constipation. Gastroenterology 1990; 98: 686-93.
84. Bassotti G, Chiarioni G, Vantini I, et al. Anorectal manometric abnormalities and colonic propulsive impairment in patients with severe chronic idiopathic constipation. Dig Dis Sci 1994; 39: 1558-64.
85. Bassotti G, Crowell MD, Whitehead WH. Contractile activity of the human colon: lessons from 24 hour studies. Gut 1993; 34: 129-33.
86. O'Brien MD, Camilleri M, von der Ohe MR, et al. Motility and lone of the left colon in constipation: a role in clinical practice? Am J Gastroenterol 1996; 91: 2532-8.
87. Weems WA, Szurszewski JH. Modulation of colonic motility by peripheral neural inputs to neurons of the inferior mesenteric ganglion. Gastroenterology 1977; 73: 273-8.
88. Kreulen DL, Szurszewski JH. Reflex pathways in the abdominal prevertebral ganglia: evidence for a colo-colonic inhibitory retlex. J Physiol 1979; 295: 21-32.
89. von der Ohe MR, Camilleri M, Carryer PW. A patient with localized megacolon anil intractable constipation: evidence for impairment of colonic muscle tone. Am J Gastroenterol 1994; 89: 1867-70.
90. Ogilvie H. Large intestine colic due to sympathetic denervation: a new clinical syndrome. Br Med J 1948; 2: 671-3.
91. Vanek VW, Al-Salti M. Acute pseudo-obstruction of the colon (Ogilvie's syndrome): an analysis of 400 cases. Dis Colon Rectum 1986; 29: 203-10.
92. Keshavarzian A, Barnes WE, Bruninga K, Nemchausky B, Mermall H, Bushnell D. Delayed colonic transit in spinal cord-injured patients measured by indium-111 Amberlite scintigraphy. Am J Gastroenterol 1995; 90: 1295-300.
93. Bruninga K, Camilleri M, Colonic motility and tone after spinal cord and cauda equina injury. Am J Gastroenterol 1997; 92: 891-4.
94. Connell AM, Frankel H, Guttmann L. The motility of the pelvic colon following complete lesions of the spinal cord. Paraplegia 1963; 1: 98-115.
95. Glick ME, Meshkinpour H, Haldeman S, Hoehler F, Downey N, Bradley WE. Colonic dysfunction in patients with thoracic spinal cord injury. Gastroenterology 1984; 86: 287-94.
96. Staniforth DH, Baird IM, Fowler J, Lister RE. The effects of dietary libre on upper and lower gastro-intestinal transit times and faecal bulking. J Int Med Res 1991; 19: 228-33.
97. Pontes FA, Silva AT, Cruz AC. Colonic transit times and the effect of lactulose or lactitol in hospitalized patients. Eur J Gastroenterol Hepatol 1995; 7: 441-6.
98. Barrow L, Steed KP, Spiller RC, et al. Scintigraphic demonstration of laetulose-induced accelerated proximal colon transit. Gastroenterology 1992; 103: 1167-73.
99. Klauser AG, Muhldorfer BE, Voderholzer WA, Wenzel G, Muller-Lissner SA. Polyethylene glycol 4000 for slow transit constipation. Z fur Gastroenterologie 1995; 33: 5-8.
100. Preston DM, Lennard-Jones JE. Pelvic motility and response to intraluminal bisacodyl in slow transit constipation. Dig Dis Sci 1985; 30: 289-94.
101. Krevsky G, Malmud LS, Maurer AH, Somers MB, Siegel JA, Fisher RS. The effect of oral cisapride on colonic transit. Aliment Pharmacol Ther 1987; 1: 293-304.
102. Krevsky B, Maurer AH, Malmud LS, Fisher RS. Cisapride accelerates colonic transit in constipated patients with colonic inertia. Am J Gastroenterol 1989; 84: 802-7.
103. Schang JC, Devroede G, Pilote M. Effects of trimebutine on colonic function in patients with chronic idiopathic constipation: evidence for the need of a physiologic rather than clinical selection. Dis Colon Rectum 1993; 36: 330-6.
104. Schiller LR, Santa Ana CA, Morawski SG, Fordtran JS. Mechanism of the antidiarrheal effect of loperamide. Gastroenterology 1984; 86: 1475-80.
105. Awouters F, Megens A, Verlinden M, Schuurkes J, Niemegeers C, Janssen PAJ. Loperamide. Survey of studies on mechanism of its antidiarrhoeal activity. Dig Dis Sci 1993; 38: 977-95.
106. Krevsky B, Maurer AH, Niewiarowski T, Cohen S. Effect of verapamil on human intestinal transit. Dig Dis Sci 1992; 37: 919-24.
107. Talley NJ, Phillips SF, Haddad A, et al. GR 38032F (ondansetron). a selective 5HT3 receptor antagonist, slows colonic transit in healthy man. Dig Dis Sci 1990; 35: 477-80.
108. Steadman CJ, Tallcy NJ, Phillips SF, Zinsmeister AR. Selective 5-hydroxytryptamine type 3 receptor antagonism with ondansetron as treatment for diarrhea-predominant irritable bowel syndrome: a pilot study. Mayo Clin Proc 1992; 67: 732-8.
109. Kamm MA, van der Sijp JR, Hawley PR, Phillips RK, Lennard-Jones JF. Left hemicolectomy with rectal excision for severe idiopathic constipation. Int J Colorect Dis 1991; 6: 49-51.
110. Stabile G, Kamm MA, Phillips RK, Hawley PR, Lennard-Jones JE. Partial colectomy and coloanal anastomosis for idiopathic megarectum and megacolon. Dis Colon Rectum 1992; 35: 158-62.
111. Vassallo M, Camilleri M, Phillips SF, Brown ML, Chapman NJ, Thomforde GM. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology 1992; 102: 102-8.
112. von der Ohe M. Camilleri M, Kvols LK, Thomforde GM. Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N Engl J Med 1993; 329: 1073-8.
113. Bazzocchi G, Ellis J, Villanueva-Meyer J, et al. Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations. Gastroenterology 1991; 101: 1298-306.
114. Sarna SK, Latimer P, Campbell D, Waterfall WE. Electrical and contractile activities of the human rectosigmoid. Gut 1982; 23: 689-705.
115. Sakari Y, Hada R, Nakajima H, Munakala A. Difficulty in estimating localized bowel contraction by colonic manometry: a simultaneous recording of intraluininal pressure and calibre. Neurogastroentcrol Motil 1996; 8: 247-53.
116. Eastwood MA, Smith AN, Brydon WG, Pritchard J. Colonic function in patients with diverticular disease. Lancet 1978; i: 1181-2.
117. Ritchie JA. Colonic motor activity and bowel function: Part 1. Normal movement of the contents Gut 1968; 9: 442-56.
118. Katshinski M, Lederer P, Ellermann A, Gansleben R, Lux G, Arnold R. Myoelectric and amanometric patterns of human rectosigmoid colon in irritable bowel syndrome and diverticulosis. Scand J Gastroenterol 1990; 25: 761-8.
119. Painter NS, Truelove SC, Ardran GM, Tuckey M. Segmentation and the localization of intraluminal pressures in the human colon with special reference to the pathogenesis of colonic diverticula. Gastroenterology 1965; 49: 169-77.
120. Choi M-G, Camilleri M, O'Brien MD, Kammer PP, Hanson RB. A pilot study of motility and tone of the left colon in diarrhea due to functional disorders and dysautonomia. Am J Gastroenterol 1997; 92: 297-302.
121. Prior A, Maxton DG, Whorwell PJ. Anorectal manometry in irritable bowel syndrome: differences between diarrhoea- and constipation-predominant subjects. Gut 1990; 31: 458-62.
122. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995; 109: 40-52.
123. Farthing MJG, Lennard-Jones JH. Sensibility of the rectum to distension and anorectal distension reflex in ulcerative colitis. Gut 1978; 19: 64-9.
124. Rao SSC, Read NW, Brown C, Bruce C, Holdsworth CD. Studies on the mechanism of bowel disturbance in ulcerative colitis. Gastroenterology 1987; 93: 934-40.
125. Reddy SN, Bazzocchi G, Chan S, et al. Colonic motility and transit in health and ulcerative colitis. Gastroenterology 1991; 101: 1289-97.
126. Donowilz M, Binder HJ. Jejunal fluid and electrolyte secretion in carcinoid syndiome. Am J Dig Dis 1975; 20: 1115-22.
127. Saslow SB, Scolapio JS, Camilleri M, et al. Medium-term effects of alosetron in patients with carcinoid diarrhea. Gut. in press.
128. Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon sydnrome. Gut 1973; 14: 125-32.
129. Whitehead WE, Holtkotter B, Enck P, et al. Tolerance for rectosigmoid distension in irritable bowel syndrome. Gastroenterology 1990; 98: 1187-92.
130. Lembo T, Munakata J, Mertz H, et al. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994; 107: 1686-96.
131. Bradette M, Delvaux M, Staumont G, Fioramonti J, Bueno L, Frexinos J. Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone. Dig Dis Sci 1994; 39: 1171-8.
132. Dapoigny M, Abitbol JL, Fraitag B. Efficacy of peripheral kappa agonist fedotozine vs. placebo in treatment of irritable bowel syndrome. A multicenter dose-response study. Dig Dis Sci 1995; 40: 2244-9.
133. Camilleri M, Zinsmeister AR. Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders. Gastroenterology 1992; 103: 36-42.
134. Bassotti G, Chiarioni G, Imbimbo BP, et al. Impaired colonic motor response to cholinergic stimulation in patients with severe chronic idiopathic (slow transit type) constipation. Dig Dis Sci 1993; 38: 1040-5.
135. Schang JC, Hemond M, Hebert M, Pilote M. Changes in colonic myoelectric spiking activity during stimulation by bisaeodyl. Can J Physiol Pharmacol 1986; 64: 39-43.