Chapter 20. Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: Facts and scopes of an unorthodox neuroculatory mechanism

Progress in Brain Research

Volumn 113, Issue C, 1996, Pages 343-359

  Szolcsányi, János ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; RESINIFERATOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CAT; ELECTROPHYSIOLOGY; GUINEA PIG; HUMAN; MONKEY; NERVE ENDING; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE;

EID: 0030445624     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)61097-3     Document Type: Article

References (141)

1. Abdel-Salam, O.M.E., Szolcsånyi, J., Barthó, L., Mózsik, Gy., Sensory nerve-mediated mechanisms, gastric mucosal damage and its protection: a critical overview. Gastroprotection 2 (1994), 4-12.
2. 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Mol. Brain Res. 35 (1996), 173-182.
3. Andersson, S.E., Responses to antidromic trigeminal nerve stimulation, SP, NKA, CGRP and capsaicin in the rat eye. Acta Physiol. Scand. 131 (1987), 371-376.
4. Baccaglini, P.J., Hogan, P.G., Some rat sensory neurons in culture express characteristic of differentiated pain sensory cells. Proc. Natl. Acad. Sci. USA 80 (1983), 594-598.
5. Baluk, P., Nadel, J.A., McDonald, D.M., Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J. Comp. Neurol. 319 (1992), 586-601.
6. Baraniuk, J.N., Kowalski, M.L., Kaliner, M.A., Relationship between permeable vessels, nerves, and mast cells in rat cutaneous inflammation. J. Appl. Physiol. 68 (1990), 2305-2318.
7. Barnes, P.J., Brown, M.J., Dollery, C.T., Fuller, R.W., Heavey, D.J., Ind, P.W., Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Br. J. Pharmacol. 88 (1986), 741-745.
8. Barthó, L., Szolcsånyi, J., The site of action of capsaicin on the guinea-pig isolated ileum. Naunyn-Schmiedeberg's Arch. Pharmacol. 305 (1978), 75-81.
9. Barthó, L., Ernst, R., Pierau, Fr., Sann, K.H., Faulstroh, K., Pethõ, G., An opioid peptide inhibits capsaicinsensitive vasodilatation in the pig's skin. Neuropeptides 23 (1992), 227-237.
10. Bauman, T.K., Simone, D.A., Shain, C.N., La Motte, R.H., Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicininduced pain and hyperalgesia. J. Neurophysiol. 66 (1991), 212-227.
11. Bayliss, W.M., On the origin from the spinal cord of the vaso-dilator fibres of the hindlimb, and on the nature of these fibres. J. Physiol. 26 (1901), 173-209.
12. Bayliss, W.M., The Vaso-motor System, 1923, Longmans Green, London.
13. Bessou, P., Perl, E.R., Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurophysiol. 32 (1969), 1025-1043.
14. Bevan, S.J., Docherty, R.J., Cellular mechanisms of the action of capsaicin. Wood, J.N., (eds.) Capsaicin in the Study of Pain, 1993, Academic Press, London, 27-44.
15. Bevan, S., Geppetti, P., Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci. 17 (1994), 509-512.
16. Bevan, S., Szolcsånyi, J., Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci 11 (1990), 330-333.
17. Bevan, S., Hothi, S., Hughes, G., James, J.F., Rang, H.P., Shah, K., Walpole, C.S.J., Yeats, J.C., Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br. J. Pharmacol. 107 (1992), 544-552.
18. Bharali, L.A.M., Lisney, S.J.W., The relationship between unmyelinated afferent type and neurogenic plasma extravasation in normal and reinnervated rat skin. Neuroscience 47 (1992), 703-712.
19. Breslauer, F., Die Pathogenese der trophischen Gewebsschäden nach der Nervenverletzung. Deutsche Zeitsch. f. Chirurgie 150 (1919), 50-81.
20. Bruce, A.N., Über die Beziehungen der sensiblen Nervenendigungen zum Entzündungsvorgang. Arch. Exp. Pathol. Pharmakol. 63 (1910), 424-433.
21. Burnstock, G., Co-transmission. Arch. Int. Pharmacodyn. 304 (1990), 7-33.
22. 2 are inhibited by a SP antagonist. Experientia 39 (1983), 996-998.
23. Celander, O., Folkow, B., The nature and the distribution of afferent fibres provided with the axon reflex arrangement. Acta Physiol. Scand. 29 (1953), 339-370.
24. Chahl, L.A., Antidromic vasodilatation and neurogenic inflammation. Beli, C., (eds.) Novel Peripheral Neurotransmitters, 1991, Pergamon Press, New York, 161-192.
25. Chahl, L.A., Szolcsånyi, J., Lembeck, F., Antidromic Vasodilatation and Neurogenic Inflammation., 1984, Akadémiai Kiadó, Budapest.
26. Chiba, T., Masuko, S., Kawano, H., Correlation of mitochondrial swelling after capsaicin treatment and substance P and somatostatin immunoreactivity in small neurons of dorsal root ganglion in the rat. Neurosci. Lett. 64 (1986), 311-316.
27. Coleridge, J.C.G., Coleridge, H.M., Afferent vagal C fibre innervation of the lung and airways and its functional significance. Rev. Physiol Biochem. Pharmacol. 99 (1984), 1-110.
28. Ferrell, W.R., Russell, N.J.W., Extravasation in the knee induced by antidromic stimulation of articular C fibre afferents of the anesthetized cat. J. Physiol. 379 (1986), 407-416.
29. Foster, R.W., Ramage, A.G., The action of some chemical irritants on somatosensory receptors of the cat. Neuropharmacology 20 (1981), 191-198.
30. Fox, A.J., Barnes, P.J., Urban, L., Dray, A., An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J. Physiol. 469 (1993), 21-35.
31. Franco-Cereceda, A., CGRP and human epicardial coronary arteries: Presence, release and vasodilator effects. Br. J. Pharmacol. 102 (1991), 506-510.
32. Franco-Cereceda, A., Lundberg, J.M., Capsazepine inhibits low pH- and lactic acid-evoked release of CGRP from sensory nerves in guinea-pig heart. Eur. J. Pharmacol. 221 (1992), 183-184.
33. Franco-Cereceda, A., Lundberg, J.M., Calcitonin gene-related peptide (CGRP) and capsaicin-induced stimulation of heart contractility rate and force. Naunyn-Schmiedeberg's Arch. Pharmacol. 331 (1995), 146-151.
34. Geppetti, P., Holzer, P., Neurogenic Inflammation., 1996, CRC. Press, Boca Raton.
35. Hakanson, R., Beding, B., Ljungquist, A., Chu, J.Y., Leander, S., Trojnar, J., Folkers, K., Blockade of sensory nerve mediated contraction of the rabbit iris sphincter by a series of novel tachykinin antagonist. Regul. Pept. 20 (1988), 99-105.
36. Handwerker, H.O., Holzer-Petsche, U., Heym, Ch., Welk, E., C-fiber functions after topical application of capsaicin to a peripheral nerve and after neonatal capsaicin treatment. Chahl, L.A., Szolcsånyi, J., Lembeck, F., (eds.) Antidromic Vasodilatation and Neurogenic Inflammation, 1984, Akadémiai Kiadó, Budapest, 57-82.
37. Heyman, I., Rang, H.P., Depolarizing responses to capsaicin in a subpopulation of rat dorsal root ganglion cells. Neurosci Lett. 56 (1985), 69-75.
38. Holzer, P., Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins and other neuropeptides. Neuroscience 24 (1988), 739-768.
39. Holzer, P., Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43 (1991), 143-201.
40. Holzer, P., Peptidergic sensory neurons in the control of vascular functions: mechanisms and significance in the cutaneous and splanchnic vascular beds. Rev. Physiol. Biochem. Pharmacol. 121 (1992), 49-146.
41. Holzer, P., Barthó, L., Sensory neurons in the intestine. Geppetti, P., Holzer, P., (eds.) Neurogenic Inflammation, 1996, CRC Press, Boca Raton, 153-167.
42. Hurley, J.V., The sequence of early events. Vane, J.R., Ferreira, S.H., (eds.) Inflammation. Handb. Exp. Pharmacol, Vol. 50/1, 1978, Springer-Verlag, Berlin, 26-67.
43. Izumi, H., Karita, K., Investigation of mechanisms of the flare and wheal reactions in human skin by band method. Brain Res. 449 (1988), 328-331.
44. Jancsó, N., Jancsó-Gåbor, A., Szolcsånyi, J., Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmacol. 31 (1967), 138-151.
45. Jancsó, N., Jancsó-Gåbor, A., Szolcsånyi, J., The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br. J. Pharmacol. 33 (1968), 32-41.
46. Jancsó, G., Kiråly, E., Jancsó-Gåbor, A., Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 270 (1977), 741-743.
47. Jessell, T.M., Kandel, E.R., Synaptic transmission: a bidirectional and self- modifiable form of cell-cell communication. Neuron, 10, 1993 Suppl. 130.
48. Joó, F., Szolcsånyi, J., Jancsó-Gåbor, A., Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin. Life Sci. 8 (1969), 621-626.
49. Kenins, P., Identification of the unmyelinated sensory nerves which evoke plasma extravasation in response to antidromic stimulation. Neurosci. Lett. 25 (1981), 137-141.
50. Kenins, P., Responses of single nerve fibres to capsaicin applied to the skin. Neurosci. Lett. 29 (1982), 83-88.
51. Konietzny, F., Hensel, H., The effect of capsaicin on the response characteristic of human C-polymodal nociceptors. J. Therm. Biol. 8 (1983), 213-215.
52. Kowalski, M.L., Kaliner, M.A., Neurogenic inflammation, vascular permeability, and mast cells. J. Immunol. 140 (1988), 3905-3911.
53. Kruger, L., Morphological features of thin sensory afferent fibers: a new interpretation of ‘nociceptor’ function. Hamann, W., Iggo, A., (eds.) Progress in Brain Research, Vol. 74, 1988, Elsevier, Amsterdam, 253-257.
54. Kumazawa, T., Mizumura, K., Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog. J. Physiol. (Lond) 273 (1977), 179-194.
55. Lam, F.Y., Ferrell, W.R., Effect of interactions of naturally-occurring neuropeptides on blood flow in the rat knee joint. Br. J. Pharmacol. 108 (1993), 694-699.
56. La Motte, R.H., Lundberg, L.E.R., Torebjörk, H.E., Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J. Physiol. 448 (1992), 749-764.
57. Lembeck, F., Sir Thomas Lewis's nocifensor system, histamine and substance-P-containing primary afferent nerves. Trends Neurosci. 6 (1983), 106-108.
58. 8-enkephalinamide. Eur. J. Pharmacol. 85 (1982), 171-176.
59. Lembeck, F., Donnerer, J., Tsuchiya, M., Nagahisa, A., The non peptide tachykinin antagonist, CP 96345, is a potent inhibitor of neurogenic inflammation. Br. J. Pharmacol. 105 (1992), 527-530.
60. Lewis, T., The Blood Vessels of the Human Skin and their Responses, 1927, Shaw, London.
61. Lewis, T., The nocifensor system of nerves and its reaction. Br. Med. J. 194 (1937), 431-435.
62. Lewis, T., The nocifensor system of nerves and its reaction. Br. Med. J. 194 (1937), 491-494.
63. Lewis, T., Grant, R.T., Vascular reactions of the skin to injury. II. The liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning: and observations upon the nervous control of certain skin reactions. Heart 11 (1924), 209-265.
64. Lisney, S.J.W., Bharali, L.A.M., The axon reflex: an outdated idea or a valid hypothesis?. New Physiol. Sci. 4 (1989), 45-48.
65. Liu, L., Simon, S.A., A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Proc. Natl. Acad. Sci. USA 91 (1994), 738-741.
66. Louis, S.M., Jamieson, A., Russell, N.J.W., Dockray, G.J., The role of SP and CGRP in neurogenic plasma extravasation and vasodilatation in the rat. Neuroscience 32 (1989), 581-586.
67. Lundberg, J.M., Capsaicin-sensitive sensory nerves in the airways — implications for protective reflexes and disease. Wood, J.N., (eds.) Capsaicin in the Study of Pain, 1993, Academic Press, London, 219-238.
68. Lundberg, J.M., Saria, A., Bronchial smooth muscle contraction induced by stimulation of capsaicin-sensitive sensory neurons. Acta Physiol. Scand. 116 (1982), 473-476.
69. Lynn, B., Cotsell, B., The delay in onset of vasodilator flare in human skin at increasing distances from a localized noxious stimulus. Microvasc. Res. 41 (1991), 197-202.
70. MacLean, D.B., Wheeler, F., Hoyes, L., Basal and stimulated release of substance P from dissociated cultures of vagal sensory neurons. Brain Res. 519 (1990), 308-314.
71. 2; capsaicin and SP. Acta Physiol. Scand. 112 (1981), 331-338.
72. Magerl, V., Szolcsånyi, J., Westerman, R.A., Handwerker, H.O., Laser Doppler measurements of skin vasodilatation elicited by percutaneous electrical stimulation of nociceptors in humans. Neurosci. Lett. 82 (1987), 349-354.
73. Maggi, C.A., The pharmacology of the efferent function of sensory nerves. J. Auton. Pharmacol. 11 (1991), 173-208.
74. Maggi, C.A., Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves. Prog. Neurobiol. 45 (1995), 1-98.
75. Maggi, C.A., Meli, A., The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen. Pharmacol. 19 (1988), 1-43.
76. Maggi, C.A., Santicioli, P., Meli, A., The effect of topical capsaicin on rat urinary bladder motility in vivo. Eur. J. Pharmacol. 103 (1984), 41-50.
77. Marsh, S.J., Stansfeld, C.E., Brown, D.A., Dave, R., McCarthy, D., The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro. Neuroscience 23 (1987), 275-289.
78. Martin, H.A., Basbaum, A.J., Kwiat, G.C., Goetzl, E.J., Levine, J.D., Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience 22 (1987), 399-406 651-669.
79. McDonald, D.M., Neurogenic inflammation in the rat trachea. I. Changes in venules, leucocytes and epithelial cells. J. Neurocytol. 17 (1988), 583-603.
80. Meehan, A.G., Hottenstein, O.D., Kreulen, D.L., Capsaicin-sensitive nerves mediate inhibitory junction potentials and dilatation in guinea-pig mesenteric artery. J. Physiol. 443 (1991), 161-172.
81. Meyer, R.A., Campbell, J.N., Raja, S.N., Antidromic nerve stimulation in monkey does not sensitize unmyelinated nociceptors to heat. Brain Res. 441 (1988), 168-172.
82. Michaelis, M., Göder, R., Häbler, H.-J., Jänig, W., Properties of afferent nerve fibres supplying the saphenous vein in the cat. J. Physiol. 474 (1994), 233-243.
83. Ninkina, N.N., Willoughby, J.J., Beech, M.M., Loote, P.R., Wood, J.N., Molecular cloning of a resiniferatoxinbinding protein. Mol. Brain Res. 22 (1994), 39-48.
84. Nordin, M., Low-threshold mechanoreceptive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. J. Physiol. 624 (1990), 229-240.
85. Ochoa, J., Torebjörk, E., Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves. J. Physiol. 415 (1989), 583-599.
86. Oh, U., Hwang, S.W., Kim, D., Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons. J. Neurosci. 16 (1996), 1659-1667.
87. Otsuka, M., Yoshioka, K., Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73 (1993), 230-308.
88. Peterson, M., La Motte, R.H., Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 54 (1993), 37-42.
89. Pethõ, G., Szolcsånyi, J., Excitation of central and peripheral terminals of primary afferent neurons by capsaicin in vivo. Life Sci. 58 (1996), PL47–PL53.
90. Pierau, Fr.-K., Szolcsånyi, J., Neurogenic inflammation: axon reflex in pigs. Agents Actions 26 (1989), 231-232.
91. Pini, A., Lynn, B., C-fibre function during the 6 weeks following brief application of capsaicin to a cutaneous nerve in the rat. Eur. J. Neurosci. 3 (1991), 274-284.
92. Pintér, E., Szolcsånyi, J., Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat. Agents Actions 25 (1988), 240-242.
93. Pintér, E., Szolcsånyi, J., Plasma extravasation in the skin and pelvic organs evoked by antidromic stimulation of the lumbosacral dorsal roots of the rat. Neuroscience 68 (1995), 603-614.
94. Pórszåsz, R., Szolcsånyi, J., Antidromic vasodilatation in the striated muscle and its sensitivity to resiniferatoxin in the rat. Neurosci. Lett. 182 (1994), 267-270.
95. Reeh, P.W., Kocher, L., Jung, S., Does neurogenic inflammation alter the sensitivity of unmyelinated nociceptors in the rat?. Brain Res. 384 (1986), 42-50.
96. Sann, H., Pintér, E., Szolcsånyi, J., Pierau, Fr.-K., Peptidergic afferents might contribute to the regulation of skin blood flow. Agents Actions 23 (1988), 14-15.
97. Sann, H., Rössler, W., Hammer, K., Pierau, Fr.-K., Substance P and calcitonin generelated peptide in the ureter of chicken and guinea-pig: distribution, binding sites and possible functions. Neuroscience 49 (1992), 699-713.
98. Santicioli, P., Del Bianco, E., Geppetti, P., Maggi, C.A., Release of CGRP-like immunoreactivity from rat isolated soleus muscle by low pH, capsaicin and potassium. Neurosci Lett. 143 (1992), 19-22.
99. Schmidt, R., Schmelz, M., Forster, C., Ringkamp, M., Torebjörk, E., Handwerker, H., Novel classes of responsive and unresponsive C nociceptors in human skin. J. Neurosci. 15 (1995), 333-341.
100. Seno, N., Dray, A., Capsaicin-induced activation of fine afferent fibres from rat skin in vitro. Neuroscience 55 (1993), 563-569.
101. Simone, D.A., Ochoa, J., Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans. Pain 47 (1991), 285-294.
102. Szållåsi, A., The vanilloid (capsaicin) receptor: receptor types and species differences. Gen. Pharmacol. 25 (1994), 223-243.
103. Szållåsi, A., Autoradiographic visualization and pharmacological characterization of vanilloid (capsaicin) receptors in several species, including man. Acta Physiol. Scand, 155, 1995 Suppl. 629.
104. Szolcsånyi, J., On the specificity of pain producing and sensory neuron blocking effect of capsaicin. Knoll, J., Vizi, E., (eds.) Symposium on Analgesics, 1976, Akadémiai Kiadó, Budapest, 167-172.
105. Szolcsånyi, J., A pharmacological approach to elucidation of the role of different nerve fibers and receptor endings in mediation of pain. J. Physiol (Paris) 73 (1977), 251-259.
106. Szolcsånyi, J., Effect of pain-producing chemical agents on the activity of slowly conducting afferent fibres. Acta Physiol. Acad. Sci. Hung., 56, 1980, 86.
107. Szolcsånyi, J., Capsaicin type pungent agents producing pyrexia. Milton, A.S., (eds.) Handbook of Experimental Pharmacology, Vol. 60., Pyretics and Antipyretics, 1982, Springer-Verlag, Berlin, 437-478.
108. Szolcsånyi, J., Disturbances of thermoregulation induced by capsaicin. J. Therm. Biol. 8 (1983), 207-212.
109. Szolcsånyi, J., Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea. Neurosci. Lett. 42 (1983), 83-88.
110. Szolcsånyi, J., Capsaicin and neurogenic inflammation: History and early findings. Chahl, L.A., Szolcsånyi, J., Lembeck, F., (eds.) Antidromic Vasodilatation and Neurogenic Inflammation., 1984, Akadémiai Kiadó, Budapest, 7-26.
111. Szolcsånyi, J., Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function. Chahl, L.A., Szolcsånyi, J., Lembeck, F., (eds.) Antidromic Vasodilatation and Neurogenic Inflammation., 1984, Akadémiai Kiadó, Budapest, 27-56.
112. Szolcsånyi, J., Sensory receptors and the antinociceptive effects of capsaicin. Hakanson, R., Sundler, F., (eds.) Tachykinin Antagonists., 1985, Elsevier, Amsterdam, 45-54.
113. Szolcsånyi, J., Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin and ultra-violet irradiation. J. Physiol. 388 (1987), 9-23.
114. Szolcsånyi, J., Antidromic vasodilatation and neurogenic inflammation. Agents Actions 23 (1988), 4-11.
115. Szolcsånyi, J., Capsaicin-sensitive chemoceptive Bafferents: A neural system with dual sensory-efferent function. Behau. Brain Sci., 13, 1990, 316.
116. Szolcsånyi, J., Capsaicin, irritation, and desensitization. Neurophysiological basis and future perspectives. Green, B.R., Mason, J.R., Kare, M.R., (eds.) Chemical Senses Vol. 2. Irritation., 1990, Marcel Dekker, New York, 141-168.
117. Szolcsånyi, J., Perspectives of capsaicin-type agents in pain therapy and research. Parris, W.C.W., (eds.) Contemporary Issues in Chronic Pain Management., 1991, Kluwer Acad. Publ., Boston, 97-122.
118. Szolcsånyi, J., Actions of capsaicin on sensory receptors. Wood, J.N., (eds.) Capsaicin in the Study of Pain., 1993, Academic Press, London, 1-26.
119. Szolcsånyi, J., Neurogenic inflammation: reevaluation of axon reflex theory. Geppetti, P., Holzer, P., (eds.) Neurogenic Inflammation., 1996, CRC Press, Boca Raton, 33-42.
120. Szolcsånyi, J., Jancsó-Gåbor, A., Sensory effects of capsaicin congeners. I. Relationship between chemical structure and pain producing potency of pungent agents. Arzneim. Forsch. (Drug Res.) 25 (1975), 1877-1881.
121. Szolcsånyi, J., Jancsó-Gåbor, A., Sensory effects of capsaicin congeners. II. Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds. Arzneim. Forsch. (Drug Res.) 26 (1976), 33-37.
122. Szolcsånyi, J., Barthó, L., New type of nervemediated cholinergic contractions of the guinea-pig small intestine and its selective blockade by capsaicin. Naunyn-Schmiedeberg's Arch. Pharmacol. 305 (1978), 83-90.
123. Szolcsånyi, J., Barthó, L., Impaired defense mechanism to peptic ulcer in the capsaicin desensitized rat. Mózsik, G., Hanninen, O., Jåvor, T., (eds.) Advances in Physiological Sciences, Vol 15, 1981, Pergamon Press, Oxford, 39-51 Akadémiai Kiadó, Budapest.
124. Szolcsånyi, J., Barthó, L., Capsaicin-sensitive noncholinergic excitatory innervation of the guinea-pig tracheobronchial smooth muscle. Neurosci. Lett. 34 (1982), 247-251.
125. Szolcsånyi, J., Pintér, Systemic antiinflammatory effect induced by antidromic stimulation of dorsal roots in the rat. Abstr. 1st Intern. Meeting European Neuropeptide Club., 1991, Igls/Insbruck 27.
126. Szolcsånyi, J., Jancsó-Gåbor, A., Joó, F., Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin. Naunyn-Schmiedeberg's Arch. Pharmacol. 287 (1975), 157-169.
127. Szolcsånyi, J., Anton, F., Reeh, P.W., Handwerker, H.O., Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res. 446 (1988), 262-268.
128. Szaßolcsånyi, J., Allåsi, Á., Joó, F., Blumberg, P.M., Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J. Pharmacol. Exp. Ther. 225 (1990), 923-928.
129. Szolcsånyi, J., Pintér, E., Pethõ, G., Role of unmyelinated afferents in regulation of microcirculation and its chronic distorsion after trauma and damage. Janig, W., Schmidt, R.F., (eds.) Reflex Sympathetic Dystrophy: Pathophysiological Mechanisms and Clinical Implications., 1992, VCH Verlaggesellschaft, Weinheim, 245-264.
130. Szolcsånyi, J., Pórszåsz, R., Pethõ, G., Capsaicin and pharmacology of nociceptors. Besson, J.M., Guilbaud, G., Ollat, H., (eds.) Peripheral Neurons in Nociception: Physio-pharmacological Aspects., 1994, John Libbey Eurotext, Paris, 109-124.
131. Szolcsånyi, J., Pierau, Fr.-K., Sann, H., Pintér, E., The role of capsaicin-sensitive sensory nerve endings in regulation of cutaneous microcirculation. J. Auton. Nerv. Syst., 1996 to be published.
132. Tillman, D.-B., Treede, R.-D., Meyer, R.A., Campbell, J.N., Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: correlation with pain threshold in humans. J. Physiol. 485 (1995), 767-774.
133. Uvnäs, B., Antidromic vasodilatation in the paw of the cat. Pharmacol. Rev. 6 (1954), 99-101.
134. Vlachovå, V., Vyklicky, L., Capsaicin-induced membrane currents in cultured sensory neurons of the rat. Physiol. Res. 42 (1993), 301-311.
135. Wallengren, J., Hakanson, Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin. Br. J. Dermatol. 126 (1992), 111-117.
136. Walpole, C.S.J., Wrigglesworth, R., Structural requirement for capsaicin agonists and antagonists. Wood, J.N., (eds.) Capsaicin in the Study of Pain, 1993, Academic Press, London, 63-81.
137. Wardell, K., Naver, H.K., Nilsson, G.E., Wallin, B.G., The cutaneous vascular axon reflex in humans characterized by laser Doppler perfusion imaging. J. Physiol. 460 (1993), 185-199.
138. Winning, A.J., Hamilton, R.D., Shea, S.A., Guz, A., Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: Evidence for pulmonary chemosensitivity. Clin. Sci. 71 (1986), 519-526.
139. Winter, J., Characterization of capsaicin-sensitive neurons in adult rat dorsal root ganglion cultures. Neurosci Lett. 80 (1987), 134-140.
140. Wood, J.N., Winter, J., James, J.F., Rang, H.P., Yeats, J., Bevan, S., Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J. Neurosci. 8 (1988), 3208-3220.
141. Zhang, S.Q., Butler, J.M., Cole, D.F., Sensory neural mechanisms in contraction of the rabbit isolated sphincter pupillae: analysis of the response to capsaicin and electrical field stimulation. Exp. Eye Res. 38 (1984), 153-163.