Small molecule vanilloid TRPV1 receptor antagonists approaching drug status: Can they live up to the expectations?

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 373, Issue 4, 2006, Pages 273-286

  Szallasi, Arpad ^a,b  

^a MONMOUTH MEDICAL CENTER   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Anandamide; Capsaicin; Hyperalgesia; Lung toxicity; Neurogenic inflammation; TRPM8 receptors; TRPV1 antagonists; Vanilloid

Indexed keywords

A 425619; ANANDAMIDE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; CAPSAICIN; CAPSAZEPINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE DERIVATIVE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INOSITOL PHOSPHATE; N (2 BROMOPHENYL) N' [2 [ETHYL (3 METHYLPHENYL)AMINO]ETHYL]UREA; N (4 TERT BUTYLPHENYL) 4 (3 CHLOROPYRIDIN 2 YL)TETRAHYDROPYRAZINE 1(2H) CARBOXAMIDE; N ARACHIDINOYLDOPAMINE; NERVE GROWTH FACTOR; PACLITAXEL; PHOSPHOLIPASE C; PRASTERONE; PREGNENOLONE; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; RECEPTOR BLOCKING AGENT; RESINIFERATOXIN; SB 366791; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 BLOCKING AGENT; VANILLOID RECEPTOR 1 STIMULATING AGENT; VANILLOID RECEPTOR 4 ANTAGONIST;

ASTHMA; BLOOD BRAIN BARRIER; BURNING SENSATION; CLINICAL RESEARCH; COUGHING; DIABETIC NEUROPATHY; DISEASE MODEL; DRUG DISCRIMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HEART INFARCTION; HUMAN; HUNTINGTON CHOREA; HYPERALGESIA; KNOCKOUT MOUSE; LUNG TOXICITY; MOLECULAR CLONING; NEUROGENIC INFLAMMATION; NEUROPATHIC PAIN; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR INTRINSIC ACTIVITY; REVIEW;

ANALGESICS; ANIMALS; DRUG DESIGN; HUMANS; TISSUE DISTRIBUTION; TRPV CATION CHANNELS;

EID: 33745712270     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0072-3     Document Type: Review

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