Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel

Gut

Volumn 53, Issue 11, 2004, Pages 1610-1616

  Langlands, S J ^b   Hopkins, M J ^c   Coleman, N ^d   Cummings, J H ^a,c  

^a NINEWELLS HOSPITAL   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE DERIVATIVE; CYCLINE; FRUCTOSE; INULIN; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN; MINICHROMOSOME MAINTENANCE PROTEIN 2; OLIGOFRUCTOSE; PREBIOTIC AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ANAEROBIC BACTERIUM; ARTICLE; BACTERIAL COUNT; BACTERIOPLANKTON; BACTERIUM CULTURE; BACTEROIDES; BIFIDOBACTERIUM; CECUM; CELL PROLIFERATION; CLOSTRIDIUM; COLIFORM BACTERIUM; COLONOSCOPY; COLONY FORMING UNIT; CONTROLLED STUDY; DESCENDING COLON; ENDOSCOPIC BIOPSY; EUBACTERIUM; FATTY ACID ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTESTINE FLORA; INTESTINE MUCOSA; LARGE INTESTINE; MALE; NONHUMAN; PRIORITY JOURNAL; RECTUM; TRANSVERSE COLON;

ADULT; AGED; BIFIDOBACTERIUM; CELL DIVISION; COLONOSCOPY; COLONY COUNT, MICROBIAL; DIETARY SUPPLEMENTS; FECES; FEMALE; FLATULENCE; HUMANS; INTESTINAL MUCOSA; INTESTINE, LARGE; INULIN; MALE; MIDDLE AGED; OLIGOSACCHARIDES; PROBIOTICS;

EID: 7244227682     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.037580     Document Type: Article

References (68)

1. Macfarlane GT, Cummings JC. Diet and the metabolism of intestinal bacteria. In: Brostoff J, Challacombe SJ, eds. Food allergy and intolerance. Amsterdam: Elsevier Science, 2002:321-41.
2. Williams BA, Verstegen MWA, Tamminga S. Fermentation in the large intestine of single-stomached animals and its relationship to animal health. Nutr Res Rev 2001;14:207-27.
3. Houghton LA, Green TJ, Donovan UM, et al. Association between dietary fiber intake and the folate status of a group of female adolescents. Am J Clin Nutr 1997;66:1414-21.
4. Rowland IR. Toxicology of the colon: role of the intestinal microflora. In: Gibson GR, Macfarlane GT, eds. Human colonic bacteria. Role in nutrition and, physiology, and pathology. Boca Raton: CRC Press, 1995:155-74.
5. Gorbach SL, Borza M, Guilano M, et al. Colonization resistance of the human intestinal microflora: testing the hypothesis in normal volunteers. Eur J Clin Microbiol Infect Dis 1988;7:98-102.
6. Gibson GR, Wang X. Regulatory effects of bifidobacteria on the growth of other colonic bacteria. J Appl Bacteriol 1994;77:412-20.
7. Schultsz C, Berg FVD, Fiebo W, et al. The intestinal mucus layer from patients with inflammatory bowel disease harbars high numbers of bacteria compared with controls. Gastroenterology 1999;117:1089-97.
8. Pathmakanthan S, Thornley JP, Hawkey CJ. Mucosally associated bacterial flora of the human colon: quantitative and species specific differences between normal and inflamed colonic biopsies. Microb Ecol Health Dis 1999;11:169-74.
9. Swidsinski A, Ladhoff A, Pernthaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology 2002;122:44-54.
10. Stephen AM, Cummings JH. Mechanism of action of dietary fibre in the human colon. Nature 1980;284:283-4.
11. Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 2002;22:283-307.
12. Sartor RB. Induction of mucosal immune responses by bacteria and bacterial components. Curr Opin Gastroenterol 2001;17:555-61.
13. Hooper LV, Wang MH, Thelin A, et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001;291:881-4.
14. Macpherson AJ, Gatto D, Sainsbury E, et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000;288:2222-6.
15. Lu L, Walker A. Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium. Am J Clin Nutr 2001;73:11224-30S.
16. Gibson GR, Beatty ER, Wang X, et al. Selective stimulation of Bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 1995;108:975-82.
17. Kleessen B, Sykura B, Zunft H-J, et al. Effects of inulin and lactose on faecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 1997;65:1397-492.
18. Ito M, Deguchi Y, Miyamori A, et al. Effects of administration of galactooligosaccharides on the human faecal microflora, stool weight and abdominal sensation. Microb Ecol Health Dis 1990;3:285-92.
19. Schley PD, Field CJ. The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr 2002;87:S221-30.
20. Zopf D, Roth S. Oligosaccharide anti-infective agents. Lancet 1996;347:1017-21.
21. Macfarlane GT, Macfarlane S. Activities of human colonic mucin degrading bacteria on surfaces and in biofilms. In: Corfield A, ed. Mucin, methods and protocols. Totowa: Humana Press, 2000:439-52.
22. Macfarlane GT, Cummings JH, Allison C. Protein degradation by human intestinal bacteria. J Gen Microbiol 1986;132:1647-56.
23. Hopkins MJ, Sharp R, Macfarlane GT. Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 2001;48:198-205.
24. Williams GH, Romanowski P, Morris L, et al. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc Natl Acad Sci U S A 1998;95:14932-7.
25. Freeman A, Morris LS, Mills AD, et al. The minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 1999;5:2121-32.
26. Stone-Dorshow T, Levitt MD. Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. Am J Clin Nutr 1987;46:61-5.
27. Finegold SM, Sutter VL, Mathisen GE. Normal indigenous intestinal flora. In: Hentges DJ, ed. Human intestinal microflora in health and disease. New York: Academic Press, 1983:3-31.
28. Kleessen B, Hartmann L, Blaut M. Fructans in the diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated bifidobacteria in gnotobiotic rats. Br J Nutr 2003;89:597-606.
29. Macfarlane GT, Macfarlance S. Human intestinal 'biofilm' communities. In: Lappin-Scott H, ed. The life and death of biofilm. Cardiff: BioLine, 1995:83-7.
30. Macfarlane S, McBain AJ, Macfarlane GT. Consequences of biofilm and sessile growth in the large intestine. Adv Dental Res 1997;11:59-68.
31. Macfarlane S, Cummings JH, Macfarlane GT. Bacterial colonisation of surfaces in the large intestine. In: Roberfroid MB, ed. Colonic microbiota, nutrition and health. Netherlands: Kluwer Academic Publishers, 1999:71-87.
32. Yazawa K, Tamura Z. Search for sugar sources for selective increase of bifidobacteria. Bifidobacteria Microflora 1982;1:39-44.
33. Tamura Z. Nutriology of bifidobacteria. Bifidobacteria Microflora 1983;2:3-16.
34. Wang X, Gibson GR. Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J Appl Bacteriol 1993;75:373-80.
35. Costerton JW, Cheng K-J, Geesey GG, et al. Bacterial biofilms in nature and disease. Annu Rev Microbiol 1987;41:435-64.
36. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999;284:1318-22.
37. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet 2001;358:135-8.
38. Bach-Knudsen KE, Hessov I. Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L.) in the small intestine of man. Br J Nutr 1995;74:101-3.
39. Ellegard L, Andersson H, Bosaeus I. Inulin and oligofructose do not influence the absorption of cholesterol, or the excretion of cholesterol, Ca, Mg, Zn, Fe, or bile acids but increases energy excretion in ileostomy subjects. Eur J Clin Nutr 1997;51:1-5.
40. Molis C, Flourie B, Ouarne F, et al. Digestion, excretion and energy value of fructooligosaccharides in healthy humans. Am J Clin Nutr 1996;64:324-8.
41. De Vries W, Stouthamer AH. Carbohydrate metabolism in Bifidobacterium bifidum var pennsylvanicus. Biochim Biophys ACTA 1967;136:415-25.
42. Scardovi V. The fructose-6-phosphate shunt as a peculiar pattern of hexose degradation in the genus Bifidobacterium. Biochim Biophys ACTA 1965;15:19-24.
43. Kaplan H, Hutkins RW. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria. Appl Environ Microbiol 2000;66:2682-4.
44. Williams CH, Witherly SA, Buddington RK. Influence of dietary neosugar on selected bacterial groups of the human faecal microbiota. Microb Ecol Health Dis 1994;7:91-7.
45. Langendijk PS, Schut F, Jansen GJ, et al. Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples. Appl Environ Microb 1995;61:3069-75.
46. Schwiertz A, le Bay G, Blaut M. Quantification of different Eubacterium spp. in human fecal samples with species-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 2000;66:375-82.
47. Croucher SC, Houston AP, Bayliss CE, et al. Bacterial populations associated with different regions of the human colon wall. Appl Environ Microbiol 1983;45:1025-33.
48. Johansson M-L, Molin G, Jeppsson B, et al. Administration of different Lactobacillus strains in fermented oatmeal soup: In vivo colonization of human intestinal mucosa and effect on the indigenous flora. Appl Environ Microbiol 1993;59:15-20.
49. Poxton IR, Brown R, Sawyerr A, et al. Mucosa-associated bacterial flora of the human colon. J Med Microbiol 1997;46:85-91.
50. Poxton IR, Brown R, Sawyerr AF. The mucosal anaerobic gram-negative bacteria of the human colon. Clin Infect Dis 1997;25:S111-13.
51. Hartley CL, Neumann CS, Richmond MH. Adhesion of commensal bacteria to the large intestine wall in humans. Infect Immun 1979;23:128-32.
52. Zoetendal EG, von Wright A, Vilpponen-Salmela T, et al. Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from faeces. Appl Environ Microbiol 2002;68:3401-7.
53. Scott IS, Morris LS, Bird K, et al. A novel immunohistochemical method to estimate cell cycle state and phase in archival tissue: implications for estimation of outcome in colorectal cancer. J Pathol 2003;201:187-97.
54. Macpherson A, Khoo UY, Forgacs I, et al. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 1996;38:365-75.
55. Landers O, Cohavy O, Misra R, et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology 2002;123:689-99.
56. Sartor RB. Intestinal microflora in human and experimental inflammatory bowel disease. Curr Opin Gastroenterol 2001;17:324-30.
57. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Report of a Joint FAO/WHO Expert Consultation. Cordoba, Argentina: FAO/WHO, 2001.
58. Lievin V, Peiffer I, Hudault S, et al. Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut 2000;47:646-52.
59. Hopkins MJ, Macfarlane GT. Non-digestible oligosaccharides enhance bacterial colonization resistance against Clostridium difficile in vitro. Appl Environ Microbiol 2003;69:1920-7.
60. Alander M, Korpela R, Saxelin M, et al. Recovery of Lactobacillus rhamnosus GG from human colonic biopsies. Lett Appl Microbiol 1997;24:361-4.
61. Bezkorovainy A. Probiotics: determinants of survival and growth in the gut. Am J Clin Nutr 2001;73:399S-405.
62. D'Sauza AL, Rajkumar C, Cooke J, et al. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002;324:1361-4.
63. Cremonini F, Di Caro S, Nista EC, et al. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2002;16:1461-7.
64. Huang JS, Bousvaros A, Lee JW, et al. Efficacy of probiotic use in acute diarrhea in children: A meta-analysis. Dig Dis Sci 2002;47:2625-34.
65. Wollowski I, Rechkemmer G, Pool-Zobel BL. Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr 2001;73:451-5S.
66. Cummings JH, Macfarlane GT. Bacteria in the pathogenesis of colorectol cancer. In: Scheurlen M, ed. Exogenous factors in colonic carcinogenesis. Amsterdam: Kluwer Academic Publishers, 2002:180-91.
67. Bolognani F, Rumney CJ, Pool-Zobel BL, et al. Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats. Eur J Nutr 2001;40:293-300.
68. Roberfroid M, Gibson G. Nutritional health benefits of inulin and oligofructose. Br J Nutr 2002;87:S1-311.