Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon

Regulatory Peptides

Volumn 105, Issue 1, 2002, Pages 59-64

  Morton, M F ^a,b   Welsh, N J ^a   Tavares, I A ^a   Shankley, N P ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

CCK 8S; CCK1 receptor; CCKA; Devazepide; In vitro

Indexed keywords

6 [[(1 ADAMANTYLMETHYL)AMINO]CARBONYL] 5 [[1 [[(3,5 DICARBOXYPHENYL)AMINO]CARBONYL] 2 PHENYLETHYLAMINO]CARBONYL]INDOLE; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; PENTAGASTRIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; ASCENDING COLON; BIOASSAY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MECHANISM; GALLBLADDER CONTRACTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTESTINE CONTRACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY; SMOOTH MUSCLE CONTRACTION; SULFATION;

CHOLECYSTOKININ; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; GALLBLADDER; HUMANS; MUSCLE CONTRACTION; ORGAN CULTURE TECHNIQUES; PENTAGASTRIN; PERISTALSIS; RECEPTORS, CHOLECYSTOKININ; SINCALIDE;

ANIMALIA;

EID: 0037089784     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(01)00383-4     Document Type: Article

References (17)

1. International Union of Pharmacology: XXI. Structure, distribution, and functions of cholecystokinin receptors
2. CCK-8, CCK-4 and gastrin-induced contractions in guinea pig ileum: Evidence for differential release of acetylcholine and substance P by CCK-A and CCK-B receptors
3. Evidence for two cholecystokinin receptors mediating the contraction of the guinea pig isolated ileum longitudinal muscle myenteric plexus
4. Functional comparisons of gastrin/cholecystokinin receptors in isolated preparations of gastric mucosa and ileum
5. Combined dose-ratio analysis of cholecystokinin receptor antagonists, devazepide, lorglumide and loxiglumide in the guinea-pig gall bladder
6. Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum
7. The effect of a novel CCK-antagonist (lorglumide) on human and guinea pig gallbladder strips: A tensiometric study
8. 2-Naphthalenesulphonyl L-aspartyl-(2-phenethyl)amide (2-NAP) - A selective cholecystokinin CCKA-receptor antagonist
9. Analysis of the motor effects of gastrin and pentagastrin on the human alimentary tract in vitro
10. Contraction and evacuation of the gallbladder by a purified "secretin" preparation
11. Pancreozymin, a stimulant of pancreatic enzymes in extracts of the small intestine
12. On the chemical mechanism of gastric secretion
13. Control of gastrointestinal motility
14. Increased endothelin ETB contractile activity in cultured segments of human temporal artery
15. An operational model of pharmacological agonism: The effect of E/[A] curve shape on agonist dissociation constant estimation
16. Evidence that variation in CCK2-receptor ligand affinity values, measured in both isolated tissue and radioligand binding assays, cannot be explained by variable expression of CCK2S and CCK2L isoforms