Cell-specific targeting of nanoparticles by multivalent attachment of small molecules

Nature Biotechnology

Volumn 23, Issue 11, 2005, Pages 1418-1423

  Weissleder, Ralph ^a   Kelly, Kimberly ^a   Sun, Eric Yi ^a   Shtatland, Timur ^a   Josephson, Lee ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; CELLS; VIRUSES;

BIOLOGICAL PROPERTIES; BIOMEDICAL APPLICATIONS; NANOMATERIALS;

NANOSTRUCTURED MATERIALS;

FLUORESCENT DYE; NANOPARTICLE;

ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL SPECIFICITY; CONJUGATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MACROPHAGE; MAGNETISM; MOLECULAR SIZE; NANOTECHNOLOGY; PANCREAS CELL; PHENOTYPE; PRIORITY JOURNAL; SYNTHESIS;

ANIMALS; BIOMEDICAL ENGINEERING; BIOTECHNOLOGY; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SEPARATION; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE LIBRARY; HUMANS; MACROPHAGES; MICE; MICE, NUDE; NANOSTRUCTURES; NANOTECHNOLOGY; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PHENOTYPE;

EID: 27944496941     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1159     Document Type: Article

References (29)

1. Whitesides, G.M. The 'right' size in nanobiotechnology. Nat. Biotechnol. 21, 1161-1165 (2003).
2. Nam, J.M., Thaxton, C.S. & Mirkin, C.A. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301, 1884-1886 (2003).
3. Tsapis, N., Bennett, D., Jackson, B., Weitz, D.A. & Edwards, D.A. Trojan particles: large porous carriers of nanoparticles for drug delivery. Proc. Natl. Acad. Sci. USA 99, 12001-12005 (2002).
4. Gao, X. & Nie, S. Molecular profiling of single cells and tissue specimens with quantum dots. Trends Biotechnol. 21, 371-373 (2003).
5. Zorov, D.B., Kobrinsky, E., Juhaszova, M. & Sollott, S.J. Examining intracellular organelle function using fluorescent probes: from animalcules to quantum dots. Circ. Res. 95, 239-252 (2004).
6. Santra, S., Yang, H., Holloway, P.M., Stanley, J.T. & Mericle, R.A. Synthesis of water-dispersible fluorescent, radio-opaque, and paramagnetic CdS:Mn/ZnS quantum dots: a multifunctional probe for bioimaging. J. Am. Chem. Soc. 127, 1656-1657 (2005).
7. Huber, M.M. et al. Fluorescently detectable magnetic resonance imaging agents. Bioconjug. Chem. 9, 242-249 (1998).
8. Modo, M. et al. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage 21, 311-317 (2004).
9. Josephson, L., Kircher, M.F., Mahmood, U., Tang, Y. & Weissleder, R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug. Chem. 13, 554-560 (2002).
10. Kircher, M.F., Weissleder, R. & Josephson, L. A dual fluorochrome probe for imaging proteases. Bioconjug. Chem. 15, 242-248 (2004).
11. Wu, Y., Xiang, J., Yang, C., Lu, W. & Lieber, C.M. Single-crystal metallic nanowires and metal/semiconductor nanowire heterostructures. Nature 430, 61-65 (2004).
12. Kang, H.W., Josephson, L., Petrovsky, A., Weissleder, R. & Bogdanov, A., Jr. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug. Chem. 13, 122-127 (2002).
13. Hogemann, D., Ntziachristos, V., Josephson, L. & Weissleder, R. High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug. Chem. 13, 116-121 (2002).
14. Akerman, M.E., Chan, W.C., Laakkonen, P., Bhatia, S.N. & Ruoslahti, E. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. USA 99, 12617-12621 (2002).
15. Kelly, K.A. et al. Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ. Res. 96, 327-336 (2005).
16. Harisinghani, M.G. et al. Noninvasive detection of clinically occult lymphnode metastases in prostate cancer. N. Engl. J. Med. 348, 2491-2499 (2003).
17. Boullier, A. et al. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann. NY Acad. Sci. 947, 214-222, discussion 222-213 (2001).
18. Denis, M.C., Mahmood, U., Benoist, C., Mathis, D. & Weissleder, R. Imaging inflammation of the pancreatic islets in type 1 diabetes. Proc. Natl. Acad. Sci. USA 101, 12634-12639 (2004).
19. Libby, P. & Aikawa, M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat. Med. 8, 1257-1262 (2002).
20. Pham, W., Kircher, M.F., Weissleder, R. & Tung, C.H. Enhancing membrane permeability by fatty acylation of oligoarginine peptides. Chem. BioChem. 5, 1148-1151 (2004).
21. Anderson, D.G., Levenberg, S. & Langer, R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat. Biotechnol. 22, 863-866 (2004).
22. Goodman, C.M., McCusker, C.D., Yilmaz, T. & Rotello, V.M. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug. Chem. 15, 897-900 (2004).
23. Mammen, M., Chio, S-K. & Whitesides, G.M. Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Edn Engl. 37, 2755-2794 (1998).
24. Schreiber, S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 287, 1964-1969 (2000).
25. Shen, T., Weissleder, R., Papisov, M., Bogdanov, A., Jr. & Brady, T.J. Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn. Reson. Med. 29, 599-604 (1993).
26. Wunderbaldinger, P., Josephson, L. & Weissleder, R. Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad. Radiol. (suppl. 2) 9, S304-S306 (2002).
27. Kelly, K.A., Reynolds, F., Weissleder, R. & Josephson, L. Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions. Anal. Biochem. 330, 181-185 (2004).
28. de Hoon, M.J., Imoto, S., Nolan, J. & Miyano, S. Open source clustering software. Bioinformatics 20, 1453-1454 (2004).
29. Saldanha, A.J. Java Treeview - extensible visualization of microarray data. Bioinformatics 20, 3246-3248 (2004).