Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: Critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric Gi-linked receptors

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1940-1949

  Piccio, Laura ^a   Rossi, Barbara ^a   Scarpini, Elio ^a   Laudanna, Carlo ^a   Giagulli, Cinzia ^a   Issekutz, Andrew C ^a   Vestweber, Dietmar ^a   Butcher, Eugene C ^a   Constantin, Gabriela ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; ENDOTHELIN; GLYCOPROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PERTUSSIS TOXIN; PROTEOLIPID PROTEIN; SELECTIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BRAIN BLOOD VESSEL; CAPILLARY ENDOTHELIUM; CHEMOTAXIS; CONTROLLED STUDY; IMAGE ANALYSIS; INFLAMMATION; LYMPHOCYTIC INFILTRATION; MOLECULAR DYNAMICS; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0037083641     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1940     Document Type: Article

References (53)

1. - T lymphocytes
2. Are current immunological concepts of multiple sclerosis reflected by the immunopathology of its lesions?
3. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis
4. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice
5. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
6. Traffic signals for lymphoid recirculation and leukocyte emigration: The multi-step paradigm
7. Lymphocyte trafficking and regional immunity
8. Lymphocyte homing and homeostasis
9. T-lymphocyte entry into the central nervous system
10. Pathophysiology of the blood-brain-barrier
11. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
12. 1 integrin
13. 4 integrin by CD4 T cells is required for their entry into the brain parenchyma
14. Both anti-CD11a (LFA-1) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis
15. 4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment
16. Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse
17. A role for platelets and endothelial selectins in TNFα-induced leukocyte recruitment in the brain microvasculature
18. Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment
19. Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin
20. Characterization of a novel adhesion function blocking monoclonal antibody to rat/mouse P-selectin generated in the P-selectin-deficient mouse
21. P-selectin glycoprotein ligand-1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo
22. Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor
23. Endothelial, not hemodynamic, differences are responsible for preferential leukocyte rolling in rat mesenteric venules
24. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes
25. Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively-induced experimental allergic encephalomyelitis
26. Cerebral vascular system
27. Hematopoietic progenitor cell rolling in bone marrow microvessels: Parallel contributions by endothelial selectins and vascular cell adhesion molecule 1
28. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse
29. Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-α in vivo
30. E-selectin expression in experimental models of inflammation in mice
31. 4 integrins mediate lymphocyte attachment and rolling under flow
32. 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo
33. 4 integrin in the inflammatory response of neutrophils
34. 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined
35. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo
36. Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules
37. 4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: An early step in the process of emigration
38. Mutants of pertussis toxin suitable for vaccine development
39. 4-integrin in acute, subacute, and chronic leukocyte recruitment in vivo
40. Importance of E-selectin for firm leukocyte adhesion in vivo
41. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo
42. The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum
43. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin
44. Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model
45. Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion
46. Inhibition of allergic encephalomyelitis in rats by treatment with sulfated polysaccharides
47. Phosphosugars are potent inhibitors of central nervous system inflammation
48. 4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
49. Adhesion molecule expression and regulation on cells of the central nervous system
50. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis
51. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion
52. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
53. 2 integrin affinity and mobility changes: Differential regulation and roles in lymphocyte arrest under flow