α4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

Journal of Clinical Investigation

Volumn 108, Issue 4, 2001, Pages 557-565

  Vajkoczy, P ^a   Laschinger, M ^a   Engelhardt, B ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; VASCULAR CELL ADHESION MOLECULE 1; ALPHA4 INTEGRIN; BORDETELLA VIRULENCE FACTOR; LEUKOCYTE ANTIGEN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; WHITE MATTER; ANIMAL; AUTOIMMUNE DISEASE; CAPILLARY; DISEASE MODEL; DRUG ANTAGONISM; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGY; METABOLISM; MICROCIRCULATION; MICROSCOPY; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; PROTEIN BINDING; SPINAL CORD; T LYMPHOCYTE SUBPOPULATION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; ANTIGENS, CD; AUTOIMMUNE DISEASES; BLOOD-BRAIN BARRIER; CAPILLARIES; CELL ADHESION; CHEMOTAXIS, LEUKOCYTE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; FEMALE; GTP-BINDING PROTEINS; INTEGRIN ALPHA4; MICE; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; NERVOUS SYSTEM AUTOIMMUNE DISEASE, EXPERIMENTAL; PROTEIN BINDING; SKIN WINDOW TECHNIQUE; SPINAL CORD; T-LYMPHOCYTE SUBSETS; VASCULAR CELL ADHESION MOLECULE-1; VIRULENCE FACTORS, BORDETELLA;

EID: 85047682713     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12440     Document Type: Article

References (30)

1. Lymphocyte trafficking and regional immunity
2. The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin
3. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion
4. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis
5. Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro
6. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
7. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
8. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry, into bran parenchyma
9. Cytokines and adhesion molecules contribute to the ability, of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis
10. Distinct roles for matrix metalloproteinase-2 and α4-integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis
11. Influence of platelet-activating factor on cerebral microcirculation in rats: Part 2. Local application
12. Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation
13. Mutants of pertussis toxin suitable for vaccine development
14. Lymphocyte migration in vivo: The mouse model
15. Endothelial, not hemodynamic, differences are responsible for preferential leukocyte rolling in rat mesenteric venules
16. L-selectin function is required for beta 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo
17. Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance
18. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
19. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo
20. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
21. High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow
22. CD45RA-RO+ (memory) but not CD45RA+RO-(naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow
23. α4β1-integrin activation is necessary for high-efficiency T cell subset interactions with VCAM-1 under flow
24. Biology of chemokine and classical chemoattractant receptors: Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells
25. Cellular immune reactivity within the CNS
26. T-lymphocyte entry into the central nervous system
27. Subsecond induction of alpha 4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
28. Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment
29. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo
30. Migration associated volume changes in neutrophils facilitate the migratory process in vitro