Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins

Science

Volumn 301, Issue 5641, 2003, Pages 1884-1886

  Nam, Jwa Min ^a   Thaxton, C Shad ^a   Mirkin, Chad A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BAR CODES; NANOSTRUCTURED MATERIALS;

ULTRASENSITIVE DETECTION;

ANTIBODIES;

ANTIBODY; DNA; NANOPARTICLE; OLIGONUCLEOTIDE; PROSTATE SPECIFIC ANTIGEN;

DNA; PROTEIN;

ANTIGEN BINDING; ANTIGEN DETECTION; ARTICLE; CONCENTRATION (PARAMETERS); GENE AMPLIFICATION; HYBRIDIZATION; MAGNETIC SEPARATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; SENSITIVITY AND SPECIFICITY; SURFACE PROPERTY;

ANTIBODIES; ANTIBODIES, MONOCLONAL; DNA; DNA, COMPLEMENTARY; GOLD; HUMANS; LIGHT; MAGNETICS; MICROSPHERES; MOLECULAR PROBE TECHNIQUES; NANOTECHNOLOGY; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTATE-SPECIFIC ANTIGEN; PROTEINS; SCATTERING, RADIATION; SENSITIVITY AND SPECIFICITY;

EID: 0141868926     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088755     Document Type: Article

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27. C.A.M. acknowledges the Air Force Office of Scientific Research, the Defense Advanced Research Projects Agency, and the NSF for support of this research. C.S.T. acknowledges the Howard Hughes Medical Institute for a Training fellowship. A. Schaeffer is acknowledged for helpful discussions, and V. Levenson assisted in PCR optimization.