Current concepts in mucosal immunity I. Antigen presentation in the intestine: New rules and regulations

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 274, Issue 1 37-1, 1998, Pages

  Mayer, Lloyd ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Antigen presentation; Intestinal epithelium; Nonclassical major histocompatibility complex

Indexed keywords

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL TYPE; HUMAN; INTESTINE EPITHELIUM; INTESTINE MUCOSA; MAJOR HISTOCOMPATIBILITY COMPLEX; MUCOSAL IMMUNITY; PRIORITY JOURNAL;

EID: 0031890080     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.274.1.g7     Document Type: Article

References (25)

1. Balk, S. P., E. Ebert, R. L. Blumenthal, F. V. McDermott, K. W. Wucherpfennig, S. B. Landau, and R. S. Blumberg. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253: 1411-1415, 1991.
2. Berin, M. C., A. J. Kiliaan, P. C. Yang, J. A. Groot, J. A. J. M. Taminiau, and M. H. Perdue. Rapid transepithelial antigen transport in rat jejunum: impact of sensitization and the hypersensitivity reaction. Gastroenterology 113: 856-864, 1997.
3. Bland, P. MHC class II expression by the gut epithelium. Immunol. Today 9: 174-178, 1988.
4. Bland, P. W., and L. G. Warren. Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. Immunology 58: 9-14, 1986.
5. Bland, P. W., and C. V. Whiting. Antigen processing by isolated rat intestinal villus enterocytes. Immunology 68: 497-502, 1989.
6. Bleicher, P. A., S. P. Balk, S. J. Hagen, R. S. Blumberg, T. J. Flotte, and C. Terhorst. Expression of murine GD1 on gastrointestinal epithelium. Science 250: 679-682, 1990.
7. Blumberg, R. S., C. Terhorst, P. Bleicher, F. V. McDermott, C. H. Allan, S. B. Landau, J. S. Trier, and S. P. Balk. Expression of a nonpolymorphic MHC class I-like molecule, CD1d, by human intestinal epithelial cells. J. Immunol. 147: 2518-2524, 1991.
8. Brandeis, J. M., M. H. Sayegh, L. Gallon, R. S. Blumberg, and C. B. Carpenter. Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells. Gastroenterology 107: 1537-1542, 1994.
9. Campbell, N. A., R. Blumberg, S. P. Balk, M. Kronenberg, and L. Mayer. The novel CD8 ligand, gp180, has the generic property of associating with non-classical class I molecules (Abstract). Gastroenterology 112: A943, 1997.
10. Castano, A. R., S. Tangri, J. E. Miller, H. R. Holcombe, M. R. Jackson, W. D. Huse, M. Kronenberg, and P. A. Peterson. Peptide binding and presentation by mouse GD1. Science 269: 223-226, 1995.
11. Gonella, P. A., and M. R. Neutra. Membrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat ileum. J. Cell Biol. 99: 907-917, 1984.
12. Gonella, P. A., and D. W. Wilmore. Co-localization of class II antigen and exogenous antigen in the rat enterocyte. J. Cell Sci. 106: 937-940, 1993.
13. Hershberg, R., P. Eghtesady, B. Sydora, K. Brorson, H. Cheroutre, R. Modlin, and M. Kronenberg. Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proc. Natl. Acad. Sci. USA 87: 9727-9731, 1990.
14. Hershberg, R. M., P. E. Framson, D. H. Cho, L. Y. Lee, S. Kovats, J. Beltz, J. S. Blum, and G. T. Nepom. Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing. J. Clin. Invest. 100: 204-215, 1997.
15. Kaiserlian, D., K. Vidal, and J. P. Revillard. Murine enterocytes can present soluble antigen to specific class II restricted CD4+ T cells. Eur. J. Immunol. 19: 1513-1516, 1989.
16. Lenschow, D. J., and J. A. Bluestone. T cell co-stimulation and in vivo tolerance. Curr. Opin. Immunol. 5: 747-752, 1993.
17. Li, Y., X. Y. Yio, and L. Mayer. Human intestinal epithelial cell induced CD8+ T cell activation is mediated through CD8 and the activation of CD8-associated p56lck. J. Exp. Med. 182: 1079-1088, 1995.
18. Mason, D. W., M. Dallman, and A. N. Barclay. Graft versus host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium. Nature 293: 150-151, 1981.
19. Mayer, L., and R. Shlien. Evidence for function of a Ia molecule on gut epithelial cells in man. J. Exp. Med. 166: 1471-1483, 1987.
20. Mayer, L,. E. Siden, S. Becker, and D. Eisenhardt. Antigen handling in the intestine mediated by normal enterocytes. In: Advances in Mucosal Immunology, edited by T. MacDonald, S. Challacombe, P. W. Bland, C. R. Stokes, R. V. Heatly, and A. N. Mowat. Dordrecht, The Netherlands: Kluwer Academic, 1990, p. 23-28.
21. Mayer, L., L. P. So, X. Y. Yio, and G. Small. Antigen trafficking in the intestine. Ann. NY Acad. Sci. 778: 28-35, 1996.
22. Panja, A., R. S. Blumberg, S. P. Balk, and L. Mayer. CD1d is involved in T cell-epithelial cell interactions. J. Exp. Med. 178: 1115-1119, 1993.
23. Scott, H., B. G. Solheim, P. Brandtzaeg, and E. Thorsby. HLA-DR-like antigens in the epithelium of the human small intestine. Scand. J. Immunol. 12: 77-82, 1980.
24. Wiman, K., B. Curman, U. Forsum, L. Klareskvg, U. Malmas-TJernlund, L. Rask, L. Tragardh, and P. A. Peterson. Occurrence of Ia antigens on tissues of non-lymphoid origin. Nature 276: 711-713, 1978.
25. Yio, X. Y., and L. Mayer. Characterization of a 180-kDa intestinal epithelial cell membrane glycoprotein, gp180. A candidate molecule mediating T cell-epithelial cell interactions. J. Biol. Chem. 272: 12786-12792, 1997.