Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity

Biochemical Journal

Volumn 377, Issue 3, 2004, Pages 617-628

  McIntyre, J Oliver ^a   Fingleton, Barbara ^a   Wells, K Sam ^a   Piston, David W ^a   Lynch, Conor C ^a   Gautam, Shiva ^a,b   Matrisian, Lynn M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Fluorescence assay; Fluorogenic dendrimer; Matrix metalloproteinase 7 (MMP 7); Optical molecular imaging; Proteolytic beacon; SW480 xenograft

Indexed keywords

CELLS; FLUORESCENCE; MEDICAL IMAGING; OPTICAL SENSORS; OPTIMIZATION; ORGANIC ACIDS; ORGANOMETALLICS; POLYMERS; SOLUBILITY; SUBSTRATES;

REAGENTS; SPECIFICITY;

TUMORS;

BATIMASTAT; CONTRAST MEDIUM; DENDRIMER; FLUORESCEIN DERIVATIVE; GELATINASE A; HEXANOIC ACID DERIVATIVE; MATRILYSIN; MATRILYSIN INHIBITOR; METALLOPROTEINASE; PB M7VIS; PEPTIDE DERIVATIVE; POLYAMIDE; POLYMER; RHODAMINE; STROMELYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; COVALENT BOND; DIAGNOSTIC VALUE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEGRADATION; EXPERIMENTAL MODEL; FLUORESCENCE; HUMAN; HUMAN CELL; IMAGING; IN VIVO STUDY; MOUSE; NONHUMAN; OPTICAL BIOSENSOR; PHANTOM; PRIORITY JOURNAL; PROTEIN DEGRADATION; SOLUBILITY; TUMOR; XENOGRAFT;

ANIMALIA; FELIS CATUS;

EID: 1242343929     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj20030582     Document Type: Article

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