TRP channels in airway smooth muscle as therapeutic targets

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 371, Issue 4, 2005, Pages 277-284

  Gosling, Martin ^a   Poll, Chris ^a   Li, Su ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Airway smooth muscle; Asthma; Bronchoconstriction; Bronchodilator; Non selective cation channel; Receptor activated calcium entry; TRP channel

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CAPSAICIN; CAPSAZEPINE; CATION CHANNEL; CYCLOPIAZONIC ACID; HISTAMINE; METHACHOLINE; NIFEDIPINE; THAPSIGARGIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

AIRWAY; ASTHMA; BREATHING MUSCLE; BRONCHOSPASM; CALCIUM TRANSPORT; DRUG TARGETING; GENE EXPRESSION; HUMAN; MEMBRANE DEPOLARIZATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY TRACT DISEASE; REVIEW; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTILITY;

ANIMALS; ASTHMA; BRONCHODILATOR AGENTS; DRUG DESIGN; HUMANS; MUSCLE, SMOOTH; RESPIRATORY SYSTEM; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 21344447323     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-005-1058-2     Document Type: Review

References (67)

1. Allegra L, Bianco S (1980) Non-specific broncho-reactivity obtained with an ultrasonic aerosol of distilled water. Eur J Respir Dis Suppl 106:41-49
2. Anderson SD, Schoeffel RE, Finney M (1983) Evaluation of ultrasonically nebulised solutions for provocation testing in patients with asthma. Thorax 38:284-291
3. 2+ entry in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 286:L909-L917
4. Barnes PJ (1985) Clinical studies with calcium antagonists in asthma. Br J Clin Pharmacol 20 [Suppl 2]:289S-298S
5. 2+ signalling requirements. Biochem J 337(Pt 2):153-169
6. Basora N, Boulay G, Bilodeau L, Rousseau E, Payet MD (2003) 20-Hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. J Biol Chem 278:31709-31716
7. Beech DJ, Xu SZ, McHugh D, Flemming R (2003) TRPC1 store-operated cationic channel subunit. Cell Calcium 33:433-440
8. Beech DJ, Muraki K, Flemming R (2004) Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559:685-706
9. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709-720
10. Birnbaumer L, Zhu X, Jiang M, Boulay G, Peyton M, Vannier B, Brown D, Platano D, Sadeghi H, Stefani E, Birnbaumer M (1996) On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins. Proc Natl Acad Sci USA 93:15195-15202
11. Bourdillat B, Haye-Legrand I, Labat C, Raffestin B, Norel X, Benveniste J, Brink C (1987) Effects of various pharmacological agents on isolated human bronchial and pulmonary arterial and venous muscle preparations contracted by leukotriene D4. Fundam Clin Pharmacol 1:433-444
12. Clapham DE, Montell C, Schultz G, Julius D (2003) International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev 55:591-596
13. Cloutier M, Campbell S, Basora N, Proteau S, Payet MD, Rousseau E (2003) 20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 285:L560-L568
14. Cohen P, Noveral JP, Bhala A, Nunn SE, Herrick DJ, Grunstein MM (1995) Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis. Am J Physiol 269:L151-L157
15. Corteling RL, Li S, Giddings J, Westwick J, Poll C, Hall IP (2004) Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. Am J Respir Cell Mol Biol 30:145-154
16. 2+ release in agonist-induced contractions in guinea pig trachea. Am J Physiol 266:L620-L627
17. Dietrich A, Mederos y Schnitzler M, Kalwa H, Storch U, Gudermann T (2005) Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn-Schmiedebergs Arch Pharmacol (in press)
18. Elias JA, Zhu Z, Chupp G, Homer RJ (1999) Airway remodeling in asthma. J Clin Invest 104:1001-1006
19. + channel mediates regulatory volume decrease response in a human bronchial epithelial cell line. Am J Physiol Cell Physiol 283:C1705-C1714
20. Ferrari M, Olivieri M, De Gasperi M, Lechi A (1989) Differential effects of nifedipine and diltiazem on methacholine-induced bronchospasm in allergic asthma. Ann Allergy 63:196-200
21. Finney MJ, Anderson SD, Black JL (1987) The effect of non-isotonic solutions on human isolated airway smooth muscle. Respir Physiol 69:277-286
22. Fleig A, Penner R (2004) The TRPM ion channel subfamily: molecular, biophysical and functional features. Trends Pharmacol Sci 25:633-639
23. Goel M, Sinkins WG, Schilling WP (2002) Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem 277:48303-48310
24. Gorenne I, Labat C, Gascard JP, Norel X, Nashashibi N, Brink C (1998) Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. J Pharmacol Exp Ther 284:549-552
25. Gosens R, Schaafsma D, Grootte Bromhaar MM, Vrugt B, Zaagsma J, Meurs H, Nelemans SA (2004) Growth factor-induced contraction of human bronchial smooth muscle is rho-kinase-dependent. Eur J Pharmacol 494:73-76
26. Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493-21501
27. Gunthorpe MJ, Benham CD, Randall A, Davis JB (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci 23:183-191
28. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163-173
29. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263
30. Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99:7461-7466
31. Hofmann T, Chubanov V, Gudermann T, Montell C (2003) TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol 13:1153-1158
32. 2+-permeable cation channel. Circ Res 88:325-332
33. 2+ entry by rho-kinase in tracheal smooth muscle. Am J Respir Cell Mol Biol 26:491-498
34. Jia Y, Wang X, Varty L, Rizzo CA, Yang R, Correll CC, Phelps PT, Egan RW, Hey JA (2004) Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 287:L272-L278
35. Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol 1:165-170
36. Kotlikoff MI (1988) Calcium currents in isolated canine airway smooth muscle cells. Am J Physiol 254:C793-C801
37. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T (1985) Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 131:599-606
38. Landsberg JW, Yuan JX (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci 19:44-50
39. 2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109:397-407
40. -/- mice. Proc Natl Acad Sci USA 100:13698-13703
41. Liedtke W, Simon SA (2004) A possible role for TRPV4 receptors in asthma. Am J Physiol Lung Cell Mol Physiol 287:L269-L271
42. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525-535
43. Lofdahl CG, Barnes PJ (1986) Calcium, calcium channel blockade and airways function. Acta Pharmacol Toxicol (Copenh) 58 [Suppl 2]:91-111
44. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93:829-838
45. Murray RK, Kotlikoff MI (1991) Receptor-activated calcium influx in human airway smooth muscle cells. J Physiol 435:123-144
46. Murray RK, Fleischmann BK, Kotlikoff MI (1993) Receptor-activated Ca influx in human airway smooth muscle: use of Ca imaging and perforated patch-clamp techniques. Am J Physiol 264:C485-C490
47. 2+ channel protein (TRPC7) highly expressed in brain. Genomics 54:124-131
48. O'Neil RG, Brown RC (2003) The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli. News Physiol Sci 18:226-231
49. Ong HL, Brereton HM, Harland ML, Barritt GJ (2003) Evidence for the expression of transient receptor potential proteins in guinea pig airway smooth muscle cells. Respirology 8:23-32
50. Oonuma H, Nakajima T, Nagata T, Iwasawa K, Wang Y, Hazama H, Morita Y, Yamamoto K, Nagai R, Omata M (2000) Endothelin-1 is a potent activator of non-selective cation currents in human bronchial smooth muscle cells. Am J Respir Cell Mol Biol 23:213-221
51. Panettieri RA Jr (1998) Cellular and molecular mechanisms regulating airway smooth muscle proliferation and cell adhesion molecule expression. Am J Respir Crit Care Med 158:S133-S140
52. Rodger I (1989) Drugs affecting calcium ions in airway smooth muscle. In: Barnes PJ (ed) New drugs for asthma. IBC, London, pp 455-456
53. Rousseau E, Cloutier M, Morin C, Proteau S (2005) Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 288:L460-L470
54. Schoeffel RE, Anderson SD, Altounyan RE (1981) Bronchial hyperreactivity in response to inhalation of ultrasonically nebulised solutions of distilled water and saline. Br Med J (Clin Res Ed) 283:1285-1287
55. Sinkins WG, Estacion M, Schilling WP (1998) Functional expression of TrpC1: a human homologue of the Drosophila Trp channel. Biochem J 331(Pt 1):331-339
56. Snetkov VA, Hapgood KJ, McVicker CG, Lee TH, Ward JP (2001) Mechanisms of leukotriene D4-induced constriction in human small bronchioles. Br J Pharmacol 133:243-252
57. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702
58. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645-655
59. 2+ entry in bronchial contraction and remodeling. J Appl Physiol 92:1594-1602
60. Vennekens R, Voets T, Bindels RJ, Droogmans G, Nilius B (2002) Current understanding of mammalian TRP homologues. Cell Calcium 31:253-264
61. Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, Flockerzi V, Droogmans G, Benham CD, Nilius B (2002) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277:13569-13577
62. Welsh DG, Morielli AD, Nelson MT, Brayden JE (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90:248-250
63. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656
64. Worley JF III, Kotlikoff MI (1990) Dihydropyridine-sensitive single calcium channels in airway smooth muscle cells. Am J Physiol 259:L468-L480
65. Yamada A, Sato O, Watanabe M, Walsh MP, Ogawa Y, Imaizumi Y (2000) Inhibition of smooth-muscle myosin-light-chain phosphatase by ruthenium red. Biochem J 349(Pt 3):797-804
66. Yu Y, Sweeney M, Zhang S, Platoshyn O, Landsberg J, Rothman A, Yuan JX (2003) PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol 284:C316-C330
67. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX (2004) Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101:13861-13866