The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis

Biomolecular Engineering

Volumn 23, Issue 4, 2006, Pages 171-184

  Emerich, Dwaine F ^a   Thanos, Christopher G ^a  

^a LCT BioPharma Inc   (United States)

Author keywords

Drug delivery; Molecular diagnosis; Nanomedicine; Nanoparticle; Targeted delivery

Indexed keywords

BIOMEDICAL ENGINEERING; DIAGNOSIS; DIAGNOSTIC PRODUCTS; DRUG PRODUCTS; MEDICAL APPLICATIONS; MOLECULAR DYNAMICS; NANOSTRUCTURED MATERIALS; ROBOTICS;

DRUG DELIVERY; MOLECULAR DIAGNOSIS; NANOMEDICINE; NANOPARTICLE; TARGETED DELIVERY;

PHARMACOKINETICS;

ALBUMIN; ANTIGEN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTIVIRUS AGENT; CALCIUM PHOSPHATE; CARBON NANOTUBE; CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLODEXTRIN; DENDRIMER; DORNASE ALFA; FULLERENE DERIVATIVE; IMMUNOLIPOSOME; INSULIN; IRON OXIDE; LIPOSOME; LYSOZYME; NANOPARTICLE; NK 105; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OLIGONUCLEOTIDE; PACLITAXEL; PHOSPHINE DERIVATIVE; POLYAMIDOAMINE; POLYDENTATE PHOSPHINE; POLYGLACTIN; POLYMER; POLYVINYL ALCOHOL; POVIDONE; QUANTUM DOT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACCINE;

AMYOTROPHIC LATERAL SCLEROSIS; ANEMIA; BRAIN TUMOR; CANCER; CONTROLLED DRUG RELEASE; DIAGNOSTIC PROCEDURE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TRANSPORT; ENCAPSULATION; ENDOTHELIUM; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENOMICS; HEALTH CARE COST; HUMAN; INTERPERSONAL COMMUNICATION; KAPOSI SARCOMA; NANOTECHNOLOGY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; OSMOTIC PUMP; PARKINSON DISEASE; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; ROBOTICS; SCIENCE; SCREENING; TISSUE ENGINEERING; UNSPECIFIED SIDE EFFECT; VACCINATION;

ANIMALS; BIOTECHNOLOGY; DRUG CARRIERS; GENE THERAPY; HUMANS; MICE; MOLECULAR DIAGNOSTIC TECHNIQUES; NANOSTRUCTURES; NANOTECHNOLOGY;

EID: 33746565966     PISSN: 13890344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioeng.2006.05.026     Document Type: Review

References (137)

1. Allen T.M. Ligand-targeted therapeutics in anticancer therapy. Nat. Rev. Cancer 2 (2002) 750-763
2. Allen T.M., and Cullis P.R. Drug delivery systems: entering the mainstream. Science 303 (2004) 1818-1822
3. Akerman M.E., Chan W.C., Laakkonen P., Bhatia S.N., and Ruoslahti E. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. USA 99 (2002) 12617-12621
4. Anderson S.A., Rader R.K., Westlin W.F., Null C., Kackson D., Lanza G.M., Wickline S.A., and Kotyk J.J. Magnetic resonance contrast enhancement of neovascular with v3-targeted nanoparticles. Magn. Reson. Med. 44 (2000) 433-439
5. 2 activation of liposome-forming prodrugs. J. Med. Chem. 47 (2004) 1694-1703
6. Antohe F., Heltianu C., and Simionescu M. Albumin-binding proteins of endothelial cells: immunocytochemical detection of the 18 kDa peptide. Eur. J. Cell Biol. 56 (1991) 34-42
7. Antohe F., Dobrila L., Heltianu C., Simionescu N., and Simionescu M. Albumin-binding proteins function in the receptor-mediated binding and transcytosis of albumin across cultured endothelial cells. Eur. J. Cell Biol. 60 (1993) 268-275
8. Arap W., Pasqualini R., and Ruoslahti E. Cancer treatment by targeted drug delivery to tumour vasculature in a mouse model. Science 279 (1998) 377-380
9. Assa-Munt N., Jia X., Laakkonen P., and Ruoslahti E. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry 40 (2001) 2373-2378
10. Ballou B., Lagerholm B.C., Ernst L.A., Bruchez M.P., and Waggoner A.S. Noninvasive imaging of quantum dots in mice. Bioconjug. Chem. 15 (2004) 79-86
11. Barathur R., Bookout J., Sreevatsan S., Gordon J., Werner M., Thor G., and Worthington M. New disc-based technologies for diagnostic and research applications. Psychiatr. Genet. 12 (2002) 193-206
12. Barenholz Y. Liposome application: problems and prospects. Curr. Opin. Colloid Interface Sci. 6 (2001) 66-77
13. Berton M., Turelli P., Trono D., Stein C.A., Allemann E., and Gurny R. Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles. Pharm. Res. 18 (2001) 1096-1101
14. Bos G.W., Kanellos T., Crommelin D.J., Hennink W.E., and Howard C.R. Cationic polymers that enhance the performance of HbsAg DNA in vivo. Vaccine 23 (2004) 460-469
15. Bosi S., Da Ros T., Castellano S., Banfi E., and Prato M. Antimycobacterial activity of ionic fullerene derivatives. Bioorg. Med. Chem. Lett. 10 (2000) 1043-1045
16. Bruchez M., Moronne M., Gin P., Weiss S., and Alivisatos A.P. Semiconductor nanocrystals as fluorescent biological labels. Science 281 (1998) 2013-2016
17. Bustami R., Chan H., Dehghani F., and Foster N.R. Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide. Pharm. Res. 17 (2000) 1360-1366
18. Cao Y.C., Jin R., and Mirkin C.A. Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science 297 (2002) 1536-1540
19. Cao Y.C., Jin R., Nam J.M., Thaxton C.S., and Mirkin C.A. Raman dye-labeled nanoparticle probes for proteins. J. Am. Chem. Soc. 125 (2003) 1467-4676
20. Chan W.C., Maxwell D.J., Gao X., Bailey R.E., Han M., and Nie S. Luminescent quantum dots for multiplexed biological detection and imaging. Curr. Opin. Biotechnol. 13 (2002) 40-46
21. Chen R., Zhang Y., Wang D., and Dai H. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J. Am. Chem. Soc. 123 (2001) 3838-3839
22. Chen S., Webster S., Czerw R., Xu J., and Carroll D.L. Morphology effects on the optical properties of silver nanoparticles. J. Nanosci. Nanotechnol. 4 (2004) 254-259
23. Christofidou-Solomidou M., Pietra G.G., Solomides C.C., Arguiris E., Harshaw D., Fitzgerald G.A., Albelda S.M., and Muzykantov V.R. Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs. Am. J. Physiol. 278 (2000) 794-805
24. Cherukuri P., Bachilo S.M., Litovsky S.H., and Weisman R.B. Near-infrared fluorescence microscopy of single-walled carbon nanotunes in phagocytic cells. J. Am. Chem., Soc. 126 (2004) 15638-15639
25. Clark H., Kopelman R., Tjalkens R., and Philbert M.A. Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors. Anal. Chem. 71 (1999) 4837-4843
26. Cohen-Sacks H., Najajreh Y., Tchaikovski V., Gao G., Elazer V., Dahan R., Gati I., Kanaan M., Waltenberger J., and Golomb G. Novel PDGFbetaR antisense encapsulated in polymeric nanospheres for the treatment of restenosis. Gene Ther. 9 (2002) 1607-1616
27. Csaki A., Moller R., and Fritzsche W. Gold nanoparticles as novel label for DNA diagnostics. Expert Rev. Mol. Diagn. 2 (2002) 187-193
28. Curnis F., Sacchi A., and Corti A. Improving chemotherapeutic drug penetration in tumours by vascular targeting and barrier alteration. J. Clin. Invest. 110 (2002) 475-482
29. Davidson J., Mouritsen O.G., and Jørgensen K. Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes. Biochim. Biophys. Acta 1564 (2002) 256-262
30. 2 as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue. Biochim. Biophys. Acta 1609 (2003) 95-101
31. Drummond D.C., Meyer O., Hong K., Kirpotin D.B., and Papahajopoulos D. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumours. Pharmacol. Rev. 51 (1991) 691-743
32. Dugan L.L., Lovette E., and Cuddihy S. Carboxyfullerenes as neuroprotective antioxidants. In: Kadish K.M., and Ruoff R.S. (Eds). Fullerenes: Chemistry, Physics, and Technology (2000), John Wiley & Sons, New York 467-480
33. Dunning M.D., Lakatos A., Loizou L., Kettunen M., French-Constant C., Brindle K.M., and Franklin R.J. Superparamagnetic iron oxide-labeled Schwaan cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain their functional properties after transplantation into the CNS. J. Neurosci. 24 (2004) 9799-9810
34. Eliceiri B.P., and Cheresh D.A. The role of alpha v integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J. Clin. Invest. 103 (1999) 1227-1230
35. Emerich D.F., and Thanos C. Nanotechnology and medicine: the here and now and future prospects. Expert Opin. Biol. Ther. 3 (2003) 655-663
36. Feynman R. Engineering and Science. (1959), California Institute of Technology
37. Flacke S., Fischer S., Scott M.J., Fuhrhop R.J., Allen J.S., McLean M., Winter P., Sicard G.A., Gaffney P.J., Wickline S.A., and Lanza G.M. Novel MRI contrast agent for molecular imaging of fibrin Implications for detecting vulnerable plaques. Circulation 104 (2001) 1280-1285
38. Freitas R.A. Nanomedicine, Volume I: Basic Capabilities (1999), Landes BioScience, Georgetown, TX
39. Gabizon A., Shmeeda H., and Barenholz Y. Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies. Clin. Pharmacokinet. 42 (2003) 419-436
40. Galindo-Rodriguez S.A., Allemann E., Fessi H., and Doelker E. Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies. Crit. Rev. Ther. Drug Carrier Syst. 22 (2005) 419-464
41. Gao X., Cui Y., Levenson R.M., Chung L.W.K., and Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22 (2004) 969-976
42. Gilles E.R., and Frechet J.M. Dendrimers and dendritic polymers in drug delivery. Drug. Discov. Today 10 (2005) 35-43
43. Goldstein A., Amory J., Martin S., Vernon C., Matsumoto A., and Yager P. Testosterone delivery using glutamide-based complex high axial ratio microstructures. Bioorg. Med. Chem. 9 (2001) 2819-2825
44. Goren D., Horwitz A.T., Tzemach D., Tarshish M., Zalipsky S., and Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin. Cancer Res. 6 (2000) 1949-1957
45. Gourley P.L. Brief overview of BioMicroNano technologies. Biotechnol. Prog. 21 (2005) 2-10
46. Grubisha D.S., Lipert R.J., Park H.Y., Driskell J., and Porter M.D. Femtomolar detection of prostate-specific antigen: an immunoassay based on surface-enhanced Raman scattering and immunogold labels. Anal. Chem. 75 (2003) 5936-5943
47. Hamaguchi T., Matusmura Y., Suzuki M., Shimizu K., Goda R., Nakamura I., Nakatomi I., Yokoyama m., Kataoka K., and Kakizoe T. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumor activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer 92 (2005) 1240-1246
48. Harisinghani M.G., Barentsz J., Hahn P.F., Deserno W.M., Tabatabaei S., Hulsbergen, van de KaaF C.H., de la Rosette J., and Weissleder R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med. 348 (2003) 2491-2499
49. Hillyer J., and Albrecht R. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 90 (2001) 1927-1936
50. Hirsch L.R., Jackson J.B., Lee A., Halas N.J., and West J.L. A whole blood immunoassay using gold nanoshells. Anal. Chem. 75 (2003) 2377-2381
51. Hood J.D., Bednarski M., Frausto R., Guccione S., Reisfeld R.A., Xiang R., and Cheresh D.A. Tumor regression by targeted gene delivery to the neovasculature. Science 296 (2002) 2404-2407
52. Hussain N., Jaitley V., and Florence A. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 50 (2001) 107-142
53. Ito T., Sun L., and Crooks R.M. Simultaneous determination of the size and surface charge of individual nanoparticles using a carbon nanotube-based coulter counter. Anal. Chem. 75 (2003) 2399-2406
54. Jin R., Cao Y., Mirkin C.A., Kelley K.L., Schatz G.C., and Zheng J.G. Photoinduced conversion of silver nanospheres to nanoprisms. Science 294 (2001) 1901-1903
55. 2 activation and their use in liposome-based drug delivery. FEBS Lett. 531 (2002) 23-27
56. Kim S., Bell K., Mousa S.A., and Varner J.A. A regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell-binding domain of fibronectin. Am. J. Pathol. 156 (2000) 1345-1362
57. Kim S., Lim Y.T., Soltesz E.G., De Grand A.M., Lee J., Nakayama A., Parker J.A., Mihaljevic T., Laurence R.G., and Dor D.M. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22 (2004) 93-97
58. Koushik K., Dhanda D.S., Cheruvu N.P., and Kompella U.B. Pulmonary delivery of deslorelin: large-porous PLGA particles and HpbetaCD complexes. Pharm. Res. 21 (2004) 1119-1126
59. Kukowska-Latallo J., Raczka E., Quintana A., Chen C., Rymaszewski M., and Baker J.R. Intravascular and endobronchial DNA delivery to murine lung tissue using a novel, nonviral vector. Hum. Gene Ther. 11 (2000) 1385-1395
60. Labhasetwar V. Nanotechnology for drug and gene therapy: the importance of understanding molecular mechanisms of delivery. Curr. Opin. Biotechnol. (2005) 674-680
61. Lanza G.M., Wallace K.D., Scott M.J., Cacheris W.P., Abendschein D.R., Christy D.H., Sharkey A.M., Miller J.G., Gaffney P.J., and Wickline S.A. A novel site-targeted ultrasonic contrast agent with broad biomedical application. Circulation 94 (1996) 3334-3340
62. Lanza G.M., Lorenz C.H., Fischer S.E., Scott M.J., Cacheris W.P., Kaufman R.J., Gaffney P.J., and Wickline S.A. Enhanced detection of thrombi with a novel fibrin targeted magnetic resonance imaging agent. Acad. Radiol. 5 Suppl. 1 (1998) S173-S176
63. Lanza G.M., Trousil R.L., Wallace K.D., Rose J.H., Hall C.S., Scott M.J., Miller J.G., Eisenberg P.R., Gaffney P.J., and Wickline S.A. In vitro characterization of a novel, tissue-targeted ultrasonic contrast system with acoustic microscopy. J. Acoust. Soc. Am. 104 (1998) 3665-3672
64. Lanza G.M., Abendschein D.R., Hall C.S., Marsh J.N., Scott M.J., Scherrer D.E., and Wickline S.A. Molecular imaging of stretch induced tissue factor expression in carotid arteries with intravascular ultrasound. Invest. Radiol. 35 (2000) 227-234
65. Lanza G.M., Yu X., Winter P.M., Abendschein D.R., Karukstis K.K., Scott M.J., Chinen L.K., Fuhrhop R.W., Scherrer D.E., and Wickline S.A. Targeted antiproliferative drug delivery to vascular smooth muscle cells with magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation 106 (2002) 2842-2847
66. Lanza G.M., Winter P.M., Neubauer A.M., Caruthers S.D., Hockette F.D., and Wickline S.A. (1)H/(19)F magnetic resonance molecular imaging with perfluorocarbon nanoparticles. Curr. Top. Dev. Biol. 70 (2005) 57-76
67. Li J., Ng H.T., Cassell A., Fan W., Chen H., Ye Q., Koehne J., Han J., and Meyyappan M. Carbon nanotube nanoelectrode array for ultrasensitive DNA detection. Nano Lett. 3 (2003) 597-602
68. Liu L., Zern M., Lizarzaburu M., Nantz M.H., and Wu J. Poly(cationic lipid)-mediated in vivo gene delivery to mouse liver. Gene Ther. 10 (2003) 180-187
69. Loscertales I., Barrero A., Guerrero I., Cortijo R., Marquez M., and Ganan-Calvo A.M. Micro/nano encapsulation via electrified coaxial liquid jets. Science 295 (2002) 1695-1698
70. Low P.S., and Antony A.C. Folate receptor targeted drugs for cancer and inflammatory diseases. Adv. Drug. Deliv. Rev. 56 (2004) 1055-1058
71. Lu Y., and Low P.S. Folate-mdeiated delivery of macromolecular anticancer therapeutic agents. Adv. Drug. Deliv. Rev. 54 (2002) 675-693
72. Lubben I.V.D., Konings F., and Borchard G. In vivo uptake of chitosan microparticles by murine Peyer's patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry. J. Drug Target. 9 (2001) 39-47
73. Lutsiak M., Robinson D., Coester C., Kwon G.S., and Samuel J. Analysis of poly(d,l lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro. Pharm. Res. 19 (2002) 1480-1487
74. Maksimento A., Mandroguine V., and Gottikh M. Optimisation of dendrimer-mediated gene transfer by anionic oligomers. J. Gene Med. 5 (2003) 61-71
75. Martin C., and Kohli P. The emerging field of nanotube biotechnology. Nat. Rev. Drug Discov. 2 (2002) 29-35
76. McIntyre J.O., Fingleton B., Wells K.S., Piston D.W., Lynch C.C., Gautam S., and Matrisian L.M. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem. J. 377 (2004) 617-628
77. McKinnie J. Nanobiotechnology offers a promising solution overcoming common drug delivery failures. Drug Deliv. Technol. 5 (2006) 11-15
78. McShane M. Potential for glucose monitoring with nanoengineered fluorescent biosensors. Diabetes. Technol. Ther. 4 (2002) 533-538
79. Miyata N., and Yamakoshi T. In: Kadish K.M., and Ruoff R.S. (Eds). Fullerenes: Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials vol. 5 (1997), Electrochemical Society, Pennington, NJ 345-357
80. Moghimi S.M., and Bonnemain B. Subcutaneous and intravenous delivery of diagnostic agents to the lymphatic system: applications in lymphoscintigraphy and indirect lymphography. Adv. Drug Deliv. Rev. 37 (1999) 295-312
81. Moghimi S.M., and Hunter A.C. Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups. Pharm. Res. 18 (2001) 1-8
82. Moghimi S.M., Hunter A.C., and Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53 (2001) 283-318
83. Moghimi S.M. Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration. FEBS Lett. 540 (2003) 241-244
84. Moghimi S.M., Hunter A.C., and Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53 (2003) 283-318
85. Moghimi S.M., and Szebeni J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog. Lipid Res. 42 (2003) 463-478
86. Moghimi M., Hunter A.C., and Murray J.C. Nanomedicine: current status and future prospects. FASEB 19 (2005) 311-330
87. Maloney J.M., Uhland S.A., Polito B.F., Sheppard N.F., Pelta C.M., and Santini J.T. Electrothermally activated microchips for implantable drug delivery and biosensing. J. Control. Rel. 109 (2005) 244-255
88. Murray J.C., and Moghimi S.M. Endothelial cells as therapeutic targets in cancer: new biology and novel delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 20 (2003) 139-152
89. Muzykantov V.R., Christofidou-Solomidou M., Balyasnikova I.V., Harshaw D., Schultz L., Fisher A.B., and Albelda S.M. Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule-1): a strategy for vascular immunotargeting of drugs. Proc. Natl. Acad. Sci. USA 96 (1999) 2379-2384
90. Nam J.M., Thaxton C.S., and Mirkin C.A. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301 (2003) 1884-1886
91. Nam J.M., Stoeva S.I., and Mirkin C.A. Biol-bar-code-based DNA detection with PCR like sensitivity. J. Am. Chem. Soc. 126 (2004) 5932-5933
92. Nel A., Xia T., Madler L., and Li N. Tox potential of materials at the nanolevel. Science (2006) 622-627
93. Oh P., Li Y., Yu J., Durr E., Krasinka K.M., Carver L.A., Testa J.E., and Schnitzer J.E. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature (London) 429 (2004) 629-635
94. Panyam J., and Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 12 (2003) 329-347
95. Pasqualini R., Arap W., and McDonald D.M. Probing the structural and molecular diversity of tumour vasculature. Trend. Mol. Med. 8 (2002) 563-571
96. Pastorino F., Brignole C., Marimpietri D., Cilli M., Gambini C., Ribatti D., Longhi R., Allen T.M., Corti A., and Ponzoni M. Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy. Cancer Res. 63 (2003) 7400-7409
97. Perez C., Sanchez A., Putnam D., Ting D., Langer R., and Alonso M.J. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J. Control. Rel. 75 (2001) 211-224
98. Prescott J.H., Lipka S., Baldwin S., Sheppard N.F., Maloney J.M., Coppeta J., Yomtov B., Staples M.A., and Santini J.T. Chronic, programmed polypeptide delivery from an implanted multireservoir microchip device. Nat. Biotechnol. 24 (2006) 437-438
99. Ran S., Gao B., Duffy S., Watkins L., Rote N., and Thorpe P.E. Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumour vasculature. Cancer Res. 58 (1998) 4646-4653
100. Remaut K., Lucas B., Braeckmans K., Sanders N.N., Demeester J., and DeSmedt S.C. Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy. J. Control. Rel. 110 (2005) 212-226
101. Richards Grayson S.C., Choi I.S., Tyler B.M., Wang P.P., Brem H., Cima M.J., and Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat. Mater. 2 (2003) 767-772
102. Roney C., Kulkarni P., and Arora V. Targeted nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease. J. Control. Rel. 108 (2005) 193-214
103. Rosi N.L., and Mirkin C.A. Nanostructures in biodiagnostics. Chem Rev. 105 (2005) 1547-1562
104. Ruoslahti E. Drug targeting to specific vascular sites. Drug Discov. Today 7 (2002) 1138-1143
105. Santini J., Cima M., and Langer R. A controlled-release microchip. Nature 397 (1999) 335-338
106. Sapra P., and Allen T.M. Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. Cancer Res. 62 (2002) 7190-7194
107. Scherpereel A., Wiewrodt R., Christofidou-Solomidou M., Gervais R., Murciano J.C., Albelda S.M., and Muzykantov V.R. Cell-selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting. FASEB J. 15 (2001) 416-426
108. Schinazi R.F., Sijbesma R., Srdanov G., Hill C.L., and Wudl F. Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene. Antimicrob. Agents Chemother. 37 (1993) 1707-1710
109. Silva G.A. Neurocience nanotechnology: progress, opportunities and challenges. Nat. Rev. Neurosci. 7 (2006) 65-74
110. Singh R., Pantarotto D., Lacerdo L., Pastorin G., Klumpp C., Prato M., Bianco A., and Kostarelos K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. PNAS 103 (2006) 3357-3362
111. St Croix B., Rago C., Velculescu V., Traverso G., Romans K.E., Montgomery E., Lal A., Riggins G.J., Lengauer C., Vogelstein B., and Kinzler K.W. Genes expressed in human tumor endothelium. Science 289 (2000) 1197-1202
112. Sudimack J., and Lee R.J. Targeted drug delivery via the folate receptor. Adv. Drug Deliv. Rev. 41 (2000) 147-162
113. Sumner J.P., Aylott J.W., Monson E., and Kopelman R. A fluorescent PEBBLE nanosensor for intracellular free zinc. Analyst 127 (2002) 11-16
114. Tabata Y., Murakami Y., and Ikada Y. Photodynamic effect of polyethylene glycolmodified fullerene on tumor. Jpn. J. Cancer Res. 88 (1997) 1108-1116
115. Tabata Y., Murakami Y., and Ikada Y. Antitumor effect of poly(ethylene glycol)-modified fullerene. Fullerene Sci. Technol. 5 (1997) 989-1007
116. Taton T.A., Mirkin C.A., and Letsonger R.L. Scanometric DNA array detection with nanoparticle probes. Science 289 (2000) 1757-1760
117. Torche A., Jouan H., Corre P.L., Chevanne F., and Le Verge R. Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment. Int. J. Pharm. 201 (2000) 15-27
118. Torchillin V.P., Lukyanov A.N., and Gao Z.G. Papahadjopoulos-Sternberg B. Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs. Proc. Natl. Acad. Sci. USA 100 (2003) 6039-6044
119. Tsao N., Kanakaama P.P., Luh T.Y., Chou C.K., and Lei H.Y. Inhibition of Escherichia coli-induced meningitis by carboxyfullerence. Antimicrob. Agents Chemother. 43 (1999) 2273-2277
120. Tsao N., Luh T.Y., Chou C.K., Wu J.J., Lin Y.S., and Lei H.Y. Inhibition of group A streptococcus infection by carboxyfullerene. Antimicrob. Agents Chemother. 45 (2001) 1788-1793
121. Turunen M.P., Puhakka H.L., Koponen J.K., Hiltunen M.O., Rutanen J., Leppanen O., Turunen A.M., Narvanen A., Newby A.C., and Baker A.H. Peptide re-targeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer. Mol. Ther. 6 (2002) 306-312
122. Tziveleka L.A., Kontoyianni C., Sideratou Z., Tsiourvas D., and Paleos C.M. Novel hyperbranched polyether polyols as prospective drug delivery systems. Macromol. Biosci. 6 (2006) 161-169
123. Varde N.K., and Pack D.W. Microspheres for controlled release drug delivery. Expert Opin. Biol. Ther. 4 (2004) 35-51
124. Vasir J.K., and Labhasetwar V. Targeted drug delivery in cancer therapy. Technol. Cancer Res. Treat. (2005) 363-374
125. VisionGain. Drug Delivery 2003 New Technologies in the Global Market (2003), VisionGain
126. Walovitch R., Kwan O., and Picard M. Initial Safety and Myocardial Perfusion Imaging Results with AI-700: a New Ultrasound Contrast Agent (2003), Acusphere, Inc. http://www.acusphere.com/ab_5.html http://www.acusphere.com/ab_5.html
127. Wang J., and Musameh M. Carbon nanotube/teflon composite electrochemical sensors and biosensors. Anal. Chem. 75 (2003) 2075-2079
128. Weissleder R., Kelly K., Sun E.Y., Shtatland T., and Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat. Biotechnol. 11 (2005) 1418-1423
129. Whitesides G.M. The "right" size in nanotechnology. Nat. Biotechnol. 10 (2003) 1161-1165
130. Wickline S.A., and Lanza G.M. Nanotechnology for molecular imaging and targeted therapy. Circulation 107 (2003) 1092-1095
131. Winter P.M., Caruthers S.D., Kassner A., Harris T.D., Chinen L.K., Allen J.S., Lacy E.K., Zhang H.Y., Robertson J.D., and Wickline S.A. Molecular imaging of angiogenesis in nascent vx-2 rabbit tumours using a novel alpha(v)beta(3)-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res. 63 (2003) 5838-5843
132. Woolley A.T., Guillemette C., LiCheung C., Housman D.E., and Lieber C.M. Direct haplotyping of kilobase-size DNA using carbon nanotube probes. Nat. Biotechnol. 18 (2000) 760-763
133. Wunderbaldinger P., Josephson L., and Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug. Chem. 13 (2002) 264-268
134. Yang J., Mayer M., Kriebel J.K., Garstecki P., and Whitesides G.M. Self-assembled aggregates of IgGs as templates for the growth of clusters of gold nanoparticles. Angew. Chem. Int. Ed. Engl. 43 (2004) 1555-1558
135. Yu X., Song S.-K., Chen J., Scott M.J., Fuhrhop R.J., Hall C.S., Gaffney P.J., Wickline S.A., and Lanza G.M. High resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent. Magn. Reson. Med. 44 (2000) 867-872
136. Zhang Y., Schlachetzkif F., and Pardridge W. Global non-viral gene transfer to the primate brain following intravenous administration. Mol. Ther. 7 (2003) 11-18
137. Zitzmann S., Ehemann V., and Schwab M. Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo. Cancer Res. 62 (2002) 5139-5143