Sodium channels and their genes: Dynamic expression in the normal nervous system, dysregulation in disease states

Brain Research

Volumn 886, Issue 1-2, 2000, Pages 5-14

  Waxman, Stephen G ^a,b   Dib Hajj, Sulayman ^a,b   Cummins, Theodore R ^a,b   Black, Joel A ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Electrogenesis; Ion channel; Plasticity

Indexed keywords

SODIUM CHANNEL;

AUTOPSY; CELL TYPE; CHRONIC PAIN; DEMYELINATION; DOWN REGULATION; DYNAMICS; EXCITABLE MEMBRANE; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION AND TRANSLATION; GIANT CELL; HUMAN; HYPOTHALAMUS; MULTIPLE SCLEROSIS; NERVE CELL; NERVE FIBER; NERVE TRANSECTION; NERVOUS SYSTEM; NEUROLOGIC DISEASE; NEUROPHYSIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PERIKARYON; PLASTICITY; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; SYNAPTIC TRANSMISSION;

EID: 0034672430     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02774-8     Document Type: Article

References (48)

1. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
2. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
3. + channel α subunit with novel gating properties
4. + channel lll and SNS gene expression in spinal sensory neurons
5. Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons
6. Abnormal expression of SNS/PN3 sodium channel in cerebellar Purkinje cells following loss of myelin in the taiep rat
7. Effects of electrical and mechanical stimulation on two foci of spontaneous activity which develop in primary afferent neurons after peripheral axotomy
8. Three types of sodium channels in adult rat dorsal root ganglion neurons
9. Cellular and molecular biology of voltage-gated sodium channels
10. Down-regulation of tetrodotoxin-resistant sodium currents and up-regulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury
11. Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel
12. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons
13. + channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus
14. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy
15. Insertion of a SNS-specific tetrapeptide in the S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na channel μ1 in HEK293 cells
16. NaN, a novel voltage-gated Na channel preferentially expressed in peripheral sensory neurons and down-regulated following axotomy
17. Rescue of α-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo
18. Coding sequence genomic organization and conserved chromosomal localization of mouse gene Scn11a encoding the sodium channel NaN
19. Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons
20. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
21. The behavior of chromatolysed motoneurons studied by intracellular recording
22. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia
23. Sodium channels accumulate at the tips of injured axons
24. Sodium channel accumulation in humans with painful neuromas
25. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
26. A quantitative description of membrane current and its application to conduction and excitation in nerve
27. Distinct regulation of sodium channel types I, II, and III following nerve transection
28. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting
29. Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurons of the cat
30. 2+ and gap junctions
31. Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slice
32. + conductance and the threshold for repetitive neuronal firing
33. Primary structure of Electrophorus electricus sodium channel deduced from complementary DNA sequence
34. Existence of distinct sodium channel messenger RNAs in rat brain
35. Resurgent sodium current and action potential formation in dissociated cerebellar purkinje neurons
36. Altered subthreshold sodium currents and disrupted currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice
37. Structure and function of a novel voltage-gated tetrodotoxin-resistant sodium channel specific to sensory neurons
38. Development of ongoing activity, mechanosensitivity, and adrenalin sensitivity in severed peripheral nerve axons
39. + current heterogeneity in rat nodose neurons and its impact on neuronal discharge
40. Sodium-dependent regenerative responses in dendrites of axotomized motoneurons in the cat
41. Molecular and functional remodeling of electrogenic membrane of hypothalamic neurons in response to changes in their input
42. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
43. A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction
44. Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells
45. The neuron as a dynamic electrogenic machine: modulation of sodium channel expression as a basis for functional plasticity in neurons
46. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is re-expressed following axotomy