High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent

Magnetic Resonance in Medicine

Volumn 44, Issue 6, 2000, Pages 867-872

  Yu, Xin ^a,e   Song, Sheng Kwei ^b   Chen, Junjie ^c   Scott, Michael J ^a   Fuhrhop, Ralph J ^a   Hall, Christopher S ^a   Gaffney, Patrick J ^d   Wickline, Samuel A ^a   Lanza, Gregory M ^a  

^a BARNES JEWISH HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d ST THOMAS HOSPITAL   (United Kingdom)

^e Campus Box 8086 ^*  (United States)

Author keywords

Fibrin; Gadolinium DTPA; Molecular imaging; MRI; Nanoparticles

Indexed keywords

GADOLINIUM COMPOUNDS; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; SCANNING ELECTRON MICROSCOPY;

ATHEROSCLEROTIC PLAQUE; CONTRAST AGENT; FIBRIN; HIGH RESOLUTION; NANOPARTICLE CONTRAST AGENT; PERFLUOROCARBONS; SPECIFIC DETECTION; TARGETED CONTRAST AGENTS;

MOLECULAR IMAGING;

CONTRAST MEDIUM; NANOPARTICLE; PENTETIC ACID DERIVATIVE;

ARTICLE; ATHEROSCLEROSIS; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; ELECTRON SPIN RESONANCE; HUMAN; IMAGE QUALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; SCANNING ELECTRON MICROSCOPY; THROMBUS;

EID: 0033646270     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/1522-2594(200012)44:6<867::AID-MRM7>3.0.CO;2-P     Document Type: Article

References (32)

1. Compensatory enlargement of human atherosclerotic coronary arteries
2. Molecular bases of the acute coronary syndromes
3. Pathophysiology and clinical significance of atherosclerotic plaque rupture
4. Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo
5. Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging
6. Noninvasive in vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice
7. High-resolution intravascular magnetic resonance imaging: Monitoring of plaque formation in heritable hyperlipidemic rabbits
8. Molecular imaging: Exploring the next frontier
9. Enhanced detection of thrombi with a novel fibrin-targeted magnetic resonance imaging agent
10. 3 targeted nanoparticles
11. Evaluation of the fibrin binding profile of two anti-fibrin monoclonal antibodies
12. A novel site-targeted ultrasonic contrast agent with broad biomedical application
13. Magnetic resonance images lipid, fibrous, calcified, hemorrhagic, and thrombotic components of human atherosclerosis in vivo
14. Strategies to achieve coronary arterial plaque stabilization
15. Cause of thrombosis in human atherosclerotic arteries
16. Noninvasive detection of atherosclerotic lesions by 99mTc-based immunoscintigraphic targeting of proliferating smooth muscle cells
17. Detection of atherosclerotic plaques in carotid arteries by the use of 123I-fibrinogen
18. In vitro targeting of antibody-conjugated echogenic liposomes for site-specific ultrasonic image enhancement
19. Iodine-131-labeled fibronectin: Potential agent for imaging atherosclerotic lesion and thrombus
20. Targeted contrast agents in MR imaging
21. Theory of paramagnetic contrast agents in liposome systems
22. The design of liposomal paramagnetic MR agents: Effect of vesicle size upon the relaxivity of surface-incorporated lipophilic chelates
23. Pharmacokinetics of stealth versus conventional liposomes: Effect of dose
24. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
25. Paramagnetic polymerized liposomes as new recirculating MR contrast agents
26. 3-targeted magnetic resonance imaging
27. Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents
28. Synthesis and relaxometry of high-generation (G = 5, 7, 9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates
29. In vivo efficacy of fibrin targeted perfluorocarbon contrast system following intravenous injection reflects prolonged systemic half-life and persistent acoustic contrast effect
30. Generation and partial characterization of five monoclonal antibodies with high affinities for fibrin
31. 3 epitopes using a nanoparticulate emulsion
32. Molecular imaging of stretch-induced tissue factor expression in carotid arteries with intravascular ultrasound