Motor neurons rely on motor proteins

Trends in Cell Biology

Volumn 14, Issue 5, 2004, Pages 233-240

  Holzbaur, Erika L F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; POLYPEPTIDE; PROTEIN;

ALZHEIMER DISEASE; CELL FUNCTION; CYTOSKELETON; DEGENERATIVE DISEASE; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; MICROTUBULE; MOLECULAR MECHANICS; MOTONEURON; MOTOR NEURON DISEASE; MUTATION; NERVE FIBER; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SPASTIC PARAPLEGIA; SPINAL MUSCULAR ATROPHY;

ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; MICROTUBULES; MOLECULAR MOTOR PROTEINS; MOTOR NEURONS; NEURODEGENERATIVE DISEASES;

EID: 2342561865     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2004.03.009     Document Type: Review

References (60)

1. Vale R.D., et al. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 42:1985;39-50
2. Paschal B.M., Vallee R.B. Retrograde transport by the microtubule-associated protein MAP 1C. Nature. 330:1987;181-183
3. Saxton W.M., et al. Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis. Cell. 64:1991;1093-1102
4. Hurd D.D., Saxton W.M. Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics. 144:1996;1075-1085
5. Tanaka Y., et al. Targeted disruption of mouse conventional kinesin heavy chain, Kif5B, results in abnormal perinuclear clustering of mitochondria. Cell. 93:1998;1147-1158
6. Xia C.-H., et al. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J. Cell Biol. 161:2003;55-66
7. Miki H., et al. All kinesin superfamily protein, KIF, genes in mouse and human. Proc. Natl. Acad. Sci. U. S. A. 98:2001;7004-7011
8. Hall D.H., Hedgecock E.M. Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell. 65:1991;837-847
9. Yonekawa Y., et al. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. J. Cell Biol. 141:1998;431-441
10. Okada Y., et al. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell. 81:1995;769-780
11. Gepner J., et al. Cytoplasmic dynein function is essential in Drosophila melanogaster. Genetics. 142:1996;865-878
12. Harada A., et al. Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein. J. Cell Biol. 141:1998;51-59
13. Karki S., Holzbaur E.L. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J. Biol. Chem. 270:1995;28806-28811
14. Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp1). Proc. Natl. Acad. Sci. U. S. A. 92:1995;1634-1638
15. King S.J., Schroer T.A. Dynactin increases the processivity of the cytoplasmic dynein motor. Nat. Cell Biol. 2:2000;20-24
16. Garen S.H., Kankel D.R. Golgi and genetic mosaic analyses of visual system mutants in Drosophila melanogaster. Dev. Biol. 96:1983;445-466
17. Reddy S., et al. Mutant molecular motors disrupt neural circuits in Drosophila. J. Neurobiol. 33:1997;711-723
18. Phillis R., et al. Mutations in the 8 kDa dynein light chain gene disrupt sensory axon projections in the Drosophila imaginal CNS. Development. 122:1996;2955-2963
19. Murphey R.K., et al. Dynein-dynactin function and sensory axon growth during Drosophila metamorphosis: a role for retrograde motors. Dev. Biol. 209:1999;86-97
20. Eaton B.A., et al. Dynactin is necessary for synapse stabilization. Neuron. 34:2002;729-741
21. Bowman A.B., et al. Drosophila Roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. J. Cell Biol. 146:1999;165-179
22. Hafezparast M., et al. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science. 300:2003;808-812
23. Xiang X., et al. NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. Mol. Biol. Cell. 6:1995;297-310
24. Kato M., Dobyns W.B. Lissencephaly and the molecular basis of neuronal migration. Hum. Mol. Genet. 12:2003;R89-R96
25. Brady S.T., et al. A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm. Proc. Natl. Acad. Sci. U. S. A. 87:1990;1061-1065
26. Stenoien D.L., Brady S.T. Immunochemical analysis of kinesin light chain function. Mol. Biol. Cell. 8:1997;675-689
27. Waterman-Storer C.M., et al. The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. Proc. Natl. Acad. Sci. U. S. A. 94:1997;12180-12185
28. Martin A.A., et al. Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Mol. Biol. Cell. 10:1999;3717-3728
29. Ligon, et al. (2004) A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J. Biol. Chem. 10.1074/jbc.M313472200 (www.jbc.org).
30. Deacon S.W., et al. Dynactin is required for bidirectional organelle transport. J. Cell Biol. 160:2003;297-301
31. Wang L., et al. Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nat. Cell Biol. 2:2000;137-141
32. Shah J.V., et al. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol. Biol. Cell. 11:2000;3495-3508
33. Tanaka Y., Hirokawa N. Mouse models of Charcot-Marie-Tooth disease. Trends Genet. 18:2002;S39-S44
34. Zhao C., et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bβ Cell. 105:2001;587-597
35. Reid E., et al. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am. J. Hum. Genet. 71:2002;1189-1194
36. Marszalek J.R., et al. Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. J. Cell Biol. 145:1999;469-479
37. Yamada K., et al. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Nat. Genet. 35:2003;318-321
38. Chao M.V. Retrograde transport redux. Neuron. 39:2003;1-2
39. Ye H., et al. Evidence in support of signaling endosomes-based retrograde survival of sympathetic neurons. Neuron. 39:2003;57-68
40. Yano H., et al. Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. J. Neurosci. 21:2001;. RC125 (1-7)
41. LaMonte B.H., et al. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron. 34:2002;715-727
42. Echeverri C.J., et al. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132:1996;617-633
43. Puls I., et al. Dynactin mutation in motor neuron disease. Nat. Genet. 33:2003;455-456
44. Subramaniam J.R., et al. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat. Neurosci. 5:2002;301-307
45. Elam J.S., et al. Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. Nat. Struct. Biol. 10:2003;461-467
46. Williamson T.L., Cleveland D.W. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat. Neurosci. 2:1999;50-56
47. Zhang B., et al. Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J. Cell Biol. 139:1997;1307-1315
48. Frugier T., et al. The molecular basis of spinal muscular atrophy. Curr. Opin. Genet. Dev. 12:2002;294-298
49. Zhang H.L., et al. Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization. J. Neurosci. 23:2003;6627-6637
50. Rossoll W., et al. SMN, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneurons. J. Cell Biol. 163:2003;801-812
51. Mandelkow E., et al. Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol. Aging. 24:2003;1079-1085
52. Kamal A., et al. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 28:2000;449-459
53. Block-Galarza J., et al. Fast transport and retrograde movement of huntingtin and HAP 1 in axons. Neuroreport. 8:1997;2247-2251
54. Glued subunit of dynactin. Hum. Mol. Genet. 6:1997;2205-2212
55. Glued. J. Neurosci. 18:1998;1261-1269
56. Szebenyi G., et al. Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. Neuron. 40:2003;41-52
57. Gunawardena S., et al. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 40:2003;25-40
58. Liu J.-J., et al. BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J. Cell Biol. 163:2003;223-229
59. Kaspar B.K., et al. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science. 301:2003;839-842
60. Vale R.D. The molecular motor toolbox for intracellular transport. Cell. 112:2003;467-480