Relaxant effect of capsazepine in the isolated rat ileum

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 3, 2002, Pages 187-192

  Nocerino, Emilia ^a,b   Izzo, Angelo A ^a,b   Borrelli, Francesca ^a,b   Capasso, Francesco ^a,b   Capasso, Raffaele ^a,b   Pinto, Aldo ^a,b   Sautebin, Lidia ^a,b   Mascolo, Nicola ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Capsazepine; Enteric nervous system; Intestinal motility; Intestine; Piperine; Primary afferent neurones; Resiniferatoxin; Vanilloid (capsaicin) receptors

Indexed keywords

ATROPINE; CALCITONIN GENE RELATED PEPTIDE; CALCIUM CHANNEL; CAPSAZEPINE; HEXAMETHONIUM; ISOPRENALINE; METHYSERGIDE; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NOLPITANTIUM; OMEGA CONOTOXIN; OSANETANT; PHENTOLAMINE; PROPRANOLOL DERIVATIVE; SAREDUTANT; TETRODOTOXIN; VANILLOID RECEPTOR; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; GASTROINTESTINAL TRANSIT; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUSCLE; MALE; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; RAT; UPPER GASTROINTESTINAL TRACT;

ALKALOIDS; ANIMALS; BENZODIOXOLES; CALCIUM CHANNELS, L-TYPE; CAPSAICIN; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL TRANSIT; ILEUM; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PIPERIDINES; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG;

EID: 0036192467     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0522-x     Document Type: Article

References (45)

1. Effect of arachidonic acid hydroperoxides on vascular and non-vascular smooth muscle
2. Ascending neural pathways in the rat ileum in vitro: Effect of capsaicin and involvement of nitric oxide
3. The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide
4. Antagonism of the effects of calcitonin gene-related peptide and of capsaicin on the guinea-pig isolated ileum by human alpha-calcitonin gene-related peptides(8-37)
5. 2 receptors mediate atropine-resistant ileal circular muscle contractions evoked by capsaicin
6. Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine
7. Capsazepine: A competitive antagonist of the sensory neurone excitant capsaicin
8. The vanilloid receptor: A molecular gateway to the pain pathway
9. The capsaicin receptor: A heat-activated ion channel in the pain pathway
10. Both ATP and the peptide VIP are inhibitory neurotransmitters in guinea-pig ileum circular muscle
11. Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture
12. Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea-pig trachea
13. Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: Evidence from the use of selective VIP antagonists and VIP antiserum
14. Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia
15. Capsaicin: Cellular targets, mechanism of action, and selectivity of thin sensory neurons
16. Effect of capsaicin on gastric corpus smooth muscle of the rat in vitro
17. Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
18. Excitatory transmission to the circular muscle of the guinea-pig ileum: Evidence for the involvement of cannabinoid CB1 receptor
19. Contractile effect of (+)-glaucine in the isolated guinea pig ileum
20. Effect of vanilloid drugs on gastrointestinal transit in mice
21. Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
22. Inhibitory effect of capsaicin on the ascending pathway of the guinea-pig ileum and antagonism of this effect by ruthenium red
23. Capsaicin, protons and heat: New excitement about nociceptors
24. Relaxant effect of capsaicin in the rat gastric fundus
25. Similarities and differences in the currents activated by capsaicin, piperine and zingerone in rat trigeminal ganglion cells
26. Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine
27. Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: Possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons
28. Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxation of the isolated rat duodenum
29. A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens
30. 1 receptors
31. The ligand that came from within
32. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
33. ATP and nitric oxide: Inhibitory NANC neurotransmitters in the longitudinal muscle-myenteric plexus preparation of the rat ileum
34. Novel natural vanilloid receptor agonists: New therapeutic targets for drug development
35. Vanilloid (capsaicin) receptors and mechanisms
36. New perspectives on enigmatic vanilloid receptors
37. Structure/activity analysis of resiniferatoxin analogs
38. The rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglionic neurones
39. Effects of piperine on the motility of the isolated guinea-pig ileum: Comparison with capsaicin
40. Ionic channels in smooth muscle
41. Neuroendocrine regulation of gastrointestinal motility. Normal and abnormal physiology
42. The endogenous cannabinoid agonist, anandamide, stimulates sensory nerves in guinea-pig airways
43. Pharmacological evidence for the existence of multiple P2 receptors in the circular muscle of guinea-pig colon
44. Vanilloid receptors on sensory nerves mediate the vasodilatator action of anandamide