Chapter 2 History of Ion Channels in the Pain Sensory System

Current Topics in Membranes

Volumn 57, Issue , 2006, Pages 21-72

  Szolcsanyi J ^a   Petho G ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33745354362     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1063-5823(06)57001-2     Document Type: Review

References (239)

1. Abdulla F.A., and Smith P.A. Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy. Neurophysiology 88 (2002) 2518-2529
2. Ács G., Bíró T., Ács P., Moderras S., and Blumberg P. Differential activation and desensitization of sensory neurons by resiniferatoxin. J. Neurosci. 17 (1997) 5622-5628
3. Agrawal S.G., and Evans R.H. The primary afferent depolarizing action of kainate in the rat. Br. J. Pharmacol. 87 (1986) 345-355
4. Adrian E.D. The impulses produced by sensory nerve endings. J. Physiol. 61 (1926) 49-72
5. Akopian A.N., Sivilotti L., and Wood J.N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379 (1996) 257-262
6. Akopian A.,N., Souslova V., England S., Okuse K., Ogata N., Ure J., Smith A., Kerr B.J., McMahon S.B., Boyce S., Hill R., Stanfa L.C., et al. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat. Neurosci. 2 (1999) 541-548
7. Alexander S.P.H., Mathie A., and Peters J.A. Guide to receptors and channels. Br. J. Pharmacol. 147 (2004) S6-S7
8. Amaya F., Decosterd I., Samad T.A., Plumpton C., Tate S., Mannion R.J., Costigan M., and Woolf C.J. Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Mol. Cell. Neurosci. 15 (2000) 331-342
9. Anand A., and Paintal A.S. Possible role of capillary permeability in the excitation of sensory receptors by chemical substances. Prog. Brain Res. 74 (1988) 337-340
10. Arbuckle J.B., and Docherty R.J. Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats. Neurosci. Lett. 185 (1995) 70-73
11. Baccaglini P.J., and Hogan P.G. Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells. Proc. Natl. Acad. Sci. USA 80 (1983) 594-598
12. + current regulates excitability in mouse and rat small diameter sensory neurones. J. Physiol. 548 (2003) 373-382
13. Beck P.W., and Handwerker H.O. Bradykinin and serotonin effects on various tpes of cutaneous nerve fibres. Pflügers Arch. 347 (1974) 209-222
14. Belcher S.M., Zerillo C.A., Levenson R., Ritchie J.M., and Howe J.R. Cloning of a sodium channel α subunit from rabbit Schwann cells. Proc. Natl. Acad. Sci. USA 92 (1995) 11034-11038
15. Belmonte C., and Cervero F. "Neurobiology of Nociceptors." (1996), Oxford University Press, Oxford
16. V1.9 (SNS2) in primary sensory neurons. J. Neurosci. 21 (2001) 6077-6085
17. Bernardini N., Sauer S.K., Haberberger R., Fischer M.J.M., and Reeh P.W. Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin. J. Neurosci. 21 (2001) 3295-3302
18. Bessou P., and Perl E.R. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurophysiol. 32 (1969) 1025-1043
19. Bevan S., and Szolcsányi J. Sensory neuron-specific actions of capsaicin: Mechanisms and applications. Trends Pharmacol. Sci. 11 (1990) 330-333
20. Bevan S., Hothi S., Hughes G.A., James I.F., Rang H.P., Shah K., Walpole CS.J., and Yeats J.C. Capsazepine: A competitive antagonist of the sensory neurone excitant capsaicin. Br. J. Pharmacol. 107 (1992) 544-552
21. Bielefeldt K., Ozaki N., and Gebhart G.F. Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons. Gastroenterology 122 (2002) 394-405
22. Bielefeldt K., Ozaki N., and Gebhart G.F. Mild gastritis alters voltage-sensitive sodium currents in gastric sensory neurons in rats. Gastroenterology 122 (2002) 752-761
23. Bielefeldt K., Ozaki N., and Gebhart G.F. Role of nerve growth factor in modulation of gastric afferent neurons in the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 284 (2003) G499-G507
24. Black J.A., and Waxman S.G. Molecular identities of two tetrodotoxin-resistant sodium channels in corneal axons. Exp. Eye Res. 75 (2002) 193-199
25. Black J.A., Dib-Hajj S., McNabola K., Jeste S., Rizzo M.A., Kocsis J.D., and Waxman S.G. Spinal sensory neurons express multiple sodium channel α-subunit mRNAs. Mol. Brain Res. 43 (1996) 117-131
26. + channel III and SNS gene expression in spinal sensory neurons. Neuroreport 8 (1997) 2331-2335
27. Black J.A., Cummins T.R., Plumpton C., Chen Y.H., Hormuzdiar W., Clare J.J., and Waxman S.G. Upregulation of a silent sodium channel after peripheral, but not central nerve injury in DRG neurons. J. Neurophyisol. 82 (1999) 2776-2785
28. V1.6 is expressed along nonmyelinated axons and it contributes to conduction. Mol. Brain Res. 105 (2002) 19-28
29. V1.9/NaN in afferent neurons innervating urinary bladder in control and spinal cord injured rats. Brain Res. 963 (2003) 132-138
30. Black J.A., Liu S., Tanaka M., Cummins T.R., and Waxman S.G. Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain. Pain 108 (2004) 237-247
31. 2+ current in the action potentials of nociceptive sensory neurons. J. Neurosci. 22 (2002) 10277-10290
32. + current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. J. Neurosci. 23 (2003) 10338-10350
33. Bongenhielm U., Nosrat C.A., Nosrat I., Eriksson J., Fjell J., and Fired K. Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat. Exp. Neurol. 164 (2000) 384-395
34. Boucher T.J., Okuse K., Bennett D.L., Munson J.B., Wood J.N., and McMahon S.B. Potent analgesic effects of GDNF in neuropathic pain states. Science 290 (2000) 124-127
35. Boyd R.T., Jacob M.H., McEachern A.E., Caron S., and Berg D.K. Nicotine acetylcholine receptor mRNA in dorsal root ganglion neurons. J. Neurobiol. 22 (1991) 1-14
36. Brock J.A., McLachlan E.M., and Belmonte C. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J. Physiol. 512 (1998) 211-217
37. Brock J.A., Pianova S., and Belmonte C. Differences between nerve terminal impulses of polymodal nociceptors and cold sensory receptors of the guinea-pig cornea. J. Physiol. 533 (2001) 493-501
38. Brown G.L., and Gray J.A.B. Some effects of nicotine-like substances and their relation to sensory nerve endings. J. Physiol. 107 (1948) 306-317
39. Buck S.H., and Burks T.F. The neuropharmacology of capsaicin: A review of some recent observations. Pharmacol. Rev. 38 (1986) 179-226
40. Burgess P.R., and Perl E.R. Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J. Physiol. (London) 190 (1967) 541-562
41. Caffrey J.M., Eng D.L., Black J.A., Waxman S.G., and Kocsis J.D. Three types of sodium channels in adult rat dorsal root ganglion neurons. Brain Res. 592 (1992) 283-297
42. Cain D.M., Khasabov S.G., and Simone D.A. Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: An in vivo study. J. Neurophysiol. 85 (2001) 1561-1574
43. V1.6 is localized at nodes of Ranvier, dendrites, and synapses. Proc. Natl. Acad. Sci. USA 97 (2000) 5616-5620
44. + channels. J. Neurophysiol. 86 (2001) 241-248
45. Carlton S.M., McNearney T.A., and Cairns B.E. Peripheral glutamate receptors: Novel targets for analgesics. "Proceedings of the 10th World Congeress on Pain," Vol. 24 (2003), IASP Press, Seattle 125-139
46. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., and Julius D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 (1997) 816-824
47. Caterina G., Rosen T.A., Tominaga M., Brake A.J., and Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398 (1999) 436-441
48. Cauna N. Fine structure of the receptor organs and its functional significance. In "Touch, Heat and Pain Symposium of Ciba Foundation," (1966), Churchill, London 117-127
49. Chung K., Klein C.M., and Coggeshall R.E. The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats. Neurosci. Lett. 53 (1990) 221-226
50. Clapham D.E., Montell C., Schultz G., and Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: Transient receptor potential channels. Pharmacol. Rev. 55 (2003) 591-596
51. Coggeshall R.E., and Carlton S.M. Ultrastructural analysis of NMDA, AMPA and kainate receptors on unmyelinated and myelinated axons in the periphery. J. Comp. Neurol. 391 (1998) 78-86
52. V1.9 in normal and inflamed rats. Neurosci. Lett. 355 (2004) 45-48
53. Coward K., Plumpton C., Facer P., Birch R., Tate C.S., Bountra C., and Anand P. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels inhuman pain states. Pain 85 (2000) 41-50
54. Craner M.J., Klein J.P., Renganathan M., Black J.A., and Waxman S.G. Changes of sodium channel expression in experimental painful diabetic neuropathy. Ann. Neurol. 52 (2002) 786-792
55. Cummins T.R., and Waxman S.G. Downregulation of tetorodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetorodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J. Neurosci. 17 (1997) 3503-3514
56. Cummins T.R., Howe J.R., and Waxman S.G. Slow closed-state inactivation: A novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. J. Neurosci. 18 (1998) 9607-9619
57. Cummins T.R., Dib-Hajj S.D., Black J.A., Akopian A.N., Wood J.N., and Waxman S.G. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J. Neurosci. 19 (1999) 1-6
58. Cummins T.R., Black J.A., Dib-Hajj S.D., and Waxmann S.G. Glial-derived neuropathic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons. J. Neurosci. 20 (2000) 8754-8761
59. D'Arcangelo G., Paradiso K., Shepherd D., Brehm P., Halegoua S., and Mandel G. Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways. J. Cell Biol. 122 (1993) 915-921
60. V1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. Pain 96 (2002) 269-277
61. Dib-Hajj S., Black A., Felts P., and Waxman S.G. Downregulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy. Neurobiology 93 (1996) 14950-14954
62. Dib-Hajj S.D., Tyrrell L., Black J.A., and Waxman S.G. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Neurobiology 95 (1998) 8963-8968
63. Dib-Hajj S.D., Black J.A., Cummins T.R., Kenney A.M., Kocsis J.D., and Waxman S.G. Rescue of α-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo. J. Neurophysiol. 79 (1998) 2668-2676
64. Dib-Hajj S.D., Tyrrell L., Escayg A., Wood P.M., Meisler M.H., and Waxman S.G. Coding sequence, genomic organization and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Genomics 59 (1999) 309-318
65. Dib-Hajj S.D., Tyrrell L., Cummins T.R., Black J.A., Wood P.M., and Waxman S.G. Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons. FEBS Lett. 462 (1999) 117-120
66. v 1.9: A sodium channel with unique properties. Trends Neurosci. 25 (2002) 253-259
67. + channel α subunit protein. J. Physiol. 546 (2003) 565-576
68. Douglas W.W., and Ritchie J.M. The excitatory action of acetylcholine on cutaneous non-myelinated fibres. J. Physiol. 150 (1960) 501-514
69. Douglas W.W., Ritchie J.M., and Straub R.W. The role of non-myelinated fibres in signalling cooling of the skin. J. Physiol. 150 (1960) 266-283
70. Du J., Koltzenburg M., and Carlton S.M. Glutamate-induced excitation and sensitization of nociceptors in rat glabrous skin. Pain 89 (2001) 187-198
71. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J. Physiol. 495 (1996) 429-440
72. V1.9 (NaN) in nociceptive primary afferent neurons. J. Neurosci. 22 (2002) 7425-7433
73. Fischer T.E., and Bourque C.V. Distinct ω-agatoxin-sensitive calcium currents in somata and axon-terminals of rat supraoptic neurones. J. Physiol. 489 (1995) 383-388
74. Fitzgerald E.M., Okuse K., Wood J.N., Dolphin A.C., and Moss S.J. cAMP-dependent phoshorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. J. Physiol. 516 (1999) 433-446
75. Fitzgerald M. Capsaicin and sensory neurones: A review. Pain 15 (1983) 109-130
76. Fjällbrant N., and Iggo A. The effect of histamine, 5-hydroxytryptamine and acetylcholine on cutaneous afferent fibres. J. Physiol. (London) 156 (1961) 578-590
77. Fjell J., Cummins T.R., Dib-Hajj S.D., Fried K., Black J.A., and Waxman S.G. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Mol. Brain Res. 67 (1999) 267-282
78. Fjell J., Cummins T.R., Fried K., Black J.A., and Waxman S.G. In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons. J. Neurophysiol. 81 (1999) 803-810
79. Fjell J., Hjelmström P., Hormuzdiar W., Milenkovic M., Aglieco F., Tyrrell L., Dib-Hajj S., Waxman S.G., and Black J.A. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors. Neuroreport 11 (2000) 199-202
80. Flake N.M., Lancaster E., Weinreich D., and Gold M.S. Absence of an association between axotomy-induced changes in sodium currents and excitability in DRG neurons from the adult rat. Pain 109 (2004) 471-480
81. Flores C.M. The promise and pitfalls of a nicotinic cholinergic approach to pain management. Pain 88 (2000) 1-6
82. Fock S., and Mense S. Excitatory effects of 5-hydroxytryptamine, histamine, and potassium ions on muscular group IV afferent units: A comparison with bradykinin. Brain Res. 105 (1976) 459-469
83. Foster R.W., and Ramage A.G. The action of some chemical irritants on somatosensory receptors of the cat. Neuropharmacology 20 (1981) 191-198
84. Fu L.W., and Longhurst J.C. Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats. J. Physiol. 509 (1998) 729-740
85. Garrido J.J., Giraud P., Carlier E., Fernandes F., Moussif A., Fache M.P., Debanne D., and Dargent B. A targeting motif involved in sodium channel clustering at the axonal initial segment. Science 300 (2003) 2091-2097
86. Genzen J.R., Van Cleve W., and McGehee D.S. Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes. J. Neurophysiol. 86 (2001) 1773-1781
87. Ginzel K.H. The importance of sensory nerve endings as sites of drug action. Naunyn Schmiedebergs Arch. Pharmacol. 288 (1975) 29-56
88. + current in nociceptors. Neurobiology 93 (1996) 1108-1112
89. Gold M.S., Levine J.D., and Correa A.M. Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J. Neurosci. 18 (1998) 10345-10355
90. Na in rat colonic sensory neurons. J. Neurophysiol. 88 (2002) 1512-1522
91. V1.8 in uninjured axons enables neuropathic pain. J. Neurosci. 23 (2003) 158-166
92. Gover T.D., Kao J.P.Y., and Weinreich D. Calcium signaling in single peripheral sensory nerve terminals. J. Neurosci. 23 (2003) 4793-4797
93. Gray J.A.B. Initiation of impulses at receptors. In: Field J., and Magoun H.W. (Eds). "Handbook of Physiology, Section I. Neurophysiology" Vol. 1 (1959), American Physiological Society, Washington 123-145
94. Handwerker H.O., Reeh P.W., and Sten K.H. Effects of 5-HT on nociceptors. In: Besson J.-M. (Ed). "Serotonin and Pain" (1990), Elsevier Science, Amsterdam 1-15
95. Helyes Z., Pintér E., Németh J., and Szolcsányi J. Pharmacological targets for the inhibition of neurogenic inflammation. Curr. Med. Chem. Anti-Inflammatory and Anti-Allergy Agents 2 (2003) 191-218
96. Heppelmann B., Messlinger K., Neiss W.A., and Schmidt R.F. Ultrastructural three-dimensional reconstruction of group III and group IV sensory nerve endings ("free nerve endings") in the knee joint capsule of the cat: Evidence for multiple receptive sites. J. Comp. Neurol. 292 (1990) 103-116
97. + current affects resting potential and response to depolarization is simulated spinal sensory neurons. J. Neurophysiol. 86 (2001) 1351-1364
98. Hillsley K., and Grundy D. Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum. J. Physiol. 509 (1998) 717-727
99. Hirade M., Yasuda H., Omatsu-Kanbe M., Kikkawa R., and Kitasato H. Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats. Neuroscience 90 (1999) 933-939
100. Holz G.G., Shefner S.A., and Anderson E.G. Serotonin depolarizes type A and C primary afferents: An intracellular study in bullfrog dorsal root ganglion. Brain Res. 327 (1985) 71-79
101. Holzer P. Capsaicin: Cellular targets, mechanism of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43 (1991) 143-201
102. Högyes A. Beitrage zur physiologischen Wirkung der Bestandteile des Capsicum annuum. Arch. Exp. Pathol. Pharmakol. 9 (1878) 117-130
103. Iggo A. Cutaneous heat and cold receptors with slowly conducting (C) afferent fibres. Q. J. Exp. Physiol. 44 (1959) 362-370
104. Iriuchijima J., and Zotterman Y. The specificity of afferent cutaneous C fibres in mammals. Acta Physiol. Scand. 49 (1960) 267-278
105. Jancsó G., and Király E. Sensory neurotoxins: Chemically induced selective destruction of primary sensory neurons. Brain Res. 210 (1981) 83-89
106. Jancsó G., Király E., and Jancsó-Gábor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 270 (1977) 741-743
107. Jancsó N. Histamine as a physiological activator of the reticulo-endothelial system. Nature 160 (1947) 227
108. Jancsó N. "Speicherung. Stoffanreicherung im Retikuloendothel und in der Niere". (1955), Akadémiai Kiadó, Budapest
109. Jancsó N. Role of nerve terminals in the mechanism of inflammatory reactions. Bull. Millard Fillmore Hosp. (Buffalo, NY) 7 (1960) 53-77
110. Jancsó N., Jancsó-Gábor A., and Takáts I. Pain and inflammation induced by nicotine, acetylcholine and structurally-related compounds and their prevention by desensitizing agents. Acta Physiol. Hung. 19 (1961) 113-132
111. Jancsó N., Jancsó-Gábor A., and Szolcsányi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmacol. 31 (1967) 138-151 (the late)
112. Jancsó N., Jancsó-Gábor A., and Szolcsányi J. The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br. J. Pharmacol. 33 (1968) 32-41 (the late)
113. Jancsó-Gábor A., Szolcsányi J., and Jancsó N. Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J. Physiol. 206 (1970) 495-507
114. Jancsó-Gábor A., Szolcsányi J., and Jancsó N. Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats. J. Physiol. 208 (1970) 449-459
115. Jeftinija S. The role of tetrodotoxin-resistant sodium channels of small primary afferent fibers. Brain Res. 639 (1994) 125-134
116. Joó F., Szolcsányi J., and Jancsó-Gábor A. Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin. Life Sci. 8 (1969) 621-626
117. Juan H. Nicotinic nociceptors on perivascular sensory nerve endings. Pain 12 (1982) 259-264
118. Keele C.A., and Armstrong D. "Substances Producing Pain and Itch," (1964), Edward Arnold Ltd., London 107-123
119. Kenins P. Responses of single nerve fibres to capsaicin applied to the skin. Neurosci. Lett. 29 (1982) 83-88
120. V1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport 12 (2001) 3077-3080
121. Khasar S.G., Gold M.S., and Levine J.D. A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat. Neurosci. Lett. 256 (1998) 17-20
122. Khasar S.G., McCarter G., and Levine J.D. Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J. Neurophysiol. 81 (1999) 1104-1112
123. Kim C.H., Oh Y., Chung J.M., and Chung K. The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation. Mol. Brain Res. 95 (2001) 153-161
124. Klugbauer N., Lacinova L., Flockerzi V., and Hofmann F. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J. 14 (1995) 1084-1090
125. Konietzny F., and Hensel H. The effect of capsaicin on the response characteristics of human C-polymodal nociceptors. J. Therm. Biol. 8 (1983) 213-215
126. Krishtal O.A., and Pidoplichko V.J. A "receptor" for protons in small neurones of trigeminal ganglia: Possible role in nociceptors. Neurosci Lett. 24 (1981) 243-246
127. Krishtal O.A., Marchenko S.M., and Pidoplichko V.I. Receptor for ATP in the membrane of mammalian sensory neurones. Neurosci. Lett. 35 (1983) 44-45
128. Kruger L. Morphological features of thin sensory affeent fibers: A new interpretation of "nociceptor" function. Prog. Brain Res. 74 (1988) 253-257
129. Kruger L. The functional morphology of thin sensory axons: Some principles and problems. Prog. Brain Res. 113 (1996) 255-272
130. Kumazawa T., Kruger L., and Mizumura K. The polymodal receptor: A gateway to pathological pain. "Progress in Brain Research," Vol. 112 (1996), Elsevier Science BV, Amsterdam
131. V1.8. Pain 95 (2002) 143-152
132. Lai J., Porreca F., Hunter J.C., and Gold S.M. Voltage-gated sodium channels and hyperalgesia. Ann. Rev. Pharmacol. Toxicol. 44 (2004) 371-397
133. v1.8 (SNS) PN3)-Null mice. J. Neurosci. 22 (2002) 8352-8356
134. Lancaster E., and Weinreich D. Sodium currents in vagotomized primary afferent neurones of the rat. J. Physiol. 536 (2001) 445-458
135. Lancaster E., Oh E.J., and Weinreich D. Vagotomy decreases excitability in primary vagal afferent somata. J. Neurophysiol. 85 (2001) 247-253
136. Lang E., Novak A., Reeh P.W., and Handwerker H.O. Chemosensitivity of fine afferents from rat skin in vitro. J. Neurophysiol. 63 (1990) 887-901
137. Lawson S.N. The morphological consequences of neonatal treatment with capsaicin on primary afferent neurones in adult rats. Acta Physiol. Hung. 69 (1987) 315-321
138. Lawson S.N. Peptides and cutaneous polymodal nociceptor neurones. Brain Res. 113 (1996) 369-385
139. Lembeck F. Epibatidine: High potency and broad spectrum activity on neural and neuromuscular nicotinic acetylcholine receptors. Naunyn Schmiedebergs Arch. Pharmacol. 359 (1999) 378-385
140. V1.9/NaN to the cell membrane. J. Biol. Chem. 49 (2001) 46553-46561
141. Liu L., Pugh W., Ma H., and Simon S.A. Identification of acetylcholine receptors in adult trigeminal ganglion neurons. Brain Res. 617 (1997) 37-42
142. Lovinger D.M., and Weigh F.F. Glutamate induces depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptors. Neurosci. Lett. 94 (1988) 314-320
143. Lynn B., Ye W., and Cotsell B. The actions of capsaicin applied topically to the skin of the rat on C-fibre afferents, antidromic vasodilatation and substance P levels. Br. J. Pharmacol. 107 (1992) 400-406
144. Lynn B., Faulstroh K., and Piearu F.-K. The classification and properties of nociceptive afferent units from the skin of the anaesthetized pig. J. Neurosci. 7 (1995) 431-437
145. Lynn B., Schutterle S., and Piearu F.K. The vasodilator component of neurogenic inflammation is caused by a special subclass of heat-sensitive nociceptors in the skin of the pig. J. Physiol. 494 (1996) 587-593
146. Maggi C.A. Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog. Neurobiol. 45 (1995) 1-98
147. Martin III H.F., and Manning J.W. Rapid thermal cutaneous stimulation: Peripheral nerve responses. Brain Res. 16 (1969) 524-526
148. McCleane G.J., Suzuki R., and Dickenson A.H. Does a single intravenous injection of the 5-HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth. Analg. 97 (2003) 1474-1478
149. Melzack R., and Wall P.D. Pain mechanisms: A new theory. Science 150 (1965) 971-979
150. Meuser T., Pietruck C., Gabriel A., Xie G.X., Lim K.J., and Pierce P.P. 5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons. Life Sci. 19 (2002) 2279-2289
151. V1.7 (PN1) in acute and inflammatory pain. Proc. Natl. Acad. Sci. USA 101 (2004) 12706-12711
152. Németh J., Helyes Zs., Oroszi G., Jakab B., Pintér E., Szilvássy Z., and Szolcsányi J. Role of voltage-gated cation channels and axon reflexes in the release of sensory neuropeptides by capsaicin from isolated rat trachea. Eur. J. Pharmacol. 458 (2003) 313-318
153. Nolano M., Simone D.A., Wendelschafer-Crabb G., Johnson T., Hazen E., and Kennedy W.R. Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation. Pain 81 (1999) 135-145
154. Novakovic S.D., Tzoumaka E., McGivern J.G., Haraguchi M., Sangameswaran L., Gogas K.R., Eglen R.M., and Hunter J.C. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J. Neurosci. 18 (1998) 2174-2187
155. Oh U., Hwang S.W., and Kim D. Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons. J. Neurosci. 16 (1996) 1659-1667
156. Okuse K., Chaplan S.R., McMahon S.B., Luo Z.D., Calcutt N.A., Scott B.P., Akopian A.N., and Wood J.N. Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain. Mol. Cell. Neurosci. 10 (1997) 196-207
157. Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., and Wood J.N. Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature 417 (2002) 653-656
158. Paintal A.S. Effect of drugs on vertebrate mechanoreceptors. Pharm. Rev. 16 (1964) 341-380
159. Perl E.R. Cutaneous polymodal receptors: Characteristics and plasticity. Prog. Brain Res. 113 (1996) 21-37
160. Petersen K., and Rowbotham M. A new human experimental pain model: The heat/capsaicin sensitization model. Neuroreport 10 (1999) 1511-1516
161. Pethö G., and Szolcsányi J. Excitation of central and peripheral terminals of primary affrent neurons by capsaicin in vivo. Life Sci. 58 (1996) 47-53
162. Porreca F., Lai J., Bian D., Wegert S., Ossipov M.H., Eglen R.M., Kassotakis L., Novakovics S., Rabert D.K., Sangameswaran L., and Hunter J.C. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc. Natl. Acad. Sci. USA 96 (1999) 7640-7644
163. Quasthoff S., Grosskreutz J., Schröder J.M., Schneider U., and Grafe P. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C-fibres of biopsied human sural nerve. Neuroscience 69 (1995) 955-965
164. Rabert D.K., Koch B.D., Ilnicka M., Obernolte R.A., Naylor S.L., Herman R.C., Eglen R.M., Hunter J.C., and Sangameswaran L. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain 78 (1998) 107-114
165. v1.8 sodium channels to action potential electrogenesis in DRG neurons. J. Neurophysiol. 86 (2001) 629-640
166. V1.5 underlies the "third TTX-R sodium current" in rat small DRG neurons. Mol. Brain Res. 106 (2002) 70-82
167. Ringkamp M., Peng Y.B., Wu G., Hartke T.V., Campbell J.N., and Meyer R.A. Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors. J. Neurosci. 21 (2001) 4460-4468
168. + currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiol. Dis. 2 (1995) 87-96
169. Roberts R.G., Stevenson J.E., Westerman R.A., and Pennefather J. Nicotine acetylcholine receptors on capsaicin-sensitive nerves. Neuroreport 6 (1995) 1578-1582
170. Robertson B., and Bevan S. Properties of 5-hydroxtryptamine-3 receptor-gated current adult rat dorsal root ganglion neurones. Br. J. Pharmacol. 102 (1991) 272-276
171. V1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J. Physiol. 550 (2003) 921-926
172. Rush A.M., Brau M.E., Elliott A.A., and Elliott J.R. Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia. J. Physiol. 511 (1998) 771-789
173. Russell L.C., and Burchiel K.J. Neurophysiological effects of capsaicin. Brain Res. Rev. 8 (1984) 165-176
174. Sangameswaran L., Delgado S.G., Fish L.M., Koch B.D., Jakeman L.B., Stewart G.R., Sze P., Hunter J.C., Eglen R.M., and Herman R.C. Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons. J. Biol. Chem. 271 (1996) 5953-5956
175. Sangameswaran L., Fish L.M., Koch B.D., Rabert D.K., Delgado S.G., Ilnicka M., Jakeman L.B., Novakovic S., Wong K., Eglen R.M., and Hunter J.C. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J. Biol. Chem. 272 (1997) 14805-14809
176. Sato K., Kiyama H., Park H.T., and Tohyama M. AMPA, KA and NMDA receptors are expressed in the rat DRG neurones. Neuroreport 4 (1993) 1263-1265
177. Schmelz M., Schmid R., Handwerker H.O., and Torebjörk H.E. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain 123 (2000) 560-571
178. + channel in rdorsal root ganglion neurons and their blockade by halothane. Eur. J. Neurosci. 10 (1998) 2547-2556
179. Sherrington C.S. "The Integrative Action of the Nervous System," (1906), Scribner, New York 433
180. Sleeper A.A., Cummins T.R., Dib-Hajj S.D., Hormuzdiar W., Tyrrell L., Waxman S.G., and Black J.A. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy. J. Neurosci. 20 (2000) 7279-7289
181. Smith G.D., Gunthorpe M.J., Kelsell R.E., Hayes P.D., Reilly P., Facer P., Wright J.E., Jerman J.C., Walhin J.-P., Ooi L., Egerton J., Charles K.J., et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418 (2002) 186-190
182. Souslova V.A., Fox M., Wood J.N., and Akopian A.N. Cloning and characterization of mouse sensory neuron tetrodotoxin-resistant voltage-gated sodium channel gane, Scn10a. Genomics 41 (1997) 201-209
183. Spande T.F., Garraffo H.M., Edwards M.W., Yeh H.J.C., Pannel M.L., and Daly J.W. Epibatidine: A novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadorian poison frog. J. Am. Chem. Soc. 14 (1992) 3475-3478
184. Steen K.H., and Reeh P.W. Actions of cholinergic agonists and antagonists on sensory nerve endings in rat skin, in vitro. J. Neurophysiol. 70 (1993) 397-405
185. Strassmann A.M., and Raymond S.A. Electrophysiological evidence for tetrodotoxin-resistant sodium channels in slowly conducting dural sensory fibers. J. Neurophysiol. 81 (1999) 413-424
186. 4-positive and -negative nociceptors are functionally distinct. J. Neurosci. 19 (1999) 6497-6505
187. + conductance in rat optic nerve axons. Proc. Natl. Acad. Sci. USA 90 (1993) 6976-6980
188. Szállási A., and Blumberg P.M. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res. 524 (1990) 106-111
189. Szállási A., and Blumberg P.M. Vanilloid (capsaicin) receptors and mechanism. Pharmacol. Rev. 51 (1999) 159-211
190. Szállási A., Joo F., and Blumberg P.M. Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog. Brain Res. 503 (1989) 68-72
191. Szállási A., Blumberg P.M., Annicelli L.L., Krause J.E., and Cortright P.N. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Mol. Pharmacol. 56 (1999) 581-587
192. Szolcsányi J. On the specificity of pain producing and sensory neuron blocking effect of capsaicin. In: Knoll J., and Vizi E. (Eds). "Symposium on Analgesics" (1976), Akadémiai Kiadó, Budapest 167-172
193. Szolcsányi J. A pharmacological approach to elucidate the role of different nerve fibres and receptor endings in mediation of pain. J. Physiol. (Paris) 73 (1977) 251-259
194. Szolcsányi J. Effect of pain producing chemical agents on the activity of slowly conducting afferent fibres. Acta Physiol. Hung. 56 (1980) 86
195. Szolcsányi J. Capsaicin type pungent agents producing pyrexia. In: Milton A.S. (Ed). "Handbook of Experimental Pharmacology". "Pyretics and Antipyretics," Vol. 60 (1982), Springer-Verlag, Berlin 437-478
196. Szolcsányi J. Disturbances of thermoregulation induced by capsaicin. J. Therm. Biol. 8 (1983) 207-212
197. Szolcsányi J. Capsaicin and neurogenic inflammation: History and early findings. In: Chahl L.A., Szolcsányi J., and Lembeck F. (Eds). "Antidromic Vasodilatation and Neurogenic Inflammation" (1984), Akadémiai Kiadó, Budapest 7-26
198. Szolcsányi J. Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function. In: Chahl L.A., Szolcsányi J., and Lembeck F. (Eds). "Antidromic Vasodilatation and Neurogenic Inflammation" (1984), Akadémiai Kiadó, Budapest 27-56
199. Szolcsányi J. Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin and ultra-violet irradiation. J. Physiol. 388 (1987) 9-23
200. Szolcsányi J. Antidromic vasodilatation and neurogenic inflammation. Agents Actions 23 (1988) 4-11
201. Szolcsányi J. Capsaicin, irritation and desensitization: Neurophysiological basis and future perspectives. In: Green B.R., Mason J.R., and Kare M.R. (Eds). "Chemical Senses". "Irritation," Vol. 2 (1990), Marcel Dekker, New York 141-168
202. Szolcsányi J. Perspectives of capsaicin-type agents in pain therapy and research. In: Parris W.C.V. (Ed). "Contemporary Issues in Chronic Pain Management" (1991), Kluwer Academic Press, Boston 97-122
203. Szolcsányi J. Actions of capsaicin on sensory receptors. In: Wood J.N. (Ed). "Capsaicin in the Study of Pain" (1993), Academic Press, London 1-26
204. Szolcsányi J. Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: Facts and scopes of an unorthodox neuroregulatory mechanism. Prog. Brain Res. 113 (1996) 343-359
205. Szolcsányi J. Neurogenic inflammation: Reevaluation of axon reflex theory. In: Geppetti P., and Holzer P. (Eds). "Neurogenic Inflammation" (1996), CRC Press, Boca Raton, FL 35-44
206. Szolcsányi J. Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents. In: Kéri Gy., and Toth J. (Eds). "Molecular Pathomechanisms and New Trends in Drug Research" (2002), Taylor and Francis, London 319-333
207. Szolcsányi J. Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptides 38 (2004) 377-384
208. Szolcsányi J., and Jancsó-Gábor A. Capsaicin and other pungent agents as pharmacological tools in studies on thermoregulation. In: Schönbaum E., and Lomax P. (Eds). "The Pharmacology of Thermoregulation" (1973), Karger, Basel 395-409
209. Szolcsányi J., and Jancsó-Gábor A. Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency. Arzneim. Forsch. (Drug Res.) 25 (1975) 1877-1881
210. Szolcsányi J., and Jancsó-Gábor A. Sensory effects of capsaicin congeners II. Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds. Arzneim. Forsch. (Drug Res.) 26 (1976) 33-37
211. Szolcsányi J., Joó F., and Jancsó-Gábor A. Mitochondrial changes in preoptic neurones after capsaicin desensitization of the hypothalamic thermodetectors in rats. Nature 229 (1971) 116-117
212. Szolcsányi J., Jancsó-Gábor A., and Joó F. Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin. Naunyn Schmiedebergs Arch. Pharmacol. 287 (1975) 157-169
213. Szolcsányi J., Sann H., and Piearu Fr.-K. Nociception in pigeons is not impaired by capsaicin. Pain 27 (1986) 247-260
214. Szolcsányi J., Anton F., Reeh P.W., and Handwerker H.O. Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res. 446 (1988) 262-268
215. Szolcsányi J., Szállási A., Szállási Z., Joó F., and Blumberg P.M. Resiniferatoxin: An ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J. Pharmacol. Exp. Ther. 255 (1990) 923-928
216. Szolcsányi J., Barthó L., and Pethö G. Capsaicin-sensitive bronchopulmonary receptors with dual sensory-efferent function: Made of action of capsaicin antagonists. Acta Physiol. Hung. 77 (1991) 293-304
217. Szolcsányi J., Pórszász R., and Pethö G. Capsaicin and pharmacology of nociceptors. In: Besson J.M., Guilbaud G., and Ollat H. (Eds). "Peripheral Neurons in Nociception Physio-Pharmacological Aspects" (1994), John Libbey Eurotext, Paris 109-124
218. Szolcsányi J., Pintér E., and Helyes Zs. Sensocrine function of capsaicin-sensitive nociceptors mediated by somatostatin regulates against inflammation and hyperalgesia. In: Brune K., and Handwerker H.O. (Eds). "Hyperalgesia: Molecular Mechanism and Clinical Implications". "Progress in Pain Research and Management" Vol. 30 (2004), IASP Press, Seattle 113-128
219. Szöke E., Seress L., and Szolcsányi J. Neonatal capsaicin treatment results in prolonged mitochondrial damage and delayed cell death of B cells in the rat trigeminal ganglia. Neuroscience 113 (2002) 925-937
220. Szöke E., Czéh G., Szolcsányi J., and Seress L. Neonatal anandamide treatment results in prolonged mitochondrial damage in the vanilloid receptor type 1-immunoreactive B-type neurons of the rat trigeminal ganglion. Neuroscience 115 (2002) 805-814
221. + channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport 20 (1998) 967-972
222. Tate S., Benn S., Hick C., Trezise D., John V., Mannion R.J., Costigan M., Plumpton C., Grose D., Gladwell Z., Kendall G., Dale K., et al. Two sodium channels contribute to the TTX-R sodium current in primary sensory. Nat. Neurosci. 1 (1998) 653-655
223. Toledo-Aral J.J., Brehm P., Halegoua S., and Mandel G. A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction. Neuron 14 (1995) 607-611
224. Toledo-Aral J.J., Moss B.L., He Z.J., Koszowski A.G., Whisenand T., Levinson S.R., Wolf J.J., Silos-Santiago I., Halegoua S., and Mandel G. Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Neurobiology 94 (1997) 1527-1532
225. Tóth A., Blumberg P.M., Chen Z., and Kozikowski A.P. Design of a high-affinity competitive antagonist of the vanilloid receptor selective for the calcium entry-linked receptor population. Mol. Pharmacol. 65 (2004) 282-291
226. Voets T., Droogmans G., Wissenbach U., Janssens A., Flockerzi V., and Nilius B. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430 (2004) 748-754
227. Vyklicky L., Knotkova-Urbancova H., Vitaskova Z., Vlachova W., Kress M., and Reeh P.W. Inflammatory mediators at acidic pH activate capsaicin receptor in cultured sensory neurons from newborn rats. J. Neurophysiol. 79 (1998) 670-676
228. Waldman R., Champigny G., Bessilana F., Heurteaux C., and Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 386 (1997) 173-177
229. Walpole C.S.J., and Wrigglesworth. Structural requirement for capsaicin agonists and antagonists. In: Wood J.N. (Ed). "Capsaicin in the Study of Pain" (1993), Academic Press, London 63-81
230. Walpole C.S.J., Bevan S., Bloomfield G., Breckenridge R., James I.E., Ritchie T., Szállási A., Winter J., and Wrigglesworth R. Similarities and differences in the structure-activity relationships of capsaicin and resiniferatoxin analogues. J. Med. Chem. 39 (1996) 2932-2952
231. Waxman S.G., Kocsi J.D., and Black J.A. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J. Neurophysiol. 72 (1994) 466-470
232. Waxman S.G., Dib-Hajj S., Cummins T.R., and Black J.A. Sodium channels and pain. Proc. Natl. Acad. Sci. USA 96 (1999) 7635-7639
233. Waxman S.G., Dib-Hajj S., Cummins T.R., and Black J.A. Sodium channels and their genes: Dynamic expression in the normal nervous system, dysregulation in disease states. Brain Res. 886 (2000) 5-14
234. Wood J.N., Winter J., James I.F., Rang H.P., Yeats J., and Bevan S. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J. Neurosci. 8 (1988) 3208-3220
235. Yiangou Y., Birch R., Sangameswaran L., Eglen R., and Anand P. SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves. FEBS Lett. 467 (2000) 249-252
236. V1.8 (PN3/SNS) in a rat model of visceral pain. J. Neurosci. 21 (2001) 8690-8696
237. + current in rat sensory neurons. J. Physiol. 544 (2002) 385-402
238. Zhou Z., Bonasera L., and Carlton S.M. Peripheral administration of NMDA, AMPA or KA results in pain behaviour in rats. Neuroreport 7 (1996) 895-900
239. Zottermann Y. Studies in the peripheral nervous mechanism of pain. Acta Med. Scand. 80 (1933) 185-242