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Volumn 42, Issue 5, 2003, Pages 419-436

Pharmacokinetics of pegylated liposomal doxorubicin: Review of animal and human studies

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; LIPOSOME; MACROGOL; UNCLASSIFIED DRUG;

EID: 0037681850     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200342050-00002     Document Type: Review
Times cited : (1424)

References (78)
  • 1
    • 0019463519 scopus 로고
    • Targeting of drugs: Implications in medicine
    • Gregoriadis G. Targeting of drugs: implications in medicine. Lancet 1981; II: 241-6
    • (1981) Lancet , vol.2 , pp. 241-246
    • Gregoriadis, G.1
  • 2
    • 0016612425 scopus 로고
    • The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs
    • Juliano R, Stamp D. The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs. Biochem Biophys Res Commun 1975; 63: 651-8
    • (1975) Biochem Biophys Res Commun , vol.63 , pp. 651-658
    • Juliano, R.1    Stamp, D.2
  • 3
    • 0020049344 scopus 로고
    • Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery
    • Poste G, Bucana C, Raz A, et al. Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res 1982; 42: 1412-22
    • (1982) Cancer Res , vol.42 , pp. 1412-1422
    • Poste, G.1    Bucana, C.2    Raz, A.3
  • 4
    • 0023649923 scopus 로고
    • Uptake of small liposomes by non-reticuloendothelial tissues
    • Hwang KJ, Padki MM, Chow DD, et al. Uptake of small liposomes by non-reticuloendothelial tissues. Biochim Biophys Acta 1987; 901: 88-96
    • (1987) Biochim Biophys Acta , vol.901 , pp. 88-96
    • Hwang, K.J.1    Padki, M.M.2    Chow, D.D.3
  • 5
    • 0842279809 scopus 로고
    • Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
    • Gabizon A, Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc Natl Acad Sci U S A 1988; 85: 6949-53
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 6949-6953
    • Gabizon, A.1    Papahadjopoulos, D.2
  • 6
    • 0030778570 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: Scientific rationale and preclinical pharmacology
    • Martin FJ. Pegylated liposomal doxorubicin: scientific rationale and preclinical pharmacology. Oncology 1997; 11: 11-32
    • (1997) Oncology , vol.11 , pp. 11-32
    • Martin, F.J.1
  • 7
    • 0032580445 scopus 로고    scopus 로고
    • Development of liposomal anthracyclines: From basics to clinical applications
    • Gabizon A, Goren D, Cohen R, et al. Development of liposomal anthracyclines: from basics to clinical applications. J Control Release 1998; 53: 275-9
    • (1998) J Control Release , vol.53 , pp. 275-279
    • Gabizon, A.1    Goren, D.2    Cohen, R.3
  • 8
    • 0028920270 scopus 로고
    • Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin
    • Gill PS, Espina BM, Muggia F, et al. Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin. J Clin Oncol 1995; 13: 996-1003
    • (1995) J Clin Oncol , vol.13 , pp. 996-1003
    • Gill, P.S.1    Espina, B.M.2    Muggia, F.3
  • 9
    • 0032974761 scopus 로고    scopus 로고
    • Phase I study of liposomal vincristine
    • Gelmon KA, Tolcher A, Diab AR, et al. Phase I study of liposomal vincristine. J Clin Oncol 1999; 17: 697-705
    • (1999) J Clin Oncol , vol.17 , pp. 697-705
    • Gelmon, K.A.1    Tolcher, A.2    Diab, A.R.3
  • 10
    • 0035005359 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy
    • Gabizon AA. Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest 2001; 19: 424-36
    • (2001) Cancer Invest , vol.19 , pp. 424-436
    • Gabizon, A.A.1
  • 12
    • 0002985635 scopus 로고
    • Polyethylene glycol-lipid conjugates
    • Lasic D, Martin F, editors. Boca Raton: CRC Press
    • Zalipsky S. Polyethylene glycol-lipid conjugates. In: Lasic D, Martin F, editors. Stealth liposomes. Boca Raton: CRC Press, 1995: 93-102
    • (1995) Stealth Liposomes , pp. 93-102
    • Zalipsky, S.1
  • 14
    • 0035085192 scopus 로고    scopus 로고
    • Liposome application: Problems and prospects
    • Barenholz Y. Liposome application: problems and prospects. Curr Opin Colloid Interface Sci 2001; 6: 66-77
    • (2001) Curr Opin Colloid Interface Sci , vol.6 , pp. 66-77
    • Barenholz, Y.1
  • 15
    • 0030886615 scopus 로고    scopus 로고
    • Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles
    • Cullis PR, Hope MJ, Bally MB, et al. Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochim Biophys Acta 1997; 1331: 187-211
    • (1997) Biochim Biophys Acta , vol.1331 , pp. 187-211
    • Cullis, P.R.1    Hope, M.J.2    Bally, M.B.3
  • 16
    • 0343923453 scopus 로고    scopus 로고
    • Long-circulating liposomes for drug delivery in cancer therapy: A review of biodistribution studies in tumor-beating animals
    • Gabizon A, Goren D, Horowitz AT, et al. Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-beating animals. Adv Drug Deliv Rev 1997; 24: 337-44
    • (1997) Adv Drug Deliv Rev , vol.24 , pp. 337-344
    • Gabizon, A.1    Goren, D.2    Horowitz, A.T.3
  • 17
    • 0003377686 scopus 로고    scopus 로고
    • Reduced cardiac toxicity and comparable efficacy in a phase III trial of pegylated lipsomal doxorubicin (Caelyx/Doxil) vs doxorubicin for first-line treatment of metastatic breast cancer
    • Wigler N, Inbar M, O'Brien M, et al. Reduced cardiac toxicity and comparable efficacy in a phase III trial of pegylated lipsomal doxorubicin (Caelyx/Doxil) vs doxorubicin for first-line treatment of metastatic breast cancer [abstract]. Proc Am Soc Clin Oncol (ASCO) 2002; 177
    • (2002) Proc Am Soc Clin Oncol (ASCO) , pp. 177
    • Wigler, N.1    Inbar, M.2    O'Brien, M.3
  • 18
    • 0035286282 scopus 로고    scopus 로고
    • Liposomal encapsulated anthracyclines: New therapeutic horizons
    • Muggia FM. Liposomal encapsulated anthracyclines: new therapeutic horizons. Curr Oncol Rep 2001; 3: 156-62
    • (2001) Curr Oncol Rep , vol.3 , pp. 156-162
    • Muggia, F.M.1
  • 19
    • 0036402578 scopus 로고    scopus 로고
    • Polyethylene glycol-liposomal doxorubicin: A review of its use in the management of solid and haematological malignancies and AIDS related Kaposi's sarcoma
    • Sharpe M, Easthope SE, Keating GM, et al. Polyethylene glycol-liposomal doxorubicin: a review of its use in the management of solid and haematological malignancies and AIDS related Kaposi's sarcoma. Drugs 2002; 62: 2089-126
    • (2002) Drugs , vol.62 , pp. 2089-2126
    • Sharpe, M.1    Easthope, S.E.2    Keating, G.M.3
  • 20
    • 0029765442 scopus 로고    scopus 로고
    • Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl)
    • Working PK, Dayan AD. Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl). Hum Exp Toxicol 1996; 15: 751-85
    • (1996) Hum Exp Toxicol , vol.15 , pp. 751-785
    • Working, P.K.1    Dayan, A.D.2
  • 21
    • 0032516078 scopus 로고    scopus 로고
    • Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
    • Hobbs SK, Monsky WL, Yuan F, et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci U S A 1998; 95: 4607-12
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4607-4612
    • Hobbs, S.K.1    Monsky, W.L.2    Yuan, F.3
  • 22
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • Hashizume H, Baluk P, Morikawa S, et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 2000; 156: 1363-80
    • (2000) Am J Pathol , vol.156 , pp. 1363-1380
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3
  • 23
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
    • Yuan F, Dellian M, Fukumura D, et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 1995; 55: 3752-6
    • (1995) Cancer Res , vol.55 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3
  • 25
    • 0034955555 scopus 로고    scopus 로고
    • DRV liposomal bupivacaine: Preparation, characterization, and in vivo evaluation in mice
    • Grant GJ, Barenholz Y, Piskoun B, et al. DRV liposomal bupivacaine: preparation, characterization, and in vivo evaluation in mice. Pharm Res 2001; 18: 336-43
    • (2001) Pharm Res , vol.18 , pp. 336-343
    • Grant, G.J.1    Barenholz, Y.2    Piskoun, B.3
  • 26
    • 0026453662 scopus 로고
    • Gelation of liposome interior: A novel method for drug encapsulation
    • Lasic DD, Frederik PM, Stuart MC, et al. Gelation of liposome interior: a novel method for drug encapsulation. FEBS Lett 1992; 312: 255-8
    • (1992) FEBS Lett , vol.312 , pp. 255-258
    • Lasic, D.D.1    Frederik, P.M.2    Stuart, M.C.3
  • 27
    • 0028886643 scopus 로고
    • Transmembrane gradient driven phase transitions within vesicles: Lessons for drug delivery
    • Lasic DD, Ceh B, Stuart MC, et al. Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery. Biochim Biophys Acta 1995; 1239: 145-56
    • (1995) Biochim Biophys Acta , vol.1239 , pp. 145-156
    • Lasic, D.D.1    Ceh, B.2    Stuart, M.C.3
  • 28
    • 0027514941 scopus 로고
    • Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases
    • Haran G, Cohen R, Bar LK, et al. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993; 1151: 201-15
    • (1993) Biochim Biophys Acta , vol.1151 , pp. 201-215
    • Haran, G.1    Cohen, R.2    Bar, L.K.3
  • 29
    • 0028324117 scopus 로고
    • Ammonium sulfate gradients for efficient and stable remote loading of amphipathic weak bases into liposomes and ligandoliposomes
    • Bolotin EM, Cohen R, Bar LK, et al. Ammonium sulfate gradients for efficient and stable remote loading of amphipathic weak bases into liposomes and ligandoliposomes. J Liposome Res 1994; 4: 455-79
    • (1994) J Liposome Res , vol.4 , pp. 455-479
    • Bolotin, E.M.1    Cohen, R.2    Bar, L.K.3
  • 30
    • 0026672406 scopus 로고
    • In vitro cytotoxicity of liposome-encapsulated doxorubicin: Dependence on liposome composition and drug release
    • Horowitz AT, Barenholz Y, Gabizon AA. In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug release. Biochim Biophys Acta 1992; 1109: 203-9
    • (1992) Biochim Biophys Acta , vol.1109 , pp. 203-209
    • Horowitz, A.T.1    Barenholz, Y.2    Gabizon, A.A.3
  • 31
    • 0029360317 scopus 로고
    • Liposome circulation time and tumor targeting: Implications for cancer chemotherapy
    • Gabizon AA. Liposome circulation time and tumor targeting: implications for cancer chemotherapy. Adv Drug Deliv Rev 1995; 16: 285-94
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 285-294
    • Gabizon, A.A.1
  • 32
    • 0033400567 scopus 로고    scopus 로고
    • Pharmacological studies of cisplatin encapsulated in long-circulating liposomes in mouse tumor models
    • Bandak S, Goren D, Horowitz A, et al. Pharmacological studies of cisplatin encapsulated in long-circulating liposomes in mouse tumor models. Anticancer Drugs 1999; 10: 911-20
    • (1999) Anticancer Drugs , vol.10 , pp. 911-920
    • Bandak, S.1    Goren, D.2    Horowitz, A.3
  • 33
    • 0029585915 scopus 로고
    • Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: Biodistribution and therapeutic efficacy
    • Siegal T, Horowitz A, Gabizon A. Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy. J Neurosurg 1995; 83: 1029-37
    • (1995) J Neurosurg , vol.83 , pp. 1029-1037
    • Siegal, T.1    Horowitz, A.2    Gabizon, A.3
  • 34
    • 0027162899 scopus 로고
    • Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: Pharmacokinetic studies in rodents and dogs
    • Gabizon AA, Barenholz Y, Bialer M. Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: pharmacokinetic studies in rodents and dogs. Pharm Res 1993; 10: 703-8
    • (1993) Pharm Res , vol.10 , pp. 703-708
    • Gabizon, A.A.1    Barenholz, Y.2    Bialer, M.3
  • 35
    • 0032958460 scopus 로고    scopus 로고
    • Relationship of dose intensity to the induction of palmar-plantar erythrodysesthia by pegylated liposomal doxorubicin in dogs
    • Amantea M, Newman MS, Sullivan TM, et al. Relationship of dose intensity to the induction of palmar-plantar erythrodysesthia by pegylated liposomal doxorubicin in dogs. Hum Exp Toxicol 1999; 18: 17-26
    • (1999) Hum Exp Toxicol , vol.18 , pp. 17-26
    • Amantea, M.1    Newman, M.S.2    Sullivan, T.M.3
  • 36
    • 0025789143 scopus 로고
    • Pharmacokinetics of stealth versus conventional liposomes: Effect of dose
    • Allen TM, Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim Biophys Acta 1991; 1068: 133-41
    • (1991) Biochim Biophys Acta , vol.1068 , pp. 133-141
    • Allen, T.M.1    Hansen, C.2
  • 37
    • 0036875746 scopus 로고    scopus 로고
    • Dose dependency of pharmacokinetics and therapeutic efficacy of pegylated liposomal doxorubicin (DOXIL) in murine models
    • Gabizon A, Tzemach D, Mak L, et al. Dose dependency of pharmacokinetics and therapeutic efficacy of pegylated liposomal doxorubicin (DOXIL) in murine models. J Drug Target 2002; 10: 539-48
    • (2002) J Drug Target , vol.10 , pp. 539-548
    • Gabizon, A.1    Tzemach, D.2    Mak, L.3
  • 38
    • 0027133225 scopus 로고
    • Preclinical studies with doxorubicin encapsulated in polyethyleneglycol-coated liposomes
    • Gabizon AA, Pappo O, Goren D, et al. Preclinical studies with doxorubicin encapsulated in polyethyleneglycol-coated liposomes. J Liposome Res 1993; 3: 517-28
    • (1993) J Liposome Res , vol.3 , pp. 517-528
    • Gabizon, A.A.1    Pappo, O.2    Goren, D.3
  • 39
    • 0000058786 scopus 로고
    • Clinical pharmacokinetics of anthracycline antibiotics
    • Ames MM, Powis G, Kovach JS, editors. Amsterdam: Elsevier
    • Riggs Jr ER, Bachur R. Clinical pharmacokinetics of anthracycline antibiotics. In: Ames MM, Powis G, Kovach JS, editors. Pharmacokinetics of anticancer agents in humans. Amsterdam: Elsevier, 1983: 229-278
    • (1983) Pharmacokinetics of Anticancer Agents in Humans , pp. 229-278
    • Riggs E.R., Jr.1    Bachur, R.2
  • 40
    • 0026352832 scopus 로고
    • Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
    • Papahadjopoulos D, Allen TM, Gabizon A, et al. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci U S A 1991; 88: 11460-4
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 11460-11464
    • Papahadjopoulos, D.1    Allen, T.M.2    Gabizon, A.3
  • 41
    • 0030669086 scopus 로고    scopus 로고
    • Polyethylene glycol-coated (pegylated) liposomal doxorubicin: Rationale for use in solid tumours
    • Gabizon A, Martin F. Polyethylene glycol-coated (pegylated) liposomal doxorubicin: rationale for use in solid tumours. Drugs 1997; 54: 15-21
    • (1997) Drugs , vol.54 , pp. 15-21
    • Gabizon, A.1    Martin, F.2
  • 42
    • 0028324859 scopus 로고
    • Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth liposomes (Doxil®)
    • Working PK, Newman MS, Huang SK, et al. Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth liposomes (Doxil®). J Liposome Res 1994; 4: 667-87
    • (1994) J Liposome Res , vol.4 , pp. 667-687
    • Working, P.K.1    Newman, M.S.2    Huang, S.K.3
  • 43
    • 0031045691 scopus 로고    scopus 로고
    • Tumor uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma
    • Vaage J, Donovan D, Uster P, et al. Tumor uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma. Br J Cancer 1997; 75: 482-6
    • (1997) Br J Cancer , vol.75 , pp. 482-486
    • Vaage, J.1    Donovan, D.2    Uster, P.3
  • 44
    • 0028219430 scopus 로고
    • Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts
    • Vaage J, Barbera-Guillem E, Abra R, et al. Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts. Cancer 1994; 73: 1478-84
    • (1994) Cancer , vol.73 , pp. 1478-1484
    • Vaage, J.1    Barbera-Guillem, E.2    Abra, R.3
  • 45
    • 0031045691 scopus 로고    scopus 로고
    • Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma
    • Vaage J, Donovan D, Uster P, et al. Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma. Br J Cancer 1997; 75: 482-6
    • (1997) Br J Cancer , vol.75 , pp. 482-486
    • Vaage, J.1    Donovan, D.2    Uster, P.3
  • 46
    • 0026733476 scopus 로고
    • Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice
    • Huang SK, Lee KD, Hong K, et al. Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res 1992; 52: 5135-43
    • (1992) Cancer Res , vol.52 , pp. 5135-5143
    • Huang, S.K.1    Lee, K.D.2    Hong, K.3
  • 47
    • 0028304405 scopus 로고
    • Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft
    • Yuan F, Leunig M, Huang SK, et al. Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft. Cancer Res 1994; 54: 3352-6
    • (1994) Cancer Res , vol.54 , pp. 3352-3356
    • Yuan, F.1    Leunig, M.2    Huang, S.K.3
  • 48
    • 0026603586 scopus 로고
    • Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
    • Gabizon AA. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res 1992; 52: 891-6
    • (1992) Cancer Res , vol.52 , pp. 891-896
    • Gabizon, A.A.1
  • 49
    • 0028290796 scopus 로고
    • Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice
    • Bally MB, Masin D, Nayar R, et al. Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice. Cancer Chemother Pharmacol 1994; 34: 137-46
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 137-146
    • Bally, M.B.1    Masin, D.2    Nayar, R.3
  • 50
    • 0030042023 scopus 로고    scopus 로고
    • Liposome longevity and stability in circulation: Effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines
    • Gabizon A, Chemla M, Tzemach D, et al. Liposome longevity and stability in circulation: effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines. J Drug Target 1996; 3: 391-8
    • (1996) J Drug Target , vol.3 , pp. 391-398
    • Gabizon, A.1    Chemla, M.2    Tzemach, D.3
  • 51
    • 0032713936 scopus 로고    scopus 로고
    • Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: Is surface coating with polyethylene glycol beneficial?
    • Hong RL, Huang CJ, Tseng YL, et al. Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial? Clin Cancer Res 1999; 5: 3645-52
    • (1999) Clin Cancer Res , vol.5 , pp. 3645-3652
    • Hong, R.L.1    Huang, C.J.2    Tseng, Y.L.3
  • 52
    • 0032793990 scopus 로고    scopus 로고
    • Significant increase in antitumor potency of doxorubicin HCl by its encapsulation in pegylated liposomes
    • Colbern GT, Hiller AJ, Musterer RS, et al. Significant increase in antitumor potency of doxorubicin HCl by its encapsulation in pegylated liposomes. J Liposome Res 1999; 9: 523-38
    • (1999) J Liposome Res , vol.9 , pp. 523-538
    • Colbern, G.T.1    Hiller, A.J.2    Musterer, R.S.3
  • 53
    • 0029038996 scopus 로고
    • Liposomal doxorubicin: Antitumor activity and unique toxicities during two complementary phase I studies
    • Uziely B, Jeffers S, Isacson R, et al. Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies. J Clin Oncol 1995; 13: 1777-85
    • (1995) J Clin Oncol , vol.13 , pp. 1777-1785
    • Uziely, B.1    Jeffers, S.2    Isacson, R.3
  • 54
    • 0031749555 scopus 로고    scopus 로고
    • Efficacy of pyridoxine to ameliorate the cutaneous toxicity associated with doxorubicin containing pegylated (Stealth) liposomes: A randomized, double-blind clinical trial using a canine model
    • Vail DM, Chun R, Thamm DH, et al. Efficacy of pyridoxine to ameliorate the cutaneous toxicity associated with doxorubicin containing pegylated (Stealth) liposomes: a randomized, double-blind clinical trial using a canine model. Clin Cancer Res 1998; 4: 1567-71
    • (1998) Clin Cancer Res , vol.4 , pp. 1567-1571
    • Vail, D.M.1    Chun, R.2    Thamm, D.H.3
  • 55
    • 0032925683 scopus 로고    scopus 로고
    • Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes
    • Working PK, Newman MS, Sullivan T, et al. Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long-circulating, pegylated liposomes. J Pharmacol Exp Ther 1999; 289: 1128-33
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1128-1133
    • Working, P.K.1    Newman, M.S.2    Sullivan, T.3
  • 56
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon A, Catane R, Uziely B, et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res 1994; 54: 987-92
    • (1994) Cancer Res , vol.54 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3
  • 57
    • 0036188460 scopus 로고    scopus 로고
    • Dose escalation and pharmacokinetics of pegylated liposomal doxorubicin (Doxil®) in children with solid tumors: A pediatric oncology group study
    • Marina NM, Cochrane D, Harney E, et al. Dose escalation and pharmacokinetics of pegylated liposomal doxorubicin (Doxil®) in children with solid tumors: a pediatric oncology group study. Clin Cancer Res 2002; 8: 413-8
    • (2002) Clin Cancer Res , vol.8 , pp. 413-418
    • Marina, N.M.1    Cochrane, D.2    Harney, E.3
  • 58
    • 0035340417 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of a stable, polyethylene-glycolated liposomal doxorubicin in patients with solid tumors: The relation between pharmacokinetic property and toxicity
    • Hong RL, Tseng YL. Phase I and pharmacokinetic study of a stable, polyethylene-glycolated liposomal doxorubicin in patients with solid tumors: the relation between pharmacokinetic property and toxicity. Cancer 2001; 91: 1826-33
    • (2001) Cancer , vol.91 , pp. 1826-1833
    • Hong, R.L.1    Tseng, Y.L.2
  • 59
    • 0034284335 scopus 로고    scopus 로고
    • Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil®) in metastatic breast carcinoma
    • Lyass O, Uziely B, Ben-Yosef R, et al. Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil®) in metastatic breast carcinoma. Cancer 2000; 89: 1037-47
    • (2000) Cancer , vol.89 , pp. 1037-1047
    • Lyass, O.1    Uziely, B.2    Ben-Yosef, R.3
  • 60
    • 0036597855 scopus 로고    scopus 로고
    • EORTC 10968: A phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx®, Doxil®) at a 6-week interval in patients with metastatic breast cancer. European Organization for Research and Treatment of Cancer
    • Hamilton A, Biganzoli L, Coleman R, et al. EORTC 10968: a phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx®, Doxil®) at a 6-week interval in patients with metastatic breast cancer. European Organization for Research and Treatment of Cancer. Ann Oncol 2002; 13: 910-8
    • (2002) Ann Oncol , vol.13 , pp. 910-918
    • Hamilton, A.1    Biganzoli, L.2    Coleman, R.3
  • 61
    • 0034126252 scopus 로고    scopus 로고
    • Doxil® (Caelyx®): An exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer
    • Hubert A, Lyass O, Pode D, et al. Doxil® (Caelyx®): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer. Anticancer Drugs 2000; 11: 123-7
    • (2000) Anticancer Drugs , vol.11 , pp. 123-127
    • Hubert, A.1    Lyass, O.2    Pode, D.3
  • 62
    • 0030898351 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of pegylated-liposomal doxorubicin in patients with AIDS-related Kaposi's sarcoma
    • Amantea MA, Forrest A, Northfelt DW, et al. Population pharmacokinetics and pharmacodynamics of pegylated-liposomal doxorubicin in patients with AIDS-related Kaposi's sarcoma. Clin Pharmacol Ther 1997; 61: 301-11
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 301-311
    • Amantea, M.A.1    Forrest, A.2    Northfelt, D.W.3
  • 63
    • 0030024958 scopus 로고    scopus 로고
    • Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: Pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma
    • Northfelt DW, Martin FJ, Working P, et al. Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma. J Clin Pharmacol 1996; 36: 55-63
    • (1996) J Clin Pharmacol , vol.36 , pp. 55-63
    • Northfelt, D.W.1    Martin, F.J.2    Working, P.3
  • 64
    • 0020038042 scopus 로고
    • Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion
    • Legha SS, Benjamin RS, Mackay B, et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 1982; 96: 133-9
    • (1982) Ann Intern Med , vol.96 , pp. 133-139
    • Legha, S.S.1    Benjamin, R.S.2    Mackay, B.3
  • 65
    • 0000220985 scopus 로고
    • Doxorubicin encapsulated in polyethylene glycol-coated liposomes: Initial clinical-pharmacokinetic studies in solid tumors
    • Lasic DD, Martin FJ, editors. Boca Raton: CRC Press
    • Gabizon A, Huang A, Martin F, et al. Doxorubicin encapsulated in polyethylene glycol-coated liposomes: initial clinical-pharmacokinetic studies in solid tumors. In: Lasic DD, Martin FJ, editors. Stealth liposomes. Boca Raton: CRC Press, 1995: 251-61
    • (1995) Stealth Liposomes , pp. 251-261
    • Gabizon, A.1    Huang, A.2    Martin, F.3
  • 66
    • 0030959798 scopus 로고    scopus 로고
    • Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: Results of a multicenter phase II trial
    • Ranson MR, Carmichael J, O'Byrne K, et al. Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial. J Clin Oncol 1997; 15: 3185-91
    • (1997) J Clin Oncol , vol.15 , pp. 3185-3191
    • Ranson, M.R.1    Carmichael, J.2    O'Byrne, K.3
  • 67
    • 0034109686 scopus 로고    scopus 로고
    • Liposomal doxorubicin (Caelyx) in advanced pretreated soft tissue sarcomas: A phase II study of the Italian Sarcoma Group (ISG)
    • Toma S, Tucci A, Villani G, et al. Liposomal doxorubicin (Caelyx) in advanced pretreated soft tissue sarcomas: a phase II study of the Italian Sarcoma Group (ISG). Anticancer Res 2000; 20: 485-91
    • (2000) Anticancer Res , vol.20 , pp. 485-491
    • Toma, S.1    Tucci, A.2    Villani, G.3
  • 68
    • 0031795043 scopus 로고    scopus 로고
    • A phase II study of Doxil® (liposomal doxorubicin): Lack of activity in poor prognosis soft tissue sarcomas
    • Garcia AA, Kempf RA, Rogers M, et al. A phase II study of Doxil® (liposomal doxorubicin): lack of activity in poor prognosis soft tissue sarcomas. Ann Oncol 1998; 9: 1131-3
    • (1998) Ann Oncol , vol.9 , pp. 1131-1133
    • Garcia, A.A.1    Kempf, R.A.2    Rogers, M.3
  • 69
    • 0003015811 scopus 로고    scopus 로고
    • Initial clinical evaluation of pegylated liposomal doxorubicin in solid tumors
    • Woodle M, Storm G, editors. Austin: Landes Bioscience
    • Gabizon AA, Muggia FM. Initial clinical evaluation of pegylated liposomal doxorubicin in solid tumors. In: Woodle M, Storm G, editors. Long-circulating liposomes: old drugs, new therapeutics. Austin: Landes Bioscience, 1998: 165-74
    • (1998) Long-circulating Liposomes: Old Drugs, New Therapeutics , pp. 165-174
    • Gabizon, A.A.1    Muggia, F.M.2
  • 70
    • 0034793680 scopus 로고    scopus 로고
    • Phase I study of doxilcisplatin combination chemotherapy in patients with advanced malignancies
    • Lyass O, Hubert A, Gabizon AA. Phase I study of doxilcisplatin combination chemotherapy in patients with advanced malignancies. Clin Cancer Res 2001; 7: 3040-6
    • (2001) Clin Cancer Res , vol.7 , pp. 3040-3046
    • Lyass, O.1    Hubert, A.2    Gabizon, A.A.3
  • 71
    • 0030731376 scopus 로고    scopus 로고
    • Liposomal anthracycline chemotherapy in the treatment of AIDS-related Kaposi' s sarcoma
    • Northfelt DW. Liposomal anthracycline chemotherapy in the treatment of AIDS-related Kaposi' s sarcoma. Oncology 1997; 11: 21-32
    • (1997) Oncology , vol.11 , pp. 21-32
    • Northfelt, D.W.1
  • 72
    • 0033168435 scopus 로고    scopus 로고
    • Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes
    • Symon Z, Peyser A, Tzemach D, et al. Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes. Cancer 1999; 86: 72-8
    • (1999) Cancer , vol.86 , pp. 72-78
    • Symon, Z.1    Peyser, A.2    Tzemach, D.3
  • 73
    • 0035127410 scopus 로고    scopus 로고
    • Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes
    • Harrington KJ, Mohammadtaghi S, Uster PS, et al. Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res 2001; 7: 243-54
    • (2001) Clin Cancer Res , vol.7 , pp. 243-254
    • Harrington, K.J.1    Mohammadtaghi, S.2    Uster, P.S.3
  • 74
    • 0035165412 scopus 로고    scopus 로고
    • Treatment of patients with ovarian carcinoma with pegylated liposomal doxorubicin: Analysis of toxicities and predictors of outcome
    • Safra T, Groshen S, Jeffers S, et al. Treatment of patients with ovarian carcinoma with pegylated liposomal doxorubicin: analysis of toxicities and predictors of outcome. Cancer 2001; 91: 90-100
    • (2001) Cancer , vol.91 , pp. 90-100
    • Safra, T.1    Groshen, S.2    Jeffers, S.3
  • 75
    • 0032700799 scopus 로고    scopus 로고
    • Liposomal doxorubicin and conventionally fractionated radiotherapy in the treatment of locally advanced non-small-cell lung cancer and head and neck cancer
    • Koukourakis MI, Koukouraki S, Giatromanolaki A, et al. Liposomal doxorubicin and conventionally fractionated radiotherapy in the treatment of locally advanced non-small-cell lung cancer and head and neck cancer. J Clin Oncol 1999; 17: 3512-21
    • (1999) J Clin Oncol , vol.17 , pp. 3512-3521
    • Koukourakis, M.I.1    Koukouraki, S.2    Giatromanolaki, A.3
  • 76
    • 0033734065 scopus 로고    scopus 로고
    • High intratumoural accumulation of stealth liposomal doxorubicin (Caelyx) in glioblastomas and in metastatic brain tumours
    • Koukourakis MI, Koukouraki S, Fezoulidis I, et al. High intratumoural accumulation of stealth liposomal doxorubicin (Caelyx) in glioblastomas and in metastatic brain tumours. Br J Cancer 2000; 83: 1281-6
    • (2000) Br J Cancer , vol.83 , pp. 1281-1286
    • Koukourakis, M.I.1    Koukouraki, S.2    Fezoulidis, I.3
  • 77
    • 0034065024 scopus 로고    scopus 로고
    • High intratumoral accumulation of stealth liposomal doxorubicin in sarcomas - Rationale for combination with radiotherapy
    • Koukourakis MI, Koukouraki S, Giatromanolaki A, et al. High intratumoral accumulation of stealth liposomal doxorubicin in sarcomas - rationale for combination with radiotherapy. Acta Oncol 2000; 39: 207-11
    • (2000) Acta Oncol , vol.39 , pp. 207-211
    • Koukourakis, M.I.1    Koukouraki, S.2    Giatromanolaki, A.3
  • 78
    • 0033802643 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2
    • Safra T, Muggia F, Jeffers S, et al. Pegylated liposomal doxorubicin (doxil): reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2. Ann Oncol 2000; 11: 1029-33
    • (2000) Ann Oncol , vol.11 , pp. 1029-1033
    • Safra, T.1    Muggia, F.2    Jeffers, S.3


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