Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes

Biochimica et Biophysica Acta - Biomembranes

Volumn 1564, Issue 1, 2002, Pages 256-262

  Davidsen, Jesper ^a,b   Mouritsen, Ole G ^c   Jorgensen, Kent ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Drug delivery; Enhancer; Fatty acid; Liposome; Lysophospholipid; Membrane; Permeability; Surfactant

Indexed keywords

1 PALMITOYL 2 LYSOGLYCERO 3 PHOSPHOCHOLINE; CALCEIN; FATTY ACID; LYSOPHOSPHOLIPID; PALMITIC ACID; SURFACTANT; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; GEL; HYDROPHILICITY; LIPID MEMBRANE; LIQUID; MEMBRANE PERMEABILITY; PHYSIOLOGY; PRIORITY JOURNAL; TEMPERATURE; TIME;

DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; FLUORESCEINS; FLUORESCENT DYES; GELS; LYSOPHOSPHATIDYLCHOLINES; MEMBRANE LIPIDS; PALMITIC ACID; PERMEABILITY; SURFACE-ACTIVE AGENTS;

EID: 0037136068     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2736(02)00461-3     Document Type: Article

References (34)

1. Special issue of functional dynamics of lipids in biomembranes
2. Structure and dynamics of membranes
3. A new look at lipid-membrane structure in relation to drug research
4. Dynamical order and disorder in lipid bilayers
5. Small-scale lipid-membrane structure: Simulation versus experiment
6. Lipid membrane partitioning of lysolipids and fatty acids: Effects of membrane phase structure and detergent chain length
7. The effect of chain length and lipid phase transitions on the selective permeability properties of liposomes
8. The effect of aging on the physical stability of liposome dispersions
9. Effect of exogenous lysolecithin on liposomal membranes. Its relation to membrane fluidity
10. Effect of free fatty acids on the permeability of 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayer at the main phase transition
11. Free fatty acid effects on leakage, phase properties and fusion of fully hydrated model membranes
12. Studies on the lysis of red cells and bimolecular lipid leaflets by synthetic lysolecithins, lecithins and structural analogs
13. Effects of lysophosphatidylcholines on phosphatidylcholine and phosphatidylcholine/cholesterol liposome systems as revealed by 31P-NMR, electron microscopy and permeability studies
14. Cytolytic and membrane-perturbing properties of lysophosphatidylcholine
15. Interactions of lyso 1-palmitoylphosphatidylcholine with phospholipids-A C-13 and P-31 NMR-study
16. Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers
17. Fatty acid flip-flop in phospholipid bilayers is extremely fast
18. Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers
19. Structure of 1-acyl lysophosphatidylcholine and fatty acid complex in bilayers
20. Lysophosphatidylcholine-cholesterol complex
21. Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
22. Systematic relationship between phospholipase A2 activity and dynamic lipid bilayer microheterogeneity
23. Phospholipase A2 activity and physical properties of lipid-bilayer substrates
24. Surfactant-induced leakage and structural-change of lecithin vesicles - Effect of surfactant headgroup size
25. Kinetics of surfactant-induced leakage and growth of unilamellar vesicles
26. Lysolipid exchange with lipid vesicle membranes
27. Role of lateral phase separation in the modulation of phospholipase A2 activity
28. Enhancement of Agkistrodon piscivorus piscivorus venom phospholipase A2 activity toward phosphatidylcholine vesicles by lysolecithin and palmitic acid: Studies with fluorescent probes of membrane structure
29. Relationships between bilayer structure and phospholipase A2 activity: Interactions among temperature, diacylglycerol, lysolecithin, palmitic acid, and dipalmitoylphosphatidylcholine
30. Osmotic dependence of the lysophosphatidylcholine lytic action on liposomes in the gel state
31. Theory of thermal anomalies in the specific-heat of lipid bilayers containing cholesterol
32. Quantitative studies on lysolecithin mediated hemolysis. Benzylated lysolecithin as a probe to study effects of temperature and red cell species on the hemolytic reaction
33. Quantitative studies on lysolecithin-mediated hemolysis. Use of ether-deoxy lysolecithin analogs with varying aliphatic chain-lengths