Enzymatic Release of Antitumor Ether Lipids by Specific Phospholipase A2 Activation of Liposome-Forming Prodrugs

Journal of Medicinal Chemistry

Volumn 47, Issue 7, 2004, Pages 1694-1703

  Andresen, Thomas L ^a   Davidsen, Jesper ^a   Begtrup, Mikael ^b   Mouritsen, Ole G ^c   Jørgensen, Kent ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 O HEXADECYL 2 PALMITOYLGLYCERO 3 PHOSPHOCHOLINE; 1 O HEXADECYL 2 PALMITOYLGLYCERO 3 PHOSPHOETHANOLAMINE MACROGOL 350; 1,2 BIS O OCTADECYLGLYCERO 3 PHOSPHOCHOLINE; CALCEIN; ETHER LIPID; GLYCIDOL; LIPOSOME; MACROGOL 2000; METHYL DICHLOROPHOSPHATE; PHOSPHATE; PHOSPHOLIPASE A2; PRODRUG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD TOXICITY; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG HYDROLYSIS; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; ETHERS; FLUORESCEINS; HEMOLYSIS; HUMANS; HYDROLYSIS; LIPID BILAYERS; LIPOSOMES; PERMEABILITY; PHOSPHOLIPASES A; PHOSPHOLIPID ETHERS; POLYETHYLENE GLYCOLS; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1642285882     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031029r     Document Type: Article

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