Targeted nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease

Journal of Controlled Release

Volumn 108, Issue 2-3, 2005, Pages 193-214

  Roney, Celeste ^a   Kulkarni, Padmakar ^a   Arora, Veera ^a   Antich, Peter ^a   Bonte, Frederick ^a   Wu, Aimei ^b   Mallikarjuana, N N ^b   Manohar, Sanjeev ^b   Liang, Hsiang Fa ^c   Kulkarni, Anandrao R ^c   Sung, Hsing Wen ^c   Sairam, Malladi ^d   Aminabhavi, Tejraj M ^d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d KARNATAK UNIVERSITY   (India)

Author keywords

Alzheimer's disease; Blood brain barrier; Central nervous system; Nanoparticles; Targeted drug delivery

Indexed keywords

BIODEGRADATION; BLOOD; BRAIN; DISEASES; DRUG DOSAGE; NEUROLOGY; PROTEINS;

ALZHEIMER'S DISEASE; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; NANOPARTICLES; TARGETED DRUG DELIVERY;

NANOSTRUCTURED MATERIALS;

1,2 DIOLEOYLGLYCERO 3 PHOSPHOETHANOLAMINE N [3 (2 PYRIDYLDITHIO)PROPIONATE]; 1,2 DIOLEOYLGLYCERO 3 PHOSPHOETHANOLAMINE N [4 (4 MALEIMIDOPHENYL) BUTYRAMIDE]; ACRYLIC ACID DERIVATIVE; AMYLOID BETA PROTEIN; ANTIBIOTIC AGENT; BIOTIN; BOVINE SERUM ALBUMIN; CHITOSAN; CLIOQUINOL; EDETIC ACID; ETHANOLAMINE DERIVATIVE; ETHER DERIVATIVE; GLUTAMIC ACID DERIVATIVE; MACROGOL; MACROGOL DERIVATIVE; NANOPARTICLE; OLIGONUCLEOTIDE; PENICILLAMINE; POLY GAMMA GLUTAMIC ACID; POLY(BUTYL 2 CYANOACRYLATE); POLY(ETHYLENE GLYCOL)POLY(LACTIDE); POLY(VINYLMETHYL ETHER MALEICANHYDRIDE); POLYETHYLENEIMINE; POLYMER; POLYOXYETHYLENE STEARYL ETHER; PROPIONIC ACID DERIVATIVE; QUINOLINE DERIVATIVE; TAU PROTEIN; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; BRAIN CORTEX ATROPHY; CENTRAL NERVOUS SYSTEM; CONCENTRATION (PARAMETERS); DEGENERATIVE DISEASE; DEMENTIA; DENATURATION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; EMULSION; GENOMICS; HUMAN; MEDICAL LITERATURE; MYELOOPTIC NEUROPATHY; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NONHUMAN; OPSONIZATION; OXIDATIVE STRESS; PERMEABILITY BARRIER; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SENILE PLAQUE;

EID: 27744599588     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.07.024     Document Type: Article

References (90)

1. R. Gutman, G. Peacock, and D. Lu Targeted drug delivery for brain cancer treatment J. Control. Release 65 2000 31 41
2. Z. Zhuang, M. Kung, C. Hou, D. Skrovonsky, T. Gur, K. Plossl, J. Trojanoski, and H. Kung Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates J. Med. Chem. 44 2001 1905 1914
3. Q. Smith A Review of Blood Brain Barrier Transport Techniques 2003 Humana Press, Inc. Totowa, NJ
4. X. Huang, M. Cuajungco, and C. Atwood Cu (II) potentiation of Alzheimer AB neurotoxicity J. Biol. Chem. 274 1999 37111 37116
5. C. Ritchie, A. Bush, A. Mackinnon, S. Macfarlane, M. Mastwyk, L. MacGregor, L. Kiers, R. Cherny, Q. Li, A. Tammer, D. Carrington, C. Mavros, I. Volitakis, M. Xilinas, D. Ames, S. Davis, K. Beyreuther, R. Tanzi, and C. Masters Metal-protein attenuation with iodochlorhydorxyquin (clioquinol) targeting AB amyloid deposition and toxicity in Alzheimer disease Arch. Neurol. 60 2003 1685 1691
6. T. Reese, and M. Karnovsky Fine structural localization of a blood-brain barrier to exogenous peroxidase J. Cell Biol. 34 1967 207 217
7. S. Nag Morphology and Molecular Properties of Cellular Components of Normal Cerebral Vessels 2003 Humana Press Totowa, NJ
8. Q. Yan, and E. Sage Transforming growth factor-beta 1 induces apoptotic death in cultured retinal endothelial cells but not in pericytes: association with decreased expression of p21 wafl/cip1 J. Cell. Biochem. 70 1998 70 83
9. K. Hirshi, and P. D'Armore Control of angiogenesis by pericytes: molecular mechanisms and significance EXS 79 1997 419 428
10. C. Johanson Permeability and vascularity of the developing brain: cerebellum vs. cerebral cortex Brain Res. 190 1980 3 16
11. W. Pardridge Molecular Biology of the Blood-Brain Barrier 2003 Humana Press Totowa, NJ
12. C. Crone, and S. Olesen Electrical resistance of brain microvascular endothelium Brain Res. 241 1982 49 55
13. D. Krause, U. Mischeck, H. Galla, and R. Dermietzel Correlation of zonua occludens ZO-1 antigen and transendothelial resistance in porcine and rat cultured cerebral endothelial cells Neurosci. Lett. 128 1991 301 304
14. Q. Smith, and S. Rapoport Cerebrovascular permeability coefficients to sodium, potassium and chloride J. Neurochem. 46 1986 1732 1742
15. M. Furuse, T. Hirase, and M. Ito Occludin: a novel integral membrane protein localizing at tight junctions J. Cell Biol. 123 1993 1777 1788
16. H. Wolburg, and A. Lippoldt Tight junctions of the blood-brain barrier: development, composition and regulation Vasc. Pharmacol. 38 2002 323 337
17. H. Wolburg, K. Wolburg-Bucholz, J. Kraus, G. Rascher-Eggstein, S. Liebner, S. Hamm, F. Duffner, E.-H. Grote, W. Risau, and B. Engelhardt Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme Acta Neuropathol. 105 2003 586 592
18. I. Martin-Padura, S. Lostaglio, and M. Schneemann Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration J. Cell Biol. 142 1998 117 127
19. K. Morita, H. Sasaki, M. Furuse, and S. Tsukita Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells J. Cell Biol. 147 1999 185 194
20. L. Mitic, C.V. Itallie, and J. Anderson Molecular physiology and pathophysiology of tight junctions Am. J. Physiol.: Gasterointest. Liver Physiol. 279 2000 G250 G254
21. M. Furuse, K. Fujimoto, N. Sato, T. Hirase, S. Tsukita, and S. Tsukita Overexpression of occludin, a tight junction integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures J. Cell. Sci. 109 1996 429 435
22. L. Mitic, and J. Anderson Molecular architecture of tight junctions Annu. Rev. Physiol. 60 1998 121 142
23. A. Reichel, D. Begley, and N. Abbott S. Nag Methods in Molecular Medicine: The Blood-Brain Barrier: Biology and Research Protocols 2003 Humana Press, Inc. Totowa, NJ 307 325
24. A. Ring, J. Weiser, and E. Tuomanen Pneumococcal trafficking across the blood-brain barrier: molecular analysis of a novel bidirectional pathway J. Clin. Invest. 102 1998 347 360
25. B. Pron, M. Taha, C. Rambaud, J. Fournet, N. Pattey, J. Monnet, M. Musilek, J. Beretti, and X. Nassif Interaction of Neisseria meningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC J. Infect. Dis. 176 1997 1285 1292
26. E. Neuwelt Mechanisms of disease: the blood-brain barrier Neurosurgery 54 2004 131 141
27. J. Huber, K. Witt, S. Hom, R. Egleton, K. Mark, and T. Davis Inflammatory pain alters blood-brain barrier permeablility and tight junctional protein expression Am. J. Physiol. 280 2001 H1241 H1248
28. Q. Smith E. Neuwelt Implications of the Blood Brain Barrier and its Manipulation 1989 Plenum Press New York 85 118
29. G. Lee, S. Dallas, M. Hong, and R. Bendayan Drug transporters in the central nervous system: brain barriers and brain parenchymal considerations Pharmacol. Rev. 53 2001 569 596
30. A. Kabanov, and E. Batrakova New technologies for drug delivery across the blood-brain barrier Curr. Pharm. Des. 10 2004 1355 1363
31. J. Kreuter J.B.J. Swarbrick Encyclopedia of Pharma. Tech. 1994 Marcel Dekker New York 165 190
32. S.A. Agnihotri, N.N. Mallikaujuana, and T.M. Aminabhavi Recent advances on chitosan-based micro and nanoparticles in drug delivery J. Control. Release 100 2004 5 28
33. T.M. Aminabhavi, K.S. Soppimath, A.R. Kulkarni, and W.E. Rudzinski Biodebradable polymeric nanoparticles as drug delivery devices J. Control. Release 70 2001 1 20
34. N. Behan, C. Birkinshaw, and N. Clarke Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerization and particle formation Biomaterials 22 2001 1335 1344
35. H. Fessi, F. Puisieux, J. Devissaguet, N. Ammoury, and S. Benita Nanocapsule formation by interfacial polymer deposition following solvent displacement Int. J. Pharm. 55 1989 R1 R4
36. S. Gubha, and B. Mandal Dispersion polymerization of acrylamide J. Colloid Interface Sci. 271 2004 55 59
37. J. Leroux, E. Allemann, E. Doelker, and R. Gurnay New approach for the preparation of nanoparticles by an emulsification-diffusion method Eur. J. Pharm. Biopharm. 41 1995 14 18
38. Y. Li, Y. Pei, Z. Zhou, X. Zhang, Z. Gu, J. Ding, J. Zhou, and X. Gao PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers J. Control. Release 73 2001 287 296
39. R. Lobenberg, L. Araujo, H. Briesen, E. Rodgers, and J. Kreuter Body distribution of azidothymidine bound to hexyl-cyanoacrylate nanoparticles after i.v. injection to rats J. Control. Release 50 1998 21 30
40. H. Murakami, M. Yoshino, M. Mizobe, M. Kobayashi, H. Takeuchi, and Y. Kawashima Preparation of poly(d,l-lactide-co-glycolide) latex for surface modifying material by a double coacervation method Proc. Int. Symp. Control. Release Bioact. Mater. 23 1996 361 362
41. T. Niwa, H. Takeuchi, T. Hino, N. Kunou, and Y. Kawashima Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d,l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method and the drug release behavior J. Control. Release 25 1993
42. M. Peracchia, C. Vauthier, D. Desmaele, A. Gulik, J. Dedieu, M. Demoy, J. d'Angelo, and P. Couvreur PEGylated nanoparticles from a novel MePEGcyanoacrylate hexadecylcyanoacrylate amyphiphilic copolymer Pharm. Res. 15 1998 548 554
43. G. Quintanar, Q. Ganem, E. Allemann, and G. Fessi Influence of the stabilizer coating layer on the purification and freeze drying of poly (d,l-lactic acid) nanoparticles prepared by the emulsification-diffusion technique J. Microencapsul. 15 1998 107 119
44. P. Scholes, A. Coombes, L. Illum, S. Davis, M. Vert, and M. Davies The preparation of sub-500 nm poly(lactide-co-glycolide) microspheres for site-specific drug delivery J. Control. Release 25 1993 145 153
45. P. Wehrle, P. Magenheim, and S. Benita Influence of process parameters on the PLA nanoparticle size distribution evaluated by means of factorial design J. Pharm. Biopharm. 41 1995 19 26
46. M. Zambaux, F. Bonneaux, R. Gref, P. Maincent, E. Dellacherie, M. Alonso, P. Labrude, and C. Vigernon Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by double emulsion method J. Control. Release 50 1998 31 40
47. J. Kreuter Nanoparticulate systems for brain delivery of drugs Adv. Drug Deliv. Rev. 47 2001 65 81
48. J. Kreuter, R. Alyautdin, D. Kharkevich, and A. Ivanov Passage of peptides through the blood-brain barrier with collodial polymer particles (nanoparticles) Brain Res. 674 1995 171 174
49. U. Schroeder, P. Sommerfeld, and B. Sabel Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrier Peptides 19 1998 777 780
50. U. Schroeder, B. Sabel, and H. Schroeder Diffusion enhancement of drugs by loaded nanoparticles in vitro Prog. Neuro-Psychopharmacol. Biol. Psychiatry 23 1999 941 949
51. C. Vauthier, C. Dubernet, C. Chauvierre, I. Brigger, and P. Couvreur Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles J. Control. Release 93 2003 151 160
52. P. Munk, and T.M. Aminabhavi Introduction to Macromolecular Science 2002 John Wiley & Sons, Inc. New York
53. P. Lockman, R. Mumper, M. Khan, and D. Allen Nanoparticle technology for drug delivery across the blood-brain barrier Drug Dev. Ind. Pharm. 28 2002 1 13
54. J. Koziara, P. Lockman, D. Allen, and R. Mumper In situ blood-brain barrier transport of nanoparticles Pharm. Res. 20 2003 1772 1778
55. C. Yang, C. Chang, P. Tsai, W. Chen, F. Tseng, and L. Lo Nanoparticle-based in vivo investigation on blood-brain barrier permeability following ischemia and reperfusion Anal. Chem. 76 2004 4465 4471
56. W. Broaddus, C. Prabhu, S. Wu-Pong, G. Gillies, and H. Fillmore Strategies for the design and delivery of antisense oligonucleotides in central nervous system Methods Enzymol. 314 2000 121 135
57. S. Yang, L. Lu, Y. Cai, J. Zhu, B. Liang, and C. Yang Body distribution in mice of intravenously injected campothecin solid lipid nanoparticles and targeting effect on brain J. Control. Release 59 1999 299 307
58. O. Boussif, F. Lezoualc'h, M. Zanta, M. Mergny, D. Scherman, B. Demeneix, and J. Behr A versatile vector for gene and oligonucleotide transgene into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U. S. A. 92 1995 7297 7303
59. J. Jeong, S. Kim, and T. Park A new antisense oligonucleotide delivery system based on self-assembled ODN-PEG hybrid conjugate micelles J. Control. Release 93 2003 183 191
60. J. Kim, B. Kim, A. Maruyama, T. Akaike, and S. Kim A new non-viral DNA delivery vector: the terplex system J. Control. Release 53 1998 175 182
61. O. Meyer, D. Kirpotin, K. Hong, B. Sternberg, J. Park, M. Woodlei, and D. Papahadjopoulos Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides J. Biol. Chem. 25 1998 15621 15627
62. S. Vinogradov, E. Batrakova, and A. Kabanov Poly(ethyleneglycol)- [polyethyleneimine NanoGel particles: novel drug delivery systems for antisense oligonucleotides Colloids Surf., B Biointerfaces 16 1999 291 304
63. K.S. Soppimath, A.R. Kulkarni, and T.M. Aminabhavi Chemically modified polyacrylamide-g-guar gum based cross-linked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization J. Control. Release 75 2001 331 345
64. Y.-H. Lin, C.K. Chung, C.T. Chen, H.F. Liang, S.C. Chen, and H.W. Sung Preparation of nanoparticles composed of chitosan/poly-Á-glutamic acid and evaluation of their permeability through Caco-2 cells Biomacromolecules 6 2005 1104 1112
65. M. Furuse, K. Fujita, T. Hiiragi, K. Fujimoto, and S. Tsukita Claudin-1 and -2: novel integral membrane protein localizing at tight junctions J. Cell Biol. 141 1998 1539 1550
66. C. Chavany, T. Doan, P. Couvreur, F. Puisieux, and C. Helene Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides Pharm. Res. 9 1992 441 449
67. Y.-H. Lin, C.K. Chung, C.-T. Chen, H.-F. Liang, S.-C. Chen, and H.W. Sung Preparation of nanoparticles composed of chitosan/poly-r-glutamic acid and evaluation of their permeability through Caco-2 cells Biomacromolecules 6 2005 1104 1112
68. E. Garcia-Garcia, K. Andrieux, S. Gil, and P. Couvreur Collodial carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain? Int. J. Pharm. 298 2005 274 292
69. P. Lockman, M. Oyewumi, J. Koziara, K. Roder, R. Mumper, and D. Allen Brain uptake of thiamine-coated nanoparticles J. Control. Release 93 2003 271 282
70. J.-X. Wang, X. Sun, and Z.-R. Zhang Enhanced brain targeting by synthesis of 3′,5′-diocyanoyl-5-fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles Eur. J. Pharm. Biopharm. 54 2002 285 290
71. W. Lu, Y.-Z. Tan, K.-L. Hu, and X.-G. Jiang Cationic albumin conjugated pegylated nanoparticle with its transcytosis ability and little toxicity against blood-brain barrier Int. J. Pharm. 295 2005 247 260
72. M. Olson, and C. Shaw Presenile dementia and Alzheimer's disease in mongolism Brain 92 1969 147
73. J. Hardy, and D. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
74. D. Walsh, and D. Selkoe Deciphering the molecular basis of memory failure in Alzheimer's disease Neuron 44 2004 181 193
75. M.S. Wolfe Presenilin and gamma-secretase: structure meets function J. Neurochem. 76 2001 1615 1620
76. A. Fagan, M. Watson, M. Parasadanian, K. Bales, S. Paul, and D. Holtzman Human and murine ApoE markedly alters Abeta metabolism before and after plaque formation in a mouse model of Alzheimer's disease Neurobiol. Dis. 9 2002 305 318
77. T. Lynch, R. Cherny, and A. Bush Oxidative process in Alzheimer's disease. The role of AB-metal interactions Exp. Neurol. 35 2000 445 451
78. A. Finefrock, A. Bush, and M. Doraiswamy Current status of metals as therapeutic targets in Alzheimer's disease J. Am. Geriatr. Soc. 51 2003 1143 1148
79. A. Bush The metallobiology of Alzheimer's disease Trends Neurosci. 26 2003 207 214
80. 2 J. Biol. Chem. 277 2002 40302 40308
81. M.P. Cuajungco, L.E. Goldstein, A. Nunomura, M.A. Smith, J.T. Lim, and C.S. Atwood Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombent of AB by zinc J. Biol. Chem. 275 2000 19439 19442
82. R. Brueckner, T. Coster, D. Wescher, M. Shmuklarsky, and B. Schuster Prophylaxis of Plasmodium flaciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial Antimicrob. Agents Chemother. 42 1998 1293 1294
83. X. Huang, C.S. Atwood, M.A. Hartshorn, G. Multhaup, L.E. Goldstein, and R.C. Scarpa The AB peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry 38 1999 7609 7616
84. R.A. Cherney, C.S. Atwood, M.E. Xilinas, D.N. Gray, W.D. Jones, and C.A. McLean Treatment with a copper-zinc chelator markedly and rigidly inhibits B-amyloid accumulation in Alzheimer's disease transgenic mice Neuron 30 2001 665 676
85. Y. Wadghiri, E. Sigurdsson, M. Sadowski, J. Wlliott, Y. Li, H. Scholtzova, C. Tang, G. Aguinaldo, M. Pappolla, K. Duff, T. Wizniewski, and D. Turnbull Detection of Alzheimer's amyloid in transgenic mice using magnetic mice using magnetic resonance microimaging Mag. Res. Med. 50 2003 293 302
86. C. Roney, V. Arora, P. Kulkarni, M. Bennett, P. Antich, F. Bonte, Unpublished data.
87. W. Hartig, B. Paulke, C. Varga, J. Seeger, T. Harkany, and J. Kacza Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting β-amyloid in Alzheimer's disease Neurosci. Lett. 338 2003 174 176
88. J. Dong, C. Atwood, V. Anderson, S. Siedlak, M. Smith, G. Perry, and P. Carey Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence Biochemistry 42 2003 2768 2773
89. M. Lovell, J. Robertson, W. Teesadale, J. Campbell, and W. Markesbery Copper, iron and zinc in Alzheimer's disease senile plaques J. Neurol. Sci. 158 1998 47 52
90. Z. Cui, P. Lockman, C. Atwood, C. Hsu, A. Gupte, D. Allen, and R. Mumper Novel d-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases Eur. J. Pharm. Biopharm. 59 2005 263 272