Chapter 2. Cutaneous polymodal receptors: Characteristics and plasticity

Progress in Brain Research

Volumn 113, Issue C, 1996, Pages 21-37

  Perl, Edward R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; CAT; ELECTROPHYSIOLOGY; NERVE CELL PLASTICITY; NOCICEPTION; NONHUMAN; PAIN RECEPTOR; PRIORITY JOURNAL; REVIEW; SENSITIZATION; SKIN;

EID: 0030477079     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)61079-1     Document Type: Article

References (51)

1. Akaike, N., Krishtal, O.A., Maruyama, T., Protoninduced sodium current in frog isolated dorsal root ganglion cells. J. Neurophysiol 63 (1990), 805-813.
2. Barasi, S., Lynn, B., Effects of sympathetic stimulation on mechanoreceptive and nociceptive afferent units from the rabbit pinna. Brain Res. 378 (1986), 21-27.
3. Beitel, R.E., Dubner, R., Response of unmyelinated C polymodal nociceptors to thermal stumuli applied to monkey's face. J. Neurophysiol. 39 (1976), 1160-1175.
4. Bessou, P., Perl, E., Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurphysiol. 32 (1969), 1025-1043.
5. Bevan, S., Yeats, J., Protons activated a cation conductance in a sub-population of rat dorsal root ganglion neurones. J. Physiol. (Lond.) 433 (1991), 145-161.
6. Bonica, J.J., Causalgia and other reflex sympathetic dystrophies. Bonica, J.J., Loeser, J.D., Chapman, R.C., Fordyce, W.E., (eds.) The Management of Pain, Vol. 1, 1990, Lea and Feibiger, Philadelphia, 220-229.
7. Bossut, D.F., Shea, V.K., Perl, E.R., Sympathectomy induces adrenergic excitability of cutaneous C-fiber nociceptors. J. Neurophysiol. 75 (1996), 514-517.
8. Brigham, K.L., Mediators of the inflammatory process: prostanoids. Henson, P.M., Murphy, R.C., (eds.) Mediators of the Inflammatory Process Handbook of Inflammation, Vol. 6, 1989, Elsevier, Amsterdam, 1-14.
9. Burgess, P.R., Perl, E., Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J. Physiol. (Lond.) 190 (1967), 541-562.
10. Campbell, J.N., Meyer, R.A., Sensitization of unmyelinated nociceptive afferents in monkey varies with skin type. J. Neurophsyiol. 49 (1983), 98-110.
11. Cannon, W.B., Rosenbleuth, A., The Supersensitivity of Denervated Structures: A Law of Denervation, 1949, MacMillan, New York.
12. Cohen, R.H., Perl, E.R., Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. J. Neurophysiol. 64 (1990), 457-464.
13. Crunkhorn, P., Willis, A.L., Cutaneous reactions to intradermal prostaglandins. Br. J. Pharmacol. 41 (1978), 57-64.
14. Davies, B., Sudera, D., Sagnella, G., Marchesi-Saviotti, E., Mathias, C., Bannister, R., Sever, P., Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man. Clin. Invest. 69 (1982), 779-784.
15. Ferreira, S.H., Prostaglandins, aspirin-like drugs and analgesia. Nature New Biol. 240 (1972), 200-203.
16. Fitzgerald, M., Lynn, B., The sensitization of high threshold mechanoreceptors with myelinated axons by repeated heating. J. Physiol. (Lond.) 365 (1977), 549-563.
17. Handwerker, H.O., Pharmacological modulation of the discharge of nociceptive C-fibers. Zotterman, Y., (eds.) Sensory Functions of the Skin in Primates, 1976, Pergamon, Oxford, 427-439.
18. 1 on tissues which respond to bradykinin. Nature (Lond.), 200, 1963, 892.
19. Iggo, A., Cutaneous heat and cold receptors with slowly conducting (C) afferent fibres. Q. J. Exp. Physiol. 44 (1959), 362-370.
20. Iriuchijima, J., Zotterman, Y., The specificity of afferent cutaneous C fibres in mammals. Acta Physiol. Scand. 49 (1960), 267-278.
21. Keele, C.A., Armstrong, D., Substances Producing Pain and Itch., 1964, Arnold, London.
22. King, J.S., Gallant, P., Myerson, V., Perl, E.R., The effects of anti-inflammatory agents on the responses and the sensitization of unmyelinated C-fiber polymodal nociceptors. Zotterman, Y., (eds.) Sensory Functions of the Skin in Primates, 1976, Pergamon, Oxford, 441-454.
23. Kumazawa, T., Perl, E.R., Primate cutaneous sensory units with unmyelinated C afferent fibers. J. Neurophysiol. 40 (1977), 1325-1338.
24. Lewis, T., Pain., 1942, Macmillan, New York.
25. Lindahl, O., Experimental skin pain. Acta Physiol Scand. 51 (1961), 1-90.
26. Lynn, B., Carpenter, S.E., Primary afferent units from the hairy skin of the rat hind limb. Brain Res. 238 (1982), 29-43.
27. Maruhashi, J., Mizuguchi, K., Tasaki, I., Action currents in single afferent nerve fibres elicited by stimulation of the skin of the toad and the cat. J. Physiol. (Lond.) 117 (1952), 129-151.
28. Nathan, P.W., On the pathogenesis of causalgia in peripheral nerve injuries. Brain 70 (1947), 145-170.
29. 2-adrenergic receptor expression by some DRG neurons. Soc. Neurosci. Abstr., 19, 1993, 499.
30. 2-adrenergic receptor expression in DRG neurons after peripheral nerve injury and sympathectomy. 4th IBRO World Congress of Neuroscience Abstr., 1995, 115 A3.72.
31. Ochoa, J., Torebjörk, E., Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. J. Physiol. (Lond.) 415 (1989), 583-599.
32. Perl, E.R., A reevaluation of mechanisms leading to sympathetically related pain. Fields, H.L., Liebeskind, J.C., (eds.) Pharmacological Approach to the Treatment of Chronic Pain: New Concepts and Critical Issues. Progress in Pain Research and Management, Vol. 1, 1994, International Association for the Study of Pain, Seattle.
33. Perl, E.R., Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli. J. Physiol. (Lond.) 197 (1968), 593-615.
34. Perl, E.R., Mode of action of nociceptors. Hirsch, C., Zotterman, Y., (eds.) Cervical Pain, Proceedings of the International Symposium held in Wenner-Gren Center, Stockholm, 1971-1972, Pergamon Press, Oxford, 157-164 January 25-27.
35. Revici, E., Stoopen, E., Frank, E., Ravich, R.A., The painful focus: II. The relation of pain to local physico-chemical changes. Bull. Inst. Appl. Biol., 1, 1949, 21.
36. Roberts, W.J., A hypothesis on the physiological basis for causalgia and related pains. Pain 24 (1986), 297-311.
37. Sato, J., Perl, E.R., Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251 (1991), 1608-1610.
38. Schott, G.D., Mechanisms of causalgia and related clinical conditions. Brain 109 (1986), 717-738.
39. Shea, V.K., Perl, E.R., Sensory receptors with unmyelinated C-fibers innervating the skin of the rabbit's ear. J. Neurophysiol. 54 (1985), 491-501.
40. Shea, V.K., Perl, E.R., Regeneration of cutaneous afferent unmyelinated C-fibers after transection. J. Neurophysiol. 54 (1985), 502-512.
41. Shea, V.K., Perl, E.R., Failure of sympathetic stimulation to affect responsiveness of rabbit polymodal nociceptors. J. Neurophysiol. 54 (1985), 513-519.
42. Sherrington, C.S., The Integrative Action of the Nervous System., 1906, Scribner, New York, 433.
43. Steen, K.H., Reeh, P.W., Anton, F., Handwerker, H.O., Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J. Neurosci 12 (1992), 86-95.
44. Stuart, J.M., Roles for kinins in inflammation. Henson, P.M., Murhpy, R.C., (eds.) Mediators of the Inflammatory Process Vol. 6 Handbook of Inflammation, 1989, Elsevier, Amsterdam, 189-217.
45. Szolcsånyi, J., Effects of pain-producing chemical agents on the activity of slowly conducting afferent fibres. Acta Physiol. Acad. Sci. Hung., 1979, 86.
46. Szolcsånyi, J., Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin and ultra-violet irradiation. J. Physiol. (Lond.) 388 (1987), 9-23.
47. Thalhammer, J.G., LaMotte, R.H., Spatial properties of nociception sensitization following heat injury of the skin. Brain Res. 231 (1982), 257-265.
48. Torebjörk, H.E., Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. Acta Physiol. Scand. 29 (1974), 374-390.
49. Torebjörk, E., Ochoa, J., Pain and itch from C-fibre stimulation. Soc. Neurosci. Abstr., 7, 1981, 7.
50. Treede, R.-D., Meyer, R.A., Campbell, J.N., Comparison of heat and mechanical receptive fields of cutaneous C-fiber nociceptors in monkey. J. Neurophysiol. 64 (1990), 1502-1513.
51. von Frey, M., Beiträge zur Physiologie des Schmerzsinns. Koenigl. Saechs. Ges. Wiss., Math.-Phys. Klasse 46 (1894), 185-196.