Looking and listening to light: The evolution of whole-body photonic imaging

Nature Biotechnology

Volumn 23, Issue 3, 2005, Pages 313-320

  Ntziachristos, Vasilis ^a   Ripoll, Jorge ^a,b   Wang, Lihong V ^c   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b INSTITUTE OF COMPUTER SCIENCE   (Greece)

^c Texas A and M University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLUMINESCENCE; BIOMEDICAL ENGINEERING; DATA ACQUISITION; FLUORESCENCE; MICROSCOPIC EXAMINATION; PHOTONS;

OPTICAL IMAGING; PHOTONIC IMAGING; PHOTONIC TECHNOLOGY;

IMAGING TECHNIQUES;

ANALYTIC METHOD; ANIMAL CELL; BIOLUMINESCENCE; BODY IMAGE; EVOLUTION; IMAGE ANALYSIS; IMAGING SYSTEM; INSTRUMENTATION; LIGHT; MEDICAL RESEARCH; MOUSE; NONHUMAN; PHOTOGRAPHY; PHOTON; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; TECHNIQUE; ECHOGRAPHY; FLUORESCENCE MICROSCOPY; IMAGE ENHANCEMENT; LUMINESCENCE; METHODOLOGY; OPTICAL TOMOGRAPHY; THREE DIMENSIONAL IMAGING;

ANIMALIA;

DIAGNOSTIC AGENT;

IMAGE ENHANCEMENT; IMAGING, THREE-DIMENSIONAL; LUMINESCENT MEASUREMENTS; MICROSCOPY, FLUORESCENCE; PHOTONS; TOMOGRAPHY, OPTICAL; ULTRASONOGRAPHY;

EID: 21444441373     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1074     Document Type: Review

References (58)

1. Massoud, T.F. & Gambhir, S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 17, 545-580 (2003).
2. Blasberg, R.G. In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations. Nucl. Med. Biol. 30, 879-888 (2003).
3. Budinger, T.F., Benaron, D.A. & Koretsky, A.P. Imaging transgenic animals. Annu. Rev. Biorned. Eng. 1, 611-648 (1999).
4. Contag, C.H. & Bachmann, M.H. Advances in in vivo bioluminescence imaging of gene expression. Annu. Rev. Biorned. Eng. 4, 235-260 (2002).
5. Piwnica-Worms, D., Schuster, D.P. & Garbow, J.R. Molecular imaging of host-pathogen interactions in intact small animals. Cell. Microbiol. 6, 319-331 (2004).
6. Weissleder, R. Scaling down imaging: molecular mapping of cancer in mice. Nat. Rev. Cancer 2, 11-18 (2002).
7. Hoffman, R. Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Lancet Oncol. 3, 546-556 (2002).
8. Bornhop, D.J., Contag, C.H., Licha, K. & Murphy, C.J. Advance in contrast agents, reporters, and detection. J. Biomed. Opt. 6, 106-110 (2001).
9. Tung, C., Mahmood, U., Bredow, S. & Weissleder, R. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res. 60, 4953-4958 (2000).
10. Herschman, H.R. Molecular imaging: looking at problems, seeing solutions. Science 302, 605-608 (2003).
11. Weissleder, R. & Ntziachristos, V. Shedding light onto live molecular targets. Nat. Med. 9, 123-128 (2003).
12. Reynolds, J.S. et al. Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem. Photobiol. 70, 87-94 (1999).
13. Mahmood, U., Tung, C., Bogdanov, A. & Weissleder, R. Near infrared optical imaging system to detect tumor protease activity. Radiology 213, 866-870 (1999).
14. Yang, M. et al. Whole-body optical imaging of green fluorescent protein-expressing tumorsand metastases. Proc. Natl. Acad. Sci. USA 97, 1206-1211 (2000).
15. Contag, C.H. & Ross, B.D. It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology. J. Magn. Reson. Imaging 16, 378-387 (2002).
16. Farkas, D.L. et al. Non-invasive image acquisition and advanced processing in optical bioimaging. Comput. Med. Imaging Graph. 22, 89-102 (1998).
17. Gao, X., Cui, Y., Levenson, R. M., Chung, L.W.K. & Nie, S, In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969-976 (2004).
18. Arridge, S.R., Schweiger, M., Hiraoka, M. & Delpy, D.T.A. Finite-Element Approach For Modeling Photon Transport In Tissue. Med. Phys. 20, 299-309 (1993).
19. Graber, H.L. & Barbour, R.L. High-resolution near-infrared (nir) imaging of dense scattering media by diffusion tomography. FASEBJ. 7, A720-A720 (1993).
20. Schotland, J.C. & Leigh, J.S. Photon diffusion imaging. FASEB J. 6, A446-A446 (1992).
21. Yodh, A.G. & Chance, B. Spectroscopy and imaging with diffusing light. Phys. Today 48, 34-40 (1995).
22. Chance, B. Optical Method. Annu. Rev. Biophys. Biophys. Chem. 20, 1-28 (1991).
23. Jobsis, F.F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198, 1264-1267 (1977).
24. Patterson, M.S., Chance, B. & Wilson, B.C. Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical-properties. Appl. Opt. 28, 2331-2335 (1989).
25. Graves, E., Ripoll, J., Weissleder, R. & Ntziachristos, V.A. Sub-millimeter resolution fluorescence molecular imaging system for small animal imaging. Med. Phys. 30, 901-911 (2003).
26. Alfano, R.R. et al. Time-resolved and nonlinear optical imaging for medical applications. Ann. NY Acad. Sci. 838, 14-28 (1998).
27. Sevick, E.M., Chance, B., Leigh, J., Nioka, S. & Maris, M. Quantitation of time-resolved and frequency-resolved optical-spectra for the determination of tissue oxygenation. Anal. Biochem. 195, 330-351 (1991).
28. Cai, W. et al. Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements. Appl. Opt. 38, 4237-4246 (1999).
29. Chen, K., Perelman, L.T., Zhang, Q.G., Dasari, R.R. & Feld, M.S. Optical computed tomography in a turbid medium using early arriving photons, J. Biomed. Opt. 5, 144-154 (2000).
30. Turner, G., Zacharakis, I., Soubret, A. & Ntziachristos, V. Complete angle projection diffuse optical tomography using early photons. Optics Letters 30, 409-411 (2005).
31. Boas, O.A., Oleary, M.A., Chance, B. & Yodh, A.G. Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media - analytic solution and applications. Proc. Natl. Acad. Sci. USA 91, 4887-4891 (1994).
32. Godavarty, A. et al. Fluorescence-enhanced optical imaging in large tissue volumes using a gain-modulated ICCD camera. Phys. Med. Biol. 48, 1701-1720 (2003).
33. Boas, D.A. et al. Imaging the body with diffuse optical tomography. IEEE Signal Process. Mag. 18, 57-75 (2001).
34. Ripoll, J., Schultz, R. & Ntziachristos, V. Free-space propagation of diffuse light: Theory and Experiments. Phys. Rev. Lett. 91, 103901-103904 (2003).
35. Schultz, R., Ripoll, J. & Ntziachristos, V. Experimental fluorescence tomography of arbitrarily shaped diffuse objects using non-contact measurements. Opt. Lett. 28, 1701-1703 (2003).
36. Schultz, R., Ripoll, J. & Ntziachristos, V. Fluorescence tomography of tissues with non-contact measurements. IEEE Med. Imag. 23, 492-500 (2004).
37. Chang, J., Graber, H.L. & Barbour, R.L. Imaging of fluorescence in highly scattering media. IEEE Trans. Biomed. Eng. 44, 810-822 (1997).
38. Eppstein, M.J., Hawrysz, D.J., Godavarty, A. & Sevick-Muraca, E.M. Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography. Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
39. Jiang, H.B. Frequency-domain fluorescent diffusion tomography: a finite- element-based algorithm and simulations. Appl. Opt. 37, 5337-5343 (1998).
40. Milstein, A.B. et al. Fluorescence optical diffusion tomography. Appl. Opt 42, 3081-3094 (2003).
41. Ntziachristos, V. & Weissleder, R. Experimental three-dimensional fluorescence reconstruction of diffuse media using a normalized Born approximation. Opt. Lett. 26, 893-895 (2001).
42. Klose, A.D. & Hielscher, A.H. Fluorescence tomography with simulated data based on the equation of radiative transfer. Opt. Lett. 28, 1019-1021 (2003).
43. Dehghani, H., Arridge, S.R., Schweiger, M. & Delpy, D.T. Optical tomography in the presence of void regions. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 17, 1659-1670 (2000).
44. Ntziachristos, V., Tung, C., Bremer, C. & Weissleder, R. Fluorescence-mediated tomography resolves protease activity in vivo. Nat. Med. 8, 757-760 (2002).
45. Ripoll, J., Nieto-Vesperinas, M., Weissleder, R. & Ntziachristos, V. Fast analytical approximation for arbitrary geometries in diffuse optical tomography. Opt. Lett. 27, 527-529 (2002).
46. Gu, X., Xu, Y. & Jiang, H. Mesh-based enhancement schemes in diffuse optical tomography. Med. Phys. 30, 861-869 (2003).
47. Ye, J.C., Bouman, C.A., Webb, K.J. & Millane, R.P. Nonlinear multigrid algorithms for Bayesian optical diffusion tomography. IEEE Trans. Image Process. 10, 909-922 (2001).
48. Vernooy, J., Dentener, M., van Suylen, R., Buurman, W. & Wouters, E. Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology. Am. J. Respir. Cell Mol. Biol. 26, 152-159 (2002).
49. Lautwein, A. et al. Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells. Eur. J. Immunol. 32, 3348-3357 (2002).
50. Prin-Mathieu, C. et al. Enzymatic activities of bovine peripheral blood leukocytes and milk polymorphonuclear neutrophils during intramammary inflammation caused by lipopolysaccharide. Clin. Diagn. Lab. Immunol. 9, 812-817 (2002).
51. Weissleder, R., Tung, C.H., Mahmood, U. & Bogdanov, A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat. Biotechnol. 17, 375-378 (1999).
52. Ntziachristos, V. et al. Visualization of anti-tumor treatment by means of fluorescence molecular tomography using an annexin V - Cy5.5 conjugate. Proc. Natl, Acad. Sci. USA 101, 12294-12299 (2004).
53. Wang, G., Li, Y. & Jiang, M. Uniqueness theorems in bioluminescence tomography. Med. Phys. 31, 2289-2299 (2004).
54. Gu, X., Zhang, Q., Larcom, L. & Jiang, H.B. Three-dimensional bioluminescence tomography with model-based reconstruction. Opt. Express 12, 3996-4000 (2004).
55. Hoelen, C.G.A. & de Mul, F.F.M. Image reconstruction for photoacoustic scanning of tissue structures. Appl. Opt. 39, 5872-5883 (2000).
56. Wang, X. et al. Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent. Opt. Lett. 29, 730-732 (2004).
57. Wang, X. et al. Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain. Nat. Biotechnol. 21, 803-806 (2003).
58. Karabutov, A.A., Savateeva, E.V. & Oraevsky, A.A. Optoacoustlc tomography: new modality of laser diagnostic systems. Laser Phys. 13, 711-723 (2003).