Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum

Journal of Physiology

Volumn 509, Issue 3, 1998, Pages 717-727

  Hillsley, K ^a,b   Grundy, D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; HEXAMETHONIUM; HYDROCHLORIC ACID; LIDOCAINE; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 3 RECEPTOR; ACID; GRANISETRON; LUMINAL ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE; COMPUTER PROGRAM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENTEROCHROMAFFIN CELL; INTESTINE INNERVATION; JEJUNUM; MECHANORECEPTOR; MESENTERY; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; VAGUS NERVE; ANIMAL CELL; CELL SUBPOPULATION; CENTRAL NERVOUS SYSTEM; CHOLINERGIC TONE; CHRONIC VAGOTOMY; EXPERIMENTAL DESIGN; LATENT PERIOD; MALE; MECHANOSENSITIVITY; MESENTERIC NERVE; MOLECULAR DYNAMICS; NERVE CELL STIMULATION; NERVE POTENTIAL; NERVOUS SYSTEM FUNCTION; NEUROMODULATION; NEUROTRANSMISSION; NICOTINIC TRANSMISSION; PHYSICAL SENSITIVITY; SENSITIVITY ANALYSIS; VAGOTOMY; WHOLE CELL PATCH CLAMP;

ACTION POTENTIALS; ANESTHETICS, LOCAL; ANIMALS; CHOLINERGIC ANTAGONISTS; ELECTROPHYSIOLOGY; ENTERIC NERVOUS SYSTEM; GANGLIONIC BLOCKERS; HEXAMETHONIUM; HYDROCHLORIC ACID; JEJUNUM; LIDOCAINE; MALE; NEURONS, AFFERENT; PHYSICAL STIMULATION; RATS; RATS, WISTAR; SEROTONIN; STRESS, MECHANICAL; VAGOTOMY;

EID: 0032526215     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.717bm.x     Document Type: Article

References (27)

1. AKOEV, G. N., FILIPPOVA, L. V. & SHERMAN, N. O. (1996). Mast cell mediators excite the afferents of cat small intestine. Neuroscience 71, 1163-1166.
2. ANTHONY, T. L. & KREULEN, D. L. (1990). Volume-sensitive synaptic input to neurons in guinea pig inferior mesenteric ganglion. American Journal of Physiology 259, G490-497.
3. BERTHOUD, H. R., KRESSEL, M., RAYBOULD, H. E. & NEUHUBER, W. L. (1995). Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiL-tracing. Anatomy and Embryology 191, 203-212.
4. BERTHOUD, H. R. & PATTERSON, L. M. (1996). Anatomical relationship between vagal afferent fibers and CCK-immunoreactive entero-endocrine cells in the rat small intestinal mucosa. Acta Anatomica 156, 123-131.
5. BERTRAND, P. P., KUNZE, W. A., BORNSTEIN, J. C., FURNESS, J. B. & SMITH, M. L. (1997). Analysis of the response of myenteric neurons in the small intestine to chemical stimulation of the mucosa. American Journal of Physiology 273, G422-435.
6. BLACKSHAW, L. A. & GRUNDY, D. (1993). Effect of 5-HT on discharge of vagal mucosal afferent fibres from the upper gastrointestinal tract of the ferret. Journal of the Autonomic Nervous System 45, 41-50.
7. BÜLBRING, E. & LIN, R. C. Y. (1958). The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. Journal of Physiology 140, 381-407.
8. CERVERO, F. & SHARKEY, K. A. (1988). An electrophysiological and anatomical study of intestinal afferent fibres in the rat. Journal of Physiology 401, 381-397.
9. CLARK, G. D. & DAVISON, J. S. (1978). Mucosal receptors in the gastric antrum and small intestine of the rat with afferent fibres in the cervical vagus. Journal of Physiology 274, 55-67.
10. COTTRELL, D. F. & IGGO, A. (1984). Mucosal enteroceptors with vagal afferent fibres in the proximal duodenum of sheep. Journal of Physiology 354, 497-522.
11. DAVISON, J. S. (1972). Response of single vagal afferent fibres to mechanical and chemical stimulation of the gastric and duodenal mucosa in cats. Quarterly Journal of Experimental Physiology 57, 405-416.
12. EL OUAZZANI, T. & MEI, N. (1981). Vagal acido- and glucoreceptors in the gastro-duodenal region. Experimental Brain Research 42, 442-452.
13. GERSHON, M. D. (1991). Serotonin: its role and receptors in enteric neurotransmission. Advances in Experimental Medicine and Biology 294, 221-230.
14. GERSHON, M. D., KIRCHGESSNER, A. L. & WADE, P. R. (1994). Functional anatomy of the enteric nervous system. In Physiology of the Gastrointestinal Tract, 3rd edn, vol. 1, ed. JOHNSON, L. R., pp. 381-422. Raven Press, New York.
15. GIBBINS, I. L., FURNESS, J. B., COSTA, M., MACINTYRE, I., HILLYARD, C. J. & GIRGIS, S. (1985). Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs. Neuroscience Letters 572, 125-130.
16. GRIDER, J. R. & JIN, J. G. (1994). Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation. Journal of Neuroscience 14, 2854-2860.
17. GRIDER, J. R., KUEMMERLE, J. F. & JIN, J. G. (1996). 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. American Journal of Physiology 270, G778-7782.
18. GRUNDY, D. (1988). Speculations on the structure/function relationship for vagal and splanchnic afferent endings supplying the gastrointestinal tract. Journal of the Autonomic Nervous System 22, 175-180.
19. HARDCASTLE, J., HARDCASTLE, P. T., CARSTAIRS, J. W. & FRANKS, C. M. (1994). Is desensitization of intestinal 5-hydroxytryptamine receptors an in-vitro phenomenon? Journal of Pharmacy and Pharmacology 46, 322-325.
20. HILLSLEY, K., KIRKUP, A. J. & GRUNDY, D. (1998). Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum. Journal of Physiology 506, 551-561.
21. IGGO, A. (1957). Gastric mucosal receptors with afferent fibres in the cat. Quarterly Journal of Experimental Physiology 42, 398-409.
22. KIRCHGESSNER, A. L., LIU, M. T. & GERSHON, M. D. (1996). In situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexes. Journal of Comparative Neurology 371, 270-286.
23. KIRCHGESSNER, A. L., TAMIR, H. & GERSHON, M. D. (1992). Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. Journal of Neuroscience 12, 235-248.
24. LEW, W. Y. W. & LONGHURST, J. C. (1986). Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferent fibre endings in cats. American Journal of Physiology 250, R465-473.
25. MILLER, S. M. & SZURSZEWSKI, J. H. (1997). Colonic mechanosensory afferent input to neurons in the mouse superior mesenteric ganglion. American Journal of Physiology 272, G357-366.
26. RICHARDS, W., HILLSLEY, K., EASTWOOD, C. & GRUNDY, D. (1996). Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat. Journal of Physiology 497, 473-481.
27. SENGUPTA, J. M. & GEBHART, G. F. (1994). Gastrointestinal afferent fibers and sensation. In Physiology of the Gastrointestinal Tract, 3rd edn, vol. 1, ed. JOHNSON, L. R., pp. 483-519. Raven Press, New York.