Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: Role of cannabinoid and vanilloid receptors

Gut

Volumn 54, Issue 4, 2005, Pages 522-527

  Domenicali, M ^a   Ros, J ^a   Fernandez Varo G ^a   Cejudo Martin P ^a   Crespo, M ^a   Morales Ruiz, M ^a   Briones, A M ^b   Campistol, J M ^a   Arroyo, V ^a   Vila, E ^b   Rodes J ^a   Jimenez W ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; MESSENGER RNA; NITRIC OXIDE; TRANSIENT RECEPTOR POTENTIAL VANILLOID TYPE 1 PROTEIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ADOLESCENT; ADVENTITIA; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; FEMORAL ARTERY; HYPOTENSION; IMMUNOCYTOCHEMISTRY; LIVER CIRRHOSIS; MALE; MESENTERIC ARTERY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR BLOCKING; RESISTANCE BLOOD VESSEL; SENSORY NERVE; SPLANCHNIC BLOOD FLOW; VASCULAR ENDOTHELIUM;

ANIMALS; ARACHIDONIC ACIDS; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; ION CHANNELS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MESENTERIC ARTERIES; POLYUNSATURATED ALKAMIDES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RNA, MESSENGER; TRPV CATION CHANNELS; VASODILATION;

EID: 20144379143     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.051599     Document Type: Article

References (24)

1. Walker JM, Krey, Chu CJ, et al. Endocannabinoids and related fatty acid derivatives in pain modulation. Chem Phys Lipids 2002;121:159-72.
2. Högestätt ED, Zygmunt PM. Cardiovascular pharmacology of anandamide. Prostaglandins Leukot Essent Fatty Acids 2002;66:343-51.
3. Garcia N Jr, Jarai Z, Mirshahi F, et al. Systemic and portal hemodynamic effect of anandamide. Am J Physiol 2001;280;G14-20.
4. Ralevic V, Kendall DA, Randall MD, et al. Cannabinoid modulation of sensory neurotrasmission via cannabinoid an vanilloid receptor: roles in regulation of cardiovascular system. Life Sci 2002;71:2577-94.
5. Ros J, Clària J, To-Figueras J, et al. Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. Gastroenterology 2002;122:85-93.
6. Barkai S, Jarai Z, Wagner JA, et al. Endocannabinoids acting at vascular CB1 receptor mediate the vasodilatated state in advanced liver cirrhosis. Nat Med 2001;7:827-32.
7. Clària J, Jimenez W. Renal dysfunction and ascites in carbon tetrachloride-induced cirrhosis in rats. In: Arrayo V, Ginès P, Rodés J, et al. Ascites and renal dysfunction in the liver disease. Pathogenesis, diagnosis and treatment. Malden MA: Blackwell Science, 1999:379-96.
8. Wigg ST, Tare M, Tonta MA, et al. Comparison of effect of diabetes mellitus on an EDHF-dependent and EDHF-independent artery. Am J Physiol Heart Circ Physiol 2001;281:H232-40.
9. Harris D, McCulloch AI, Kendall DA, et al. Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed. J Physiol 2002;539:893-902.
10. White R, Hiley CR. A comparison of EDHF-mediated and anandamide-induced relaxation in the rat mesenteric artery. Br J Phamacol 1997;122:1573-84.
11. Di Marzo V, De Petrocellis L, Fezza F, et al. Anandamide receptors. Prostaglandins Leukot Essent Fatty Acids, 2002;66:377-91.
12. Ralevic V. Cannabinoid modulation of peripheral autonomic and sensory neurotransmission. Eur J Pharmacol 2003;472:1-21.
13. Zygmunt PM, Petersson J, Andersson BA, et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999;400:452-7.
14. Li Y, Song D, Lee SS. Effect of neonatal capsaicin treatment on haemodynamics and renal function in cirrhotic rats. Gut 2003;52:293-9.
15. Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-212.
16. Randall MD, Alexander SPH, Bennett T, et al. An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem Biophys Res Commun 1996;229:114-20.
17. 9-THC dilation of cerebral arterioles is blocked by indomethacin. Am J Physiol 1995;38:H1859-64.
18. Randall MD, McCulloch AI, Kendall DA. Comparative pharmacology of endothelium-derived hyperpolarizing factor and anandamide in rat isolated mesentery. Eur J Pharmacol 1997;333:191-7.
19. O to inhibition of adenylyl cyclase in carotid artery smooth muscle. Br J Pharmacol 1999;128:597-604.
20. Darker IT, Millns PJ, Selbie L, et al. Cannabinoid (CB1) receptor expression is associated with mesenteric resistance vessels but not thoracic aorta in the rat. Br J Pharmacol 1998;125:95P.
21. Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 2003;140:790-801.
22. Andersson DA, Adner M, Hogestatt ED, et al. Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists. Mol Pharmacol 2002;62:705-13.
23. De Petrocellis L, Cascio MG, Di Marzo V. The endocannabinoid system: a general view and latest additions. Br J Pharmacol 2004;141:765-74.
24. Caterina MJ, Julius D. The vanilloid receptor: a molecular gate-way to the pain pathway. Annu Rev Neurosci 2001;24:487-517.