메뉴 건너뛰기




Volumn 7, Issue 6, 2006, Pages 449-463

In vivo imaging of the diseased nervous system

Author keywords

[No Author keywords available]

Indexed keywords

GADOLINIUM;

EID: 33745740498     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn1905     Document Type: Review
Times cited : (162)

References (172)
  • 1
    • 0035513604 scopus 로고    scopus 로고
    • The neuronal naturalist: Watching neurons in their native habitat
    • Lichtman, J. W. & Fraser, S. E. The neuronal naturalist: watching neurons in their native habitat. Nature Neurosci. 4 (Suppl.), 1215-1220 (2001). An overview of the conceptual advantages of in vivo imaging studies in the nervous system.
    • (2001) Nature Neurosci. , vol.4 , Issue.SUPPL. , pp. 1215-1220
    • Lichtman, J.W.1    Fraser, S.E.2
  • 2
    • 0037180832 scopus 로고    scopus 로고
    • Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    • Trachtenberg, J. T. et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420, 788-794 (2002).
    • (2002) Nature , vol.420 , pp. 788-794
    • Trachtenberg, J.T.1
  • 3
    • 0037180796 scopus 로고    scopus 로고
    • Long-term dendritic spine stability in the adult cortex
    • Grutzendler, J., Kasthuri, N. & Gan, W. B. Long-term dendritic spine stability in the adult cortex. Nature 420, 812-816 (2002).
    • (2002) Nature , vol.420 , pp. 812-816
    • Grutzendler, J.1    Kasthuri, N.2    Gan, W.B.3
  • 4
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neurosci. 8, 752-758 (2005).
    • (2005) Nature Neurosci. , vol.8 , pp. 752-758
    • Davalos, D.1
  • 5
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005). References 4 and 5 are the first reports to illustrate the remarkable in vivo dynamics of microglia cells in the brain.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 6
    • 0037459839 scopus 로고    scopus 로고
    • False resurrections: Distinguishing regenerated from spared axons in the injured central nervous system
    • Steward, O., Zheng, B. & Tessier-Lavigne, M. False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol. 459, 1-8 (2003).
    • (2003) J. Comp. Neurol. , vol.459 , pp. 1-8
    • Steward, O.1    Zheng, B.2    Tessier-Lavigne, M.3
  • 7
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • Medana, I., Martinic, M. A., Wekerle, H. & Neumann, H. Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am. J. Pathol. 159, 809-815 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 8
    • 0033401226 scopus 로고    scopus 로고
    • Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease
    • Merrill, J. E. & Scolding, N. J. Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease. Neuropathol. Appl. Neurobiol. 25, 435-458 (1999).
    • (1999) Neuropathol. Appl. Neurobiol. , vol.25 , pp. 435-458
    • Merrill, J.E.1    Scolding, N.J.2
  • 9
    • 0032486428 scopus 로고    scopus 로고
    • Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    • Griffiths, I. et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280, 1610-1613 (1998).
    • (1998) Science , vol.280 , pp. 1610-1613
    • Griffiths, I.1
  • 10
    • 0037441487 scopus 로고    scopus 로고
    • Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
    • Bjartmar, C., Wujek, J. R. & Trapp, B. D. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J. Neurol. Sci. 206, 165-171 (2003).
    • (2003) J. Neurol. Sci. , vol.206 , pp. 165-171
    • Bjartmar, C.1    Wujek, J.R.2    Trapp, B.D.3
  • 11
    • 0034656415 scopus 로고    scopus 로고
    • IFNγ enhances microglial reactions to hippocampal axonal degeneration
    • Jensen, M. B., Hegelund, I. V., Lomholt, N. D., Finsen, B. & Owens, T. IFNγ enhances microglial reactions to hippocampal axonal degeneration. J. Neurosci. 20, 3612-3621 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 3612-3621
    • Jensen, M.B.1    Hegelund, I.V.2    Lomholt, N.D.3    Finsen, B.4    Owens, T.5
  • 12
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Bacskai, B. J. et al. Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Med. 7, 369-372 (2001). Introduces important tools for in vivo multiphoton studies in animal models of Alzheimer's disease.
    • (2001) Nature Med. , vol.7 , pp. 369-372
    • Bacskai, B.J.1
  • 13
    • 0015344426 scopus 로고
    • Neuronal dynamics and axonal flow: Axonal peristalsis
    • Weiss, P. A. Neuronal dynamics and axonal flow: axonal peristalsis. Proc. Natl Acad. Sci. USA 69, 1309-1312 (1972).
    • (1972) Proc. Natl Acad. Sci. USA , vol.69 , pp. 1309-1312
    • Weiss, P.A.1
  • 14
    • 0014766574 scopus 로고
    • Surface movements during the growth of single explanted neurons
    • Bray, D. Surface movements during the growth of single explanted neurons. Proc. Natl Acad. Sci. USA 65, 905-910 (1970).
    • (1970) Proc. Natl Acad. Sci. USA , vol.65 , pp. 905-910
    • Bray, D.1
  • 16
    • 0025342635 scopus 로고
    • Two-photon laser scanning fluorescence microscopy
    • Denk, W., Strickler, J. H. & Webb, W. W. Two-photon laser scanning fluorescence microscopy. Science 248, 73-76 (1990).
    • (1990) Science , vol.248 , pp. 73-76
    • Denk, W.1    Strickler, J.H.2    Webb, W.W.3
  • 17
    • 0242353872 scopus 로고    scopus 로고
    • Nonlinear magic: Multiphoton microscopy in the biosciences
    • Zipfel, W. R., Williams, R. M. & Webb, W. W. Nonlinear magic: multiphoton microscopy in the biosciences. Nature Biotechnol. 21, 1369-1377 (2003).
    • (2003) Nature Biotechnol. , vol.21 , pp. 1369-1377
    • Zipfel, W.R.1    Williams, R.M.2    Webb, W.W.3
  • 18
    • 30944450665 scopus 로고    scopus 로고
    • Deep tissue two-photon microscopy
    • Helmchen, F. & Denk, W. Deep tissue two-photon microscopy. Nature Methods 2, 932-940 (2005).
    • (2005) Nature Methods , vol.2 , pp. 932-940
    • Helmchen, F.1    Denk, W.2
  • 20
    • 1842610983 scopus 로고    scopus 로고
    • High-resolution in vivo imaging of hippocampal dendrites and spines
    • Mizrahi, A., Crowley, J. C., Shtoyerman, E. & Katz, L. C. High-resolution in vivo imaging of hippocampal dendrites and spines. J. Neurosci. 24, 3147-3151 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 3147-3151
    • Mizrahi, A.1    Crowley, J.C.2    Shtoyerman, E.3    Katz, L.C.4
  • 22
    • 0035959949 scopus 로고    scopus 로고
    • A miniature head-mounted two-photon microscope. High-resolution brain imaging in freely moving animals
    • Helmchen, F., Fee, M. S., Tank, D. W. & Denk, W. A miniature head-mounted two-photon microscope. High-resolution brain imaging in freely moving animals. Neuron 31, 903-912 (2001). Describes a new approach for in vivo imaging with cellular resolution in awake, behaving rodents.
    • (2001) Neuron , vol.31 , pp. 903-912
    • Helmchen, F.1    Fee, M.S.2    Tank, D.W.3    Denk, W.4
  • 23
    • 30944448496 scopus 로고    scopus 로고
    • Fiber-optic fluorescence imaging
    • Flusberg, B. A. et al. Fiber-optic fluorescence imaging. Nature Methods 2, 941-950 (2005).
    • (2005) Nature Methods , vol.2 , pp. 941-950
    • Flusberg, B.A.1
  • 24
    • 5344222679 scopus 로고    scopus 로고
    • Labeling neurons in vivo for morphological and functional studies
    • Young, P. & Feng, G. Labeling neurons in vivo for morphological and functional studies. Curr. Opin. Neurobiol. 14, 642-646 (2004).
    • (2004) Curr. Opin. Neurobiol. , vol.14 , pp. 642-646
    • Young, P.1    Feng, G.2
  • 25
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng, G. et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28, 41-51 (2000). The introduction of Thy1-XFP transgenic mice, which are the basis for most in vivo imaging studies of neurons.
    • (2000) Neuron , vol.28 , pp. 41-51
    • Feng, G.1
  • 27
    • 33244459814 scopus 로고    scopus 로고
    • Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex
    • Lee, W. C. et al. Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol. 4, e29 (2005).
    • (2005) PLoS Biol. , vol.4
    • Lee, W.C.1
  • 28
    • 0035899304 scopus 로고    scopus 로고
    • Asynchronous synapse elimination in neonatal motor units: Studies using GFP transgenic mice
    • Keller-Peck, C. R. et al. Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice. Neuron 31, 381-394 (2001).
    • (2001) Neuron , vol.31 , pp. 381-394
    • Keller-Peck, C.R.1
  • 29
    • 28644436113 scopus 로고    scopus 로고
    • Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury
    • Bareyre, F. M., Kerschensteiner, M., Misgeld, T. & Sanes, J. R. Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. Nature Med. 11, 1355-1360 (2005).
    • (2005) Nature Med. , vol.11 , pp. 1355-1360
    • Bareyre, F.M.1    Kerschensteiner, M.2    Misgeld, T.3    Sanes, J.R.4
  • 30
    • 0347927492 scopus 로고    scopus 로고
    • Visualization of S100B-positive neurons and glia in the central nervous system of EGFP transgenic mice
    • Vives, V., Alonso, G., Solal, A. C., Joubert, D. & Legraverend, C. Visualization of S100B-positive neurons and glia in the central nervous system of EGFP transgenic mice. J. Comp. Neurol. 457, 404-419 (2003).
    • (2003) J. Comp. Neurol. , vol.457 , pp. 404-419
    • Vives, V.1    Alonso, G.2    Solal, A.C.3    Joubert, D.4    Legraverend, C.5
  • 31
    • 19944421733 scopus 로고    scopus 로고
    • Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells for vital examination
    • Zuo, Y. et al. Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells for vital examination. J. Neurosci. 24, 10999-11009 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 10999-11009
    • Zuo, Y.1
  • 32
    • 0031193324 scopus 로고    scopus 로고
    • Live astrocytes visualized by green fluorescent protein in transgenic mice
    • Zhuo, L. et al. Live astrocytes visualized by green fluorescent protein in transgenic mice. Dev. Biol. 187, 36-42 (1997).
    • (1997) Dev. Biol. , vol.187 , pp. 36-42
    • Zhuo, L.1
  • 33
    • 0035132767 scopus 로고    scopus 로고
    • GFAP promoter-controlled EGFP-expressing transgenic mice: A tool to visualize astrocytes and astrogliosis in living brain tissue
    • Nolte, C. et al. GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue. Glia 33, 72-86 (2001).
    • (2001) Glia , vol.33 , pp. 72-86
    • Nolte, C.1
  • 34
    • 26244439673 scopus 로고    scopus 로고
    • Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice
    • Hirrlinger, P. G. et al. Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice. Mol. Cell. Neurosci. 30, 291-303 (2005).
    • (2005) Mol. Cell. Neurosci. , vol.30 , pp. 291-303
    • Hirrlinger, P.G.1
  • 35
    • 0034651644 scopus 로고    scopus 로고
    • Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein
    • Fuss, B. et al. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev. Biol. 218, 259-274 (2000).
    • (2000) Dev. Biol. , vol.218 , pp. 259-274
    • Fuss, B.1
  • 36
    • 0034028817 scopus 로고    scopus 로고
    • 3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • 3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106-4114 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4106-4114
    • Jung, S.1
  • 37
    • 3042734521 scopus 로고    scopus 로고
    • In vivo imaging of leukocyte trafficking in blood vessels and tissues
    • Mempel, T. R., Scimone, M. L., Mora, J. R. & von Andrian, U. H. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 16, 406-417 (2004).
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 406-417
    • Mempel, T.R.1    Scimone, M.L.2    Mora, J.R.3    Von Andrian, U.H.4
  • 38
    • 19944429120 scopus 로고    scopus 로고
    • Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo
    • Dittgen, T. et al. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc. Natl Acad. Sci. USA 101, 18206-18211 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 18206-18211
    • Dittgen, T.1
  • 39
    • 0344780200 scopus 로고    scopus 로고
    • + T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses
    • + T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Med. 5, 843-847 (1999).
    • (1999) Nature Med. , vol.5 , pp. 843-847
    • Flugel, A.1    Willem, M.2    Berkowicz, T.3    Wekerle, H.4
  • 40
    • 16244423322 scopus 로고    scopus 로고
    • Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation
    • Borrell, V., Yoshimura, Y. & Callaway, E. M. Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation. J. Neurosci. Methods 143, 151-158 (2005).
    • (2005) J. Neurosci. Methods , vol.143 , pp. 151-158
    • Borrell, V.1    Yoshimura, Y.2    Callaway, E.M.3
  • 41
    • 0035046041 scopus 로고    scopus 로고
    • Single-cell electroporation for gene transfer in vivo
    • Haas, K., Sin, W. C., Javaherian, A., Li, Z. & Cline, H. T. Single-cell electroporation for gene transfer in vivo. Neuron 29, 583-591 (2001).
    • (2001) Neuron , vol.29 , pp. 583-591
    • Haas, K.1    Sin, W.C.2    Javaherian, A.3    Li, Z.4    Cline, H.T.5
  • 42
    • 18744409106 scopus 로고    scopus 로고
    • Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    • Nimmerjahn, A., Kirchhoff, F., Kerr, J. N. & Helmchen, F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nature Methods 1, 31-37 (2004).
    • (2004) Nature Methods , vol.1 , pp. 31-37
    • Nimmerjahn, A.1    Kirchhoff, F.2    Kerr, J.N.3    Helmchen, F.4
  • 43
    • 0024458923 scopus 로고
    • Development of glomerular pattern visualized in the olfactory bulbs of living mice
    • LaMantia, A. S. & Purves, D. Development of glomerular pattern visualized in the olfactory bulbs of living mice. Nature 341, 646-649 (1989).
    • (1989) Nature , vol.341 , pp. 646-649
    • Lamantia, A.S.1    Purves, D.2
  • 44
    • 0014816955 scopus 로고
    • In vivo observations on mature myelinated nerve fibres of the mouse
    • Williams, P. L. & Hall, S. M. In vivo observations on mature myelinated nerve fibres of the mouse. J. Anat. 107, 31-38 (1970).
    • (1970) J. Anat. , vol.107 , pp. 31-38
    • Williams, P.L.1    Hall, S.M.2
  • 45
    • 0031025151 scopus 로고    scopus 로고
    • Measuring serotonin distribution in live cells with three-photon excitation
    • Maiti, S., Shear, J. B., Williams, R. M., Zipfel, W. R. & Webb, W. W. Measuring serotonin distribution in live cells with three-photon excitation. Science 275, 530-532 (1997).
    • (1997) Science , vol.275 , pp. 530-532
    • Maiti, S.1    Shear, J.B.2    Williams, R.M.3    Zipfel, W.R.4    Webb, W.W.5
  • 46
    • 0023126794 scopus 로고
    • Fluorescent probes that stain living nerve terminals
    • Magrassi, L., Purves, D. & Lichtman, J. W. Fluorescent probes that stain living nerve terminals. J. Neurosci. 7, 1207-1214 (1987).
    • (1987) J. Neurosci. , vol.7 , pp. 1207-1214
    • Magrassi, L.1    Purves, D.2    Lichtman, J.W.3
  • 47
    • 0021918560 scopus 로고
    • Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes
    • Lichtman, J. W., Wilkinson, R. S. & Rich, M. M. Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes. Nature 314, 357-359 (1985).
    • (1985) Nature , vol.314 , pp. 357-359
    • Lichtman, J.W.1    Wilkinson, R.S.2    Rich, M.M.3
  • 48
    • 0032937384 scopus 로고    scopus 로고
    • Monitoring secretory membrane with FM1-43 fluorescence
    • Cochilla, A. J., Angleson, J. K. & Betz, W. J. Monitoring secretory membrane with FM1-43 fluorescence. Annu. Rev. Neurosci. 22, 1-10 (1999).
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 1-10
    • Cochilla, A.J.1    Angleson, J.K.2    Betz, W.J.3
  • 49
    • 0032622376 scopus 로고    scopus 로고
    • Targeting GFP to organelles
    • De, G. F. et al. Targeting GFP to organelles. Methods Cell Biol. 58, 75-85 (1999).
    • (1999) Methods Cell Biol. , vol.58 , pp. 75-85
    • De, G.F.1
  • 50
    • 0242585297 scopus 로고    scopus 로고
    • AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks
    • DePaola, V., Arber, S. & Caroni, P. AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks. Nature Neurosci. 6, 491-500 (2003).
    • (2003) Nature Neurosci. , vol.6 , pp. 491-500
    • Depaola, V.1    Arber, S.2    Caroni, P.3
  • 51
    • 3242661158 scopus 로고    scopus 로고
    • FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain
    • Umemori, H., Linhoff, M. W., Ornitz, D. M. & Sanes, J. R. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell 118, 257-270 (2004).
    • (2004) Cell , vol.118 , pp. 257-270
    • Umemori, H.1    Linhoff, M.W.2    Ornitz, D.M.3    Sanes, J.R.4
  • 52
    • 17844366567 scopus 로고    scopus 로고
    • Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin
    • Li, Z. et al. Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin. Proc. Natl Acad. Sci. USA 102, 6131-6136 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 6131-6136
    • Li, Z.1
  • 53
    • 2942522631 scopus 로고    scopus 로고
    • Genetic methods for illuminating the function of neural circuits
    • Miesenbock, G. Genetic methods for illuminating the function of neural circuits. Curr. Opin. Neurobiol. 14, 395-402 (2004).
    • (2004) Curr. Opin. Neurobiol. , vol.14 , pp. 395-402
    • Miesenbock, G.1
  • 54
    • 0027426008 scopus 로고
    • The layout of iso-orientation domains in area 18 of cat visual cortex: Optical imaging reveals a pinwheel-like organization
    • Bonhoeffer, T. & Grinvald, A. The layout of iso-orientation domains in area 18 of cat visual cortex: optical imaging reveals a pinwheel-like organization. J. Neurosci. 13, 4157-4180 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 4157-4180
    • Bonhoeffer, T.1    Grinvald, A.2
  • 55
    • 0036432572 scopus 로고    scopus 로고
    • Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord
    • Sasaki, S. et al. Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord. Neuroimage 17, 1240-1255 (2002).
    • (2002) Neuroimage , vol.17 , pp. 1240-1255
    • Sasaki, S.1
  • 56
    • 0026658279 scopus 로고
    • Optical imaging of epileptiform and functional activity in human cerebral cortex
    • Haglund, M. M., Ojemann, G. A. & Hochman, D. W. Optical imaging of epileptiform and functional activity in human cerebral cortex. Nature 358, 668-671 (1992). This study was one of the first to show that intrinsic optical imaging can be used to generate maps of epileptiform or physiological activity in the human cortex.
    • (1992) Nature , vol.358 , pp. 668-671
    • Haglund, M.M.1    Ojemann, G.A.2    Hochman, D.W.3
  • 58
    • 0031021713 scopus 로고    scopus 로고
    • In vivo dendritic calcium dynamics in neocortical pyramidal neurons
    • Svoboda, K., Denk, W., Kleinfeld, D. & Tank, D. W. In vivo dendritic calcium dynamics in neocortical pyramidal neurons. Nature 385, 161-165 (1997). Illustrates that multiphoton imaging can be used to follow stimulation-induced calcium dynamics in cortical dendrites in vivo.
    • (1997) Nature , vol.385 , pp. 161-165
    • Svoboda, K.1    Denk, W.2    Kleinfeld, D.3    Tank, D.W.4
  • 59
    • 0025924376 scopus 로고
    • 2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters
    • 2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters. Neuron 6, 333-344 (1991).
    • (1991) Neuron , vol.6 , pp. 333-344
    • Yuste, R.1    Katz, L.C.2
  • 60
    • 0038809066 scopus 로고    scopus 로고
    • In vivo two-photon calcium imaging of neuronal networks
    • Stosiek, C., Garaschuk, O., Holthoff, K. & Konnerth, A. In vivo two-photon calcium imaging of neuronal networks. Proc. Natl Acad. Sci. USA 100, 7319-7324 (2003). Introduces the 'multicell bolus loading' technique that is used widely to label neurons and glial cells with calcium indicators in vivo.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7319-7324
    • Stosiek, C.1    Garaschuk, O.2    Holthoff, K.3    Konnerth, A.4
  • 61
    • 14144249743 scopus 로고    scopus 로고
    • Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
    • Ohki, K., Chung, S., Ch'ng, Y. H., Kara, P. & Reid, R. C. Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Nature 433, 597-603 (2005).
    • (2005) Nature , vol.433 , pp. 597-603
    • Ohki, K.1    Chung, S.2    Ch'ng, Y.H.3    Kara, P.4    Reid, R.C.5
  • 63
    • 16644367431 scopus 로고    scopus 로고
    • 2+ indicator proteins in transgenic mice under TET control
    • 2+ indicator proteins in transgenic mice under TET control. PLoS Biol. 2, e163 (2004).
    • (2004) PLoS Biol. , vol.2
    • Hasan, M.T.1
  • 64
    • 26944499780 scopus 로고    scopus 로고
    • Innovations in the imaging of brain functions using fluorescent proteins
    • Miyawaki, A. Innovations in the imaging of brain functions using fluorescent proteins. Neuron 48, 189-199 (2005).
    • (2005) Neuron , vol.48 , pp. 189-199
    • Miyawaki, A.1
  • 65
    • 0742287636 scopus 로고    scopus 로고
    • Optical recording of action potentials with second-harmonic generation microscopy
    • Dombeck, D. A., Blanchard-Desce, M. & Webb, W. W. Optical recording of action potentials with second-harmonic generation microscopy. J. Neurosci. 24, 999-1003 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 999-1003
    • Dombeck, D.A.1    Blanchard-Desce, M.2    Webb, W.W.3
  • 67
    • 3042856289 scopus 로고    scopus 로고
    • High sensitivity of Stark-shift voltage-sensing dyes by one- or two-photon excitation near the red spectral edge
    • Kuhn, B., Fromherz, P. & Denk, W. High sensitivity of Stark-shift voltage-sensing dyes by one- or two-photon excitation near the red spectral edge. Biophys. J. 87, 631-639 (2004).
    • (2004) Biophys. J. , vol.87 , pp. 631-639
    • Kuhn, B.1    Fromherz, P.2    Denk, W.3
  • 68
    • 0036929862 scopus 로고    scopus 로고
    • Tuning FlaSh: Redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential
    • Guerrero, G., Siegel, M. S., Roska, B., Loots, E. & Isacoff, E. Y. Tuning FlaSh: redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential. Biophys. J. 83, 3607-3618 (2002).
    • (2002) Biophys. J. , vol.83 , pp. 3607-3618
    • Guerrero, G.1    Siegel, M.S.2    Roska, B.3    Loots, E.4    Isacoff, E.Y.5
  • 69
    • 0013986904 scopus 로고
    • On the mechanics of myelin sphere formation in Wallerian degeneration. Intravital microscopic studies of single degenerating motor fibers of the frog
    • Hollander, H. & Mehraein, P. On the mechanics of myelin sphere formation in Wallerian degeneration. Intravital microscopic studies of single degenerating motor fibers of the frog. Z. Zellforsch. Mikrosk. Anat. 72, 276-280 (1966).
    • (1966) Z. Zellforsch. Mikrosk. Anat. , vol.72 , pp. 276-280
    • Hollander, H.1    Mehraein, P.2
  • 70
    • 0015044534 scopus 로고
    • Prolonged in vivo observations of normal peripheral nerve fibres and their acute reactions to crush and deliberate trauma
    • Williams, P. L. & Hall, S. M. Prolonged in vivo observations of normal peripheral nerve fibres and their acute reactions to crush and deliberate trauma. J. Anat. 108, 397-408 (1971).
    • (1971) J. Anat. , vol.108 , pp. 397-408
    • Williams, P.L.1    Hall, S.M.2
  • 71
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: Commonality amid diversity
    • Coleman, M. Axon degeneration mechanisms: commonality amid diversity. Nature Rev. Neurosci. 6, 889-898 (2005).
    • (2005) Nature Rev. Neurosci. , vol.6 , pp. 889-898
    • Coleman, M.1
  • 72
    • 0036727464 scopus 로고    scopus 로고
    • Pre-existing pathways promote precise projection patterns
    • Nguyen, Q. T., Sanes, J. R. & Lichtman, J. W. Pre-existing pathways promote precise projection patterns. Nature Neurosci. 5, 861-867 (2002).
    • (2002) Nature Neurosci. , vol.5 , pp. 861-867
    • Nguyen, Q.T.1    Sanes, J.R.2    Lichtman, J.W.3
  • 73
    • 0348109345 scopus 로고    scopus 로고
    • Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo
    • Pan, Y. A., Misgeld, T., Lichtman, J. W. & Sanes, J. R. Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. J. Neurosci. 23, 11479-11488 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 11479-11488
    • Pan, Y.A.1    Misgeld, T.2    Lichtman, J.W.3    Sanes, J.R.4
  • 74
    • 18844436224 scopus 로고    scopus 로고
    • In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    • Kerschensteiner, M., Schwab, M. E., Lichtman, J. W. & Misgeld, T. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nature Med. 11, 572-577 (2005).
    • (2005) Nature Med. , vol.11 , pp. 572-577
    • Kerschensteiner, M.1    Schwab, M.E.2    Lichtman, J.W.3    Misgeld, T.4
  • 75
    • 4043079197 scopus 로고    scopus 로고
    • P2X7 receptor inhibition improves recovery after spinal cord injury
    • Wang, X. et al. P2X7 receptor inhibition improves recovery after spinal cord injury. Nature Med. 10, 821-827 (2004).
    • (2004) Nature Med. , vol.10 , pp. 821-827
    • Wang, X.1
  • 76
    • 3042807052 scopus 로고    scopus 로고
    • Cyclic AMP-induced repair of zebrafish spinal circuits
    • Bhatt, D. H., Otto, S. J., Depoister, B. & Fetcho, J. R. Cyclic AMP-induced repair of zebrafish spinal circuits. Science 305, 254-258 (2004). Shows that in vivo imaging can help to document axonal regeneration and functional reconnection in the CNS of zebrafish.
    • (2004) Science , vol.305 , pp. 254-258
    • Bhatt, D.H.1    Otto, S.J.2    Depoister, B.3    Fetcho, J.R.4
  • 77
    • 0037071880 scopus 로고    scopus 로고
    • Spinal axon regeneration induced by elevation of cyclic AMP
    • Qiu, J. et al. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron 34, 895-903 (2002).
    • (2002) Neuron , vol.34 , pp. 895-903
    • Qiu, J.1
  • 78
    • 0037572316 scopus 로고    scopus 로고
    • Controlled damage in thick specimens by multiphoton excitation
    • Galbraith, J. A. & Terasaki, M. Controlled damage in thick specimens by multiphoton excitation. Mol. Biol. Cell 14, 1808-1817 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1808-1817
    • Galbraith, J.A.1    Terasaki, M.2
  • 79
    • 16544363197 scopus 로고    scopus 로고
    • Neurosurgery: Functional regeneration after laser axotomy
    • Yanik, M. F. et al. Neurosurgery: functional regeneration after laser axotomy. Nature 432, 822 (2004).
    • (2004) Nature , vol.432 , pp. 822
    • Yanik, M.F.1
  • 80
    • 0035116442 scopus 로고    scopus 로고
    • Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy
    • Christie, R. H. et al. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J. Neurosci. 21, 858-864 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 858-864
    • Christie, R.H.1
  • 81
    • 0037444553 scopus 로고    scopus 로고
    • In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy
    • McLellan, M. E., Kajdasz, S. T., Hyman, B. T. & Bacskai, B. J. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J. Neurosci. 23, 2212-2217 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 2212-2217
    • McLellan, M.E.1    Kajdasz, S.T.2    Hyman, B.T.3    Bacskai, B.J.4
  • 82
    • 7044220336 scopus 로고    scopus 로고
    • Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
    • Tsai, J., Grutzendler, J., Duff, K. & Gan, W. B. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nature Neurosci. 7, 1181-1183 (2004).
    • (2004) Nature Neurosci. , vol.7 , pp. 1181-1183
    • Tsai, J.1    Grutzendler, J.2    Duff, K.3    Gan, W.B.4
  • 83
    • 23444448170 scopus 로고    scopus 로고
    • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    • Spires, T. L. et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 25, 7278-7287 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 7278-7287
    • Spires, T.L.1
  • 84
    • 85047691873 scopus 로고    scopus 로고
    • Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
    • Brendza, R. P. et al. Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J. Clin. Invest. 115, 428-433 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 428-433
    • Brendza, R.P.1
  • 85
    • 2442711566 scopus 로고    scopus 로고
    • Cortical synaptic integration in vivo is disrupted by amyloid-β plaques
    • Stern, E. A. et al. Cortical synaptic integration in vivo is disrupted by amyloid-β plaques. J. Neurosci. 24, 4535-4540 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 4535-4540
    • Stern, E.A.1
  • 86
    • 23744445580 scopus 로고    scopus 로고
    • A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
    • Schaefer, A. M., Sanes, J. R. & Lichtman, J. W. A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis. J. Comp. Neurol. 490, 209-219 (2005).
    • (2005) J. Comp. Neurol. , vol.490 , pp. 209-219
    • Schaefer, A.M.1    Sanes, J.R.2    Lichtman, J.W.3
  • 87
    • 2342561865 scopus 로고    scopus 로고
    • Motor neurons rely on motor proteins
    • Holzbaur, E. L. Motor neurons rely on motor proteins. Trends Cell Biol. 14, 233-240 (2004).
    • (2004) Trends Cell Biol. , vol.14 , pp. 233-240
    • Holzbaur, E.L.1
  • 88
    • 11144355226 scopus 로고    scopus 로고
    • Dysmyelinated lower motor neurons retract and regenerate dysfunctional synaptic terminals
    • Yin, X. et al. Dysmyelinated lower motor neurons retract and regenerate dysfunctional synaptic terminals. J. Neurosci. 24, 3890-3898 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 3890-3898
    • Yin, X.1
  • 89
    • 0028290563 scopus 로고
    • Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study
    • Villringer, A., Them, A., Lindauer, U., Einhaupl, K. & Dirnagl, U. Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. Circ. Res. 75, 55-62 (1994).
    • (1994) Circ. Res. , vol.75 , pp. 55-62
    • Villringer, A.1    Them, A.2    Lindauer, U.3    Einhaupl, K.4    Dirnagl, U.5
  • 90
    • 0031154065 scopus 로고    scopus 로고
    • Blood flow in the cerebral capillary network: A review emphasizing observations with intravital microscopy
    • Hudetz, A. G. Blood flow in the cerebral capillary network: a review emphasizing observations with intravital microscopy. Microcirculation 4, 233-252 (1997).
    • (1997) Microcirculation , vol.4 , pp. 233-252
    • Hudetz, A.G.1
  • 91
    • 0032417876 scopus 로고    scopus 로고
    • Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex
    • Kleinfeld, D., Mitra, P. P., Helmchen, F. & Denk, W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc. Natl Acad. Sci. USA 95, 15741-15746 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 15741-15746
    • Kleinfeld, D.1    Mitra, P.P.2    Helmchen, F.3    Denk, W.4
  • 92
    • 33244478081 scopus 로고    scopus 로고
    • Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion
    • Schaffer, C. B. et al. Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol. 4, e22 (2006).
    • (2006) PLoS Biol. , vol.4
    • Schaffer, C.B.1
  • 93
    • 31744448499 scopus 로고    scopus 로고
    • Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: Three models of stroke
    • Nishimura, N. et al. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nature Methods 3, 99-108 (2006). Together with reference 92, this publication introduces a new multiphoton-based toolkit to study vessel occlusion and ischaemia in the brain.
    • (2006) Nature Methods , vol.3 , pp. 99-108
    • Nishimura, N.1
  • 94
    • 33644664042 scopus 로고    scopus 로고
    • A model of mini-embolic stroke offers measurements of the neurovascular unit response in the living mouse
    • Zhang, Z. G. et al. A model of mini-embolic stroke offers measurements of the neurovascular unit response in the living mouse. Stroke 36, 2701-2704 (2005).
    • (2005) Stroke , vol.36 , pp. 2701-2704
    • Zhang, Z.G.1
  • 95
    • 20044374010 scopus 로고    scopus 로고
    • Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia
    • Zhang, S., Boyd, J., Delaney, K. & Murphy, T. H. Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. J. Neurosci. 25, 5333-5338 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 5333-5338
    • Zhang, S.1    Boyd, J.2    Delaney, K.3    Murphy, T.H.4
  • 96
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature Rev. Neurosci. 5, 347-360 (2004).
    • (2004) Nature Rev. Neurosci. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 97
    • 31544456102 scopus 로고    scopus 로고
    • Astrocyte-mediated control of cerebral blood flow
    • Takano, T. et al. Astrocyte-mediated control of cerebral blood flow. Nature Neurosci. 9, 260-267 (2006).
    • (2006) Nature Neurosci. , vol.9 , pp. 260-267
    • Takano, T.1
  • 98
    • 0037223147 scopus 로고    scopus 로고
    • Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    • Zonta, M. et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature Neurosci. 6, 43-50 (2003).
    • (2003) Nature Neurosci. , vol.6 , pp. 43-50
    • Zonta, M.1
  • 99
    • 4544222190 scopus 로고    scopus 로고
    • Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
    • Mulligan, S. J. & MacVicar, B. A. Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature 431, 195-199 (2004).
    • (2004) Nature , vol.431 , pp. 195-199
    • Mulligan, S.J.1    MacVicar, B.A.2
  • 100
    • 85047682713 scopus 로고    scopus 로고
    • α4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
    • Vajkoczy, P., Laschinger, M. & Engelhardt, B. α4-integrin-VCAM- 1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J. Clin. Invest. 108, 557-565 (2001). Introduction of a spinal cord window technique that provides a direct view of the spinal microcirculation, and that is used to study the molecular interactions underlying transmigration of encephalitogenic T cells.
    • (2001) J. Clin. Invest. , vol.108 , pp. 557-565
    • Vajkoczy, P.1    Laschinger, M.2    Engelhardt, B.3
  • 101
    • 0037083641 scopus 로고    scopus 로고
    • i-linked receptors
    • i-linked receptors. J. Immunol. 168, 1940-1949 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1940-1949
    • Piccio, L.1
  • 102
    • 17044372405 scopus 로고    scopus 로고
    • CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis - An intravital microscopy study
    • dos Santos, A. C. et al. CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis - an intravital microscopy study. J. Neuroimmunol. 162, 122-129 (2005).
    • (2005) J. Neuroimmunol. , vol.162 , pp. 122-129
    • Dos Santos, A.C.1
  • 103
    • 0037413467 scopus 로고    scopus 로고
    • A controlled trial of natalizumab for relapsing multiple sclerosis
    • Miller, D. H. et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 348, 15-23 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 15-23
    • Miller, D.H.1
  • 104
    • 10344264520 scopus 로고    scopus 로고
    • IVIg therapy in brain inflammation: Etiology-dependent differential effects on leucocyte recruitment
    • Lapointe, B. M., Herx, L. M., Gill, V., Metz, L. M. & Kubes, P. IVIg therapy in brain inflammation: etiology-dependent differential effects on leucocyte recruitment. Brain 127, 2649-2656 (2004).
    • (2004) Brain , vol.127 , pp. 2649-2656
    • Lapointe, B.M.1    Herx, L.M.2    Gill, V.3    Metz, L.M.4    Kubes, P.5
  • 105
    • 1542267742 scopus 로고    scopus 로고
    • Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue
    • Nitsch, R. et al. Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. J. Neurosci. 24, 2458-2464 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 2458-2464
    • Nitsch, R.1
  • 106
    • 22344453196 scopus 로고    scopus 로고
    • Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
    • Kawakami, N. et al. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J. Exp. Med. 201, 1805-1814 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1805-1814
    • Kawakami, N.1
  • 107
    • 0027988845 scopus 로고
    • In vivo imaging shows loss of synaptic sites from neuromuscular junctions in a model of myasthenia gravis
    • Rich, M. M., Colman, H. & Lichtman, J. W. In vivo imaging shows loss of synaptic sites from neuromuscular junctions in a model of myasthenia gravis. Neurology 44, 2138-2145 (1994).
    • (1994) Neurology , vol.44 , pp. 2138-2145
    • Rich, M.M.1    Colman, H.2    Lichtman, J.W.3
  • 108
    • 0034785699 scopus 로고    scopus 로고
    • In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex
    • Schwartz, T. H. & Bonhoeffer, T. In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex. Nature Med. 7, 1063-1067 (2001).
    • (2001) Nature Med. , vol.7 , pp. 1063-1067
    • Schwartz, T.H.1    Bonhoeffer, T.2
  • 109
    • 0035812457 scopus 로고    scopus 로고
    • Calcium imaging of epileptiform events with single-cell resolution
    • Badea, T., Goldberg, J., Mao, B. & Yuste, R. Calcium imaging of epileptiform events with single-cell resolution. J. Neurobiol. 48, 215-227 (2001).
    • (2001) J. Neurobiol. , vol.48 , pp. 215-227
    • Badea, T.1    Goldberg, J.2    Mao, B.3    Yuste, R.4
  • 110
    • 25444487761 scopus 로고    scopus 로고
    • Imaging input and output of neocortical networks in vivo
    • Kerr, J. N., Greenberg, D. & Helmchen, F. Imaging input and output of neocortical networks in vivo. Proc. Natl Acad. Sci. USA 102, 14063-14068 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14063-14068
    • Kerr, J.N.1    Greenberg, D.2    Helmchen, F.3
  • 111
    • 24744449939 scopus 로고    scopus 로고
    • An astrocytic basis of epilepsy
    • Tian, G. F. et al. An astrocytic basis of epilepsy. Nature Med. 11, 973-981 (2005). Uses in vivo calcium imaging to reveal a potential role of astrocytic calcium signalling in epileptiform neuronal activity, and shows that antiepileptic drugs influence astrocytic calcium spikes.
    • (2005) Nature Med. , vol.11 , pp. 973-981
    • Tian, G.F.1
  • 112
    • 28544444869 scopus 로고    scopus 로고
    • In vivo imaging of dendritic spines during electrographic seizures
    • Rensing, N. et al. In vivo imaging of dendritic spines during electrographic seizures. Ann. Neurol. 58, 888-898 (2005).
    • (2005) Ann. Neurol. , vol.58 , pp. 888-898
    • Rensing, N.1
  • 113
    • 4344594838 scopus 로고    scopus 로고
    • Capillary level imaging of local cerebral blood flow in bicuculline-induced epileptic foci
    • Hirase, H., Creso, J. & Buzsaki, G. Capillary level imaging of local cerebral blood flow in bicuculline-induced epileptic foci. Neuroscience 128, 209-216 (2004).
    • (2004) Neuroscience , vol.128 , pp. 209-216
    • Hirase, H.1    Creso, J.2    Buzsaki, G.3
  • 115
    • 0035879180 scopus 로고    scopus 로고
    • Abnormal development of dendritic spines in FMR1 knock-out mice
    • Nimchinsky, E. A., Oberlander, A. M. & Svoboda, K. Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neurosci. 21, 5139-5146 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 5139-5146
    • Nimchinsky, E.A.1    Oberlander, A.M.2    Svoboda, K.3
  • 116
    • 33344469599 scopus 로고    scopus 로고
    • You say lipofuscin, we say ceroid: Defining autofluorescent storage material. Neurobiol
    • Seehafer, S. S. & Pearce, D. A. You say lipofuscin, we say ceroid: defining autofluorescent storage material. Neurobiol. Aging 27, 576-588 (2006).
    • (2006) Aging , vol.27 , pp. 576-588
    • Seehafer, S.S.1    Pearce, D.A.2
  • 117
    • 0141750468 scopus 로고    scopus 로고
    • 2+ channel activation of ryanodine receptors
    • 2+ channel activation of ryanodine receptors. Neuron 40, 53-63 (2003).
    • (2003) Neuron , vol.40 , pp. 53-63
    • Ouardouz, M.1
  • 118
    • 33644520285 scopus 로고    scopus 로고
    • NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
    • Micu, I. et al. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 439, 988-992 (2006).
    • (2006) Nature , vol.439 , pp. 988-992
    • Micu, I.1
  • 119
    • 0037168582 scopus 로고    scopus 로고
    • Noninvasive real-time imaging of apoptosis
    • Laxman, B. et al. Noninvasive real-time imaging of apoptosis. Proc. Natl Acad. Sci. USA 99, 16551-16555 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 16551-16555
    • Laxman, B.1
  • 120
    • 28444481360 scopus 로고    scopus 로고
    • Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response
    • Kadurugamuwa, J. L. et al. Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response. Infect. Immun. 73, 7836-7843 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 7836-7843
    • Kadurugamuwa, J.L.1
  • 121
    • 21244447539 scopus 로고    scopus 로고
    • Global analysis of Smad2/3-dependent TGF-β signaling in living mice reveals prominent tissue-specific responses to injury
    • Lin, A. H. et al. Global analysis of Smad2/3-dependent TGF-β signaling in living mice reveals prominent tissue-specific responses to injury. J. Immunol. 175, 547-554 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 547-554
    • Lin, A.H.1
  • 122
    • 0034954524 scopus 로고    scopus 로고
    • In vivo molecular target assessment of matrix metalloproteinase inhibition
    • Bremer, C., Tung, C. H. & Weissleder, R. In vivo molecular target assessment of matrix metalloproteinase inhibition. Nature Med. 7, 743-748 (2001).
    • (2001) Nature Med. , vol.7 , pp. 743-748
    • Bremer, C.1    Tung, C.H.2    Weissleder, R.3
  • 124
    • 21444441373 scopus 로고    scopus 로고
    • Looking and listening to light: The evolution of whole-body photonic imaging
    • Ntziachristos, V., Ripoll, J., Wang, L. V. & Weissleder, R. Looking and listening to light: the evolution of whole-body photonic imaging. Nature Biotechnol. 23, 313-320 (2005). A comprehensive introduction to biophotonic imaging techniques and their current capabilities and limitations.
    • (2005) Nature Biotechnol. , vol.23 , pp. 313-320
    • Ntziachristos, V.1    Ripoll, J.2    Wang, L.V.3    Weissleder, R.4
  • 125
    • 19944433260 scopus 로고    scopus 로고
    • Quantum dots for live cells, in vivo imaging, and diagnostics
    • Michalet, X. et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544 (2005).
    • (2005) Science , vol.307 , pp. 538-544
    • Michalet, X.1
  • 126
    • 33644854853 scopus 로고    scopus 로고
    • Self-illuminating quantum dot conjugates for in vivo imaging
    • So, M. K., Xu, C., Loening, A. M., Gambhir, S. S. & Rao, J. Self-illuminating quantum dot conjugates for in vivo imaging. Nature Biotechnol. 24, 339-343 (2006).
    • (2006) Nature Biotechnol. , vol.24 , pp. 339-343
    • So, M.K.1    Xu, C.2    Loening, A.M.3    Gambhir, S.S.4    Rao, J.5
  • 127
    • 0037795542 scopus 로고    scopus 로고
    • Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation
    • Zipfel, W. R. et al. Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc. Natl Acad. Sci. USA 100, 7075-7080 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7075-7080
    • Zipfel, W.R.1
  • 128
    • 3042793425 scopus 로고    scopus 로고
    • Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
    • Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R. & Webb, W. W. Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305, 99-103 (2004).
    • (2004) Science , vol.305 , pp. 99-103
    • Kasischke, K.A.1    Vishwasrao, H.D.2    Fisher, P.J.3    Zipfel, W.R.4    Webb, W.W.5
  • 129
    • 0242385409 scopus 로고    scopus 로고
    • Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms
    • Campagnola, P. J. & Loew, L. M. Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms. Nature Biotechnol. 21, 1356-1360 (2003).
    • (2003) Nature Biotechnol. , vol.21 , pp. 1356-1360
    • Campagnola, P.J.1    Loew, L.M.2
  • 130
    • 13844297577 scopus 로고    scopus 로고
    • Imaging protein molecules using FRET and FLIM microscopy
    • Wallrabe, H. & Periasamy, A. Imaging protein molecules using FRET and FLIM microscopy. Curr. Opin. Biotechnol. 16, 19-27 (2005).
    • (2005) Curr. Opin. Biotechnol. , vol.16 , pp. 19-27
    • Wallrabe, H.1    Periasamy, A.2
  • 131
    • 12344316047 scopus 로고    scopus 로고
    • Imaging calpain protease activity by multiphoton FRET in living mice
    • Stockholm, D. et al. Imaging calpain protease activity by multiphoton FRET in living mice. J. Mol. Biol. 346, 215-222 (2005). An example of multiphoton FRET imaging in living mice to visualize the kinetics of calpain activation in muscle on the basis of a genetic sensor.
    • (2005) J. Mol. Biol. , vol.346 , pp. 215-222
    • Stockholm, D.1
  • 132
    • 31544462618 scopus 로고    scopus 로고
    • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging
    • Yasuda, R. et al. Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. Nature Neurosci. 9, 283-291 (2006).
    • (2006) Nature Neurosci. , vol.9 , pp. 283-291
    • Yasuda, R.1
  • 133
    • 0036405351 scopus 로고    scopus 로고
    • Three-dimensional confocal microscopy of the living human eye
    • Masters, B. R. & Bohnke, M. Three-dimensional confocal microscopy of the living human eye. Annu. Rev. Biomed. Eng. 4, 69-91 (2002).
    • (2002) Annu. Rev. Biomed. Eng. , vol.4 , pp. 69-91
    • Masters, B.R.1    Bohnke, M.2
  • 134
    • 4444274637 scopus 로고    scopus 로고
    • Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration
    • Cordeiro, M. F. et al. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration. Proc. Natl Acad. Sci. USA 101, 13352-13356 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 13352-13356
    • Cordeiro, M.F.1
  • 135
    • 30444441616 scopus 로고    scopus 로고
    • High resolution fundus imaging by confocal scanning laser ophthalmoscopy in the mouse
    • Paques, M. et al. High resolution fundus imaging by confocal scanning laser ophthalmoscopy in the mouse. Vision Res. 46, 1336-1345 (2006).
    • (2006) Vision Res. , vol.46 , pp. 1336-1345
    • Paques, M.1
  • 136
    • 0842266594 scopus 로고    scopus 로고
    • Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye
    • Imanishi, Y., Batten, M. L., Piston, D. W., Baehr, W. & Palczewski, K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J. Cell Biol. 164, 373-383 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 373-383
    • Imanishi, Y.1    Batten, M.L.2    Piston, D.W.3    Baehr, W.4    Palczewski, K.5
  • 137
    • 0035051325 scopus 로고    scopus 로고
    • Ultrahigh-resolution ophthalmic optical coherence tomography
    • Drexler, W. et al. Ultrahigh-resolution ophthalmic optical coherence tomography. Nature Med. 7, 502-507 (2001).
    • (2001) Nature Med. , vol.7 , pp. 502-507
    • Drexler, W.1
  • 138
    • 20444418166 scopus 로고    scopus 로고
    • Mapping postnatal mouse brain development with diffusion tensor microimaging
    • Zhang, J. et al. Mapping postnatal mouse brain development with diffusion tensor microimaging. Neuroimage 26, 1042-1051 (2005).
    • (2005) Neuroimage , vol.26 , pp. 1042-1051
    • Zhang, J.1
  • 139
    • 2942711595 scopus 로고    scopus 로고
    • Diffusion tensor imaging of the brain: Review of clinical applications
    • Sundgren, P. C. et al. Diffusion tensor imaging of the brain: review of clinical applications. Neuroradiology 46, 339-350 (2004).
    • (2004) Neuroradiology , vol.46 , pp. 339-350
    • Sundgren, P.C.1
  • 140
    • 0038262749 scopus 로고    scopus 로고
    • In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI)
    • Pautler, R. G., Mongeau, R. & Jacobs, R. E. In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI). Magn. Reson. Med. 50, 33-39 (2003).
    • (2003) Magn. Reson. Med. , vol.50 , pp. 33-39
    • Pautler, R.G.1    Mongeau, R.2    Jacobs, R.E.3
  • 141
    • 27644594658 scopus 로고    scopus 로고
    • 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: A meta-analytic review
    • Caramanos, Z., Narayanan, S. & Arnold, D. L. 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review. Brain 128, 2483-2506 (2005).
    • (2005) Brain , vol.128 , pp. 2483-2506
    • Caramanos, Z.1    Narayanan, S.2    Arnold, D.L.3
  • 142
    • 0037201962 scopus 로고    scopus 로고
    • High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo
    • Natt, O. et al. High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo. J. Neurosci. Methods 120, 203-209 (2002).
    • (2002) J. Neurosci. Methods , vol.120 , pp. 203-209
    • Natt, O.1
  • 143
    • 32544453658 scopus 로고    scopus 로고
    • Axonal growth and guidance defects in Frizzled3 knock-out mice: A comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling
    • Wang, Y., Zhang, J., Mori, S. & Nathans, J. Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling. J. Neurosci. 26, 355-364 (2006). An interesting comparison of non-optical and optical techniques that illustrates the recent advances of diffusion tensor imaging of axonal tracts and shows how such non-optical approaches could converge with light microscopic techniques.
    • (2006) J. Neurosci. , vol.26 , pp. 355-364
    • Wang, Y.1    Zhang, J.2    Mori, S.3    Nathans, J.4
  • 144
    • 33745750132 scopus 로고    scopus 로고
    • Electrical stimulation of cortex improves corticospinal tract tracing in rat spinal cord using manganese-enhanced MRI
    • 9 Mar doi:10.1016/j.jneumeth.2006.02.001
    • Bilgen, M. et al. Electrical stimulation of cortex improves corticospinal tract tracing in rat spinal cord using manganese-enhanced MRI. J. Neurosci. Methods 9 Mar 2006 (doi:10.1016/j.jneumeth.2006.02.001).
    • (2006) J. Neurosci. Methods
    • Bilgen, M.1
  • 145
    • 14844322216 scopus 로고    scopus 로고
    • Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging
    • Bendszus, M. et al. Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging. Ann. Neurol. 57, 388-395 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 388-395
    • Bendszus, M.1
  • 146
    • 27344439224 scopus 로고    scopus 로고
    • In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice
    • Jack, C. R. Jr et al. In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. J. Neurosci. 25, 10041-10048 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 10041-10048
    • Jack Jr., C.R.1
  • 147
    • 0042405135 scopus 로고    scopus 로고
    • The year(s) of the contrast agent - Micro-MRI in the new millennium
    • Pautler, R. G. & Fraser, S. E. The year(s) of the contrast agent - micro-MRI in the new millennium. Curr. Opin. Immunol. 15, 385-392 (2003).
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 385-392
    • Pautler, R.G.1    Fraser, S.E.2
  • 148
    • 14644404877 scopus 로고    scopus 로고
    • Functional MRI using molecular imaging agents
    • Jasanoff, A. Functional MRI using molecular imaging agents. Trends Neurosci. 28, 120-126 (2005).
    • (2005) Trends Neurosci. , vol.28 , pp. 120-126
    • Jasanoff, A.1
  • 149
    • 0345491876 scopus 로고    scopus 로고
    • Caught in the act: In vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging
    • Bendszus, M. & Stoll, G. Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging. J. Neurosci. 23, 10892-10896 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 10892-10896
    • Bendszus, M.1    Stoll, G.2
  • 150
    • 2142753047 scopus 로고    scopus 로고
    • Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis
    • Anderson, S. A. et al. Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis. Ann. Neurol. 55, 654-659 (2004).
    • (2004) Ann. Neurol. , vol.55 , pp. 654-659
    • Anderson, S.A.1
  • 151
    • 0036422713 scopus 로고    scopus 로고
    • Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging
    • Modo, M. et al. Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage 17, 803-811 (2002).
    • (2002) Neuroimage , vol.17 , pp. 803-811
    • Modo, M.1
  • 152
    • 0035173736 scopus 로고    scopus 로고
    • Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
    • Zhao, M., Beauregard, D. A., Loizou, L., Davletov, B. & Brindle, K. M. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nature Med. 7, 1241-1244 (2001).
    • (2001) Nature Med. , vol.7 , pp. 1241-1244
    • Zhao, M.1    Beauregard, D.A.2    Loizou, L.3    Davletov, B.4    Brindle, K.M.5
  • 153
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk, W. E. et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55, 306-319 (2004).
    • (2004) Ann. Neurol. , vol.55 , pp. 306-319
    • Klunk, W.E.1
  • 155
    • 0034062857 scopus 로고    scopus 로고
    • In vivo magnetic resonance imaging of transgene expression
    • Weissleder, R. et al. In vivo magnetic resonance imaging of transgene expression. Nature Med. 6, 351-355 (2000).
    • (2000) Nature Med. , vol.6 , pp. 351-355
    • Weissleder, R.1
  • 156
    • 20044392910 scopus 로고    scopus 로고
    • 1H MRI detection of amyloid-β plaques in vivo
    • 1H MRI detection of amyloid-β plaques in vivo. Nature Neurosci. 8, 527-533 (2005).
    • (2005) Nature Neurosci. , vol.8 , pp. 527-533
    • Higuchi, M.1
  • 157
    • 4644255822 scopus 로고    scopus 로고
    • Cellular imaging at 1.5 T: Detecting cells in neuroinflammation using active labeling with superparamagnetic iron oxide
    • Oweida, A. J., Dunn, E. A. & Foster, P. J. Cellular imaging at 1.5 T: detecting cells in neuroinflammation using active labeling with superparamagnetic iron oxide. Mol. Imaging 3, 85-95 (2004).
    • (2004) Mol. Imaging , vol.3 , pp. 85-95
    • Oweida, A.J.1    Dunn, E.A.2    Foster, P.J.3
  • 158
    • 33644864762 scopus 로고    scopus 로고
    • Axons and synaptic boutons are highly dynamic in adult visual cortex
    • Stettler, D. D., Yamahachi, H., Li, W., Denk, W. & Gilbert, C. D. Axons and synaptic boutons are highly dynamic in adult visual cortex. Neuron 49, 877-887 (2006).
    • (2006) Neuron , vol.49 , pp. 877-887
    • Stettler, D.D.1    Yamahachi, H.2    Li, W.3    Denk, W.4    Gilbert, C.D.5
  • 159
    • 0242322565 scopus 로고    scopus 로고
    • Toward fluorescence nanoscopy
    • Hell, S. W. Toward fluorescence nanoscopy. Nature Biotechnol. 21, 1347-1355 (2003).
    • (2003) Nature Biotechnol. , vol.21 , pp. 1347-1355
    • Hell, S.W.1
  • 160
    • 5444270623 scopus 로고    scopus 로고
    • Concepts for nanoscale resolution in fluorescence microscopy
    • Hell, S. W., Dyba, M. & Jakobs, S. Concepts for nanoscale resolution in fluorescence microscopy. Curr. Opin. Neurobiol. 14, 599-609 (2004). References 159 and 160 provide a stimulating introduction to recent technological developments towards fluorescence imaging beyond the diffraction limit.
    • (2004) Curr. Opin. Neurobiol. , vol.14 , pp. 599-609
    • Hell, S.W.1    Dyba, M.2    Jakobs, S.3
  • 161
    • 26444467060 scopus 로고    scopus 로고
    • From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging
    • Kleinfeld, D. & Griesbeck, O. From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging. PLoS Biol. 3, e355 (2005).
    • (2005) PLoS Biol. , vol.3
    • Kleinfeld, D.1    Griesbeck, O.2
  • 163
    • 0034491940 scopus 로고    scopus 로고
    • A custom-made two-photon microscope and deconvolution system
    • Majewska, A., Yiu, G. & Yuste, R. A custom-made two-photon microscope and deconvolution system. Pflugers Arch. 441, 398-408 (2000).
    • (2000) Pflugers Arch. , vol.441 , pp. 398-408
    • Majewska, A.1    Yiu, G.2    Yuste, R.3
  • 164
    • 0038644225 scopus 로고    scopus 로고
    • All-optical histology using ultrashort laser pulses
    • Tsai, P. S. et al. All-optical histology using ultrashort laser pulses. Neuron 39, 27-41 (2003).
    • (2003) Neuron , vol.39 , pp. 27-41
    • Tsai, P.S.1
  • 165
    • 0023120978 scopus 로고
    • Visualization of neuromuscular junctions over periods of several months in living mice
    • Lichtman, J. W., Magrassi, L. & Purves, D. Visualization of neuromuscular junctions over periods of several months in living mice. J. Neurosci. 7, 1215-1222 (1987).
    • (1987) J. Neurosci. , vol.7 , pp. 1215-1222
    • Lichtman, J.W.1    Magrassi, L.2    Purves, D.3
  • 166
    • 14344272346 scopus 로고    scopus 로고
    • Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons
    • Sawamoto, K. et al. Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons. Proc. Natl Acad. Sci. USA 98, 6423-6428 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 6423-6428
    • Sawamoto, K.1
  • 167
    • 0242401835 scopus 로고    scopus 로고
    • A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
    • Gong, S. et al. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 425, 917-925 (2003).
    • (2003) Nature , vol.425 , pp. 917-925
    • Gong, S.1
  • 168
    • 0348013146 scopus 로고    scopus 로고
    • Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins
    • Tanaka, D., Nakaya, Y., Yanagawa, Y., Obata, K. & Murakami, F. Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins. Development 130, 5803-5813 (2003).
    • (2003) Development , vol.130 , pp. 5803-5813
    • Tanaka, D.1    Nakaya, Y.2    Yanagawa, Y.3    Obata, K.4    Murakami, F.5
  • 169
    • 22244450972 scopus 로고    scopus 로고
    • Transgenic mouse lines expressing synaptopHluorin in hippocampus and cerebellar cortex
    • Araki, R. et al. Transgenic mouse lines expressing synaptopHluorin in hippocampus and cerebellar cortex. Genesis 42, 53-60 (2005).
    • (2005) Genesis , vol.42 , pp. 53-60
    • Araki, R.1
  • 170
    • 29544445660 scopus 로고    scopus 로고
    • Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    • Duebel, J. et al. Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon. Neuron 49, 81-94 (2006).
    • (2006) Neuron , vol.49 , pp. 81-94
    • Duebel, J.1
  • 171
    • 0036469299 scopus 로고    scopus 로고
    • Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development
    • Mallon, B. S., Shick, H. E., Kidd, G. J. & Macklin, W. B. Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development. J. Neurosci. 22, 876-885 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 876-885
    • Mallon, B.S.1    Shick, H.E.2    Kidd, G.J.3    Macklin, W.B.4
  • 172
    • 0033694598 scopus 로고    scopus 로고
    • Universal GFP reporter for the study of vascular development
    • Motoike, T. et al. Universal GFP reporter for the study of vascular development. Genesis 28, 75-81 (2000).
    • (2000) Genesis , vol.28 , pp. 75-81
    • Motoike, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.